Outputs (105)

Automated quality control for within and between studies diffusion MRI data using a non-parametric framework for movement and distortion correction (2018)
Journal Article
Bastiani, M., Cottaar, M., Fitzgibbon, S. P., Suri, S., Alfaro-Almagro, F., Sotiropoulos, S. N., Jbabdi, S., & Andersson, J. (2019). Automated quality control for within and between studies diffusion MRI data using a non-parametric framework for movement and distortion correction. NeuroImage, 184, 801-812. https://doi.org/10.1016/j.neuroimage.2018.09.073

Diffusion MRI data can be affected by hardware and subject-related artefacts that can adversely affect downstream analyses. Therefore, automated quality control (QC) is of great importance, especially in large population studies where visual QC is no... Read More about Automated quality control for within and between studies diffusion MRI data using a non-parametric framework for movement and distortion correction.

Urinary extracellular vesicle protein profiling and endogenous lithium clearance support excessive renal sodium wasting and water reabsorption in thiazide induced hyponatremia (2018)
Journal Article
Channavajjhala, S. K., Bramley, R., Peltz, T., Oosthuyzen, W., Jia, W., Kinnear, S., Sampson, B., Martin, N., Hall, I. P., Bailey, M. A., Dear, J. W., & Glover, M. (2019). Urinary extracellular vesicle protein profiling and endogenous lithium clearance support excessive renal sodium wasting and water reabsorption in thiazide induced hyponatremia. Kidney International Reports, 4(1), 139-147. https://doi.org/10.1016/j.ekir.2018.09.011

Introduction

Thiazide diuretics are amongst the most widely used anti-hypertensive medicines worldwide. Thiazide-Induced Hyponatremia (TIH) is one of their most clinically significant adverse effects. A priori TIH must result from excessive saliur... Read More about Urinary extracellular vesicle protein profiling and endogenous lithium clearance support excessive renal sodium wasting and water reabsorption in thiazide induced hyponatremia.

Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training (2018)
Journal Article
Ahtiainen, J. P., Lensu, S., Ruotsalainen, I., Schumann, M., Ihalainen, J. K., Fachada, V., Mendias, C. L., Brook, M. S., Smith, K., Atherton, P. J., Koch, L. G., Britton, S. L., & Kainulainen, H. (2018). Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. Experimental Physiology, https://doi.org/10.1113/ep087144

The purpose of this study was to determine whether rats selectively bred for low and high response to aerobic exercise training co-segregate for differences in muscle adaptations to ladder-climbing resistance training. Five high-responder (HRT) and f... Read More about Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training.

Short-Term Impact of Bariatric Surgery on Best-Corrected Distance Visual Acuity and Diabetic Retinopathy Progression (2018)
Journal Article
Richardson, P., Hulpus, A., & Idris, I. (2018). Short-Term Impact of Bariatric Surgery on Best-Corrected Distance Visual Acuity and Diabetic Retinopathy Progression. Obesity Surgery, 28(11), 3711-3713. https://doi.org/10.1007/s11695-018-3445-z

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The immediate impact of rapid glucose lowering induced by bariatric surgery on diabetic retinopathy (DR) progression remains unclear. We present 3-year changes in the best-correct... Read More about Short-Term Impact of Bariatric Surgery on Best-Corrected Distance Visual Acuity and Diabetic Retinopathy Progression.

Short-term (<8 weeks) high-intensity interval training in diseased cohorts (2018)
Journal Article
Blackwell, J. E., Doleman, B., Herrod, P., Ricketts, S., Phillips, B. E., Lund, J. N., & Williams, J. P. (2018). Short-term (

Background & Aim:
Exercise training regimes can lead to improvements in measures of cardiorespiratory fitness (CRF), improved general health, and reduced morbidity and overall mortality risk. High intensity interval training (HIIT) offers a time-eff... Read More about Short-term (<8 weeks) high-intensity interval training in diseased cohorts.

The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells (2018)
Journal Article
Crossland, H., Smith, K., Atherton, P. J., & Wilkinson, D. J. (2018). The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells. Journal of Cellular Physiology, 233(12), 9663-9673. https://doi.org/10.1002/jcp.26881

Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopathy in liver disease i.e. cirrhosis. Despite this, the singular and combined impacts of ethanol and ammonia induced protein catabolism are poorly defi... Read More about The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells.

Attachment style, psychotic phenomena and the relationship with aggression: investigation in a general population sample (2018)
Journal Article
Whale, K., Green, K., & Browne, K. (2019). Attachment style, psychotic phenomena and the relationship with aggression: investigation in a general population sample. Journal of Aggression, Conflict and Peace Research, 11(1), 47-58. https://doi.org/10.1108/JACPR-04-2018-0356

Purpose: This study aimed to explore the relationship between attachment style, sub-clinical symptoms of psychosis and aggression in a general population sample.
Design: Using both convenience and snowball sampling, participants in the community (n=... Read More about Attachment style, psychotic phenomena and the relationship with aggression: investigation in a general population sample.

Visualising ligand-binding to a GPCR in vivo using nanoBRET (2018)
Journal Article
Carvalheira Alcobia, D., Ziegler, A. I., Kondrashov, A., Comeo, E., Mistry, S., Kellam, B., Chang, A., Woolard, J., Hill, S. J., & Sloan, E. K. (2018). Visualising ligand-binding to a GPCR in vivo using nanoBRET. iScience, 6(8), 280-288. https://doi.org/10.1016/j.isci.2018.08.006

© 2018 The Author(s) The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs direc... Read More about Visualising ligand-binding to a GPCR in vivo using nanoBRET.

Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours (2018)
Journal Article
Bennett, C. D., Kohe, S. E., Gill, S. K., Davies, N. P., Wilson, M., Storer, L. C. D., Ritzmann, T., Paine, S. M. L., Scott, I. S., Nicklaus-Wollenteit, I., Tennant, D. A., Grundy, R. G., & Peet, A. C. (2018). Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours. Scientific Reports, 8, Article 11992. https://doi.org/10.1038/s41598-018-30342-8

Paediatric brain tumors are becoming well characterized due to large genomic and epigenomic studies. Metabolomics is a powerful analytical approach aiding in the characterization of tumors. This study shows that common cerebellar tumors have metaboli... Read More about Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours.

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study (2018)
Journal Article
STARSurg Collaborative. (2018). Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study. BJS Open, 2(6), 400-410. https://doi.org/10.1002/bjs5.86

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a... Read More about Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.