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Metabolic signatures of osteoarthritis in urine using liquid chromatography?high resolution tandem mass spectrometry (2021)
Journal Article
Abdelrazig, S., Ortori, C. A., Doherty, M., Valdes, A. M., Chapman, V., & Barrett, D. A. (2021). Metabolic signatures of osteoarthritis in urine using liquid chromatography?high resolution tandem mass spectrometry. Metabolomics, 17(3), Article 29. https://doi.org/10.1007/s11306-021-01778-3

Introduction: Osteoarthritis (OA) is a common cause of disability in older people, but its aetiology is not yet fully understood. Biomarkers of OA from metabolomics studies have shown potential use in understanding the progression and pathophysiology... Read More about Metabolic signatures of osteoarthritis in urine using liquid chromatography?high resolution tandem mass spectrometry.

Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation (2020)
Journal Article
Cooper, A. H., Hanmer, J. M., Chapman, V., & Hathway, G. J. (2020). Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation. PAIN Reports, 5(6), Article e872. https://doi.org/10.1097/PR9.0000000000000872

Introduction: Inflammation during the neonatal period can exacerbate pain severity following reinjury in adulthood. This is driven by alterations in the postnatal development of spinal and supraspinal nociceptive circuitry. However, the contribution... Read More about Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation.

Lipidomic identification of plasma lipids associated with pain behaviour and pathology in a mouse model of osteoarthritis (2020)
Journal Article
Pousinis, P., Gowler, P. R. W., Burston, J. J., Ortori, C. A., Chapman, V., & Barrett, D. A. (2020). Lipidomic identification of plasma lipids associated with pain behaviour and pathology in a mouse model of osteoarthritis. Metabolomics, 16(3), Article 32 (2020). https://doi.org/10.1007/s11306-020-01652-8

© 2020, The Author(s). Introduction: Osteoarthritis (OA) is the most common form of joint disease, causing pain and disability. Previous studies have demonstrated the role of lipid mediators in OA pathogenesis. Objectives: To explore potential altera... Read More about Lipidomic identification of plasma lipids associated with pain behaviour and pathology in a mouse model of osteoarthritis.

Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain (2018)
Journal Article
Nwosu, L. N., Gowler, P. R., Burston, J. J., Rizoska, B., Tunblad, K., Lindström, E., …Chapman, V. (2018). Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain. PAIN Reports, 3(6), Article 685. https://doi.org/10.1097/PR9.0000000000000685

© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. Introduction: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to invest... Read More about Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain.