Professor RICHARD GRUNDY's Outputs (2)

Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature (2024)
Journal Article
Wood, J., Smith, S. J., Castellanos-Uribe, M., Lourdusamy, A., May, S. T., Barrett, D. A., Grundy, R. G., Kim, D.-H., & Rahman, R. (2025). Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature. Heliyon, 11(1), Article e41309. https://doi.org/10.1016/j.heliyon.2024.e41309

Isocitrate dehydrogenase wild-type glioblastoma (GBM) is characterised by a heterogeneous genetic landscape resulting from dynamic competition between tumour subclones to survive selective pressures. Improvements in metabolite identification and meta... Read More about Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature.

Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma (2024)
Journal Article
Serra, R., Smith, S. J., Rowlinson, J., Gorelick, N., Moloney, C., McCrorie, P., Veal, G. J., Berry, P., Chalmers, A. J., Suk, I., Shakesheff, K. M., Alexander, C., Grundy, R. G., Brem, H., Tyler, B. M., & Rahman, R. (2024). Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma. British Journal of Cancer, 131, 1858-1868. https://doi.org/10.1038/s41416-024-02878-2

Background: There is increased pan-cancer specific interest in repurposing the poly adenosine diphosphate-ribose polymerase-1 (PARP-1) inhibitor, olaparib, for newly diagnosed or recurrent isocitrate dehydrogenase wild type glioblastoma. We explore w... Read More about Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma.