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Outputs (59)

Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear (2023)
Journal Article
Stubbendorff, C., Hale, E., Bast, T., Cassaday, H. J., Martin, S. J., Suwansawang, S., …Stevenson, C. W. (2023). Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear. Scientific Reports, 13, Article 17631. https://doi.org/10.1038/s41598-023-44772-6

Contextual fear conditioning (CFC) is mediated by a neural circuit that includes the hippocampus, prefrontal cortex, and amygdala, but the neurophysiological mechanisms underlying the regulation of CFC by neuromodulators remain unclear. Dopamine D1-l... Read More about Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear.

Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries (2023)
Journal Article
Cassaday, H. J., Cavenagh, L., Aluthgamage, H., Crooks, A., Bonardi, C., Stevenson, C. W., …Muir, C. (2023). Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries. PLoS ONE, 18(8), Article e0290232. https://doi.org/10.1371/journal.pone.0290232

Three groups of participants (largely recruited from the UK) completed a survey to examine attitudes to the use of animals in biomedical research, after reading the lay (N = 182) or technical (N = 201) summary of a research project, or no summary (N... Read More about Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries.

From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures (2023)
Journal Article
Cassaday, H. J., Muir, C., Stevenson, C. W., Bonardi, C., Hock, R., & Waite, L. (2023). From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures. Neurobiology of Learning and Memory, 202, Article 107757. https://doi.org/10.1016/j.nlm.2023.107757

Inhibitory associative learning counters the effects of excitatory learning, whether appetitively or aversively motivated. Moreover, the affective responses accompanying the inhibitory associations are of opponent valence to the excitatory conditione... Read More about From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures.

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats (2022)
Journal Article
Warren, W. G., Papagianni, E. P., Hale, E., Brociek, R. A., Cassaday, H. J., & Stevenson, C. W. (2022). Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats. Frontiers in Pharmacology, 13, Article 1082760. https://doi.org/10.3389/fphar.2022.1082760

Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinct... Read More about Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats.

Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance (2022)
Journal Article
Papagianni, E. P., Warren, W. G., Cassaday, H. J., & Stevenson, C. W. (2022). Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance. International Journal of Molecular Sciences, 23(16), Article 9333. https://doi.org/10.3390/ijms23169333

Cannabidiol, the main non-psychotropic constituent of cannabis, has potential as a treatment for anxiety-related disorders since it reduces learned fear expression and enhances fear extinction. The return of fear over time after successful extinction... Read More about Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance.

URB597 induces subtle changes to aggression in adult Lister Hooded rats (2022)
Journal Article
Warren, W. G., Hale, E., Papagianni, E. P., Cassaday, H. J., Stevenson, C. W., & Stubbendorff, C. (2022). URB597 induces subtle changes to aggression in adult Lister Hooded rats. Frontiers in Psychiatry, 13, Article 885146. https://doi.org/10.3389/fpsyt.2022.885146

The endocannabinoid system has been implicated in both social and cognitive processing. The endocannabinoid metabolism inhibitor, URB597, dose-dependently improves non-social memory in adult Wistar and Sprague Dawley rats, whereas its effect on socia... Read More about URB597 induces subtle changes to aggression in adult Lister Hooded rats.

Attitudes to animal use of named species for different purposes: effects of speciesism, individualising morality, likeability and demographic factors (2022)
Journal Article
Marriott, S., & Cassaday, H. J. (2022). Attitudes to animal use of named species for different purposes: effects of speciesism, individualising morality, likeability and demographic factors. Humanities and Social Sciences Communications, 9(1), Article 138. https://doi.org/10.1057/s41599-022-01159-8

Attitudes to animals and their use are becoming increasingly important for the success of conservation and environmental initiatives. Beliefs about animals, their perceived emotional appeal, as well as individuals’ moral capacities are all likely dri... Read More about Attitudes to animal use of named species for different purposes: effects of speciesism, individualising morality, likeability and demographic factors.

Safety Learning in Anxiety, Pavlovian Conditioned Inhibition and COVID Concerns (2022)
Journal Article
Thurston, M. D., & Cassaday, H. J. (2022). Safety Learning in Anxiety, Pavlovian Conditioned Inhibition and COVID Concerns. Frontiers in Psychology, 13, Article 866771. https://doi.org/10.3389/fpsyg.2022.866771

Experimental studies of fear conditioning have identified the effectiveness of safety signals in inhibiting fear and maintaining fear-motivated behaviors. In fear conditioning procedures, the presence of safety signals means that the otherwise expect... Read More about Safety Learning in Anxiety, Pavlovian Conditioned Inhibition and COVID Concerns.

Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition (2022)
Journal Article
Williams, S. A., Gwilt, M., Hock, R., Taylor, C., Loayza, J., Stevenson, C. W., …Bast, T. (2022). Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition. eNeuro, 9(1), ENEURO.0270-21.2021. https://doi.org/10.1523/eneuro.0270-21.2021

Hippocampal neural disinhibition, i.e., reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition.

Strain comparisons in inhibitory discrimination learning and novel object recognition procedures (2021)
Journal Article
Waite, L., Bonardi, C., Stevenson, C. W., & Cassaday, H. J. (2021). Strain comparisons in inhibitory discrimination learning and novel object recognition procedures. Physiology and Behavior, 240, Article 113557. https://doi.org/10.1016/j.physbeh.2021.113557

Strain differences in visual abilities and exploratory tendencies can confound rats’ performance in cognitive tests of learning and memory. In the present study we compared the performance of albino Wistar and pigmented Lister Hooded rats in appetiti... Read More about Strain comparisons in inhibitory discrimination learning and novel object recognition procedures.

Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition (2021)
Working Paper
Williams, S. A., Gwilt, M., Hock, R., Taylor, C., Loayza, J., Stevenson, C. W., …Bast, T. Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition

Hippocampal neural disinhibition, i.e. reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition.

Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat (2020)
Journal Article
Pezze, M. A., Marshall, H. J., & Cassaday, H. J. (2020). Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat. Journal of Psychopharmacology, 34(12), 1457-1460. https://doi.org/10.1177/0269881120965914

Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol... Read More about Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat.

Man's best friends: attitudes towards the use of different kinds of animal depend on belief in different species' mental capacities and purpose of use (2020)
Journal Article
Higgs, M. J., Bipin, S., & Cassaday, H. J. (2020). Man's best friends: attitudes towards the use of different kinds of animal depend on belief in different species' mental capacities and purpose of use. Royal Society Open Science, 7(2), 191162. https://doi.org/10.1098/rsos.191162

The animal purpose questionnaire (APQ) is a new instrument to measure human attitudes to animal use systematically across both species and purpose of use. This offers a more fine-grained approach to our understanding of how the belief in a specific a... Read More about Man's best friends: attitudes towards the use of different kinds of animal depend on belief in different species' mental capacities and purpose of use.

Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use (2020)
Journal Article
Bibby, P. A., Bradley, A., Mennie, N., Bibby, P. A., & Cassaday, H. J. (2020). Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use. PLoS ONE, 15(1), https://doi.org/10.1371/journal.pone.0227948

© 2020 Bradley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr... Read More about Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use.

Data showing regional differences in rat brain monoaminergic function (2019)
Journal Article
Nelson, A. .., & Cassaday, H. (2019). Data showing regional differences in rat brain monoaminergic function. Data in Brief, 27, https://doi.org/10.1016/j.dib.2019.104814

Chemical neurotransmitters (such as dopamine) modulate cognitive function via ascending projections to various cortical and sub-cortical brain regions. This report describes and links to a relatively large dataset (up to N=112) compiled from control... Read More about Data showing regional differences in rat brain monoaminergic function.

Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues (2019)
Journal Article
Cassaday, H., & Thur, K. (2019). Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues. Pharmacology Biochemistry and Behavior, 187, 1-6. https://doi.org/10.1016/j.pbb.2019.172797

The effects of the serotonergic (5-hydroxytryptamine, 5-HT) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.2 and 0.4 mg/kg i.p.) were examined in trace conditioning (Experiment 1) and overshadowing (Experiment 2) procedures. Both experi... Read More about Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues.

EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli (2019)
Journal Article
Cassaday, H. J., & Thur, K. E. (2020). EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli. Journal of Psychopharmacology, 34(1), 145-147. https://doi.org/10.1177/0269881119882855

Activation of 5-HT6 receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known... Read More about EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli.

Age-related differences in appetitive trace conditioning and novel object recognition procedures (2019)
Journal Article
Marshall, H., Pezze, M., Fone, K., & Cassaday, H. (2019). Age-related differences in appetitive trace conditioning and novel object recognition procedures. Neurobiology of Learning and Memory, 164, https://doi.org/10.1016/j.nlm.2019.107041

Appetitive trace conditioning (TC) was examined over 6 months in younger-adult (2-8 months) and middle-aged (12-18 months) male Wistar RccHan rats to test for early age-related impairment in working memory. Novel object recognition (NOR) was included... Read More about Age-related differences in appetitive trace conditioning and novel object recognition procedures.

Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning (2019)
Journal Article
Stubbendorff, C., Hale, E., Cassaday, H. J., Bast, T., & Stevenson, C. W. (2019). Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning. Psychopharmacology, 236(6), 1771-1782. https://doi.org/10.1007/s00213-018-5162-7

Rationale Dopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or ba... Read More about Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning.

The neuropharmacology of what, where, when: how dopamine modulates recognition memory for objects and their contexts (2018)
Book Chapter
Cassaday, H., & Nelson, A. J. (2018). The neuropharmacology of what, where, when: how dopamine modulates recognition memory for objects and their contexts. In A. Ennaceur, & M. A. de Souza Silva (Eds.), Handbook of Object Novelty Recognition, 359-369. Elsevier. doi:10.1016/b978-0-12-812012-5.00024-0

Recognition of objects and their contexts is demonstrated based on the intrinsic features of objects (‘what’), as well as for spatial (‘where’) or temporal presentation (‘when’) cues. A network of structures identified in lesion studies forms a neura... Read More about The neuropharmacology of what, where, when: how dopamine modulates recognition memory for objects and their contexts.

Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure (2018)
Journal Article
Pezze, M., Marshall, H., & Cassaday, H. (2018). Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure. Brain and Behavior, https://doi.org/10.1002/brb3.1147

Trace conditioning is impaired by lesions to dorsal hippocampus, as well as by treatment with the muscarinic acetylcholine antagonist scopolamine. However, the role of muscarinic receptors within hippocampus has received little attention. The present... Read More about Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure.

Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay (2017)
Journal Article
Pezze, M. A., Marshall, H. J., Fone, K. C., & Cassaday, H. J. (2017). Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay. Learning and Memory, 24(7), 310-317. https://doi.org/10.1101/lm.044784.116

Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesi... Read More about Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay.

Scopolamine impairs appetitive but not aversive trace conditioning: role of the medial prefrontal cortex (2017)
Journal Article
Pezze, M. A., Marshall, H. J., & Cassaday, H. J. (2017). Scopolamine impairs appetitive but not aversive trace conditioning: role of the medial prefrontal cortex. Journal of Neuroscience, 37(26), https://doi.org/10.1523/JNEUROSCI.3308-16.2017

The muscarinic acetylcholine (ACh) receptor is an important modulator of medial prefrontal cortex (mPFC) functions, such as the working memory required to bridge a trace interval in associative leaning. Aversive and appetitive trace conditioning proc... Read More about Scopolamine impairs appetitive but not aversive trace conditioning: role of the medial prefrontal cortex.

Overshadowing depends on cue and reinforcement sensitivity but not schizotypy (2016)
Journal Article
Pickett, C., Cassaday, H. J., & Bibby, P. A. (2017). Overshadowing depends on cue and reinforcement sensitivity but not schizotypy. Behavioural Brain Research, 321, https://doi.org/10.1016/j.bbr.2016.12.031

There is evidence for impaired selective learning mechanisms in individuals high in schizotypy. Overshadowing provides a direct test of selective learning based on cue salience and has previously been reported to be impaired in relation to schizotypy... Read More about Overshadowing depends on cue and reinforcement sensitivity but not schizotypy.

Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare (2016)
Journal Article
Davies, G. F., Greenhough, B. J., Hobson-West, P., Kirk, R. G., Applebee, K., Bellinghan, L. C., …Friese, C. (2016). Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare. PLoS ONE, 11(7), Article e0158791. https://doi.org/10.1371/journal.pone.0158791

Improving laboratory animal science and welfare requires both new scientific research and insights from enquiry in the humanities and social sciences. Whilst scientific research provides evidence to replace, reduce and refine procedures involving lab... Read More about Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare.

The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials (2016)
Journal Article
Pezze, M. A., Marshall, H. J., & Cassaday, H. J. (2016). The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials. Learning and Motivation, 55, 53-64. https://doi.org/10.1016/j.lmot.2016.06.001

In an appetitively motivated procedure, we have previously reported that systemic treatment with the dopamine (DA) D1 receptor agonist SKF81297 (0.4 and 0.8 mg/kg) depressed acquisition at a 2s inter-stimulus-interval (ISI), suitable to detect trace... Read More about The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials.

Potentiation rather than distraction in a trace fear conditioning procedure (2016)
Journal Article
Pezze, M. A., Marshall, H. J., & Cassaday, H. J. (2016). Potentiation rather than distraction in a trace fear conditioning procedure. Behavioural Processes, 128, 41-61. https://doi.org/10.1016/j.beproc.2016.04.003

Trace conditioning procedures are defined by the introduction of a trace interval between conditioned stimulus (CS, e.g. noise or light) offset and unconditioned stimulus (US, e.g. footshock). The introduction of an additional stimulus as a distracto... Read More about Potentiation rather than distraction in a trace fear conditioning procedure.

Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes (2015)
Journal Article
Thurston, M. D., & Cassaday, H. J. (2015). Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes. Learning and Motivation, 52, https://doi.org/10.1016/j.lmot.2015.10.002

Conditioned inhibition occurs when a stimulus inhibits the responses that would normally occur to a conditioned stimulus that previously predicted an outcome of interest (the unconditioned stimulus, which elicits responding unconditionally). The pres... Read More about Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes.

Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure (2015)
Journal Article
Pezze, M. A., Marshall, H., Domonkos, A., & Cassaday, H. J. (2015). Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 65, https://doi.org/10.1016/j.pnpbp.2015.08.015

The anterior cingulate cortex (AC) component of the medial prefrontal cortex (mPFC) has been implicated in attention and working memory as measured by trace conditioning. Since dopamine (DA) is a key modulator of mPFC function, the present study eval... Read More about Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure.

Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex. (2015)
Journal Article
Cassaday, H., Pezze, M., Marshall, H., & Fone, K. (2015). Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex. European Neuropsychopharmacology, 25(11), 2145-2156. https://doi.org/10.1016/j.euroneuro.2015.07.018

© 2015 The Authors. Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selec... Read More about Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex..

Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with ??-tetrahydrocannabinol (THC) (2015)
Journal Article
Olarte-Sánchez, C., Valencia-Torres, L., Cassaday, H. J., Bradshaw, C., & Szabadi, E. (2015). Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC). Behavioural Processes, 113, https://doi.org/10.1016/j.beproc.2015.01.014

Rats’ performance on a progressive-ratio schedule maintained by sucrose (0.6 M, 50 μl) and corn oil (100%, 25 μl) reinforcers was assessed using a model derived from Killeen’s (1994) theory of scheduled-controlled behaviour, ‘Mathematical Principles... Read More about Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with ??-tetrahydrocannabinol (THC).

Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex (2015)
Journal Article
Pezze, M. A., Marshall, H., & Cassaday, H. (in press). Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex. Psychopharmacology, 232(15), https://doi.org/10.1007/s00213-015-3903-4

Rationale: Trace conditioning may provide a behavioural model suitable to examine the maintenance of ‘on line’ information and its underlying neural substrates. Objectives: Experiment la was run to establish trace conditioning in a shortened proced... Read More about Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.

Gray’s revised Reinforcement Sensitivity Theory in relation to Attention-Deficit/Hyperactivity and Tourette-like behaviors in the general population (2015)
Journal Article
Heym, N., Kantini, E., Checkley, H. L., & Cassaday, H. J. (2015). Gray’s revised Reinforcement Sensitivity Theory in relation to Attention-Deficit/Hyperactivity and Tourette-like behaviors in the general population. Personality and Individual Differences, 78, 24-28. https://doi.org/10.1016/j.paid.2015.01.012

Attention-Deficit/Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS) present as distinct conditions clinically; however, they show comorbidity and inhibitory control deficits have been proposed to underlie both. The role of reinforcement sensit... Read More about Gray’s revised Reinforcement Sensitivity Theory in relation to Attention-Deficit/Hyperactivity and Tourette-like behaviors in the general population.

Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues (2015)
Journal Article
Cassaday, H. J., & Thur, K. E. (2015). Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues. Pharmacology Biochemistry and Behavior, 129, https://doi.org/10.1016/j.pbb.2014.12.004

Treatment with selective serotonin reuptake inhibitors (SSRIs) can reduce contextual conditioning. Since contexts present a variety of potentially competing cues, impaired overshadowing may provide an account of such effects. The present study theref... Read More about Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues.

Ro 04-6790-induced cognitive enhancement: No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats (2014)
Journal Article
Thur, K. E., Nelson, A. J., & Cassaday, H. J. (2014). Ro 04-6790-induced cognitive enhancement: No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats. Pharmacology Biochemistry and Behavior, 127, https://doi.org/10.1016/j.pbb.2014.10.006

The evidence for cognitively enhancing effects of 5-hydroxytryptamine6 (5-HT6) receptor antagonists such as Ro 04-6790 is inconsistent and seems to depend on the behavioural test variant in use. Trace conditioning holds promise as a behavioral assay... Read More about Ro 04-6790-induced cognitive enhancement: No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats.

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations (2014)
Journal Article
Cassaday, H. J., Nelson, A. J., & Pezze, M. A. (2014). From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations. Frontiers in Neuroscience, 8(160), https://doi.org/10.3389/fnsys.2014.00160

Distinctions along the dorsal-ventral axis of medial prefrontal cortex (mPFC), between anterior cingulate (AC), prelimbic (PL) and infralimbic (IL) sub-regions, have been proposed on a variety of neuroanatomical and neurophysiological grounds. Conven... Read More about From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations.

Tourette-like behaviors in the normal population are associated with hyperactive/impulsive ADHD-like behaviors but do not relate to deficits in conditioned inhibition or response inhibition (2014)
Journal Article
Heym, N., Kantini, E., Checkley, H. L., & Cassaday, H. J. (2014). Tourette-like behaviors in the normal population are associated with hyperactive/impulsive ADHD-like behaviors but do not relate to deficits in conditioned inhibition or response inhibition. Frontiers in Psychology, 5(946), https://doi.org/10.3389/fpsyg.2014.00946

Attention-Deficit Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS) present as distinct conditions clinically; however, comorbidity and inhibitory control deficits have been proposed for both. Whilst such deficits have been studied widely with... Read More about Tourette-like behaviors in the normal population are associated with hyperactive/impulsive ADHD-like behaviors but do not relate to deficits in conditioned inhibition or response inhibition.

Do personality traits predict individual differences in excitatory and inhibitory learning? (2013)
Journal Article
He, Z., Cassaday, H. J., Bonardi, C., & Bibby, P. A. (2013). Do personality traits predict individual differences in excitatory and inhibitory learning?. Frontiers in Psychology, 4(245), https://doi.org/10.3389/fpsyg.2013.00245

Conditioned inhibition (CI) is demonstrated in classical conditioning when a stimulus is used to signal the omission of an otherwise expected outcome. This basic learning ability is involved in a wide range of normal behavior – and thus its disruptio... Read More about Do personality traits predict individual differences in excitatory and inhibitory learning?.

Paradoxical effects of low dose MDMA on latent inhibition in the rat (2013)
Journal Article
Nelson, A. J., Thur, K. E., Marsden, C., & Cassaday, H. J. (2013). Paradoxical effects of low dose MDMA on latent inhibition in the rat. Neuropharmacology, 67(4), https://doi.org/10.1016/j.neuropharm.2012.11.012

The cognitive effects of MDMA ('Ecstasy') are controversial, particularly in the case of acute administration of low doses. Latent inhibition (LI) refers to the reduction in conditioning to a stimulus that has received non-reinforced pre-exposure, an... Read More about Paradoxical effects of low dose MDMA on latent inhibition in the rat.

Health specific traits beyond the Five Factor Model, cognitive processes and trait expression: replies to Watson (2012), Matthews (2012) and Haslam, Jetten, Reynolds, and Reicher (2012) (2013)
Journal Article
Ferguson, E., Ward, J. W., Skatova, A., Cassaday, H. J., Bibby, P. A., & Lawrence, C. (2013). Health specific traits beyond the Five Factor Model, cognitive processes and trait expression: replies to Watson (2012), Matthews (2012) and Haslam, Jetten, Reynolds, and Reicher (2012). Health Psychology Review, 7(Supple), Article S85-S103. https://doi.org/10.1080/17437199.2012.701061

In this article we reply to the issues raised by the three commentaries on Ferguson's (2012) article. Watson argues that the four traits identified by Ferguson (2012) – health anxiety, alexithymia, empathy and Type D – do not lie outside the Five Fac... Read More about Health specific traits beyond the Five Factor Model, cognitive processes and trait expression: replies to Watson (2012), Matthews (2012) and Haslam, Jetten, Reynolds, and Reicher (2012).

