Outputs (1067)

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review (2022)
Journal Article
Markus, H. S., Van Der Flier, W. M., Smith, E. E., Bath, P., Biessels, G. J., Briceno, E., …Dichgans, M. (2022). Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review. JAMA Neurology, https://doi.org/10.1001/jamaneurol.2022.2262

Importance: Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology. Disease me... Read More about Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.

Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study (2022)
Journal Article
Ellis, R., Laviola, M., Stolady, D., Valentine, R. L., Pillai, A., & Hardman, J. G. (2022). Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study. British Journal of Anaesthesia, 129(4), 581-587. https://doi.org/10.1016/j.bja.2022.06.021

Background Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to... Read More about Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study.

The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack (2022)
Journal Article
McDermott, J. H., Leach, M., Sen, D., Smith, C. J., Newman, W. G., & Bath, P. M. (2022). The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack. Expert Review of Clinical Pharmacology, 15, 811-825. https://doi.org/10.1080/17512433.2022.2108401

Introduction: Clopidogrel is an antiplatelet agent recommended for secondary prevention of ischemic stroke (IS) and transient ischemic attack (TIA). Conversion of clopidogrel to its active metabolite by hepatic cytochrome P450-2C19 (CYP2C19) is essen... Read More about The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack.

Opt-in HIV testing in construction workplaces: an exploration of its suitability, using the socioecological framework (2022)
Journal Article
Somerset, S., Jones, W., Evans, C., Cirelli, C., Mbang, D., & Blake, H. (2022). Opt-in HIV testing in construction workplaces: an exploration of its suitability, using the socioecological framework. BMC Public Health, 22(1), Article 1409. https://doi.org/10.1186/s12889-022-13787-5

Background: Late diagnosis of HIV remains a challenge, despite improved testing and treatment. Testing is often targeted at high-risk groups; workplace events might normalise testing and allow access to a wider population. The construction workforce... Read More about Opt-in HIV testing in construction workplaces: an exploration of its suitability, using the socioecological framework.

Conversation success in one-to-one and group conversation: a group concept mapping study of adults with normal and impaired hearing (2022)
Journal Article
Nicoras, R., Gotowiec, S., V Hadley, L., Smeds, K., & Naylor, G. (2023). Conversation success in one-to-one and group conversation: a group concept mapping study of adults with normal and impaired hearing. International Journal of Audiology, 62(9), 868-876. https://doi.org/10.1080/14992027.2022.2095538

Objective: The concept of conversation success is undefined, although prior work has variously related it to accurate exchange of information, alignment between interlocutors, and good management of misunderstandings. This study aimed (1) to identify... Read More about Conversation success in one-to-one and group conversation: a group concept mapping study of adults with normal and impaired hearing.

Evaluation of opt-in HIV testing in the construction workplace using the socioecological framework (2022)
Journal Article
Blake, H., Somerset, S., Jones, W., Evans, C., Cirelli, C., & Mbang, D. (2022). Evaluation of opt-in HIV testing in the construction workplace using the socioecological framework. European Journal of Public Health, 32(Supplement_3), Article 1409. https://doi.org/10.1093/eurpub/ckac129.473

Background Late diagnosis of HIV remains a challenge and the construction workforce has several risk factors for HIV. In the Test@Work programme, we delivered HIV tests embedded within a general health check to construction workers, with high uptake... Read More about Evaluation of opt-in HIV testing in the construction workplace using the socioecological framework.

Potential Diagnostic Applications of Multi-Delay Arterial Spin Labeling in Early Alzheimer’s Disease: The Chinese Imaging, Biomarkers, and Lifestyle Study (2022)
Journal Article
Sun, M., Wang, Y. L., Li, R., Jiang, J., Zhang, Y., Li, W., …Xu, J. (2022). Potential Diagnostic Applications of Multi-Delay Arterial Spin Labeling in Early Alzheimer’s Disease: The Chinese Imaging, Biomarkers, and Lifestyle Study. Frontiers in Neuroscience, 16, Article 934471. https://doi.org/10.3389/fnins.2022.934471

Background: Cerebral blood flow (CBF) alterations are involved in the onset and progression of Alzheimer’s disease (AD) and can be a potential biomarker. However, CBF measured by single-delay arterial spin labeling (ASL) for discrimination of mild co... Read More about Potential Diagnostic Applications of Multi-Delay Arterial Spin Labeling in Early Alzheimer’s Disease: The Chinese Imaging, Biomarkers, and Lifestyle Study.

What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol (2022)
Journal Article
Broome, E., Meyer, C., Church, P., & Henshaw, H. (2022). What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol. BMJ Open, 12(7), Article e059836. https://doi.org/10.1136/bmjopen-2021-059836

INTRODUCTION: Hearing aids are the gold standard treatment to help manage hearing loss. However, not everyone who needs them has them, and of those who do, a significant proportion of people do not use them at all, or use them infrequently. Despite l... Read More about What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol.

What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol (2022)
Journal Article
Broome, E., Meyer, C., Church, P., & Henshaw, H. (2022). What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol. BMJ Open, 12(7), Article e059836. https://doi.org/10.1136/bmjopen-2021-059836

Introduction Hearing aids are the gold standard treatment to help manage hearing loss. However, not everyone who needs them has them, and of those who do, a significant proportion of people do not use them at all, or use them infrequently. Despite li... Read More about What factors are important to whom in what context, when adults are prescribed hearing aids for hearing loss? A realist review protocol.

Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells (2022)
Journal Article
Kadir, R. R. A., Alwjwaj, M., & Bayraktutan, U. (2022). Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells. Metabolic Brain Disease, https://doi.org/10.1007/s11011-022-01041-1

Outgrowth endothelial cells (OECs) provide an endogenous repair mechanism and thus maintain endothelial barrier integrity. As inhibition of protein kinase C-β (PKC-β) activity has been shown to attenuate endothelial damage in various pathological con... Read More about Protein kinase C-β distinctly regulates blood-brain barrier-forming capacity of Brain Microvascular endothelial cells and outgrowth endothelial cells.