Outputs (71)

Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer (2001)
Journal Article

Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix, a disease responsible for at least 200,000 deaths per year worldwide. Over 100 different types of HPV have been identified and these can... Read More about Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer.

Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins (2001)
Journal Article

Human papillomavirus (HPV) type 16 infects the genital tract and is generally acknowledged to be a causative agent of cervical cancer. HPV infection alone is not sufficient to induce cervical cancer and other factors such as steroid hormones are thou... Read More about Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins.

Methods of Inducing Cell Death (2000)
Other

Investigation of human T cell responses to HPV16 E2 (2000)
Conference Proceeding

The E2 proteins from high-risk and low-risk papillomaviruses differ in their ability to induce apoptotic cell death (2000)
Presentation / Conference

Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors (2000)
Journal Article

The human Surf-1 and Surf-2 genes are divergently transcribed and share a single bi-directional promoter. The addition of serum growth factors to serum-starved cells activates transcription in the Surf-1 direction, but has no effect on transcription... Read More about Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors.

The HPV 16 E2 protein induces p53-dependent apoptosis (2000)
Presentation / Conference

The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway (2000)
Journal Article

The human papillomavirus (HPV) E2 protein regulates viral gene expression and is also required for viral replication. HPV-transformed cells often contain chromosomally integrated copies of the HPV genome in which the viral E2 gene is disrupted. We ha... Read More about The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.

Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites (1999)
Journal Article

The human papillomavirus 16 E2 protein binds to four specific DNA sequences present within the HPV 16 genome and regulates viral gene expression and DNA replication. However, the E2 protein can also bind tightly to non-specific DNA sequences. Here, w... Read More about Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites.

Cellular transcirption factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein (1999)
Journal Article

Human papillomavirus type 16 (HPV-16) is a DNA tumour virus that has been implicated in the development of cervical cancer. The HPV-16 E2 protein binds to four sites that are present upstream of the viral P97 promoter and regulates transcription of t... Read More about Cellular transcirption factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein.