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Outputs (18)

Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation (2023)
Journal Article
Majrashi, M., Yang, J., Ghaemmaghami, A., Kotowska, A., Hicks, J. M., & Scurr, D. (2023). Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation. ACS Applied Materials and Interfaces, 15(49), 56623–56638. https://doi.org/10.1021/acsami.3c09774

Enhancing osteogenesis via modulating immune cells is emerging as a new approach to address current challenges in repairing bone defects and fractures. However, much remains unknown about the crosstalk between immune cells and osteolineage cells duri... Read More about Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation.

Elucidating osseointegration in vivo in 3D printed scaffolds eliciting different foreign body responses (2023)
Journal Article
Qiu, D., Cao, C., Prasopthum, A., Sun, Z., Zhang, S., Yang, H., …Yang, J. (2023). Elucidating osseointegration in vivo in 3D printed scaffolds eliciting different foreign body responses. Materials Today Bio, 22, Article 100771. https://doi.org/10.1016/j.mtbio.2023.100771

Osseointegration between biomaterial and bone is critical for the clinical success of many orthopaedic and dental implants. However, the mechanisms of in vivo interfacial bonding formation and the role of immune cells in this process remain unclear.... Read More about Elucidating osseointegration in vivo in 3D printed scaffolds eliciting different foreign body responses.

Characterisation of bone regeneration in 3D printed ductile PCL/PEG/hydroxyapatite scaffolds with high ceramic microparticle concentrations (2021)
Journal Article
Cao, C., Huang, P., Prasopthum, A., Parsons, A. J., Ai, F., & Yang, J. (2022). Characterisation of bone regeneration in 3D printed ductile PCL/PEG/hydroxyapatite scaffolds with high ceramic microparticle concentrations. Biomaterials Science, 10(1), 138-152. https://doi.org/10.1039/d1bm01645h

3D printed bioactive glass or bioceramic particle reinforced composite scaffolds for bone tissue engineering currently suffer from low particle concentration (100% breaking strain) by adding poly(ethylene glycol) which is biocompatible and FDA approv... Read More about Characterisation of bone regeneration in 3D printed ductile PCL/PEG/hydroxyapatite scaffolds with high ceramic microparticle concentrations.

3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair (2021)
Journal Article
Hamid, O. A., Eltaher, H. M., Sottile, V., & Yang, J. (2021). 3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair. Materials Science and Engineering: C, 120, Article 111707. https://doi.org/10.1016/j.msec.2020.111707

© 2020 Elsevier B.V. Development of a biomimetic tubular scaffold capable of recreating developmental neurogenesis using pluripotent stem cells offers a novel strategy for the repair of spinal cord tissues. Recent advances in 3D printing technology h... Read More about 3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair.

Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells (2020)
Journal Article
Prasopthum, A., Deng, Z., Khan, I. M., Yin, Z., Guo, B., & Yang, J. (2020). Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells. Biomaterials Science, 8(15), 4287-4298. https://doi.org/10.1039/d0bm00621a

Conductive polymers have been used for various biomedical applications including biosensors, tissue engineering and regenerative medicine. However, the poor processability and brittleness of these polymers hinder the fabrication of three-dimensional... Read More about Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells.

To Learn Image Super-Resolution, Use a GAN to Learn How to Do Image Degradation First (2018)
Presentation / Conference Contribution
Bulat, A., Yang, J., & Tzimiropoulos, G. (2018). To Learn Image Super-Resolution, Use a GAN to Learn How to Do Image Degradation First. In Computer Vision – ECCV 2018: 15th European Conference Munich, Germany, September 8–14, 2018 Proceedings, Part VI (187-202). https://doi.org/10.1007/978-3-030-01231-1_12

© Springer Nature Switzerland AG 2018. This paper is on image and face super-resolution. The vast majority of prior work for this problem focus on how to increase the resolution of low-resolution images which are artificially generated by simple bili... Read More about To Learn Image Super-Resolution, Use a GAN to Learn How to Do Image Degradation First.

Rice auxin influx carrier OsAUX1 facilitates root hair elongation in response to low external phosphate (2018)
Journal Article
Giri, J., Bhosale, R., Huang, G., Pandey, B. K., Parker, H., Zappala, S., …Bennett, M. J. (2018). Rice auxin influx carrier OsAUX1 facilitates root hair elongation in response to low external phosphate. Nature Communications, 9(1), https://doi.org/10.1038/s41467-018-03850-4

Root traits such as root angle and hair length influence resource acquisition particularly for immobile nutrients like phosphorus (P). Here, we attempted to modify root angle in rice by disrupting the OsAUX1 auxin influx transporter gene in an effort... Read More about Rice auxin influx carrier OsAUX1 facilitates root hair elongation in response to low external phosphate.

Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography (2017)
Journal Article
Yang, J., Shakesheff, K. M., & Prasopthum, A. (2018). Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography. Biofabrication, 10(2), Article 025002. https://doi.org/10.1088/1758-5090/aaa15b

Three-dimensional (3D) printing is a powerful manufacturing tool for making 3D structures with well-defined architectures for a wide range of applications. The field of tissue engineering has also adopted this technology to fabricate scaffolds for ti... Read More about Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography.

3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review (2017)
Journal Article
Prina, E., Mistry, P., Sidney, L. E., Yang, J., Wildman, R. D., Bertolin, M., …Rose, F. R. A. (2017). 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review. Stem Cell Reviews and Reports, 13(3), 430-441. https://doi.org/10.1007/s12015-017-9740-6

In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the nativ... Read More about 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review.

Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers (2016)
Journal Article
Adlington, K., Nguyen, N. T., Eaves, E., Yang, J., Chang, C. Y., Li, J., …Irvine, D. J. (2016). Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers. Biomacromolecules, 17(9), 2830-2838. https://doi.org/10.1021/acs.biomac.6b00615

© 2016 American Chemical Society. Developing medical devices that resist bacterial attachment and subsequent biofilm formation is highly desirable. In this paper, we report the optimization of the molecular structure and thus material properties of a... Read More about Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers.

Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate (2016)
Journal Article
Eltaher, H. M., Yang, J., Shakesheff, K. M., & Dixon, J. E. (2016). Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate. Acta Biomaterialia, 41, 181-192. https://doi.org/10.1016/j.actbio.2016.06.004

Fundamental behaviour such as cell fate, growth and death are mediated through the control of key genetic transcriptional regulators. These regulators are activated or repressed by the integration of multiple signalling molecules in spatio-temporal g... Read More about Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate.

Modelling and Prediction of Bacterial Attachment to Polymers (2013)
Journal Article
Epa, V., Hook, A. L., Chang, C., Yang, J., Langer, R., Anderson, D. G., …Winkler, D. A. (2014). Modelling and Prediction of Bacterial Attachment to Polymers. Advanced Functional Materials, 24(14), 2085-2093. https://doi.org/10.1002/adfm.201302877

Infection by pathogenic bacteria on implanted and indwelling medical devices during surgery causes large morbidity and mortality worldwide. Attempts to ameliorate this important medical issue have included development of antimicrobial surfaces on mat... Read More about Modelling and Prediction of Bacterial Attachment to Polymers.

Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays (2013)
Journal Article
Hook, A. L., Chang, C.-Y., Yang, J., Atkinson, S., Langer, R., Anderson, D. G., …Alexander, M. R. (2013). Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials, 25(18), https://doi.org/10.1002/adma.201204936

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacteria... Read More about Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays.

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces (2012)
Journal Article
Epa, V., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., …Winkler, D. A. (2012). Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. Journal of Materials Chemistry, 39(22), https://doi.org/10.1039/C2JM34782B

Designing materials to control biology is an intense focus of biomaterials and regenerative medicine research. Discovering and designing materials with appropriate biological compatibility or active control of cells and tissues is being increasingly... Read More about Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces.

Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray (2011)
Journal Article
Hook, A. L., Yang, J., Chen, X., Roberts, C. J., Mei, Y., Anderson, D. G., …Davies, M. C. (2011). Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray. Soft Matter, 7, https://doi.org/10.1039/c1sm06063e

Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with disparate hydrophilicities that... Read More about Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray.