Outputs (87)

Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus (2020)
Journal Article
Blower, I., Tong, C., Sun, X., Murray, E., Luckett, J., Chan, W., …Hill, P. (2020). Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus. Sensors, 20(15), 1-12. https://doi.org/10.3390/s20154305

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Gaussia luciferase (GLuc) is a secreted protein with significant potential for use as a reporter of gene expression in bacterial pathogenicity studies. To date there are relatively few example... Read More about Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus.

Using Internet of Things to Reduce Office Workers’ Sedentary Behavior: Intervention Development Applying the Behavior Change Wheel and Human-Centered Design Approach (2020)
Journal Article
Huang, Y., Benford, S., Price, D., Patel, R., Li, B., Ivanov, A., & Blake, H. (2020). Using Internet of Things to Reduce Office Workers’ Sedentary Behavior: Intervention Development Applying the Behavior Change Wheel and Human-Centered Design Approach. JMIR mHealth and uHealth, 8(7), Article e17914. https://doi.org/10.2196/17914

Background: Sedentary behavior (SB) is associated with various adverse health outcomes. The prevalence of prolonged sitting at work among office workers makes a case for SB interventions to target this setting and population. Everyday mundane objects... Read More about Using Internet of Things to Reduce Office Workers’ Sedentary Behavior: Intervention Development Applying the Behavior Change Wheel and Human-Centered Design Approach.

COVID-19 And The Provision Of Wobble Rooms And Wellbeing Centres For Healthcare Workers (2020)
Report
Blake, H., & Dennis, M. (2020). COVID-19 And The Provision Of Wobble Rooms And Wellbeing Centres For Healthcare Workers. Florence Nightingale Foundation

A Global Comparison of Initial Pharmacy Education Curricula: An Exploratory Study (2020)
Journal Article
Arakawa, N., Bruno, A., & Bates, I. (2020). A Global Comparison of Initial Pharmacy Education Curricula: An Exploratory Study. INNOVATIONS in Pharmacy, 11(1), Article 18. https://doi.org/10.24926/iip.v11i1.2093

Background: Time-tabled curricular contents and syllabi reflect the actual delivery of the academic programme and one of key quality components in healthcare professional education. There is a need of global evidence base of Initial Pharmacy Educatio... Read More about A Global Comparison of Initial Pharmacy Education Curricula: An Exploratory Study.

A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids (2020)
Journal Article
Stamatopoulos, K., Pathak, S., Marciani, L., & Turner, D. (2020). A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids. Molecular Pharmaceutics, 17(4), 1310-1323. https://doi.org/10.1021/acs.molpharmaceut.0c00019

In vivo studies have shown cyclic bile salt (BS) outputs during fasting whereas higher amounts have been observed in fed states. This leads to fluctuations of intestinal BS concentrations ([BS]) that can affect the rate and extent of absorption of li... Read More about A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids.

Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4) (2020)
Journal Article
Gunnell, E. A., Al-Noori, A., Muhsen, U., Davies, C. C., Dowden, J., & Dreveny, I. (2020). Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). Biochemical Journal, 477(4), 787–800. https://doi.org/10.1042/bcj20190826

Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for the investigation and treatment of several diseases including cardiovascular disease and cancer. Bisubstrate inhibitors that simultaneously target binding sit... Read More about Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4).

Using Light for Therapy of Glioblastoma Multiforme (GBM) (2020)
Journal Article
Kasparov, Vasilev, Teschemacher, Sofi, Smith, & Rahman, R. (2020). Using Light for Therapy of Glioblastoma Multiforme (GBM). Brain Sciences, 10(2), Article 75. https://doi.org/10.3390/brainsci10020075

Glioblastoma multiforme (GBM) is the most malignant form of primary brain tumour with extremely poor prognosis. The current standard of care for newly diagnosed GBM includes maximal surgical resection followed by radiotherapy and adjuvant chemotherap... Read More about Using Light for Therapy of Glioblastoma Multiforme (GBM).

A spoonful of sugar: Medication and the psychoanalytic body (2020)
Journal Article
Wright, C. (2020). A spoonful of sugar: Medication and the psychoanalytic body. Psychoanalysis, Culture and Society, 25, 135–154. https://doi.org/10.1057/s41282-019-00146-4

© 2020, Springer Nature Limited. This article employs a Lacanian framework to re-visit the vexed relationship between psychoanalysis and medication, which, it is claimed, also pertains to debates about the status of the psychoanalytic body. Whilst ac... Read More about A spoonful of sugar: Medication and the psychoanalytic body.

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy (2019)
Journal Article
Li, Z., Mirams, G. R., Yoshinaga, T., Ridder, B. J., Han, X., Chen, J. E., …Strauss, D. G. (2020). General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clinical Pharmacology and Therapeutics, 107(1), 102-111. https://doi.org/10.1002/cpt.1647

This white paper presents principles for validating proarrhythmia risk prediction models for regulatory use as discussed at the In Silico Breakout Session of a Cardiac Safety Research Consortium/Health and Environmental Sciences Institute/US Food and... Read More about General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.

Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii (2019)
Journal Article
Zhu, X.-Q., Zhou, C.-X., Liu, Q., Gan, Y., Cong, H., Elsheikha, H. M., & Chen, X.-Q. (2019). Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii. Antimicrobial Agents and Chemotherapy, 63(10), Article e00312-19. https://doi.org/10.1128/AAC.00312-19

In this study, we analyzed the global metabolomic changes associated with Toxoplasma gondii infection in mice in the presence or absence of sulfadiazine sodium (SDZ) treatment. BALB/c mice were infected with T. gondii GT1 strain and treated orally wi... Read More about Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii.

Education Program for Carers in Facilities with Neuro Disabled Subjects EPoCFiNDS (2019)
Journal Article
Dionyssiotis, Y., Vellidou, E., Konstantinidis, S. T., Sarafis, P., Artemi, S., Stergiopoulou, K., …Koutsouris, D. (2019). Education Program for Carers in Facilities with Neuro Disabled Subjects EPoCFiNDS. Journal of Frailty, Sarcopenia and Falls, 4(2), 45-50. https://doi.org/10.22540/JFSF-04-045

The prevalence of chronic illness and the disabilities they cause are strongly associated with age. According to
the United Nations, in most countries around the world, 8-10% of the population has some form of disability.
Carers are helping subject... Read More about Education Program for Carers in Facilities with Neuro Disabled Subjects EPoCFiNDS.

Lacan's May '68: Analysing the Institution in the Wake of the University Discourse (2019)
Book Chapter
Wright, C. (in press). Lacan's May '68: Analysing the Institution in the Wake of the University Discourse. In Other ‘68s: Lineages and Legacies of May ‘68

This chapter tracks the psychoanalyst Jacques Lacan’s evolving position on the French experi-ence of May 1968. Lacanian notions around structure and desire were clearly at play in the run up to the May events and initially Lacan was supportive of bot... Read More about Lacan's May '68: Analysing the Institution in the Wake of the University Discourse.

Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function (2019)
Journal Article
Curry, L., Almukhtar, H., Alahmed, J., Roberts, R., & Smith, P. A. (2019). Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function. Toxicological Sciences, 169(2), 543–552. https://doi.org/10.1093/toxsci/kfz068

Plasma membrane ion channels and mitochondrial electron transport complexes (mETC) are recognised “off-targets” for certain drugs. Simvastatin is one such drug, a lipophilic statin used to treat hypercholesterolaemia, but which is also associated wit... Read More about Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function.

Tactical authenticity in the production of mad narratives (2019)
Journal Article
WRIGHT, C., & CLARKE, S. (2019). Tactical authenticity in the production of mad narratives. Social Theory and Health, 17(2), 15. https://doi.org/10.1057/s41285-019-00092-2

First-person accounts of madness and of encountering psychiatric services provide important sociocultural and psychological knowledge about the subjectivity of distress. The importance of such accounts is often based upon a claim of the authenticity... Read More about Tactical authenticity in the production of mad narratives.

Discrimination of gain increments in speech-shaped noises (2019)
Journal Article
Caswell-Midwinter, B., & Whitmer, W. (2019). Discrimination of gain increments in speech-shaped noises. Trends in Hearing, 23, 1-12. https://doi.org/10.1177/2331216518820220

Frequency-dependent gain adjustments are routine in hearing-aid fittings, whether in matching to real-ear targets or fine-tuning to patient feedback. Patient feedback may be unreliable and fittings inefficient if adjustments are not discriminable. To... Read More about Discrimination of gain increments in speech-shaped noises.

The broiler chicken as a signal of a human reconfigured biosphere (2018)
Journal Article
Bennett, C. E., Thomas, R., Williams, M., Zalasiewicz, J., Edgeworth, M., Miller, H., …Marume, U. (2018). The broiler chicken as a signal of a human reconfigured biosphere. Royal Society Open Science, 5(12), 1-11. https://doi.org/10.1098/rsos.180325

© 2018 The Author(s) Published by the Royal Society. Changing patterns of human resource use and food consumption have profoundly impacted the Earth's biosphere. Until now, no individual taxa have been suggested as distinct and characteristic new mor... Read More about The broiler chicken as a signal of a human reconfigured biosphere.

Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii (2018)
Journal Article
Wang, M., Zhang, F., Elsheikha, H. M., Zhang, N., He, J., Luo, J., & Zhu, X. (2018). Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii. Parasites and Vectors, 11(1), Article 592. https://doi.org/10.1186/s13071-018-3179-8

Background: Although sexual reproduction of the parasite Toxoplasma gondii exclusively occurs in the cat intestine, knowledge about the alteration of gene expression in the intestine of cats infected with T. gondii is still limited. Here, we investig... Read More about Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii.

Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity? (2018)
Journal Article
Rowland, S. C., Hartley, D. E. H., & Wiggins, I. M. (2018). Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity?. Trends in Hearing, 22, 1-18. https://doi.org/10.1177/2331216518804116

Listening to speech in the noisy conditions of everyday life can be effortful, reflecting the increased cognitive workload involved in extracting meaning from a degraded acoustic signal. Studying the underlying neural processes has the potential to p... Read More about Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity?.

Lacan’s Cybernetic Theory of Causality: Repetition and the Unconscious in Duncan Jones’ Source Code (2018)
Book Chapter
Wright, C. (2018). Lacan’s Cybernetic Theory of Causality: Repetition and the Unconscious in Duncan Jones’ Source Code. In S. Matviyenko, & J. Roof (Eds.), Lacan and the Posthuman (67-88). London: Palgrave Macmillan. https://doi.org/10.1007/978-3-319-76327-9_5

This chapter explores the intersections between the fields of Lacanian psychoanalysis and theories of the posthuman. It argues that Lacan's early engagements with cybernetics and game theory prefigured many of the questions about artificial intellige... Read More about Lacan’s Cybernetic Theory of Causality: Repetition and the Unconscious in Duncan Jones’ Source Code.

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells (2017)
Journal Article
Shah, M., Cardenas, R., Wang, B., Persson, J., Mongan, N. P., Grabowska, A. M., & Allegrucci, C. (2017). HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Molecular Cancer, 16(38), https://doi.org/10.1186/s12943-017-0605-z

Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissue... Read More about HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.