Outputs (96)

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection (2021)
Journal Article
Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. A., Channon, K. M., Mills, N. L., Sheikh, A., & Hippisley-Cox, J. (2022). Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection. Nature Medicine, 28(2), 410-422. https://doi.org/10.1038/s41591-021-01630-0

Although myocarditis and pericarditis were not observed as adverse events in coronavirus disease 2019 (COVID-19) vaccine trials, there have been numerous reports of suspected cases following vaccination in the general population. We undertook a self-... Read More about Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection.

Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection (2021)
Journal Article
Patone, M., Handunnetthi, L., Saatci, D., Pan, J., Katikireddi, S. V., Razvi, S., Hunt, D., Mei, X. W., Dixon, S., Zaccardi, F., Khunti, K., Watkinson, P., Coupland, C. A. C., Doidge, J., Harrison, D. A., Ravanan, R., Sheikh, A., Robertson, C., & Hippisley-Cox, J. (2021). Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection. Nature Medicine, 27(12), 2144-2153. https://doi.org/10.1038/s41591-021-01556-7

Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate hospital admission... Read More about Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.

Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases. British Medical Journal, 374, Article n2182. https://doi.org/10.1136/bmj.n2182

Objective To assess the risks of developing dementia associated with different types and durations of menopausal hormone therapy. Design Two nested case-control studies. Setting UK general practices contributing to QResearch or the Clinical Practice... Read More about Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases.

Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population (2021)
Journal Article
Liao, W., Clift, A. K., Patone, M., Coupland, C., González-Izquierdo, A., Pereira, S., & Cox, J. H. (2021). Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population. British Journal of General Practice, 71(712), e836-e845. https://doi.org/10.3399/bjgp.2021.0153

Background: Pancreatic cancer has the worst survival rate among all cancers. Almost 70% of patients were diagnosed at Stage IV.

Aim: This study aimed to investigate the symptoms associated with the diagnoses of pancreatic ductal adenocarcinoma (P... Read More about Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population.

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study (2021)
Journal Article
Hippisley-Cox, J., Coupland, C. A., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., Lyons, R. A., Kee, F., Sheikh, A., Rahman, S., Valabhji, J., Harrison, E. M., Sellen, P., Haq, N., Semple, M. G., Johnson, P. W. M., Hayward, A., & Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study. BMJ, 374, Article n2244. https://doi.org/10.1136/bmj.n2244

Objectives To derive and validate risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses of covid-19 vaccination. Design Prospective, population based cohort study usin... Read More about Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study.

Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study (2021)
Journal Article
Kellezi, B., Dhiman, P., Coupland, C., Whitehead, J., Morriss, R., Joseph, S., Beckett, K., Sleney, J., Barnes, J., & Kendrick, D. (2022). Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study. Injury Prevention, 28(2), 131-140. https://doi.org/10.1136/injuryprev-2021-044311

Introduction: Mental health conditions are a major contributor to productivity loss and are common post-injury. This study quantifies post-injury productivity loss and its association with pre and post-injury mental health, injury, demographic, healt... Read More about Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study.

Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study (2021)
Journal Article
Hippisley-Cox, J., Patone, M., Mei, X. W., Saatci, D., Dixon, S., Khunti, K., Zaccardi, F., Watkinson, P., Shankar-Hari, M., Doidge, J., Harrison, D. A., Griffin, S. J., Sheikh, A., & Coupland, C. A. C. (2021). Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study. BMJ, 374, Article n1931. https://doi.org/10.1136/bmj.n1931

Objective: To assess the association between covid-19 vaccines and risk of thrombocytopenia and thromboembolic events in England among adults.

Design: Self-controlled case series study using national data on covid-19 vaccination and hospital adm... Read More about Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study.

Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper (2021)
Journal Article
Ranger, T. A., Burchardt, J., Clift, A. K., Mei, W. X., Coupland, C., Tan, P. S., Dixon, S., Cardwell, C. R., & Hippisley-Cox, J. (2021). Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper. BMJ Open, 11(8), Article e046701. https://doi.org/10.1136/bmjopen-2020-046701

Introduction Hormone replacement therapy (HRT) can help women experiencing menopausal symptoms, but usage has declined due to uncertainty around risks of cancer and some cardiovascular diseases (CVD). Moreover, improved cancer survival rates mean tha... Read More about Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper.

Prospective examination of mental health in university students during the COVID-19 pandemic (2021)
Preprint / Working Paper
Jia, R., Knight, H., Ayling, K., Coupland, C., Corner, J., Denning, C., Ball, J., Bolton, K., Morling, J. R., Figueredo, G., Morris, D. E., Tighe, P., Villalon, A., Blake, H., & Vedhara, K. Prospective examination of mental health in university students during the COVID-19 pandemic

Background The impact of changing social restrictions on the mental health of students during the COVID-19 pandemic warrants exploration.

Aims To prospectively examine changes to university students’ mental health during the pandemic.

Methods S... Read More about Prospective examination of mental health in university students during the COVID-19 pandemic.

Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study (2021)
Journal Article
Clift, A. K., Saatci, D., Coupland, C. A., Dambha-Miller, H., Hippisley-Cox, J., & International Investigator Group for Ethnicity and COVID-19. (2021). Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study. Annals of Internal Medicine, 174(10), 1483-1487. https://doi.org/10.7326/M21-1375

Background: Sickle cell disease is a collection of compound heterozygote hemoglobinopathies, including sickle cell anemia (1). The heterozygote hemoglobinopathies are characterized by erythrocyte deformation with hemolysis; immune and coagulation dys... Read More about Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study.