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Low expression of G protein-coupled oestrogen receptor 1 (GPER) is associated with adverse survival of breast cancer patients (2018)
Journal Article
Martin, S. G., Lebot, M. N., Sukkarn, B., Ball, G., Green, A. R., Rakha, E. A., Ellis, I. O., & Storr, S. J. (2018). Low expression of G protein-coupled oestrogen receptor 1 (GPER) is associated with adverse survival of breast cancer patients. Oncotarget, 9(40), 25946-25956. https://doi.org/10.18632/oncotarget.25408

G protein-coupled oestrogen receptor 1 (GPER), also called G protein-coupled receptor 30 (GPR30), is attracting considerable attention for its potential role in breast cancer development and progression. Activation by oestrogen (17β-oestradiol; E2) i... Read More about Low expression of G protein-coupled oestrogen receptor 1 (GPER) is associated with adverse survival of breast cancer patients.

Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis (2018)
Journal Article
Kurozumi, S., Joseph, C., Sonbul, S., Gorringe, K. L., Pigera, M., Aleskandarany, M. A., Diez-Rodriguez, M., Nolan, C. C., Fujii, T., Shirabe, K., Kuwano, H., Storr, S., Martin, S. G., Ellis, I. O., Green, A. R., & Rakha, E. A. (in press). Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis. Breast Cancer Research and Treatment, 170(3), https://doi.org/10.1007/s10549-018-4777-z

Background: The functions of many proteins are tightly regulated with a complex array of cellular functions including ubiquitination. In cancer cells, aberrant ubiquitination may promote the activity of oncogenic pathways with subsequent tumour progr... Read More about Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis.

High nuclear MSK1 is associated with longer survival in breast cancer patients (2018)
Journal Article
Pu, X., Storr, S. J., Ahmad, N., Rakha, E., Green, A. R., Ellis, I. O., & Martin, S. G. (2018). High nuclear MSK1 is associated with longer survival in breast cancer patients. Journal of Cancer Research and Clinical Oncology, 144(3), https://doi.org/10.1007/s00432-018-2579-7

Purpose: Mitogen- and stress- activated kinases (MSKs) are important substrates of the mitogen-activated protein kinase (MAPK)-activated protein kinase family. MSK1 and MSK2 are both nuclear serine/threonine protein kinases, with MSK1 being suggested... Read More about High nuclear MSK1 is associated with longer survival in breast cancer patients.

Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro (2017)
Journal Article
Storr, S. J., Safuan, S., Ahmad, N., El-Refaee, M., Jackson, A. M., & Martin, S. G. (2017). Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro. Cancer Immunology, Immunotherapy, 66(10), 1287-1294. https://doi.org/10.1007/s00262-017-2020-0

Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis. This study investigates the r... Read More about Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro.

The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy (2016)
Journal Article
Storr, S. J., Zhang, S., Perren, T., Lansdown, M., Fatayer, H., Sharma, N., Gahlaut, R., Shaaban, A., & Martin, S. G. (2016). The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. Oncotarget, 7(30), 47927-47937. https://doi.org/10.18632/oncotarget.10066

The calpains are a family of intracellular cysteine proteases that function in a variety of important cellular functions, including cell signalling, motility, apoptosis and survival. In early invasive breast cancer expression of calpain-1, calpain-2... Read More about The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.

Immunohistochemical Assessment of Leukocyte Involvement in Angiogenesis (2016)
Book Chapter
Ahmad, N. S., Martin, S. G., & Storr, S. J. (2016). Immunohistochemical Assessment of Leukocyte Involvement in Angiogenesis. In Angiogenesis Protocols (49-57). Springer New York. https://doi.org/10.1007/978-1-4939-3628-1_3

Angiogenesis is a hallmark of cancer and is important for tumor growth, development, and metastasis. Leukocytes, including neutrophils, eosinophils, basophils, lymphocytes, and monocytes, are found invading many solid tumors, and this inflammation is... Read More about Immunohistochemical Assessment of Leukocyte Involvement in Angiogenesis.

Lymphovascular invasion assessment and prognostic impact in melanoma and breast cancer (2015)
Journal Article
Thompson, N., Storr, S., Zhang, S., & Martin, S. (2015). Lymphovascular invasion assessment and prognostic impact in melanoma and breast cancer. Histology and Histopathology, 30(9), 1001-1009. https://doi.org/10.14670/HH-11-615

© 2015, Histology and Histopathology. All rights reserved. The presence of lymphovascular invasion is a recognised poor prognostic factor in a wide range of tumour types. Vascular invasion was historically identified through haematoxylin and eosin st... Read More about Lymphovascular invasion assessment and prognostic impact in melanoma and breast cancer.