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A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation (2016)
Journal Article
Williams, N. C., Johnson, M. A., Shaw, D. E., Spendlove, I., Vulevic, J., Sharpe, G. R., & Hunter, K. A. (2016). A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation. British Journal of Nutrition, 116(5), 798-804. https://doi.org/10.1017/S0007114516002762

Gut microbes have a substantial influence on systemic immune function and allergic sensitisation. Manipulation of the gut microbiome through prebiotics may provide a potential strategy to influence the immunopathology of asthma. This study investigat... Read More about A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation.

Can human pluripotent stem cell-derived cardiomyocytes advance understanding of muscular dystrophies? (2016)
Journal Article
Kalra, S., Montanaro, F., & Denning, C. (2016). Can human pluripotent stem cell-derived cardiomyocytes advance understanding of muscular dystrophies?. Journal of Neuromuscular Diseases, 3(3), 309-332. https://doi.org/10.3233/JND-150133

Muscular dystrophies (MDs) are clinically and molecularly a highly heterogeneous group of single-gene disorders that primarily affect striated muscles. Cardiac disease is present in several MDs where it is an important contributor to morbidity and mo... Read More about Can human pluripotent stem cell-derived cardiomyocytes advance understanding of muscular dystrophies?.

Papillary carcinoma of the breast: diagnostic agreement and management implications (2016)
Journal Article
Rakha, E. A., Ahmed, M. A., & Ellis, I. O. (2016). Papillary carcinoma of the breast: diagnostic agreement and management implications. Histopathology, 69(5), 862-870. doi:10.1111/his.13009

Aims Papillary carcinoma (PC), which is a rare type of breast cancer, comprises a heterogeneous group of tumours. The diagnostic categorization of PC as in?situ and invasive disease remains a matter of debate with respect to interpretation of its ov... Read More about Papillary carcinoma of the breast: diagnostic agreement and management implications.

Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression (2016)
Journal Article
Stepanova, V., Jayaraman, P., Zaitsev, S. V., Lebedeva, T., Bdeir, K., Kershaw, R., …Cines, D. B. (2016). Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression. Journal of Biological Chemistry, 291(29), 15029-15045. https://doi.org/10.1074/jbc.m115.678490

Urokinase-type plasminogen activator (uPA) regulates angiogenesis and vascular permeability through proteolytic degradation of extracellular matrix and intracellular signaling initiated upon its binding to uPAR/CD87 and other cell surface receptors.... Read More about Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression.

Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture (2016)
Journal Article
Pijuan-Galitó, S., Tamm, C., Schuster, J., Sobol, M., Forsberg, L., Merry, C. L., & Annerén, C. (2016). Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture. Nature Communications, 7, 1-12. https://doi.org/10.1038/ncomms12170

Reliable, scalable and time-efficient culture methods are required to fully realize the clinical and industrial applications of human pluripotent stem (hPS) cells. Here we present a completely defined, xeno-free medium that supports long-term propaga... Read More about Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture.

Overexpression of specific CD44 isoforms is associated with aggressive cell features in acquired endocrine resistance (2016)
Journal Article
Bellerby, R., Smith, C., Kyme, S., Gee, J., Günthert, U., Green, A., …Hiscox, S. (2016). Overexpression of specific CD44 isoforms is associated with aggressive cell features in acquired endocrine resistance. Frontiers in Oncology, 6, Article 145. https://doi.org/10.3389/fonc.2016.00145

While endocrine therapy is the mainstay of ER+ breast cancer, the clinical effectiveness of these agents is limited by the phenomenon of acquired resistance that is associated with disease relapse and poor prognosis. Our previous studies revealed tha... Read More about Overexpression of specific CD44 isoforms is associated with aggressive cell features in acquired endocrine resistance.

The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy (2016)
Journal Article
Storr, S. J., Zhang, S., Perren, T., Lansdown, M., Fatayer, H., Sharma, N., …Martin, S. G. (2016). The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. Oncotarget, 7(30), 47927-47937. https://doi.org/10.18632/oncotarget.10066

The calpains are a family of intracellular cysteine proteases that function in a variety of important cellular functions, including cell signalling, motility, apoptosis and survival. In early invasive breast cancer expression of calpain-1, calpain-2... Read More about The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.

SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade (2016)
Journal Article
Xue, W., Metheringham, R. L., Brentville, V. A., Gunn, B., Symonds, P., Yagita, H., …Durrant, L. (2016). SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade. OncoImmunology, 5(6), Article e1169353. https://doi.org/10.1080/2162402X.2016.1169353

Checkpoint blockade has demonstrated promising antitumor responses in approximately 10-40% of patients. However, the majority of patients do not make a productive immune response to their tumors and do not respond to checkpoint blockade. These patien... Read More about SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade.

SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis (2016)
Journal Article
Abdel-Fatah, T. M., Agarwal, D., Liu, D., Russell, R., Rueda, O. M., Liu, K., …Chan, S. Y. (2016). SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis. Lancet Oncology, 17(7), 1004-1018. https://doi.org/10.1016/S1470-2045%2816%2900174-1

Background: Proliferation markers and profiles have been recommended for guiding the choice of systemic treatments for breast cancer. However, the best molecular marker or test to use has not yet been identified. We did this study to identify factors... Read More about SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis.