The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis
(2015)
Journal Article
Parsons, M., Brancaccio, M., Sethi, S., Maywood, E., Satija, R., Edwards, J., Jagannath, A., Couch, Y., Finelli, M., Smyllie, N., Esapa, C., Butler, R., Barnard, A., Chesham, J., Saito, S., Joynson, G., Wells, S., Foster, R., Oliver, P., Simon, M., …Nolan, P. (2015). The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis. Cell, 162(3), 607-621. https://doi.org/10.1016/j.cell.2015.06.060
Outputs (19)
Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations (2015)
Journal Article
Finelli, M. J., Liu, K. X., Wu, Y., Oliver, P. L., & Davies, K. E. (2015). Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations. Human Molecular Genetics, 24(12), 3529-3544. https://doi.org/10.1093/hmg/ddv104Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neuron-like cells. Mutations in the RNA- and DNA-binding proteins, fused in sarcoma (FUS) and transactive response DNA-binding protein 43 kDa (TDP-4... Read More about Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.
Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis (2015)
Journal Article
Liu, K. X., Edwards, B., Lee, S., Finelli, M. J., Davies, B., Davies, K. E., & Oliver, P. L. (2015). Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis. Brain, 138(5), 1167-1181. https://doi.org/10.1093/brain/awv039
Laf4/Aff3, a Gene Involved in Intellectual Disability, Is Required for Cellular Migration in the Mouse Cerebral Cortex (2014)
Journal Article
Moore, J. M., Oliver, P. L., Finelli, M. J., Lee, S., Lickiss, T., Molnár, Z., & Davies, K. E. (2014). Laf4/Aff3, a Gene Involved in Intellectual Disability, Is Required for Cellular Migration in the Mouse Cerebral Cortex. PLoS ONE, 9(8), 1-11. https://doi.org/10.1371/journal.pone.0105933Members of the AFF (AF4/FMR2) family of putative transcription factors are involved in infant acute leukaemia and intellectual disability (ID), although very little is known about their transcriptional targets. For example, deletion of human lymphoid... Read More about Laf4/Aff3, a Gene Involved in Intellectual Disability, Is Required for Cellular Migration in the Mouse Cerebral Cortex.
Epigenetic Regulation of Sensory Axon Regeneration after Spinal Cord Injury (2013)
Journal Article
Finelli, M. J., Wong, J. K., & Zou, H. (2013). Epigenetic Regulation of Sensory Axon Regeneration after Spinal Cord Injury. Journal of Neuroscience, 33(50), 19664-19676. https://doi.org/10.1523/jneurosci.0589-13.2013Axon regeneration is hindered by a decline of intrinsic axon growth capability in mature neurons. Reversing this decline is associated with the induction of a large repertoire of regeneration-associated genes (RAGs), but the underlying regulatory mec... Read More about Epigenetic Regulation of Sensory Axon Regeneration after Spinal Cord Injury.
Differential Phosphorylation of Smad1 Integrates BMP and Neurotrophin Pathways through Erk/Dusp in Axon Development (2013)
Journal Article
Finelli, M., Murphy, K., Chen, L., & Zou, H. (2013). Differential Phosphorylation of Smad1 Integrates BMP and Neurotrophin Pathways through Erk/Dusp in Axon Development. Cell Reports, 3(5), 1592-1606. https://doi.org/10.1016/j.celrep.2013.04.011Sensory axon development requires concerted actions of growth factors for the precise control of axonal outgrowth and target innervation. How developing sensory neurons integrate different cues is poorly understood. We demonstrate here that Smad1 act... Read More about Differential Phosphorylation of Smad1 Integrates BMP and Neurotrophin Pathways through Erk/Dusp in Axon Development.
The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy (2013)
Journal Article
Carroll, B., Mohd-Naim, N., Maximiano, F., Frasa, M., McCormack, J., Finelli, M., Thoresen, S., Perdios, L., Daigaku, R., Francis, R., Futter, C., Dikic, I., & Braga, V. (2013). The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy. Developmental Cell, 25(1), 15-28. https://doi.org/10.1016/j.devcel.2013.03.005
Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration (2011)
Journal Article
Oliver, P. L., Finelli, M. J., Edwards, B., Bitoun, E., Butts, D. L., Becker, E. B. E., Cheeseman, M. T., Davies, B., & Davies, K. E. (2011). Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration. PLoS Genetics, 7(10), Article e1002338. https://doi.org/10.1371/journal.pgen.1002338Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Ox... Read More about Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration.
AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development (2009)
Journal Article
Bitoun, E., Finelli, M. J., Oliver, P. L., Lee, S., & Davies, K. E. (2009). AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development. Journal of Neuroscience, 29(49), 15366-15374. https://doi.org/10.1523/jneurosci.5188-09.2009Deregulation of the insulin-like growth factor 1 (IGF-1) signaling pathway is a recurrent finding in mouse models and human patients with cerebellar ataxia and thus represents a common pathological cascade in neuronal cell death that may be targeted... Read More about AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development.