Outputs (16)

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma (2015)
Journal Article
Lilburn, D. M., Tatler, A. L., Six, J. S., Lesbats, C., Habgood, A., Porte, J., …Meersmann, T. (2015). Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma. Magnetic Resonance in Medicine, 76(4), 1224-1235. https://doi.org/10.1002/mrm.26003

© 2015 The Authors. Wiley Periodicals, Inc. Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independen... Read More about Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.

Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer (2015)
Journal Article
Zamberlan, F., Lesbats, C., Rogers, N. J., Krupa, J. L., Pavlovskaya, G. E., Thomas, N. R., …Meersmann, T. (2015). Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16(11), https://doi.org/10.1002/cphc.201500367

A new approach for hyperpolarized 129Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated 129Xe within the vicinity of the paramagn... Read More about Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer.

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema (2015)
Journal Article
Lilburn, D. M., Lesbats, C., Six, J. S., Dubuis, E., Yew-Booth, L., Shaw, D. E., …Meersmann, T. (2015). Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema. Interface, 12(107), Article 20150192. https://doi.org/10.1098/rsif.2015.0192

© 2015 The Authors. Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is... Read More about Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.

Spatial mapping of flow-induced molecular alignment in a noncrystalline biopolymer fluid using double quantum filtered (DQF) 23Na MRI (2014)
Journal Article
Pavlovskaya, G. E., & Meersmann, T. (2014). Spatial mapping of flow-induced molecular alignment in a noncrystalline biopolymer fluid using double quantum filtered (DQF) 23Na MRI. Journal of Physical Chemistry Letters, 5(15), https://doi.org/10.1021/jz501075j

Flow-induced molecular alignment was observed experimentally in a non-liquid- crystalline bioplymeric fluid during developed tubular flow. The fluid was comprised of rigid rods of the polysaccharide xanthan and exhibited shear-thinning behavior. With... Read More about Spatial mapping of flow-induced molecular alignment in a noncrystalline biopolymer fluid using double quantum filtered (DQF) 23Na MRI.

Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications (2013)
Journal Article
Hughes-Riley, T., Six, J. S., Lilburn, D., Stupic, K. F., Dorkes, A. C., Shaw, D. E., …Meersmann, T. (2013). Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications. Journal of Magnetic Resonance, 237, https://doi.org/10.1016/j.jmr.2013.09.008

As an alternative to cryogenic gas handling, hyperpolarized (hp) gas mixtures were extracted directly from the spin exchange optical pumping (SEOP) process through expansion followed by compression to ambient pressure for biomedical MRI applications.... Read More about Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications.

Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr (2013)
Journal Article
Six, J. S., Hughes-Riley, T., Lilburn, D. M., Dorkes, A. C., Stupic, K. F., Shaw, D. E., …Meersmann, T. (2014). Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr. Magnetic Resonance Imaging, 32(1), 48-53. https://doi.org/10.1016/j.mri.2013.08.007

Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarizati... Read More about Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr.