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Miss JENNIFER ASHWORTH's Outputs (3)

The role of mesenchymal cells in cholangiocarcinoma (2024)
Journal Article
Sueca-Comes, M., Rusu, E. C., Ashworth, J. C., Collier, P., Probert, C., Ritchie, A., Meakin, M., Mongan, N. P., Egbuniwe, I. U., Andersen, J. B., Bates, D. O., & Grabowska, A. M. (2024). The role of mesenchymal cells in cholangiocarcinoma. Disease Models and Mechanisms, 17(12), Article dmm050716. https://doi.org/10.1242/dmm.050716

The tumour microenvironment (TME) significantly influences tumour formation and progression through dynamic interactions. Cholangiocarcinoma (CCA), a highly desmoplastic tumour, lacks early diagnostic biomarkers and has limited effective treatments o... Read More about The role of mesenchymal cells in cholangiocarcinoma.

The importance of 3D fibre architecture in cancer and implications for biomaterial model design (2024)
Journal Article
Ashworth, J. C., & Cox, T. R. (2024). The importance of 3D fibre architecture in cancer and implications for biomaterial model design. Nature Reviews Cancer, 24(7), 461-479. https://doi.org/10.1038/s41568-024-00704-8

The need for improved prediction of clinical response is driving the development of cancer models with enhanced physiological relevance. A new concept of ‘precision biomaterials’ is emerging, encompassing patient-mimetic biomaterial models that seek... Read More about The importance of 3D fibre architecture in cancer and implications for biomaterial model design.

Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML (2023)
Journal Article
James, J. R., Curd, J., Ashworth, J. C., Abuhantash, M., Grundy, M., Seedhouse, C. H., Arkill, K. P., Wright, A. J., Merry, C. L. R., & Thompson, A. (2023). Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. International Journal of Molecular Sciences, 24(4), Article 4235. https://doi.org/10.3390/ijms24044235

In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contributes to dru... Read More about Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML.