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New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo (2024)
Journal Article
Traserra, S., Alcalá-González, L. G., Barber, C., Landolfi, S., Malagelada, C., Lange, R., …Jimenez, M. (2024). New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo. European Journal of Pharmacology, 972, Article 176550. https://doi.org/10.1016/j.ejphar.2024.176550

Introduction: Hyoscine butylbromide (HBB) is one of the most used antispasmodics in clinical practice. Recent translational consensus has demonstrated a similarity between human colonic motor patterns studied ex vivo and in vivo, suggesting ex vivo c... Read More about New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo.

Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial (2023)
Journal Article
Gunn, D., Topan, R., Fried, R., Holloway, I., Brindle, R., Hartley, S., …Spiller, R. (2023). Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial. Efficacy and Mechanism Evaluation, 10(9), 1-154. https://doi.org/10.3310/ytfw7874

Background: Irritable bowel syndrome with diarrhoea is characterised by frequent, loose or watery stools with associated urgency, resulting in marked reduction of quality of life. Ondansetron, a 5-hydroxytryptamine-3 receptor antagonist, has been sho... Read More about Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial.

Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document (2023)
Journal Article
Brenner, D. M., Corsetti, M., Drossman, D., Tack, J., & Wald, A. (2024). Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document. Clinical Gastroenterology and Hepatology, 22(2), 397-412. https://doi.org/10.1016/j.cgh.2023.08.044

Background & Aims: Functional constipation is the most common of the disorders of gut-brain interaction, affecting approximately 12% of the world population. Although classically considered a chronic condition, many individuals experience shorter yet... Read More about Perceptions, definitions, and therapeutic interventions for occasional constipation: a ROME working group consensus document.

The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study (2023)
Journal Article
Jaafari, H., Houghton, L. A., West, R. M., Agrawal, A., Aziz, I., Black, C. J., …Vasant, D. H. (2023). The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study. Neurogastroenterology and Motility, 35(6), Article e14574. https://doi.org/10.1111/nmo.14574

Background: There are minimal epidemiological data comparing the burden of disorders of gut brain interaction (DGBI) in the UK with other countries. We compared the prevalence of DGBI in the UK with other countries that participated in the Rome Found... Read More about The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study.

Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial (2023)
Journal Article
Gunn, D., Topan, R., Barnard, L., Fried, R., Holloway, I., Brindle, R., …Spiller, R. (2023). Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial. Alimentary Pharmacology and Therapeutics, 57(11), 1258-1271. https://doi.org/10.1111/apt.17426

Summary: Background: Ondansetron may be beneficial in irritable bowel syndrome with diarrhoea (IBS‐D). Aim: To conduct a 12‐week parallel group, randomised, double‐blind, placebo‐controlled trial of ondansetron 4 mg o.d. (titrated up to 8 mg t.d.s.)... Read More about Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial.

Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future (2023)
Journal Article
Bassotti, G., Villanacci, V., & Corsetti, M. (2023). Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future. Journal of Clinical Medicine, 12(4), Article 1702. https://doi.org/10.3390/jcm12041702

Despite great progress in pharmaceutical research, the medical treatment of chronic idiopathic constipation is far from ideal. The aim of the present article was to review literature data, focusing on poorly studied or commercially unavailable/unappr... Read More about Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future.

A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men (2023)
Journal Article
Aliyu, A. I., Nixon, A., Hoad, C., Marciani, L., Corsetti, M., Aithal, G. P., …Taylor, M. A. (2023). A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men. British Journal of Nutrition, 130(8), 1316-1328. https://doi.org/10.1017/S0007114523000302

AbstractInclusion in nasogastric tube feeds (NGTF) of acid-sensitive, seaweed-derived alginate, expected to form a reversible gel in the stomach, may create a more normal intragastric state and modified gastrointestinal responses. This may ameliorate... Read More about A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men.

Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future (2023)
Journal Article
Bassotti, G., Villanacci, V., & Corsetti, M. (2023). Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future. Journal of Clinical Medicine, 12(4), Article 1702. https://doi.org/10.3390/jcm12041702

Despite great progress in pharmaceutical research, the medical treatment of chronic idiopathic constipation is far from ideal. The aim of the present article was to review literature data, focusing on poorly studied or commercially unavailable/unappr... Read More about Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future.

Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP) (2022)
Journal Article
Barbara, G., Cremon, C., Bellini, M., Corsetti, M., Di Nardo, G., Falangone, F., …Marasco, G. (2023). Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP). Digestive and Liver Disease, 55(2), 187-207. https://doi.org/10.1016/j.dld.2022.11.015

The irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction. IBS is still associated with areas of uncertainties, especially regarding the optimal diagnostic work-up and the more appropriate management. Experts from 7 Italian So... Read More about Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP).

Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP) (2022)
Journal Article
Barbara, G., Cremon, C., Bellini, M., Corsetti, M., Di Nardo, G., Falangone, F., …Marasco, G. (2022). Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP). Digestive and Liver Disease, https://doi.org/10.1016/j.dld.2022.11.015

The irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction. IBS is still associated with areas of uncertainties, especially regarding the optimal diagnostic work-up and the more appropriate management. Experts from 7 Italian So... Read More about Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP).

Functional Abdominal Cramping Pain: Expert Practical Guidance (2022)
Journal Article
Müller-Lissner, S., Andresen, V., Corsetti, M., Bustos Fernández, L., Forestier, S., Pace, F., & Valdovinos, M. A. (2022). Functional Abdominal Cramping Pain: Expert Practical Guidance. Journal of Clinical Gastroenterology, 56(10), 844-852. https://doi.org/10.1097/mcg.0000000000001764

Functional abdominal cramping pain (FACP) is a common complaint, which may present either on its own or in association with a functional gastrointestinal disorder. It is likely caused by a variety of, probably partly unknown, etiologies. Effective ma... Read More about Functional Abdominal Cramping Pain: Expert Practical Guidance.

Functional Abdominal Cramping Pain: Expert Practical Guidance (2022)
Journal Article
Müller-Lissner, S., Andresen, V., Corsetti, M., Bustos Fernández, L., Forestier, S., Pace, F., & Valdovinos, M. A. (2022). Functional Abdominal Cramping Pain: Expert Practical Guidance. Journal of Clinical Gastroenterology, 56(10), 844-852. https://doi.org/10.1097/MCG.0000000000001764

Functional abdominal cramping pain (FACP) is a common complaint, which may present either on its own or in association with a functional gastrointestinal disorder. It is likely caused by a variety of, probably partly unknown, etiologies. Effective ma... Read More about Functional Abdominal Cramping Pain: Expert Practical Guidance.

Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non‐diabetic dyspeptic patients (2022)
Journal Article
Hay, P. D., Corsetti, M., Tucker, E., Fox, M. R., & Perkins, A. (2022). Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non‐diabetic dyspeptic patients. Neurogastroenterology and Motility, https://doi.org/10.1111/nmo.14454

Background: Scintigraphy is used for overall assessment of gastric emptying. Adherence to an international consensus protocol is recommended to ensure quality; however, this has not been widely adopted because preparation of the “egg-beater” meal is... Read More about Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non‐diabetic dyspeptic patients.

Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice (2022)
Journal Article
Corsetti, M., Forestier, S., & Jiménez, M. (2023). Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice. Neurogastroenterology and Motility, 35(4), Article e14451. https://doi.org/10.1111/nmo.14451

Background: Hyoscine butylbromide (HBB) has been available for use as an antispasmodic since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A previous review in 2007 summarized the evidence on the mode of action of... Read More about Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice.

British Society of Gastroenterology guidelines on the management of functional dyspepsia (2022)
Journal Article
Black, C. J., Paine, P. A., Agrawal, A., Aziz, I., Eugenicos, M. P., Houghton, L. A., …Ford, A. C. (2022). British Society of Gastroenterology guidelines on the management of functional dyspepsia. Gut, 71(9), 1697-1723. https://doi.org/10.1136/gutjnl-2022-327737

Functional dyspepsia (FD) is a common disorder of gut-brain interaction, affecting approximately 7% of individuals in the community, with most patients managed in primary care. The last British Society of Gastroenterology (BSG) guideline for the mana... Read More about British Society of Gastroenterology guidelines on the management of functional dyspepsia.

Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility (2022)
Journal Article
Savarino, E., Zingone, F., Barberio, B., Marasco, G., Akyuz, F., Akpinar, H., …Barbara, G. (2022). Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility. United European Gastroenterology Journal, 10(6), 556-584. https://doi.org/10.1002/ueg2.12259

Irritable bowel syndrome with diarrhoea (IBS-D) and functional diarrhoea (FDr) are the two major functional bowel disorders characterized by diarrhoea. In spite of their high prevalence, IBS-D and FDr are associated with major uncertainties, especial... Read More about Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility.

Review article: rethinking the “ladder” approach to reflux-like symptom management in the era of PPI “resistance”: a multidisciplinary perspective (2022)
Journal Article
Hungin, A. P. S., Scarpignato, C., Keefer, L., Corsetti, M., Anastasiou, F., Muris, J. W., …Kahrilas, P. J. (2022). Review article: rethinking the “ladder” approach to reflux-like symptom management in the era of PPI “resistance”: a multidisciplinary perspective. Alimentary Pharmacology and Therapeutics, 55(12), 1492-1500. https://doi.org/10.1111/apt.16930

Background: Despite widespread adoption of potent acid suppression treatment with proton pump inhibitors (PPI) for reflux-like symptoms, persistent symptoms are commonly reported in primary care and community studies. Aims: This multidisciplinary rev... Read More about Review article: rethinking the “ladder” approach to reflux-like symptom management in the era of PPI “resistance”: a multidisciplinary perspective.

Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research (2022)
Journal Article
Senekowitsch, S., Schick, P., Abrahamsson, B., Augustijns, P., Gießmann, T., Lennernäs, H., …Koziolek, M. (2022). Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research. Pharmaceutics, 14(4), Article 801. https://doi.org/10.3390/pharmaceutics14040801

Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Un... Read More about Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research.

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia (2021)
Journal Article
Wauters, L., Dickman, R., Drug, V., Mulak, A., Serra, J., Enck, P., …Zerbib, F. (2021). United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia. Neurogastroenterology and Motility, 33(9), Article e14238. https://doi.org/10.1111/nmo.14238

Background Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite of its prevalence, FD is associated with major uncertainties in terms of its definition, underlying pathophysiology, diagnosis, treatment, and p... Read More about United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia.

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on Functional Dyspepsia (2021)
Journal Article
Wauters, L., Dickman, R., Drug, V., Mulak, A., Serra, J., Enck, P., …ESNM FD consensus group. (2021). United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on Functional Dyspepsia. United European Gastroenterology Journal, 10(3), 307-331. https://doi.org/10.1002/ueg2.12061

Background Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite of its prevalence, FD is associated with major uncertainties in terms of its definition, underlying pathophysiology, diagnosis, treatment, and... Read More about United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on Functional Dyspepsia.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021)
Journal Article
Vasant, D. H., Paine, P. A., Black, C. J., Houghton, L. A., Everitt, H. A., Corsetti, M., …Ford, A. C. (2021). British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut, 70(7), 1214-1240. https://doi.org/10.1136/gutjnl-2021-324598

Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders seen by clinicians in both primary and secondary care. Since publication of the last British Society of Gastroenterology guideline in 2007, substantial advances... Read More about British Society of Gastroenterology guidelines on the management of irritable bowel syndrome.

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis (2021)
Journal Article
Schol, J., Wauters, L., Dickman, R., Drug, V., Mulak, A., Serra, J., …Corsetti, M. (2021). United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis. United European Gastroenterology Journal, 9(3), 287-306. https://doi.org/10.1002/ueg2.12060

Background: Gastroparesis is a condition characterized by epigastric symptoms and delayed gastric emptying (GE) rate in the absence of any mechanical obstruction. The condition is challenging in clinical practice by the lack of guidance concerning... Read More about United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis.

The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis (2021)
Journal Article
Bosman, M., Elsenbruch, S., Corsetti, M., Tack, J., Simrén, M., Winkens, B., …Keszthelyi, D. (2021). The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology, 6(6), 459-473. https://doi.org/10.1016/S2468-1253%2821%2900023-6

Background Clinical trials in irritable bowel syndrome are associated with high placebo response rates. We aimed to identify the magnitude of the placebo response and the contributing factors to this occurrence. Methods We did a systematic revie... Read More about The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis.

Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review (2021)
Journal Article
Vinarov, Z., Abdallah, M., Agundez, J. A., Allegaert, K., Basit, A. W., Braeckmans, M., …Augustijns, P. (2021). Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review. European Journal of Pharmaceutical Sciences, 162, Article 105812. https://doi.org/10.1016/j.ejps.2021.105812

The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in special populat... Read More about Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review.

Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation (2021)
Journal Article
Corsetti, M., Landes, S., & Lange, R. (2021). Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation. Neurogastroenterology and Motility, 33(10), Article e14123. https://doi.org/10.1111/nmo.14123

Background: Bisacodyl is a member of the diphenylmethane family and is considered to be a stimulant laxative. It has a dual prokinetic and secretory action and needs to be converted into the active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (... Read More about Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment (2021)
Journal Article
Corsetti, M., Brown, S., Chiarioni, G., Dimidi, E., Dudding, T., Emmanuel, A., …Scott, S. M. (2021). Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment. Neurogastroenterology and Motility, 33(7), Article e14070. https://doi.org/10.1111/nmo.14070

Background: Chronic constipation is a prevalent disorder that affects quality of life of patients and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as... Read More about Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment.

High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications (2020)
Journal Article
Corsetti, M., Thys, A., Harris, A., Pagliaro, G., Deloose, E., Demedts, I., & Tack, J. (2021). High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications. Neurogastroenterology and Motility, 33(5), Article e14040. https://doi.org/10.1111/nmo.14040

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to direct... Read More about High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications.

High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications (2020)
Journal Article
Corsetti, M., Thys, A., Harris, A., Pagliaro, G., Deloose, E., Demedts, I., & Tack, J. (2021). High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications. Neurogastroenterology and Motility, 33(5), Article e14040. https://doi.org/10.1111/nmo.14040

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to direct... Read More about High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation (2020)
Journal Article
Scott, S. M., Simrén, M., Farmer, A. D., Dinning, P. G., Carrington, E. V., Benninga, M. A., …Corsetti, M. (2021). Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation. Neurogastroenterology and Motility, 33(6), 1-21. https://doi.org/10.1111/nmo.14050

Chronic constipation is a prevalent disorder that affects patients’ quality of life and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as to which treat... Read More about Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation.

In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal (2020)
Journal Article
Maruca, A., Lupia, A., Rocca, R., Keszthelyi, D., Corsetti, M., & Alcaro, S. (2020). In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal. International Journal of Molecular Sciences, 21(23), Article 9127. https://doi.org/10.3390/ijms21239127

Food-drug interaction is an infrequently considered aspect in clinical practice. Usually, drugs are taken together with meals and what follows may adversely affect pharmacokinetic and pharmacodynamic properties, and hence, the therapeutic effects. In... Read More about In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal.

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants (2020)
Journal Article
Heissam, K., Abrehart, N., Hoad, C. L., Wright, J., Menys, A., Murray, K., …Marciani, L. (2020). Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants. PLoS ONE, 15(11), e0241441. https://doi.org/10.1371/journal.pone.0241441

Objective The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo dat... Read More about Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.

Irritable Bowel Syndrome (2020)
Journal Article
Ford, A. C., Sperber, A. D., Corsetti, M., & Camilleri, M. (2020). Irritable Bowel Syndrome. Lancet, 396(10263), 1675-1688. https://doi.org/10.1016/S0140-6736%2820%2931548-8

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose symptoms include abdominal pain associated with a change in stool form or frequency. The condition affects between 5% and 10% of otherwise healthy individuals in the commu... Read More about Irritable Bowel Syndrome.

Seated anorectal manometry during simulated evacuation. A physiological exercise or a new clinically useful diagnostic test? (2020)
Journal Article
Basilisco, B., & Corsetti, M. (2020). Seated anorectal manometry during simulated evacuation. A physiological exercise or a new clinically useful diagnostic test?. Neurogastroenterology and Motility, 32(10), Article e14001. https://doi.org/10.1111/nmo.14001

Symptoms such as a feeling of incomplete evacuation, straining, absence of the call to stool, anal blockage or digitation suggest the presence a functional defecation disorder. As symptoms do not distinguish between patients with and without function... Read More about Seated anorectal manometry during simulated evacuation. A physiological exercise or a new clinically useful diagnostic test?.

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications (2020)
Journal Article
Augustijns, P., Vertzoni, M., Reppas, C., Langguth, P., Lennernäs, H., Abrahamsson, B., …Hens, B. (2020). Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications. European Journal of Pharmaceutical Sciences, 155, Article 105517. https://doi.org/10.1016/j.ejps.2020.105517

Fluid sampling from the gastrointestinal (GI) tract has been applied as a valuable tool to gain more insight into the fluids present in the human GI tract and to explore the dynamic interplay of drug release, dissolution, precipitation and absorption... Read More about Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications.

The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge (2020)
Journal Article
Wilkinson-Smith, V., Menys, A., Bradley, C., Corsetti, M., Marciani, L., Atkinson, D., …Hoad, C. (2020). The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge. Neurogastroenterology and Motility, 32(11), Article e13942. https://doi.org/10.1111/nmo.13942

Background Magnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intra-subject reproducibility of MRI measures of colonic funct... Read More about The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge.

Patient-Specific Stress–Abdominal Pain Interaction in Irritable Bowel Syndrome: An Exploratory Experience Sampling Method Study (2020)
Journal Article
Vork, L., Keszthelyi, D., van Kuijk, S. M., Quetglas, E. G., Törnblom, H., Simrén, M., …Masclee, A. A. (2020). Patient-Specific Stress–Abdominal Pain Interaction in Irritable Bowel Syndrome: An Exploratory Experience Sampling Method Study. Clinical and Translational Gastroenterology, 11(7), Article e00209. https://doi.org/10.14309/ctg.0000000000000209

INTRODUCTION: Gastrointestinal symptoms in irritable bowel syndrome (IBS) have been correlated with psychological factors using retrospective symptom assessment. However, real-time symptom assessment might reveal the interplay between abdominal a... Read More about Patient-Specific Stress–Abdominal Pain Interaction in Irritable Bowel Syndrome: An Exploratory Experience Sampling Method Study.

Manometric demonstration of duodenal/jejunal motor function consistent with the duodenal brake mechanism (2020)
Journal Article
Dent, J., Dinning, P., Corsetti, M., Rommel, N., Tack, J., Wiklendt, L., …Deloose, E. (2020). Manometric demonstration of duodenal/jejunal motor function consistent with the duodenal brake mechanism. Neurogastroenterology and Motility, 32(10), Article e13835. https://doi.org/10.1111/nmo.13835

© 2020 John Wiley & Sons Ltd Background: High-resolution manometric studies below the stomach are rare due to technical limitations of traditional manometry catheters. Consequently, specific motor patterns and their impact on gastric and small bowe... Read More about Manometric demonstration of duodenal/jejunal motor function consistent with the duodenal brake mechanism.

