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Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells (2019)
Journal Article
Ahmed, M., Jinks, N., Babaei-Jadidi, R., Kashfi, H., Castellanos-Uribe, M., May, S. T., Mukherjee, A., & Nateri, A. S. (2019). Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells. Cancers, 12(1), Article 106. https://doi.org/10.3390/cancers12010106

Tumour-promoting inflammation is involved in colorectal cancer (CRC) development and therapeutic resistance. However, the antibiotics and antibacterial drugs and signalling that regulate the potency of anticancer treatment upon forced differentiation... Read More about Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells.

Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome (2019)
Journal Article
Yakovlev, I. A., Gackowski, D., Abakir, A., Viejo, M., Ruzov, A., Olinski, R., Starczak, M., Fossdal, C. G., & Krutovsky, K. V. (2019). Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome. Scientific Reports, 9, Article 19314. https://doi.org/10.1038/s41598-019-55826-z

5-Methylcytosine (5mC) is an epigenetic modification involved in regulation of gene expression in metazoans and plants. Iron-(II)/α-ketoglutarate-dependent dioxygenases can oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-c... Read More about Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome.

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells (2019)
Journal Article
Abakir, A., Giles, T. C., Cristini, A., Foster, J. M., Dai, N., Starczak, M., Rubio-Roldan, A., Li, M., Eleftheriou, M., Crutchley, J., Flatt, L., Young, L., Gaffney, D. J., Denning, C., Dalhus, B., Emes, R. D., Gackowski, D., Corrêa, I. R., Garcia-Perez, J. L., Klungland, A., …Ruzov, A. (2020). N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nature Genetics, 52(1), 48-55. https://doi.org/10.1038/s41588-019-0549-x

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single-stranded DNA that represent a source of genomic instability in mammalian cells1–4. Her... Read More about N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.

A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition (2019)
Journal Article
Jayaraman, P.-S., Kitchen, P., Gaston, K., Lee, K. Y., Afford, S., Clark, D., Oltean, S., Lau, N., Satayavivad, J., Lertsuwan, J., & Sawasdichai, A. (2020). A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition. Cancer Research, 80(4), 757-770. https://doi.org/10.1158/0008-5472.can-19-0942

Aberrant Notch and Wnt signalling are known drivers of cholangiocarcinoma (CCA) but the underlying factors that initiate and maintain these pathways are not known. Here we show that the PRH/HHEX transcription factor forms a positive transcriptional f... Read More about A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition.

The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody (2019)
Journal Article
Soliman, C., Chua, J. X., Vankemmelbeke, M., McIntosh, R. S., Guy, A. J., Spendlove, I., Durrant, L. G., & Ramsland, P. A. (2020). The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody. Journal of Biological Chemistry, 295(4), 1009-1020. https://doi.org/10.1074/jbc.ra119.011518

Cancer remains a leading cause of morbidity and mortality worldwide, requiring ongoing development of targeted therapeutics such as monoclonal antibodies. Carbohydrates on embryonic cells are often highly expressed in cancer and are therefore attract... Read More about The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody.

Enhanced glutamine uptake influences composition of immune cell infiltrates in breast cancer (2019)
Journal Article
Ansari, R. E., Craze, M. L., Althobiti, M., Alfarsi, L., Ellis, I. O., Rakha, E. A., & Green, A. R. (2019). Enhanced glutamine uptake influences composition of immune cell infiltrates in breast cancer. British Journal of Cancer, 122(1), 94–101. https://doi.org/10.1038/s41416-019-0626-z

Background: Cancer cells must alter their metabolism to support proliferation. Immune evasion also plays a role in supporting tumour progression. This study aimed to find whether enhanced glutamine uptake in breast cancer (BC) can derive the existenc... Read More about Enhanced glutamine uptake influences composition of immune cell infiltrates in breast cancer.

Short-term integrated rehabilitation for people with newly diagnosed thoracic cancer: a multi-centre randomized controlled feasibility trial (2019)
Journal Article
Bayly, J., Fettes, L., Douglas, E., Douglas, E., Teixiera, M. J., Peat, N., Tunnard, I., Patel, V., Gao, W., Wilcock, A., Higginson, I. J., & Maddocks, M. (2020). Short-term integrated rehabilitation for people with newly diagnosed thoracic cancer: a multi-centre randomized controlled feasibility trial. Clinical Rehabilitation, 34(2), 205-219. https://doi.org/10.1177/0269215519888794

© The Author(s) 2019. Objectives: The main objective of this study is to determine the feasibility of recruiting and retaining patients recently diagnosed with thoracic cancer to a trial of short-term integrated rehabilitation; evaluate uptake of the... Read More about Short-term integrated rehabilitation for people with newly diagnosed thoracic cancer: a multi-centre randomized controlled feasibility trial.

Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients (2019)
Journal Article
Mohammed, R. A. A., El-Deek, H. E.-D. M., Aleskandarany, M. A., Green, A. R., Ellis, I. O., & Rakha, E. A. (2019). Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients. Egyptian Journal of Pathology, 16(1), 115-122. https://doi.org/10.4103/EGJP.EGJP_15_19

Background and aims: Clinicopathological features of Basal-like Breast Cancer (BLBC) in African American women have been extensively studied. Comparatively, less is known about these tumors in patients from countries in the North African region. The... Read More about Clinicopathological Characteristics of Basal-like Breast Cancer (BLBC): a Comparative Study between Egyptian and British Patients.

Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression (2019)
Journal Article
Kotecha, S., Lebot, M. N., Sukkarn, B., Ball, G., Moseley, P. M., Chan, S. Y., Green, A. R., Rakha, E., Ellis, I. O., Martin, S. G., & Storr, S. J. (2019). Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression. Scientific Reports, 9, 1-11. https://doi.org/10.1038/s41598-019-53529-z

Dopamine and cAMP regulated phosphoprotein 32 kDa (DARPP-32) also known as phosphoprotein phosphatase-1 regulatory subunit 1B and encoded by the PPP1R1B gene is an inhibitor of protein phosphatase-1 and protein kinase A. DARPP-32 is expressed in a wi... Read More about Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression.