Outputs (174)

Longitudinal analysis of the neurological features of ataxia-telangiectasia (2016)
Journal Article
Jackson, T. J., Chow, G., Suri, M., Byrd, P., Taylor, M. R., & Whitehouse, W. P. (2016). Longitudinal analysis of the neurological features of ataxia-telangiectasia. Developmental Medicine and Child Neurology, 58(7), 690-697. https://doi.org/10.1111/dmcn.13052

Aim: To assess the relationship between genotype and neurological progression in ataxia‐telangiectasia (A‐T).
Methods: Clinical and laboratory data were extracted retrospectively from the records of patients attending the UK National Ataxia‐Telangie... Read More about Longitudinal analysis of the neurological features of ataxia-telangiectasia.

“We don’t worry about diabetes that much”: a qualitative study exploring perceptions of physical activity among children with Type 1 Diabetes (2016)
Journal Article
Quirk, H., Glazebrook, C., Martin, R., & Blake, H. (2016). “We don’t worry about diabetes that much”: a qualitative study exploring perceptions of physical activity among children with Type 1 Diabetes. Advances in Pediatric Research, https://doi.org/10.12715/apr.2016.3.2

Background: Despite the health benefits of physical activity, children across the population are insufficiently active. Physical activity is essential in the management of Type 1 Diabetes Mellitus (T1DM), therefore its promotion should be a priority,... Read More about “We don’t worry about diabetes that much”: a qualitative study exploring perceptions of physical activity among children with Type 1 Diabetes.

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization (2016)
Journal Article
Felfel, R. M., Poocza, L., Gimeno-Fabra, M., Milde, T., Hildebrand, G., Ahmed, I., Scotchford, C., Sottile, V., Grant, D. M., & Liefeith, K. (2016). In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization. Biomedical Materials, 11(1), Article 015011. https://doi.org/10.1088/1748-6041/11/1/015011

© 2016 IOP Publishing Ltd. The manufacture of 3D scaffolds with specific controlled porous architecture, defined microstructure and an adjustable degradation profile was achieved using two-photon polymerization (TPP) with a size of 2 × 4 × 2 mm3. Sca... Read More about In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization.

RECQL4 helicase has oncogenic potential in sporadic breast cancers (2016)
Journal Article
Arora, A., Agarwal, D., Abdel-Fatah, T. M., Lu, H., Croteau, D. L., Moseley, P., Aleskandarany, M. A., Green, A. R., Ball, G., Rakha, E. A., Chan, S. Y., Ellis, I. O., Wang, L. L., Zhao, Y., Balajee, A. S., Bohr, V. A., & Madhusudan, S. (2016). RECQL4 helicase has oncogenic potential in sporadic breast cancers. Journal of Pathology, 238(4), 495-501. https://doi.org/10.1002/path.4681

RECQL4 helicase is a molecular motor that unwinds DNA, a process essential during DNA replication and DNA repair. Germ-line mutations in RECQL4 cause type II Rothmund–Thomson syndrome (RTS), characterized by a premature ageing phenotype and cancer pr... Read More about RECQL4 helicase has oncogenic potential in sporadic breast cancers.

Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial (2016)
Journal Article
Patel, S., Malins, S., Guo, B., James, M., Kai, J., Kaylor-Hughes, C., Rowley, E., Simpson, J., Smart, D., Stubley, M., Tyrer, H., & Morriss, R. K. (2016). Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial. BJPsych Open, 2, https://doi.org/10.1192/bjpo.bp.115.002220

Background
Health anxiety and medically unexplained symptoms cost the National Health Service (NHS) an estimated £3 billion per year in unnecessary costs with little evidence of patient benefit. Effective treatment is rarely taken up due to issues s... Read More about Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial.

Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis (2016)
Journal Article
Traboulsee, A. L., Cornelisse, P., Sandberg-Wollheim, M., Uitdehaag, B. M., Kappos, L., Jongen, P. J., Constantinescu, C. S., Verdun di Cantogno, E., & Li, D. K. (2016). Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2, https://doi.org/10.1177/2055217316666406

Objective: The objective of this article is to investigate potential clinical and MRI predictors of long-term outcomes in multiple sclerosis (MS).

Methods: This was a post hoc analysis using data from all 382 patients in the PRISMS long-term foll... Read More about Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis.

Long-term exposure to irinotecan reduces cell migration in glioma cells. (2016)
Journal Article
Al-Ghafari, A. B., Punjaruk, W., Storer, L., Carrier, D., Hussein, D., Coyle, B., & Kerr, I. D. (2016). Long-term exposure to irinotecan reduces cell migration in glioma cells. Journal of Neuro-Oncology, 127(3), 455-462. https://doi.org/10.1007/s11060-016-2058-4

In spite of considerable research into the therapies for glioblastoma multiforme this tumour type remains very difficult to treat. As well as having a tendency to be inherently resistant to chemotherapy, glioblastoma multiforme also displays local in... Read More about Long-term exposure to irinotecan reduces cell migration in glioma cells..

Comprehensive geriatric assessment on an acute medical unit: a qualitative study of older people’s and informal carer’s perspectives of the care and treatment received (2016)
Journal Article
Darby, J., Williamson, T., Logan, P., & Gladman, J. R. (2016). Comprehensive geriatric assessment on an acute medical unit: a qualitative study of older people’s and informal carer’s perspectives of the care and treatment received. Clinical Rehabilitation, 31(1), https://doi.org/10.1177/0269215515624134

Objective: This qualitative study was imbedded in a randomised controlled trial evaluating the addition of geriatricians to usual care to enable the comprehensive geriatric assessment process with older patients on acute medical units. The qualitativ... Read More about Comprehensive geriatric assessment on an acute medical unit: a qualitative study of older people’s and informal carer’s perspectives of the care and treatment received.

The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial (2016)
Journal Article
Hodgson, D., Anderson, J., Reynolds, C., Oborne, J., Meakin, G., Bailey, H., Shaw, D. E., Mortimer, K., & Harrison, T. (2016). The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial. Chest, 149(4), 1052-1060. https://doi.org/10.1016/j.chest.2015.12.036

Background

Chronic cough is a common clinical problem worldwide. Although many patients have underlying precipitating conditions such as asthma, gastroesophageal reflux, or rhinitis, many remain symptomatic despite treating these conditions. New a... Read More about The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial.

Difficulties experienced by young people with Tourette syndrome in secondary school: a mixed methods description of self, parent and staff perspectives (2016)
Journal Article
Wadman, R., Glazebrook, C., Beer, C. E., & Jackson, G. M. (2016). Difficulties experienced by young people with Tourette syndrome in secondary school: a mixed methods description of self, parent and staff perspectives. BMC Psychiatry, 16(14), https://doi.org/10.1186/s12888-016-0717-9

Background: Tourette syndrome (TS) is a neurodevelopmental disorder characterised by motor and vocal tics. These involuntary movements and vocalizations can have a negative impact in the school environment. The paper presents a mixed methods descript... Read More about Difficulties experienced by young people with Tourette syndrome in secondary school: a mixed methods description of self, parent and staff perspectives.