Investigation of colonic motility (2019)
Book Chapter
CORSETTI, M., & GUNN, D. (2019). Investigation of colonic motility. In S. Rao, Y. Lee, & U. Ghosal (Eds.), Clinical and Basic Neurogastroenterology and Motility. Elsevier

Investigation of anorectal motility (2019)
Book Chapter
WILKINSON-SMITH, V., Basilisco, G., & CORSETTI, M. (2019). Investigation of anorectal motility. In S. Rao, Y. Lee, & U. Ghoshal (Eds.), Clinical and Basic Neurogastroenterology and Motility. Elsevier

Colonic Motility (2019)
Book Chapter
Gunn, D., & Corsetti, M. (2019). Colonic Motility. In E. Kuipers (Ed.), Encyclopedia of Gastroenterology(2nd). Elsevier

Treatment of Irritable Bowel Syndrome with diarrhoea using Titrated Ondansetron (TRITON): study protocol for a randomised control trial (2019)
Journal Article
Gunn, D., Fried, R., Lalani, R., Farrin, A., Holloway, I., Morris, T., …Spiller, R. (2019). Treatment of Irritable Bowel Syndrome with diarrhoea using Titrated Ondansetron (TRITON): study protocol for a randomised control trial. Trials, 20, Article 517. https://doi.org/10.1186/s13063-019-3562-6

Background – Irritable bowel syndrome with diarrhoea (IBS-D) affects up to 4% of the general population. Symptoms include frequent, loose, or watery stools with associated urgency, resulting in marked reduction of quality of life and loss of work pro... Read More about Treatment of Irritable Bowel Syndrome with diarrhoea using Titrated Ondansetron (TRITON): study protocol for a randomised control trial.

How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery) (2019)
Journal Article
Pauwels, A., Boecxstaens, V., Andrews, C., Attwood, S. E., Berrisford, R., Bisschops, R., …Tack, J. F. (2019). How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery). Gut, 68(11), 1928-1941. https://doi.org/10.1136/gutjnl-2019-318260

Objective: Anti-reflux surgery can be proposed in patients with gastro-esophageal reflux disease, especially when proton pump inhibitor use leads to incomplete symptom improvement. However, to date, international consensus guidelines on the clinical... Read More about How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery).

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques (2019)
Journal Article
Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P., …Tack, J. (2019). First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nature Reviews Gastroenterology and Hepatology, 16(9), 559-579. https://doi.org/10.1038/s41575-019-0167-1

Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminol... Read More about First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.

“Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy (2019)
Journal Article
Hens, B., Corsetti, M., Bermejo, M., Löbenberg, R., González, P. M., Mitra, A., …Aceituno, A. (2019). “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy. AAPS Journal, 21(4), 1-16. https://doi.org/10.1208/s12248-019-0346-6

The gastrointestinal (GI) tract is one of the most popular and used routes of drug product administration due to the convenience for better patient compliance and reduced costs to the patient compared to other routes. However, its complex nature pose... Read More about “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy.

Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers (2019)
Journal Article
Zhao, D., Corsetti, M., Moeini-Jazani, M., Weltens, N., Tuk, M., Tack, J., …Van Oudenhove, L. (2019). Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers. Neurogastroenterology and Motility, 31(7), Article e13600. https://doi.org/10.1111/nmo.13600

Background: Past research has demonstrated that moderate urge to urinate improves inhibitory control, specifically among participants with higher behavioral inhibition sensitivity (BIS). The effect was absent when the urge exceeded intolerable level.... Read More about Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers.

The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group (2019)
Journal Article
Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., …Corsetti, M. (2019). The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group. European Journal of Pharmaceutical Sciences, 134, 31-59. https://doi.org/10.1016/j.ejps.2019.04.003

The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of th... Read More about The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group.

Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders? (2019)
Journal Article
Corsetti, M., Pannemans, J., & Whorwell, P. (2019). Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?. F1000Research, 8, Article 257. https://doi.org/10.12688/f1000research.15974.1

Opioids have recently received much attention because of the epidemic in their use in some countries such as the USA and the UK. Concerns have been raised about the possibility that they can increase mortality in patients when used on a long-term bas... Read More about Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?.

Prevalence and impact of self-reported irritable bowel symptoms in the general population (2018)
Journal Article
Van den Houte, K., Carbone, F., Pannemans, J., Corsetti, M., Fischler, B., Piessevaux, H., & Tack, J. (2019). Prevalence and impact of self-reported irritable bowel symptoms in the general population. United European Gastroenterology Journal, 7(2), 307-315. https://doi.org/10.1177/2050640618821804

Background and aims The symptom-based diagnostic criteria for irritable bowel syndrome (IBS) have recently been revised in the Rome IV consensus. On the other hand, with rising public awareness of IBS, self-diagnosis and self-management is also incr... Read More about Prevalence and impact of self-reported irritable bowel symptoms in the general population.

Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI? (2018)
Journal Article
Hoad, C., Clarke, C., Marciani, L., Graves, M. J., & Corsetti, M. (2018). Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI?. British Journal of Radiology, 92(1093), https://doi.org/10.1259/bjr.20180433

Cine cardiac MRI is generally accepted as the “gold-standard” for functional myocardial assessment. It only took a few years after the development of commercial MRI systems for functional cardiac imaging to be developed, with electrocardiogram (ECG)-... Read More about Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI?.

Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders? (2018)
Journal Article
Pannemans, J., & Corsetti, M. (2018). Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?. Current Opinion in Pharmacology, 43, 53-58. doi:10.1016/j.coph.2018.08.008

Opioids have been used for centuries, mostly as a sedative and to treat pain. Currently, they are used on a global scale for the treatment of acute and chronic pain in diseases as osteoarthritis, fibromyalgia, and low back pain. Binding of opioids on... Read More about Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?.

Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome (2018)
Journal Article
Barbara, G., Grover, M., Bercik, P., Corsetti, M., Ghoshal, U. C., Ohman, L., & Rajili?-Stojanovi?, M. (2019). Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome. Gastroenterology, 156(1), 46-58.e7. https://doi.org/10.1053/j.gastro.2018.07.011

Background & Aims: The existence of postinfection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence has not been well summarized, an... Read More about Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome.

When all seems lost: management of refractory constipation—Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more (2018)
Journal Article
Wilkinson-Smith, V., Bharucha, A. E., Emmanuel, A., Knowles, C., Yiannakou, Y., & Corsetti, M. (2018). When all seems lost: management of refractory constipation—Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more. Neurogastroenterology and Motility, 30(5), Article e13352. https://doi.org/10.1111/nmo.13352

© 2018 John Wiley & Sons Ltd While the pharmacological armamentarium for chronic constipation has expanded over the past few years, a substantial proportion of constipated patients do not respond to these medications. This review summarizes the pha... Read More about When all seems lost: management of refractory constipation—Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more.

Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome (2017)
Journal Article
Vork, L., Keszthely, D., Mujagic, Z., Kruimel, J., Leue, C., Pontén, I., …Masclee, A. (in press). Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome. Neurogastroenterology and Motility, 30(3), Article e13244. https://doi.org/10.1111/nmo.13244

BACKGROUND: End-of-day questionnaires, which are considered the gold standard for assessing abdominal pain and other gastrointestinal (GI) symptoms in irritable bowel syndrome (IBS), are influenced by recall and ecological bias. The Experience Sampli... Read More about Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome.

The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature? (2017)
Journal Article
Corsetti, M., & Fox, M. (2017). The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?. F1000Research, 6, Article 1778. https://doi.org/10.12688/f1000research.12089.1

© 2017 Corsetti M and Fox M. Functional dyspepsia is a prevalent functional gastrointestinal disorder that can significantly erode the quality of life of sufferers and places a major cost burden on healthcare services. In this article, we review the... Read More about The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?.

Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts (2017)
Journal Article
Tack, J., Corsetti, M., Camilleri, M., Quigley, A., Simren, M., Suzuki, H., …Van Oudenhove, L. (in press). Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts. Gut, https://doi.org/10.1136/gutjnl-2016-312230

The functional gastrointestinal disorders (FGIDs), are extremely common conditions associated with a considerable personal, social and health economic burden. Managing FGIDs in clinical practice is challenging because of the uncertainty of symptom-ba... Read More about Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts.

Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers (2017)
Journal Article
Deloose, E., Corsetti, M., Van Oudenhove, L., Depoortere, I., & Tack, J. (2017). Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers. Neurogastroenterology and Motility, 30(1), Article e13171. https://doi.org/10.1111/nmo.13171

Intragastric administration of the bitter tastant denatonium benzoate inhibits the increase of motilin plasma levels and antral contractility. While these findings suggest that gastrointestinal bitter taste receptors could be new targets to modulate... Read More about Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers.

The global impact of IBS: time to think about IBS-specific models of care? (2017)
Journal Article
Corsetti, M., & Whorwell, P. (2017). The global impact of IBS: time to think about IBS-specific models of care?. Therapeutic Advances in Gastroenterology, 10(9), 727-736. doi:10.1177/1756283x17718677

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal (GI) disorder that can significantly erode the quality of life (QoL) of sufferers and places a major cost burden on healthcare services. This paper reviews the literature on th... Read More about The global impact of IBS: time to think about IBS-specific models of care?.

New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline (2017)
Journal Article
Corsetti, M., & Whorwell, P. (2017). New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline. Expert Review of Gastroenterology and Hepatology, 11(4), 285-292. https://doi.org/10.1080/17474124.2017.1298442

Introduction: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder which represents a major cost to healthcare services. IBS-D patients represent about one-third of the IBS population and are currently treated with antis... Read More about New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline.

Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers (2017)
Journal Article
Deloose, E., Janssen, P., Corsetti, M., Biesiekierski, J., Masuy, I., Rotondo, A., …Tack, J. (2017). Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers. American Journal of Clinical Nutrition, 105(3), 580-588. https://doi.org/10.3945/ajcn.116.138297

Background: Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion. Objective: We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concen... Read More about Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers.

Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities (2016)
Journal Article
Hens, B., Corsetti, M., Spiller, R. C., Marciani, L., Vanuytsel, T., Tack, J., …Augustijns, P. (2017). Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519(1-2), https://doi.org/10.1016/j.ijpharm.2016.11.063

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables i... Read More about Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities.

Manometric evaluation of anorectal function in patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer (2016)
Journal Article
De Nardi, P., Testoni, S. G. G., Corsetti, M., Andreoletti, H., Giollo, P., Passarett, S., & Testoni, P. A. (2017). Manometric evaluation of anorectal function in patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer. Digestive Diseases and Sciences, 49(1), https://doi.org/10.1016/j.dld.2016.09.005

BACKGROUND: An altered anorectal function is reported after chemoradiotherapy (CRT) and surgery for rectal cancer. AIM: The aim of this study was to clarify the relative contribution of neoadjuvant chemoradiation and surgical resection on the impair... Read More about Manometric evaluation of anorectal function in patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer.

Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry (2016)
Journal Article
Corsetti, M., Pagliaro, G., Demedts, I., Deloose, E., Gevers, A., Scheerens, C., …Tack, J. (2017). Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry. American Journal of Gastroenterology, 112(3), https://doi.org/10.1038/ajg.2016.341

Background: Only few studies have applied high-resolution manometry (HRM) to the study of colonic motility in adults and none of them have concurrently evaluated colonic and anal motor activity. Aims: To evaluate colonic and anal motor activity by me... Read More about Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry.

Gastrointestinal and systemic monitoring of posaconazole in humans after fasted and fed state administration of a solid dispersion (2016)
Journal Article
Hens, B., Corsetti, M., Brouwers, J., & Augustijns, P. (2016). Gastrointestinal and systemic monitoring of posaconazole in humans after fasted and fed state administration of a solid dispersion. Journal of Pharmaceutical Sciences, 105(9), 2904-2912. doi:10.1016/j.xphs.2016.03.027

The purpose of this study was to explore the intraluminal behavior and systemic exposure of posaconazole in humans after oral intake of a novel delayed-release tablet (Noxafil®), containing posaconazole dispersed in a matrix of hydroxypropyl methylce... Read More about Gastrointestinal and systemic monitoring of posaconazole in humans after fasted and fed state administration of a solid dispersion.