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Outputs (28)

Risk of mortality following surgery in patients with a previous cerebrovascular accident or acute coronary syndrome: a 10-year database linkage between Hospital Episode Statistics, Myocardial Infarction National Audit Project, and Office for National Statistics (2023)
Journal Article
Chalitsios, C. V., Luney, M. S., Lindsay, W., Sanders, R. D., McKeever, T. M., & Moppett, I. (2024). Risk of mortality following surgery in patients with a previous cerebrovascular accident or acute coronary syndrome: a 10-year database linkage between Hospital Episode Statistics, Myocardial Infarction National Audit Project, and Office for National Statistics. JAMA Surgery, 159(2), 140-149. https://doi.org/10.1001/jamasurg.2023.5951

Importance: There is a lack of consensus regarding the interval of time-dependent postoperative mortality risk following an acute coronary syndrome or stroke. Objective: To determine the magnitude and duration of risk associated with the time interv... Read More about Risk of mortality following surgery in patients with a previous cerebrovascular accident or acute coronary syndrome: a 10-year database linkage between Hospital Episode Statistics, Myocardial Infarction National Audit Project, and Office for National Statistics.

Patient characteristics, anaesthetic workload and techniques in the UK: an analysis from the 7th National Audit Project (NAP7) activity survey (2023)
Journal Article
Kane, A. D., Soar, J., Armstrong, R. A., Kursumovic, E., Davies, M. T., Oglesby, F. C., …Kailainathan, P. (2023). Patient characteristics, anaesthetic workload and techniques in the UK: an analysis from the 7th National Audit Project (NAP7) activity survey. Anaesthesia, 78(6), 701-711. https://doi.org/10.1111/anae.15989

Detailed contemporary knowledge of the characteristics of the surgical population, national anaesthetic workload, anaesthetic techniques and behaviours are essential to monitor productivity, inform policy and direct research themes. Every 3–4 years,... Read More about Patient characteristics, anaesthetic workload and techniques in the UK: an analysis from the 7th National Audit Project (NAP7) activity survey.

Early mortality outcomes of patients with fragility hip fracture and concurrent SARS-CoV-2 infection: a systematic review and meta-analysis (2021)
Journal Article
Alcock, H., Moppett, E., & Moppett, I. (2021). Early mortality outcomes of patients with fragility hip fracture and concurrent SARS-CoV-2 infection: a systematic review and meta-analysis. Bone & Joint Open, 2(5), 314-322. https://doi.org/10.1302/2633-1462.25.BJO-2020-0183.R1

Aims Hip fracture is a common condition of the older, frailer person. This population is also at risk from SARS-CoV-2 infection. It is important to understand the impact of coexistent hip fracture and SARS-CoV-2 for informed decision-making at patie... Read More about Early mortality outcomes of patients with fragility hip fracture and concurrent SARS-CoV-2 infection: a systematic review and meta-analysis.

Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals (2020)
Journal Article
Luney, M., Lindsay, W., McKeever, T. M., & Moppett, I. K. (2020). Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals. BMJ Open, 10(10), Article e037904. https://doi.org/10.1136/bmjopen-2020-037904

Introduction: An increasing number of people who have a history of acute coronary syndrome or cerebrovascular accident (termed cardiovascular events) are being considered for surgery. Up-to-date evidence of the impact of these prior events is needed... Read More about Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals.

A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF) (2020)
Journal Article
Gillies, M., Ghaffar, S., Moppett, I., Docherty, A., Clarke, S., Rea, N., …Walsh, T. (2021). A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF). British Journal of Anaesthesia, 126(1), 77-86. https://doi.org/10.1016/j.bja.2020.06.048

Background The optimum transfusion strategy in patients with fractured neck of femur is uncertain, particularly if there is coexisting cardiovascular disease. Methods We conducted a prospective, single-centre, randomised feasibility trial of tw... Read More about A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF).

Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis (2020)
Journal Article
Noah, A. M., Almghairbi, D., & Moppett, I. K. (2020). Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis. Clinical Neurology and Neurosurgery, 196, Article 106036. https://doi.org/10.1016/j.clineuro.2020.106036

Thinning of retinal layers, measured using optical coherence tomography (OCT), is associated with some neurodegenerative disorders such as established Alzheimer’s disease and multiple sclerosis. The evidence for retinal layer thinning in both mild co... Read More about Optical coherence tomography in mild cognitive impairment – systematic review and meta-analysis.

Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching (2020)
Journal Article
Morgan, L., McKeever, T. M., Nightingale, J., Deakin, D. E., & Moppett, I. K. (2020). Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching. Anaesthesia, 75(9), 1173-1179. https://doi.org/10.1111/anae.15042

Around 76,000 people fracture their hip annually in the UK at a considerable personal, social and financial cost. Despite longstanding debate, the optimal mode of anaesthesia (general or spinal) remains unclear. Our aim was to assess whether there is... Read More about Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching.

