Outputs (198)

Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer (2014)
Journal Article
Rakha, E., Soria, D., Green, A. R., Lemetre, C., Powe, D. G., Nolan, C. C., Garibaldi, J. M., Ball, G., & Ellis, I. O. (2014). Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer. British Journal of Cancer, 110(7), https://doi.org/10.1038/bjc.2014.120

Current management of breast cancer (BC) relies on risk stratification based on well-defined clinicopathologic factors. Global gene expression profiling studies have demonstrated that BC comprises distinct molecular classes with clinical relevance. I... Read More about Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer.

SUMOylation proteins in breast cancer (2014)
Journal Article
Alshareeda, A. T., Negm, O. H., Green, A. R., Nolan, C., Tighe, P., Albarakati, N., Sultana, R., Madhusudan, S., Ellis, I. O., & Rakha, E. A. (2014). SUMOylation proteins in breast cancer. Breast Cancer Research and Treatment, 144(3), 519-530. https://doi.org/10.1007/s10549-014-2897-7

Small Ubiquitin-like Modifier proteins (or SUMO) modify the function of protein substrates involved in various cellular processes including DNA damage response (DDR). It is becoming apparent that dysregulated SUMO contribute to carcinogenesis by affe... Read More about SUMOylation proteins in breast cancer.

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay (2014)
Journal Article
Barros, F. F., Abdel-Fatah, T. M., Moseley, P., Nolan, C. C., Durham, A. C., Rakha, E. A., Chan, S., Ellis, I. O., & Green, A. R. (2014). Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay. Breast Cancer Research and Treatment, 144(2), 273-285. https://doi.org/10.1007/s10549-014-2871-4

HER2 plays an important role in breast cancer progression and provides predictive and prognostic information. HER2 receptor family members function through dimerisation, which can lead to impact on cell function, growth and differentiation; however,... Read More about Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay.

The updated ASCO/CAP guideline recommendations for HER2 testing in the management of invasive breast cancer: a critical review of their implications for routine practice (2014)
Journal Article
Rakha, E. A., Starczynski, J., Lee, A. H. S., & Ellis, I. O. (2014). The updated ASCO/CAP guideline recommendations for HER2 testing in the management of invasive breast cancer: a critical review of their implications for routine practice. Histopathology, 64(5), 609-615. https://doi.org/10.1111/his.12357

Updated guideline recommendations for HER2 testing (2013)
Journal Article
Rakha, E. A., & Ellis, I. O. (2014). Updated guideline recommendations for HER2 testing. Nature Reviews Clinical Oncology, 11(1), 8-9. https://doi.org/10.1038/nrclinonc.2013.230

PIASγ expression in relation to clinicopathological, tumour factors and survival in indigenous black breast cancer women (2013)
Journal Article
Agboola, A., Musa, A., Banjo, A., Ayoade, B., Deji-Agboola, M., Nolan, C., Rakha, E., Ellis, I., & Green, A. (2014). PIASγ expression in relation to clinicopathological, tumour factors and survival in indigenous black breast cancer women. Journal of Clinical Pathology, 67(4), 301-306. https://doi.org/10.1136/jclinpath-2013-201658

Aim: Indigenous black women with breast cancer (BC) show a high frequency of triple negative breast cancer (TNBC) comprising ER-, PR- and HER2- phenotypes and BRCA1 deficiency together with a high mortality rate, prompting speculation that risk facto... Read More about PIASγ expression in relation to clinicopathological, tumour factors and survival in indigenous black breast cancer women.

C-Met in invasive breast cancer: is there a relationship with the basal-like subtype? (2013)
Journal Article
Ho-Yen, C. M., Green, A. R., Brentnall, A. R., Rakha, E. A., Ellis, I. O., Kermorgant, S., & Jones, J. L. (2014). C-Met in invasive breast cancer: is there a relationship with the basal-like subtype?. Cancer, 120(2), 163-171. https://doi.org/10.1002/cncr.28386

BACKGROUND

Basal‐like (BL) breast cancer is an aggressive form of breast cancer with limited treatment options. Recent work has identified BL breast cancer as a biologically distinct form of triple‐negative breast cancer, with a worse outlook. The... Read More about C-Met in invasive breast cancer: is there a relationship with the basal-like subtype?.

Clinicopathological and molecular significance of Sumolyation marker (ubiquitin conjugating enzyme 9 (UBC9)) expression in breast cancer of black women (2013)
Journal Article
Agboola, A. J., Musa, A., Ayoade, B., Banjo, A., Anunobi, C., Deji-Agboola, A., Rakha, E., Nolan, C., Ellis, I., & Green, A. (2014). Clinicopathological and molecular significance of Sumolyation marker (ubiquitin conjugating enzyme 9 (UBC9)) expression in breast cancer of black women. Pathology - Research and Practice, 210(1), 10-17. https://doi.org/10.1016/j.prp.2013.09.011

The majority of breast cancers (BC) in Nigerian women are triple negative and show breast cancer-associated gene 1 (BRCA1) deficiency as well as the basal like phenotype, with a high mortality rate. In contrast to the well-defined predictive factors... Read More about Clinicopathological and molecular significance of Sumolyation marker (ubiquitin conjugating enzyme 9 (UBC9)) expression in breast cancer of black women.