Outputs (44)

Multiple sclerosis between genetics and infections: human endogenous retroviruses in monocytes and macrophages (2015)
Journal Article
Morandi, E., Tarlinton, R., & Gran, B. (2015). Multiple sclerosis between genetics and infections: human endogenous retroviruses in monocytes and macrophages. Frontiers in Immunology, 6, https://doi.org/10.3389/fimmu.2015.00647

The etiology of multiple sclerosis (MS) is still unknown, but there is strong evidence that genetic predisposition associated with environmental factors can trigger the disease. An estimated 30 million years ago, exogenous retroviruses are thought to... Read More about Multiple sclerosis between genetics and infections: human endogenous retroviruses in monocytes and macrophages.

Causal role of motor simulation in turn-taking behavior (2015)
Journal Article
Hadley, L. V., Novembre, G., Keller, P. E., & Pickering, M. J. (2015). Causal role of motor simulation in turn-taking behavior. Journal of Neuroscience, 35(50), 16516-16520. https://doi.org/10.1523/JNEUROSCI.1850-15.2015

© 2015 the authors. Overlap between sensory and motor representations has been documented for a range of human actions, from grasping (Rizzolatti et al., 1996b) to playing a musical instrument (Novembre and Keller, 2014). Such overlap suggests that i... Read More about Causal role of motor simulation in turn-taking behavior.

Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis (2015)
Journal Article
Krishnan, K., Scutt, P., Woodhouse, L. J., Adami, A., Becker, J. L., Berge, E., …Bath, P. M. (in press). Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis. Stroke, 47(1), 44-52. https://doi.org/10.1161/strokeaha.115.010368

Background and purpose: The Efficacy of Nitric oxide in Stroke (ENOS) trial found that transdermal glyceryl trinitrate (GTN, a nitric oxide donor) lowered blood pressure but did not improve functional outcome in patients with acute stroke. However, G... Read More about Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis.

Prevalence and risk factors for reduced sound tolerance (hyperacusis) in children (2015)
Journal Article
BAGULEY, D., HALL, A., HUMPHRISS, R., PARKER, M., & STEER, C. (2016). Prevalence and risk factors for reduced sound tolerance (hyperacusis) in children. International Journal of Audiology, 55(3), 135-141. https://doi.org/10.3109/14992027.2015.1092055

Objective: To estimate the prevalence of reduced sound tolerance (hyperacusis) in a UK population of 11-year-old children and examine the association of early life and auditory risk factors with report of hyperacusis. Design: A prospective UK populat... Read More about Prevalence and risk factors for reduced sound tolerance (hyperacusis) in children.

Effect of culture medium on propagation and phenotype of corneal stroma-derived stem cells (2015)
Journal Article
Sidney, L. E., Branch, M. J., Dua, H. S., & Hopkinson, A. (2015). Effect of culture medium on propagation and phenotype of corneal stroma-derived stem cells. Cytotherapy, 17(12), https://doi.org/10.1016/j.jcyt.2015.08.003

Background: The limbal area of the corneal stroma has been identified as a source of mesenchymal-like stem cells, which have potential for exploitation as a cell therapy. However, the optimal culture conditions are disputed and few direct media compa... Read More about Effect of culture medium on propagation and phenotype of corneal stroma-derived stem cells.

A nondestructive method to distinguish the internal constituent architecture of the intervertebral discs using 9.4 tesla magnetic resonance imaging (2015)
Journal Article
Wijayathunga, V. N., Ridgway, J. P., Ingham, E., Treanor, D., Carey, D., Bulpitt, A., …Wilcox, R. K. (2015). A nondestructive method to distinguish the internal constituent architecture of the intervertebral discs using 9.4 tesla magnetic resonance imaging. Spine, 40(24), E1315-E1322. https://doi.org/10.1097/BRS.0000000000001075

Study Design. An in vitro study of the intervertebral disc (IVD) structure using 9.4T magnetic resonance imaging (MRI). Objective. Investigate the potential of ultrahigh-field strength MRI for higher quality 3-dimensional (3D) volumetric MRI datasets... Read More about A nondestructive method to distinguish the internal constituent architecture of the intervertebral discs using 9.4 tesla magnetic resonance imaging.

Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway (2015)
Journal Article
Zhang, Y., Li, X., Ciric, B., Ma, C. G., Gran, B., Rostami, A., & Zhang, G. X. (2015). Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway. Scientific Reports, 5, Article 17407. https://doi.org/10.1038/srep17407

Natural compounds derived from medicinal plants have long been considered a rich source of novel therapeutic agents. Baicalin (Ba) is a bioactive flavonoid compound derived from the root of Scutellaria baicalensis, an herb widely used in traditional... Read More about Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway.

Surgical caseload and the risk of surgical Never Events in England (2015)
Journal Article
Moppett, I., & Moppett, S. (2015). Surgical caseload and the risk of surgical Never Events in England. Anaesthesia, 71(1), https://doi.org/10.1111/anae.13290

Never Events are medical errors that are believed to be preventable with appropriate measures. We surveyed all English acute NHS trusts to determine the number of surgical Never Events and surgical caseload for 2011–2014. There were 742 surgically re... Read More about Surgical caseload and the risk of surgical Never Events in England.

Current reported outcome domains in studies of adults with a focus on the treatment of tinnitus: protocol for a systematic review (2015)
Journal Article
Hall, D. A., Szczepek, A., & Kennedy, V. (2015). Current reported outcome domains in studies of adults with a focus on the treatment of tinnitus: protocol for a systematic review. BMJ Open, 5, Article e009091. https://doi.org/10.1136/bmjopen-2015-009091

Introduction: In Europe alone, over 70 million people experience tinnitus. Despite its considerable socioeconomic relevance, progress in developing successful treatments has been limited. Clinical effectiveness is judged according to change in primar... Read More about Current reported outcome domains in studies of adults with a focus on the treatment of tinnitus: protocol for a systematic review.

Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST) (2015)
Journal Article
Scutt, P., Blackburn, D., Krishnan, K., Ballard, C., Burns, A., Ford, G. A., …Bath, P. M. (2015). Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST). Trials, 16(1), Article 509. https://doi.org/10.1186/s13063-015-1033-2

Background A common complication after stroke is development of cognitive impairment and dementia. However, effective strategies for reducing the risk of developing these problems remain undefined. Potential strategies include intensive lowering o... Read More about Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST).