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Outputs (13)

Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable (2018)
Journal Article
Schmitt, J., Lange, T., Kottner, J., Prinsen, C. A. C., Weberschock, T., Hahnel, E., Apfelbacher, C., Brandstetter, S., Dreher, A., Stevens, G., Burden-Teh, E., Rogers, N., Spuls, P., Grainge, M. J., Williams, H. C., Jacobi, L., & Cochrane Skin Core Outcome Set Initiative (CS-COUSIN). (2019). Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable. Journal of Investigative Dermatology, 139(5), 1045-1053. https://doi.org/10.1016/j.jid.2018.11.019

Evidence-based healthcare requires that relevant outcomes for patients are included in clinical trials which investigating treatment effects allowing subsequent systematic reviews to summarize all relevant evidence to guide clinical practice. Current... Read More about Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable.

Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults (2018)
Journal Article
Ferrante di Ruffano, L., Takwoingi, Y., Dinnes, J., Chuchu, N., Bayliss, S. E., Davenport, C., Matin, R. N., Godfrey, K., O'Sullivan, C., Gulati, A., Chan, S. A., Durack, A., O'Connell, S., Gardiner, M. D., Bamber, J., Deeks, J. J., & Williams, H. C. (2018). Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013186. https://doi.org/10.1002/14651858.CD013186

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high‐risk skin cancers which have the potentia... Read More about Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.

Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation? (2018)
Journal Article
Rutter, C., Silverwood, R. J., Williams, H. C., Elwood, P., Asher, I., Garcia-Marcos, L., Strachan, D. P., Pearce, N., Langan, S. M., & ISAAC Phase Three Group. (2019). Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation?. Journal of Investigative Dermatology, 139(5), 1023-1036. https://doi.org/10.1016/j.jid.2018.08.035

Some previously described environmental associations for atopic eczema (AE) may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple AE risk factors.

ISAAC Phase Thre... Read More about Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation?.

Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT (2018)
Journal Article
Santer, M., Rumsby, K., Ridd, M. J., Francis, N. A., Stuart, B., Chorozoglou, M., Roberts, A., Liddiard, L., Nollett, C., Hooper, J., Prude, M., Wood, W., Thomas-Jones, E., Becque, T., Thomas, K. S., Williams, H. C., & Little, P. (2018). Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT. Health Technology Assessment, 22(57), 1-116. https://doi.org/10.3310/hta22570

Plain English Summary
Eczema is very common in children and can have a significant impact, causing itching and sleep problems. The main treatments are emollients, which are used to moisturise the skin, and steroid creams or ointments to treat flare-... Read More about Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.

Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema) (2018)
Journal Article
Stuart, B., Rumsby, K., Santer, M., Ridd, M. J., Francis, N. A., Chorozoglou, M., Spreadbury, C., Steele, M., Nollett, C., Liddiard, L., Prude, M., Hooper, J., Thomas‐Jones, E., Roberts, A., Thomas, K. S., Williams, H. C., & Little, P. (2018). Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema). Trials, 19, Article 582. https://doi.org/10.1186/s13063-018-2962-3

Background: Patient‐reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on outcomes that are important to patients. In relapsing‐remitting conditions such as eczema, repeated measurements may allow a more accu... Read More about Feasibility of weekly participant‐reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema).

Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 (2018)
Journal Article
Steel, N., Ford, J. A., Newton, J. N., Davis, A. C. J., Vos, T., Naghavi, M., Glenn, S., Hughes, A., Dalton, A. M., Stockton, D., Humphreys, C., Dallat, M., Schmidt, J., Flowers, J., Fox, S., Abubakar, I., Aldridge, R. W., Brayne, C., Baker, A., Brugha, T., …Murray, C. J. L. (2018). Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 392(10158), 1647-1661. https://doi.org/10.1016/S0140-6736%2818%2932207-4

Background
Previous studies have reported national and regional Global Burden of Disease (GBD) estimates for the UK. Because of substantial variation in health within the UK, action to improve it requires comparable estimates of disease burden and r... Read More about Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016.

Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18) (2018)
Journal Article
Olivry, T., Bensignor, E., Favrot, C., Griffin, C. E., Hill, P. B., Mueller, R. S., Plant, J. D., & Williams, H. C. (2018). Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18). BMC Veterinary Research, 14, 1-8. https://doi.org/10.1186/s12917-018-1569-y

Background: For decades, the efficacy of interventions in clinical trials enrolling dogs with atopic dermatitis (AD) relied on heterogeneous evaluations of skin lesions and pruritus using unvalidated tools. Although some instruments for clinical sign... Read More about Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18).

What’s new in psoriasis treatment? An analysis of systematic reviews published in 2015 (2018)
Journal Article
Foulkes, A., Ferguson, F., Grindlay, D. J., Williams, H. C., Griffiths, C., & Warren, R. (2018). What’s new in psoriasis treatment? An analysis of systematic reviews published in 2015. Clinical and Experimental Dermatology, 43(7), 759-765. https://doi.org/10.1111/ced.13601

This review provides a summary of key findings from 27 systematic reviews of 51 articles first published or indexed during 2015, focusing on the treatment of psoriasis as well as precision medicine in psoriasis. Evidence supports weight loss interven... Read More about What’s new in psoriasis treatment? An analysis of systematic reviews published in 2015.

Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial (2018)
Journal Article
Haines, R. H., Thomas, K. S., Montgomery, A. A., Ravenscroft, J. C., Akram, P., Chalmers, J., Whitman, D., Duley, L., Eleftheriadou, V., Meakin, G., Mitchell, E., White, J., Rogers, A., Sach, T., Santer, M., Tan, W., Hepburn, T., Williams, H. C., & Batchelor, J. M. (2018). Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial. BMJ Open, 8(4), Article e018649. https://doi.org/10.1136/bmjopen-2017-018649

Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. Vitiligo is often poorly managed, partly due to lack of high quality evide... Read More about Home interventions and light therapy for treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomized controlled trial.