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Outputs (12)

Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT (2022)
Journal Article
Maheshwari, A., Bari, V., Bell, J. L., Bhattacharya, S., Bhide, P., Bowler, U., Brison, D., Child, T., Chong, H. Y., Cheong, Y., Cole, C., Coomarasamy, A., Cutting, R., Goodgame, F., Hardy, P., Hamoda, H., Juszczak, E., Khalaf, Y., King, A., Kurinczuk, J. J., …Troup, S. (2022). Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT. Health Technology Assessment, 26(25), 1-142. https://doi.org/10.3310/AEFU1104

Background
Freezing all embryos, followed by thawing and transferring them into the uterine cavity at a later stage (freeze-all), instead of fresh-embryo transfer may lead to improved pregnancy rates and fewer complications during in vitro fertilisa... Read More about Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT.

Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze) (2022)
Journal Article
Maheshwari, A., Bell, J. L., Bhide, P., Brison, D., Child, T., Chong, H. Y., Cheong, Y., Cole, C., Coomarasamy, A., Cutting, R., Hardy, P., Hamoda, H., Khalaf, Y., Kurinczuk, J. J., Juszczak, E., Lavery, S., Linsell, L., Macklon, N., Mathur, R., Pundir, J., …Bhattacharya, S. (2022). Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze). Human Reproduction, 37(3), 476-487. https://doi.org/10.1093/humrep/deab279

STUDY QUESTION: Does a policy of elective freezing of embryos, followed by frozen embryo transfer result in a higher healthy baby rate, after first embryo transfer, when compared with the current policy of transferring fresh embryos? SUMMARY ANSWER:... Read More about Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze).

Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure (2020)
Journal Article
Suthaporn, S., Jayaprakasan, K., Thornton, J., Walker, K., Medrano, J. H., Castellanos, M., May, S., Polanski, L., Raine-Fenning, N., & Maalouf, W. E. (2021). Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure. Reproductive BioMedicine Online, 42(3), 595-608. https://doi.org/10.1016/j.rbmo.2020.10.018

Research question
What is the difference in endometrial transcriptomics between women with normal and with low mid-luteal progesterone during the implantation window?

Design
An endometrial biopsy and serum progesterone concentration were taken f... Read More about Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure.

Efficacy of dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): a proof of principle double blinded randomized placebo controlled trial (2017)
Journal Article
Narkwichean, A., Maalouf, W. E., Baumgarten, M., Polanski, L., Raine-Fenning, N., Campbell, B. K., & Jayaprakasan, K. (2017). Efficacy of dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): a proof of principle double blinded randomized placebo controlled trial. European Journal of Obstetrics and Gynecology and Reproductive Biology, 218, https://doi.org/10.1016/j.ejogrb.2017.09.006

Objective: To evaluate the effect of DHEA supplementation on In-Vitro Fertilisation (IVF) outcome as assessed by ovarian response, oocyte developmental competence and live birth rates in women predicted to have poor ovarian reserve (OR). The feasibil... Read More about Efficacy of dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): a proof of principle double blinded randomized placebo controlled trial.

Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology (2017)
Journal Article
Prior, M., Bagness, C., Brewin, J., Coomarasamy, A., Easthope, L., Hepworth-Jones, B., Hinshaw, K., O'Toole, E., Orford, J., Regan, L., Raine-Fenning, N., Shakespeare, J., Small, R., Thornton, J., & Metcalf, L. (2017). Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology. BMJ Open, 7, Article e016571. https://doi.org/10.1136/bmjopen-2017-016571

Objectives: To identify and prioritise important research questions for miscarriage.
Design: A priority setting partnership using prospective surveys and consensus meetings following methods advocated by the James Lind Alliance.
Setting: United Kin... Read More about Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology.

Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF (2016)
Journal Article
Massey, A., Campbell, B. K., Raine-Fenning, N., Pincott-Allen, C., Perry, J., & Vedhara, K. (2016). Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF. Psychoneuroendocrinology, 74, https://doi.org/10.1016/j.psyneuen.2016.08.027

Evidence for an association between cortisol and clinical pregnancy in women undergoing In Vitro Fertilisation (IVF) is mixed with previous studies relying exclusively on short term measures of cortisol in blood, saliva, urine, and/or follicular flui... Read More about Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF.

Anxiety associated with diagnostic uncertainties in early pregnancy. (2016)
Journal Article
Richardson, A., Raine-Fenning, N., Deb, S., Campbell, B., & Vedhara, K. (in press). Anxiety associated with diagnostic uncertainties in early pregnancy. Ultrasound in Obstetrics and Gynaecology, https://doi.org/10.1002/uog.17214

Objectives: To determine anxiety levels of women presenting to Early Pregnancy Assessment Units (EPAU) with abdominal pain and/or vaginal bleeding and assess how these change over time and according to ultrasonographic diagnosis.

Methods: We under... Read More about Anxiety associated with diagnostic uncertainties in early pregnancy..

Surgical intervention versus expectant management for endometrial polyps in subfertile women (2014)
Journal Article
Jayaprakasan, K., Polanski, L., Sahu, B., Thornton, J., & Raine-Fenning, N. (2014). Surgical intervention versus expectant management for endometrial polyps in subfertile women. Cochrane Library, https://doi.org/10.1002/14651858.CD009592.pub2

BACKGROUND:
Endometrial polyps, which are benign growths of the endometrium, may be a factor in female subfertility. Possible mechanisms include physical interference with gamete transport, alteration of the endometrial milieu and unresponsiveness t... Read More about Surgical intervention versus expectant management for endometrial polyps in subfertile women.