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Outputs (71)

Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion (2016)
Journal Article
Gaston, K., Tsitsilianos, M.-A., Wadey, K. S., & Jayaraman, P.-S. (2016). Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion. Cell and Bioscience, 6, Article 12. https://doi.org/10.1186/s13578-016-0077-7

The Proline Rich Homeodomain protein (PRH), also known as Haematopoietically Expressed homeobox (HHEX), is an essential transcription factor in embryonic development and in the adult. The PRH protein forms oligomeric complexes that bind to tandemly r... Read More about Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion.

Novel mechanisms of resistance to vemurafenib in melanoma – V600E B-Raf reversion and switching VEGF-A splice isoform expression (2014)
Journal Article
Beazley Long, N., Gaston, K., Harper, S. J., Orlando, A., & Bates, D. O. (2015). Novel mechanisms of resistance to vemurafenib in melanoma – V600E B-Raf reversion and switching VEGF-A splice isoform expression. American Journal of Cancer Research, 5(1), 433--441

Targeting activating mutations in the proto-oncogene B-Raf, in melanoma, has led to increases in progression free survival. Treatment with vemurafenib, which inhibits the most common activating-mutated form of B-Raf (B-RafV600E), eventually results i... Read More about Novel mechanisms of resistance to vemurafenib in melanoma – V600E B-Raf reversion and switching VEGF-A splice isoform expression.

Proline Rich Homeodomain (PRH/HHEX) protein in the control of haematopoiesis and myeloid cell proliferation and its potential as a therapeutic target in myeloid leukaemias and other cancers. (2013)
Book Chapter
Kershaw, R., Gaston, K., & Jayaraman, P. (2013). Proline Rich Homeodomain (PRH/HHEX) protein in the control of haematopoiesis and myeloid cell proliferation and its potential as a therapeutic target in myeloid leukaemias and other cancers. In S. Douglas (Ed.), Myeloid cells: biology & regulation, role in cancer progression and potential implications for therapy. NOVA Publishers

PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin (2013)
Journal Article
Kershaw, R. M., Siddiqui, Y. H., Roberts, D., Jayaraman, P.-S., & Gaston, K. (2014). PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin. Oncogene, 33, 5592-5600. https://doi.org/10.1038/onc.2013.496

PRH/HHex (proline-rich homeodomain protein) is a transcription factor that controls cell proliferation and cell differentiation in a variety of tissues. Aberrant subcellular localisation of PRH is associated with breast cancer and thyroid cancer. Fur... Read More about PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.

The regulation of human papillomavirus gene expression by the E2 protein: keeping a finger in every pie (2012)
Book Chapter
Graham, S. V., & Gaston, K. L. (2012). The regulation of human papillomavirus gene expression by the E2 protein: keeping a finger in every pie. In K. Gaston (Ed.), Small DNA tumour viruses (37--53). Caister Academic Press

The human papillomavirus (HPV) genome is around 8000 base pairs in length and it encodes only eight proteins, a limited number of protein isoforms and no known microRNAs. Despite this relative paucity of genes and gene products these viruses are high... Read More about The regulation of human papillomavirus gene expression by the E2 protein: keeping a finger in every pie.

Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes (2012)
Journal Article
Noy, P., Gaston, K., & Jayaraman, P.-S. (2012). Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes. Leukemia Research, 36(11), 1434-1437. https://doi.org/10.1016/j.leukres.2012.07.013

The PRH/Hhex transcription factor represses multiple genes in the VEGF signalling pathway (VSP) to inhibit myeloid cell survival. Protein kinase CK2 phosphorylates PRH and counteracts the inhibitory effect of this protein on cell survival by blocking... Read More about Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes.

Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival (2012)
Journal Article
Noy, P., Sawasdichai, A., Jayaraman, P.-S., & Gaston, K. (2012). Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival. Nucleic Acids Research, 40(18), 9008--9020. https://doi.org/10.1093/nar/gks687

Protein kinase CK2 promotes cell survival and the activity of this kinase is elevated in several cancers including chronic myeloid leukaemia. We have shown previously that phosphorylation of the Proline-Rich Homeodomain protein (PRH/Hhex) by CK2 inhi... Read More about Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival.

The proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation (2012)
Journal Article
Shukla, A., Burton, N. M., Jayaraman, P.-S., & Gaston, K. (2012). The proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation. PLoS ONE, 7(4), Article e35984. https://doi.org/10.1371/journal.pone.0035984

Background: Many transcription factors control gene expression by binding to specific DNA sequences at or near the genes that they regulate. However, some transcription factors play more global roles in the control of gene expression by altering the... Read More about The proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation.