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Outputs (85)

The role of Cas8 in type I CRISPR interference (2015)
Journal Article
Cass, S., Haas, K., Stoll, B., Alkhnbashi, O., Sharma, K., Urlaub, H., Backofen, R., Marchfelder, A., & Bolt, E. (2015). The role of Cas8 in type I CRISPR interference. Bioscience Reports, 35, Article e00197. https://doi.org/10.1042/BSR20150043

CRISPR (clustered regularly interspaced short palindromic repeat) systems provide bacteria and archaea with adapt- ive immunity to repel invasive genetic elements. Type I systems use ‘cascade’ [CRISPR-associated (Cas) complex for antiviral defence] r... Read More about The role of Cas8 in type I CRISPR interference.

Mitotic activity of survivin is regulated by acetylation at K129 (2015)
Journal Article
Aljaberi, A. M., Webster, J. R., & Wheatley, S. P. (2015). Mitotic activity of survivin is regulated by acetylation at K129. Cell Cycle, 14(11), https://doi.org/10.1080/15384101.2015.1033597

Survivin is a cancer-associated protein regulated by multiple factors, including acetylation at K129 within its C-terminal alpha-helical tail. Acetylation of survivin is being pursued as a potential prognostic marker in breast cancer. This modificat... Read More about Mitotic activity of survivin is regulated by acetylation at K129.

Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system (2015)
Journal Article
Malys, M. K., Campbell, L., & Malys, N. (2015). Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system. Medicina, 51(2), https://doi.org/10.1016/j.medici.2015.03.001

The human gut commensal microbiota forms a complex population of microorganisms that survive by maintaining a symbiotic relationship with the host. Amongst the metabolic benefits it brings, formation of adaptive immune system and maintenance of its h... Read More about Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system.

Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5 (2015)
Journal Article
Scott, D., Layfield, R., & Oldham, N. J. (2015). Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5. Proteomics, 15(16), https://doi.org/10.1002/pmic.201400457

Many proteins exhibit conformation flexibility as part of their biological function, whether through the presence of a series of well-defined states or by the existence of intrinsic disorder. Ion mobility spectrometry, in combination with MS (IM–MS),... Read More about Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.

The functional repertoire of survivin's tails (2015)
Journal Article
Wheatley, S. P. (2015). The functional repertoire of survivin's tails. Cell Cycle, 14(2), https://doi.org/10.4161/15384101.2014.979680

Survivin is a multitasking protein that can inhibit cell death and that is essential for mitosis. Due to these prosurvival activities and the correlation of its expression with tumour resistance to conventional cancer treatments, survivin has receive... Read More about The functional repertoire of survivin's tails.

Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3 (2014)
Journal Article
Gong, B., Shin, M., Sun, J., Jung, C.-H., Bolt, E. L., van der oost, J., & Kim, J.-S. (2014). Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3. Proceedings of the National Academy of Sciences, 111(46), https://doi.org/10.1073/pnas.1410806111

Mobile genetic elements in bacteria are neutralized by a system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins. Type I CRISPR-Cas systems use a “Cascade” ribonucleoprotein complex to... Read More about Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3.

P242: Prediction of falls risk with six different biomarkers in mild cognitive impairment using principal component analysis (2014)
Journal Article
de Spiegeleer, A., Masud, T., Greenhaff, P. L., Van den Noortgate, N., Petrovic, M., Hood, V. L., Gladman, J. R., van der Wardt, V., Harwood, R. H., & Booth, V. (2014). P242: Prediction of falls risk with six different biomarkers in mild cognitive impairment using principal component analysis. European Geriatric Medicine, 5(S1), Article S161. https://doi.org/10.1016/S1878-7649%2814%2970414-0

Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer (2014)
Journal Article
Aljaberi, A. M., Webster, J. R., & Wheatley, S. P. (in press). Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer. Cancer Cell International, 14, Article 78. https://doi.org/10.1186/s12935-014-0078-8

Background
Survivin is a protein that is normally present only in G2 and M-phases in somatic cells, however, in cancer cells, it is expressed throughout the cell cycle. A prosurvival factor, survivin is both an inhibitor of apoptosis and an essentia... Read More about Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer.

Etiology of the membrane potential of rat white fat adipocytes (2014)
Journal Article
Bentley, D. C., Pulbutr, P., Chan, S., & Smith, P. A. (2014). Etiology of the membrane potential of rat white fat adipocytes. AJP - Endocrinology and Metabolism, 307(2), E161-E175. https://doi.org/10.1152/ajpendo.00446.2013

The plasma membrane potential (Vm) is key to many physiological processes, however its ionic aetiology in white fat adipocytes is poorly characterised. To address this question, we have employed the perforated patch current-clamp and cell-attached pa... Read More about Etiology of the membrane potential of rat white fat adipocytes.