Guidance in an uncertain world (2020)
Journal Article
Moppett, I. K., Gardiner, D., & Harvey, D. J. R. (2020). Guidance in an uncertain world. British Journal of Anaesthesia, 125(1), 7-9. https://doi.org/10.1016/j.bja.2020.04.003

In the face of the coronavirus pandemic, clinicians are looking to multiple sources for guidance. Good guidance provides a helpful tool to support decision making by experienced and highly-trained healthcare professionals. However, in the context of... Read More about Guidance in an uncertain world.

Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine (2020)
Journal Article
Lindsay, W. A., Murphy, M. M., Almghairbi, D. S., & Moppett, I. K. (2020). Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine. Anaesthesia, 75(6), 809-815. https://doi.org/10.1111/anae.14967

The applicability of the results of any clinical trial will depend to a large extent on whether the study population is representative of the population seen in clinical practice. The growing older surgical population presents challenges for peri-ope... Read More about Age, sex, race and ethnicity representativeness of randomised controlled trials in peri‐operative medicine.

The effect of intravenous iron on erythropoiesis in older people with hip fracture (2019)
Journal Article
Moppett, I., Rowlands, M., Mannings, A., Marufu, T., Sahota, O., & Yeung, J. (2019). The effect of intravenous iron on erythropoiesis in older people with hip fracture. Age and Ageing, 48(5), 751–755. https://doi.org/10.1093/ageing/afz049

Background: Anaemia following hip fracture is common and associated with worse outcomes. Intravenous iron is a potential non-transfusion treatment for this anaemia and has been found to reduce transfusion rates in previous observational studies. Ther... Read More about The effect of intravenous iron on erythropoiesis in older people with hip fracture.

Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS) (2019)
Journal Article
Moppett, I. (2019). Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS). Injury, 50(4), 931-938. https://doi.org/10.1016/j.injury.2019.03.009

Background: We aimed to describe and quantify postoperative complications in the older hip fracture population, develop and validate a hip fracture postoperative morbidity survey tool (HF–POMS). Methods: A prospective clinical observation study o... Read More about Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS).

Hip fracture outcomes in patients with COPD (2018)
Journal Article
Buss, L., McKeever, T. M., Nightingale, J., Akyea, R., Ollivere, B., Moppett, I., & Bolton, C. E. (2018). Hip fracture outcomes in patients with COPD. British Journal of Anaesthesia, 121(6), 1377-1379. https://doi.org/10.1016/j.bja.2018.09.008+hideArticle+Info

Hip fractures are common in patients with COPD and contemporary outcome data is needed. Patients admitted with a hip fracture to one acute trust (2010-2015) were assessed prospectively (UK National Hip Fracture Database audit) and mortality data col... Read More about Hip fracture outcomes in patients with COPD.

Anaesthesia workload measurement devices: qualitative systematic review (2018)
Journal Article
Almghairbi, D. S., Marufu, T. C., & Moppett, I. K. (2018). Anaesthesia workload measurement devices: qualitative systematic review. BMJ Simulation & Technology Enhanced Learning, 4(3), 112-116. https://doi.org/10.1136/bmjstel-2017-000263

Background: Management of mental workload is a key aspect of safety in anaesthesia but there is no gold standard tool to assess mental workload, risking confusion in clinical and research use of such tools. Objective: This review assessed currentl... Read More about Anaesthesia workload measurement devices: qualitative systematic review.

Tight intra-operative blood pressure control versus standard care for patients undergoing hip fracture repair - Hip Fracture Intervention Study for Prevention of Hypotension (HIP-HOP) trial: study protocol for a randomised controlled trial (2017)
Journal Article
Moppett, I. K., White, S., Griffiths, R., & Buggy, D. (in press). Tight intra-operative blood pressure control versus standard care for patients undergoing hip fracture repair - Hip Fracture Intervention Study for Prevention of Hypotension (HIP-HOP) trial: study protocol for a randomised controlled trial. Trials, 18(1), https://doi.org/10.1186/s13063-017-2066-5

Background: Hypotension during anaesthesia for hip fracture surgery is common. Recent data suggest that there is an association between the lowest intra-operative blood pressure and mortality, even when adjusted for co-morbidities. This is consistent... Read More about Tight intra-operative blood pressure control versus standard care for patients undergoing hip fracture repair - Hip Fracture Intervention Study for Prevention of Hypotension (HIP-HOP) trial: study protocol for a randomised controlled trial.

Does achieving the best practice tariff improve outcomes in hip fracture patients? An observational cohort study (2017)
Journal Article
Oakley, B., Nightingale, J., Moran, C. G., & Moppett, I. K. (2017). Does achieving the best practice tariff improve outcomes in hip fracture patients? An observational cohort study. BMJ Open, 7(2), https://doi.org/10.1136/bmjopen-2016-014190

Objectives: To determine if the introduction of the best practice tariff (BPT) has improved survival of the elderly hip fracture population, or if achieving BPT results in improved survival for an individual. Setting: A single university-affiliated... Read More about Does achieving the best practice tariff improve outcomes in hip fracture patients? An observational cohort study.

Acute and chronic kidney disease in elderly patients with hip fracture: prevalence, risk factors and outcome with development and validation of a risk prediction model for acute kidney injury (2017)
Journal Article
Porter, C. J., Moppett, I. K., Juurlink, I., Nightingale, J., Moran, C. G., & Devonald, M. A. (2017). Acute and chronic kidney disease in elderly patients with hip fracture: prevalence, risk factors and outcome with development and validation of a risk prediction model for acute kidney injury. BMC Nephrology, 18(1), https://doi.org/10.1186/s12882-017-0437-5

Background Hip fracture is a common injury in older people with a high rate of postoperative morbidity and mortality. This patient group is also at high risk of acute kidney injury (AKI) and chronic kidney disease (CKD), but little is known of the i... Read More about Acute and chronic kidney disease in elderly patients with hip fracture: prevalence, risk factors and outcome with development and validation of a risk prediction model for acute kidney injury.

Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK Anaesthesia Sprint Audit of Practice (ASAP-2) (2016)
Journal Article
White, S., Moppett, I., Griffiths, R., Johansen, A., Wakeman, R., Boulton, C., …Grocott, M. (2016). Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK Anaesthesia Sprint Audit of Practice (ASAP-2). Anaesthesia, 71(5), https://doi.org/10.1111/anae.13415

We re-analysed prospective data collected by anaesthetists in the Anaesthesia Sprint Audit of Practice (ASAP-1) to describe associations with linked outcome data. Mortality was 165/11,085 (1.5%) 5 days and 563/11,085 (5.1%) 30 days after surgery and... Read More about Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK Anaesthesia Sprint Audit of Practice (ASAP-2).

Prediction of 30-day mortality after hip fracture surgery by the Nottingham Hip Fracture Score and the Surgical Outcome Risk Tool (2016)
Journal Article
Marufu, T. C., White, S., Griffiths, R., Moonesinghe, S., & Moppett, I. K. (in press). Prediction of 30-day mortality after hip fracture surgery by the Nottingham Hip Fracture Score and the Surgical Outcome Risk Tool. Anaesthesia, 71(5), https://doi.org/10.1111/anae.13418

The care of the elderly with hip fractures and their outcomes might be improved with resources targeted by the accurate calculation of risks of mortality and morbidity. We used a multicentre national dataset to evaluate and recalibrate the Nottingham... Read More about Prediction of 30-day mortality after hip fracture surgery by the Nottingham Hip Fracture Score and the Surgical Outcome Risk Tool.

Surgical caseload and the risk of surgical Never Events in England (2015)
Journal Article
Moppett, I., & Moppett, S. (2015). Surgical caseload and the risk of surgical Never Events in England. Anaesthesia, 71(1), https://doi.org/10.1111/anae.13290

Never Events are medical errors that are believed to be preventable with appropriate measures. We surveyed all English acute NHS trusts to determine the number of surgical Never Events and surgical caseload for 2011–2014. There were 742 surgically re... Read More about Surgical caseload and the risk of surgical Never Events in England.

Risk scoring models for predicting peri-operative morbidity and mortality in people with fragility hip fractures: Qualitative systematic review (2015)
Journal Article
Marufu, T. C., Mannings, A., & Moppett, I. K. (2015). Risk scoring models for predicting peri-operative morbidity and mortality in people with fragility hip fractures: Qualitative systematic review. Injury, 46(12), 2325-2334. https://doi.org/10.1016/j.injury.2015.10.025

Rationale Accurate peri-operative risk prediction is an essential element of clinical practice. Various risk stratification tools for assessing patients’ risk of mortality or morbidity have been developed and applied in clinical practice over the... Read More about Risk scoring models for predicting peri-operative morbidity and mortality in people with fragility hip fractures: Qualitative systematic review.

LiDCO-based fluid management in patients undergoing hip fracture surgery under spinal anaesthesia: a randomized trial and systematic review (2014)
Journal Article

Background: Hip fracture is a condition with high mortality and morbidity in elderly frail patients. Intraoperative fluid optimization may be associated with benefit in this population. We investigated whether intraoperative fluid management using pu... Read More about LiDCO-based fluid management in patients undergoing hip fracture surgery under spinal anaesthesia: a randomized trial and systematic review.

Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review (2014)
Journal Article
Lobo, D., MacDonald, N., Pearse, R. M., Parnell, W., Harrison, D. A., Niebrzegowska, E., …Treasure, T. (2014). Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review. Journal of the American Medical Association, 311(21), 2180-2190. https://doi.org/10.1001/jama.2014.5305