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Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation (2023)
Journal Article
Majrashi, M., Yang, J., Ghaemmaghami, A., Kotowska, A., Hicks, J. M., & Scurr, D. (2023). Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation. ACS Applied Materials and Interfaces, 15(49), 56623–56638. https://doi.org/10.1021/acsami.3c09774

Enhancing osteogenesis via modulating immune cells is emerging as a new approach to address current challenges in repairing bone defects and fractures. However, much remains unknown about the crosstalk between immune cells and osteolineage cells duri... Read More about Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation.

Elucidating osseointegration in vivo in 3D printed scaffolds eliciting different foreign body responses (2023)
Journal Article
Qiu, D., Cao, C., Prasopthum, A., Sun, Z., Zhang, S., Yang, H., …Yang, J. (2023). Elucidating osseointegration in vivo in 3D printed scaffolds eliciting different foreign body responses. Materials Today Bio, 22, Article 100771. https://doi.org/10.1016/j.mtbio.2023.100771

Osseointegration between biomaterial and bone is critical for the clinical success of many orthopaedic and dental implants. However, the mechanisms of in vivo interfacial bonding formation and the role of immune cells in this process remain unclear.... Read More about Elucidating osseointegration in vivo in 3D printed scaffolds eliciting different foreign body responses.

Characterisation of bone regeneration in 3D printed ductile PCL/PEG/hydroxyapatite scaffolds with high ceramic microparticle concentrations (2021)
Journal Article
Cao, C., Huang, P., Prasopthum, A., Parsons, A. J., Ai, F., & Yang, J. (2022). Characterisation of bone regeneration in 3D printed ductile PCL/PEG/hydroxyapatite scaffolds with high ceramic microparticle concentrations. Biomaterials Science, 10(1), 138-152. https://doi.org/10.1039/d1bm01645h

3D printed bioactive glass or bioceramic particle reinforced composite scaffolds for bone tissue engineering currently suffer from low particle concentration (100% breaking strain) by adding poly(ethylene glycol) which is biocompatible and FDA approv... Read More about Characterisation of bone regeneration in 3D printed ductile PCL/PEG/hydroxyapatite scaffolds with high ceramic microparticle concentrations.

3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair (2021)
Journal Article
Hamid, O. A., Eltaher, H. M., Sottile, V., & Yang, J. (2021). 3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair. Materials Science and Engineering: C, 120, Article 111707. https://doi.org/10.1016/j.msec.2020.111707

© 2020 Elsevier B.V. Development of a biomimetic tubular scaffold capable of recreating developmental neurogenesis using pluripotent stem cells offers a novel strategy for the repair of spinal cord tissues. Recent advances in 3D printing technology h... Read More about 3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair.

Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells (2020)
Journal Article
Prasopthum, A., Deng, Z., Khan, I. M., Yin, Z., Guo, B., & Yang, J. (2020). Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells. Biomaterials Science, 8(15), 4287-4298. https://doi.org/10.1039/d0bm00621a

Conductive polymers have been used for various biomedical applications including biosensors, tissue engineering and regenerative medicine. However, the poor processability and brittleness of these polymers hinder the fabrication of three-dimensional... Read More about Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells.

Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites (2020)
Journal Article
Eltaher, H. M., Abukunna, F. E., Ruiz-Cantu, L., Stone, Z., Yang, J., & Dixon, J. E. (2020). Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites. Acta Biomaterialia, 113, 339-349. https://doi.org/10.1016/j.actbio.2020.06.012

© 2020 Combating necrosis, by supplying nutrients and removing waste, presents the major challenge for engineering large three-dimensional (3D) tissues. Previous elegant work used 3D printing with carbohydrate glass as a cytocompatible sacrificial te... Read More about Human-scale tissues with patterned vascular networks by additive manufacturing of sacrificial sugar-protein composites.

Bioinspired Precision Engineering of Three-Dimensional Epithelial Stem Cell Microniches (2020)
Journal Article
Prina, E., Amer, M. H., Sidney, L., Tromayer, M., Moore, J., Liska, R., …Rose, F. R. (2020). Bioinspired Precision Engineering of Three-Dimensional Epithelial Stem Cell Microniches. Advanced Biosystems, 4(6), Article 2000016. https://doi.org/10.1002/adbi.202000016

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Maintenance of the epithelium relies on stem cells residing within specialized microenvironments, known as epithelial crypts. Two-photon polymerization (2PP) is a valuable... Read More about Bioinspired Precision Engineering of Three-Dimensional Epithelial Stem Cell Microniches.

Multi-material 3D bioprinting of porous constructs for cartilage regeneration (2019)
Journal Article
Ruiz-Cantu, L., Gleadall, A., Faris, C., Segal, J., Shakesheff, K., & Yang, J. (2020). Multi-material 3D bioprinting of porous constructs for cartilage regeneration. Materials Science and Engineering: C, 109, https://doi.org/10.1016/j.msec.2019.110578

© 2020 Elsevier B.V. The current gold standard for nasal reconstruction after rhinectomy or severe trauma includes transposition of autologous cartilage grafts in conjunction with coverage using an autologous skin flap. Harvesting autologous cartilag... Read More about Multi-material 3D bioprinting of porous constructs for cartilage regeneration.

3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells (2019)
Journal Article
Prasopthum, A., Cooper, M., Shakesheff, K. M., & Yang, J. (2019). 3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells. ACS Applied Materials and Interfaces, 11(21), 18896-18906. https://doi.org/10.1021/acsami.9b01472

The effect of topography in 3D printed polymer scaffolds on stem cell differentiation is a significantly under-explored area. Compared to 2D biomaterials on which various well-defined topographies have been incorporated and been shown to direct an ar... Read More about 3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells.

Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples (2019)
Journal Article
Dooley, M., Prasopthum, A., Liao, Z., Sinjab, F., Mclaren, J., Rose, F. R. A. J., …Notingher, I. (2019). Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples. Biomedical Optics Express, 10(4), 1678-1690. https://doi.org/10.1364/BOE.10.001678

Using phantom samples, we investigated the feasibility of spatially-offset Raman spectroscopy (SORS) as a tool for monitoring non-invasively the mineralization of bone tissue engineering scaffold in-vivo. The phantom samples consisted of 3D-printed s... Read More about Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples.

Geometry alone influences stem cell differentiation in a precision 3D printed stem cell niche (2018)
Working Paper
Prina, E., Sidney, L., Tromayer, M., Moore, J., Liska, R., Bertolin, M., …Rose, F. R. Geometry alone influences stem cell differentiation in a precision 3D printed stem cell niche

Stem cells within epithelial tissues reside in anatomical structures known as crypts that are known to contribute to the mechanical and chemical milieu important for function. To date, epithelial stem cell therapies have largely ignored the niche and... Read More about Geometry alone influences stem cell differentiation in a precision 3D printed stem cell niche.

To Learn Image Super-Resolution, Use a GAN to Learn How to Do Image Degradation First (2018)
Conference Proceeding
Bulat, A., Yang, J., & Tzimiropoulos, G. (2018). To Learn Image Super-Resolution, Use a GAN to Learn How to Do Image Degradation First. In Computer Vision – ECCV 2018: 15th European Conference Munich, Germany, September 8–14, 2018 Proceedings, Part VI (187-202). https://doi.org/10.1007/978-3-030-01231-1_12

© Springer Nature Switzerland AG 2018. This paper is on image and face super-resolution. The vast majority of prior work for this problem focus on how to increase the resolution of low-resolution images which are artificially generated by simple bili... Read More about To Learn Image Super-Resolution, Use a GAN to Learn How to Do Image Degradation First.

Erratum: Author Correction: Rice auxin influx carrier OsAUX1 facilitates root hair elongation in response to low external phosphate (Nature communications (2018) 9 1 (1408)) (2018)
Journal Article
Giri, J., Bhosale, R., Huang, G., Pandey, B. K., Parker, H., Zappala, S., …Bennett, M. J. (2018). Erratum: Author Correction: Rice auxin influx carrier OsAUX1 facilitates root hair elongation in response to low external phosphate (Nature communications (2018) 9 1 (1408)). Nature Communications, 9(1), Article 1810. https://doi.org/10.1038/s41467-018-04280-y

The original version of this Article omitted the following from the Acknowledgements:'We also thank DBT-CREST BT/HRD/03/01/2002.'This has been corrected in both the PDF and HTML versions of the Article.

Rice auxin influx carrier OsAUX1 facilitates root hair elongation in response to low external phosphate (2018)
Journal Article
Giri, J., Bhosale, R., Huang, G., Pandey, B. K., Parker, H., Zappala, S., …Bennett, M. J. (2018). Rice auxin influx carrier OsAUX1 facilitates root hair elongation in response to low external phosphate. Nature Communications, 9(1), https://doi.org/10.1038/s41467-018-03850-4

Root traits such as root angle and hair length influence resource acquisition particularly for immobile nutrients like phosphorus (P). Here, we attempted to modify root angle in rice by disrupting the OsAUX1 auxin influx transporter gene in an effort... Read More about Rice auxin influx carrier OsAUX1 facilitates root hair elongation in response to low external phosphate.

Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography (2017)
Journal Article
Yang, J., Shakesheff, K. M., & Prasopthum, A. (2018). Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography. Biofabrication, 10(2), Article 025002. https://doi.org/10.1088/1758-5090/aaa15b

Three-dimensional (3D) printing is a powerful manufacturing tool for making 3D structures with well-defined architectures for a wide range of applications. The field of tissue engineering has also adopted this technology to fabricate scaffolds for ti... Read More about Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography.

3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review (2017)
Journal Article
Prina, E., Mistry, P., Sidney, L. E., Yang, J., Wildman, R. D., Bertolin, M., …Rose, F. R. A. (2017). 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review. Stem Cell Reviews and Reports, 13(3), 430-441. https://doi.org/10.1007/s12015-017-9740-6

In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the nativ... Read More about 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review.

Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands (2017)
Journal Article
Mistry, P., Aied, A., Alexander, M. R., Shakesheff, K., Bennett, A., & Yang, J. (2017). Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands. Macromolecular Bioscience, 17(6), Article 1600472. https://doi.org/10.1002/mabi.201600472

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combinat... Read More about Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands.

Feasibility of spatially-offset Raman spectroscopy for in-vitro and in-vivo monitoring mineralisation of bone tissue-engineering scaffolds (2016)
Journal Article
Liao, Z., Sinjab, F., Nommeots-Nomm, A., Jones, J., Ruiz-Cantu, L., Yang, J., …Notingher, I. (2017). Feasibility of spatially-offset Raman spectroscopy for in-vitro and in-vivo monitoring mineralisation of bone tissue-engineering scaffolds. Analytical Chemistry, 89(1), 847-853. https://doi.org/10.1021/acs.analchem.6b03785

We investigated the feasibility of using spatially-offset Raman spectroscopy (SORS) for non-destructive characterisation of bone tissue engineering scaffolds. The deep regions of these scaffolds, or scaffolds implanted subcutaneously in live animals,... Read More about Feasibility of spatially-offset Raman spectroscopy for in-vitro and in-vivo monitoring mineralisation of bone tissue-engineering scaffolds.

Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers (2016)
Journal Article
Adlington, K., Nguyen, N. T., Eaves, E., Yang, J., Chang, C. Y., Li, J., …Irvine, D. J. (2016). Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers. Biomacromolecules, 17(9), 2830-2838. https://doi.org/10.1021/acs.biomac.6b00615

© 2016 American Chemical Society. Developing medical devices that resist bacterial attachment and subsequent biofilm formation is highly desirable. In this paper, we report the optimization of the molecular structure and thus material properties of a... Read More about Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers.

Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate (2016)
Journal Article
Eltaher, H. M., Yang, J., Shakesheff, K. M., & Dixon, J. E. (2016). Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate. Acta Biomaterialia, 41, 181-192. https://doi.org/10.1016/j.actbio.2016.06.004

Fundamental behaviour such as cell fate, growth and death are mediated through the control of key genetic transcriptional regulators. These regulators are activated or repressed by the integration of multiple signalling molecules in spatio-temporal g... Read More about Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate.

Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing (2016)
Journal Article
Ruiz-Cantu, L., Gleadall, A., Faris, C., Segal, J., Shakesheff, K., & Yang, J. (2016). Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing. Biofabrication, 8(1), Article 015016. https://doi.org/10.1088/1758-5090/8/1/015016

© 2016 IOP Publishing Ltd. 3D printing is of great interest for tissue engineering scaffolds due to the ability to form complex geometries and control internal structures, including porosity and pore size. The porous structure of scaffolds plays an i... Read More about Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing.

3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles (2015)
Journal Article
Khaled, S. A., Burley, J. C., Alexander, M. R., Yang, J., & Roberts, C. J. (in press). 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of Controlled Release, 217, https://doi.org/10.1016/j.jconrel.2015.09.028

We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypil... Read More about 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.

Cell and protein compatible 3D bioprinting of mechanically strong constructs for bone repair (2015)
Journal Article
Sawkins, M. J., Mistry, P., Brown, B. N., Shakesheff, K. M., Bonassar, L. J., & Yang, J. (2015). Cell and protein compatible 3D bioprinting of mechanically strong constructs for bone repair. Biofabrication, 7(3), Article 035004. https://doi.org/10.1088/1758-5090/7/3/035004

© 2015 IOP Publishing Ltd. Rapid prototyping of bone tissue engineering constructs often utilizes elevated temperatures, organic solvents and/or UV light for materials processing. These harsh conditions may prevent the incorporation of cells and ther... Read More about Cell and protein compatible 3D bioprinting of mechanically strong constructs for bone repair.

Modelling and Prediction of Bacterial Attachment to Polymers (2013)
Journal Article
Epa, V., Hook, A. L., Chang, C., Yang, J., Langer, R., Anderson, D. G., …Winkler, D. A. (2014). Modelling and Prediction of Bacterial Attachment to Polymers. Advanced Functional Materials, 24(14), 2085-2093. https://doi.org/10.1002/adfm.201302877

Infection by pathogenic bacteria on implanted and indwelling medical devices during surgery causes large morbidity and mortality worldwide. Attempts to ameliorate this important medical issue have included development of antimicrobial surfaces on mat... Read More about Modelling and Prediction of Bacterial Attachment to Polymers.

Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays (2013)
Journal Article
Hook, A. L., Chang, C., Yang, J., Atkinson, S., Langer, R., Anderson, D. G., …Alexander, M. R. (2013). Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials, 25(18), https://doi.org/10.1002/adma.201204936

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacteria... Read More about Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays.

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces (2012)
Journal Article
Epa, V., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., …Winkler, D. A. (2012). Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. Journal of Materials Chemistry, 39(22), https://doi.org/10.1039/C2JM34782B

Designing materials to control biology is an intense focus of biomaterials and regenerative medicine research. Discovering and designing materials with appropriate biological compatibility or active control of cells and tissues is being increasingly... Read More about Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces.

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., …Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), 868-875. https://doi.org/10.1038/nbt.2316

Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput... Read More about Combinatorial discovery of polymers resistant to bacterial attachment.

Polymers with hydro-responsive topography identi?ed using high throughput AFM of an acrylate microarray (2011)
Journal Article
Hook, A. L., Yang, J., Chen, X., Roberts, C. J., Mei, Y., Anderson, D. G., …Davies, M. C. (2011). Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray. Soft Matter, 7, https://doi.org/10.1039/c1sm06063e

Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with disparate hydrophilicities that... Read More about Polymers with hydro-responsive topography identi?ed using high throughput AFM of an acrylate microarray.