Outputs (2)

A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial (2019)
Journal Article
Hall, D., Ray, J., Watson, J., Sharman, A., Hutchison, J., Harris, P., Daniel, M., Millar, B., & Large, C. H. (2019). A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial. Hearing Research, 377, 153-166. https://doi.org/10.1016/j.heares.2019.03.018

AUT00063 is an experimental new medicine that has been demonstrated to suppress spontaneous hyperactivity by modulating the action of voltage-gated potassium-channels in central auditory cortical neurons of a rodent model. This neurobiological proper... Read More about A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial.

Recruiting ENT and audiology patients into pharmaceutical trials: evaluating the multi-center experience in the UK and USA (2018)
Journal Article
Sanchez, V. A., Hall, D. A., Millar, B., Escabi, C. D., Sharman, A., Watson, J., Thasma, S., & Harris, P. (in press). Recruiting ENT and audiology patients into pharmaceutical trials: evaluating the multi-center experience in the UK and USA. International Journal of Audiology, https://doi.org/10.1080/14992027.2018.1425002

Objective: Recruiting into clinical trials on time and on target is a major challenge, and yet often goes unreported. This study evaluated the adjustment to procedures, recruitment, and screening methods in two multi-center pharmaceutical randomized... Read More about Recruiting ENT and audiology patients into pharmaceutical trials: evaluating the multi-center experience in the UK and USA.