Dopamine D1 receptor involvement in latent inhibition and overshadowing (2012)
Journal Article
Nelson, A. J., Thur, K. E., & Cassaday, H. J. (2012). Dopamine D1 receptor involvement in latent inhibition and overshadowing. International Journal of Neuropsychopharmacology, 15(10), https://doi.org/10.1017/S1461145711001751

Latent inhibition (LI) manifests as poorer conditioning to a stimulus that has previously been experienced without consequence. There is good evidence of dopaminergic modulation of LI, as the e?ect is reliably disrupted by the indirect dopamine (DA... Read More about Dopamine D1 receptor involvement in latent inhibition and overshadowing.

When to hold that thought: an experimental study showing reduced inhibition of pre-trained associations in schizophrenia (2012)
Journal Article
He, Z., Cassaday, H. J., Park, S. B. G., & Bonardi, C. (2012). When to hold that thought: an experimental study showing reduced inhibition of pre-trained associations in schizophrenia. PLoS ONE, 7(7), Article e42175. https://doi.org/10.1371/journal.pone.0042175

Schizophrenia encompasses a wide variety of cognitive dysfunctions, a number of which can be understood as deficits of inhibition. To date, no research has examined ‘conditioned inhibition’ in schizophrenia - the ability of a stimulus that signals th... Read More about When to hold that thought: an experimental study showing reduced inhibition of pre-trained associations in schizophrenia.

Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli (2012)
Journal Article
Nelson, A. J., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2012). Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli. International Journal of Neuropsychopharmacology, 15(4), https://doi.org/10.1017/S1461145711000599

There is good evidence that forebrain serotonergic systems modulate cognitive flexibility. Latent inhibition (LI) is a cross-species phenomenon which manifests as poor conditioning to a stimulus that has previously been experienced without consequenc... Read More about Opposing effects of 5,7-DHT lesions to the core and shell of the nucleus accumbens on the processing of irrelevant stimuli.

Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing (2012)
Journal Article
Nelson, A. J., Thur, K. E., Marsden, C., & Cassaday, H. J. (2012). Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing. Journal of Psychopharmacology, 25(12), https://doi.org/10.1177/0269881110389211

Latent inhibition (LI) is demonstrated when non-reinforced pre-exposure to a to-be-conditioned stimulus retards later learning. Learning is similarly retarded in overshadowing, in this case using the relative intensity of competing cues to manipulate... Read More about Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing.

A clozapine-like effect of cyproheptadine on progressive ratio schedule performance (2011)
Journal Article
Olarte-Sánchez, C., Valencia Torres, L., Cassaday, H. J., Body, S., Bradshaw, C., Szabadi, E., & Goudie, A. (2012). A clozapine-like effect of cyproheptadine on progressive ratio schedule performance. Journal of Psychopharmacology, 26(6), 857-870. https://doi.org/10.1177/0269881111408961

The atypical antipsychotic drug clozapine has multiple pharmacological actions, some of which, including 5-hydroxytryptamine (5-HT2) and histamine (H1) receptor antagonist effects, are shared by the non-selective 5-HT receptor antagonist cyproheptadi... Read More about A clozapine-like effect of cyproheptadine on progressive ratio schedule performance.

Catecholaminergic depletion in nucleus accumbens enhances trace conditioning (2011)
Journal Article
Nelson, A. J., Thur, K. E., Spicer, C., Marsden, C., & Cassaday, H. J. (2011). Catecholaminergic depletion in nucleus accumbens enhances trace conditioning. Advances in Medical Sciences, 56(1), https://doi.org/10.2478/v10039-011-0014-2

Purpose: To examine the effect of dopamine depletion in nucleus accumbens on trace conditioning; to distinguish the role of core and shell sub-regions, as far as possible. Material/Methods: 6-hydroxydopamine was used to lesion dopamine terminals with... Read More about Catecholaminergic depletion in nucleus accumbens enhances trace conditioning.

The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects (2011)
Journal Article
Nelson, A. J., Cooper, M. T., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2011). The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects. Behavioral Neuroscience, 125(3), https://doi.org/10.1037/a0023337

There is good evidence that the medial prefrontal cortex (mPFC) is involved in different aspects of recognition memory. However, the mPFC is a heterogeneous structure, and the contribution of the prelimbic (PL) and infralimbic (IL) cortices to recogn... Read More about The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects.

Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition (2011)
Journal Article
Nelson, A. J., Thur, K. E., Horsley, R., Spicer, C., Marsden, C., & Cassaday, H. J. (2011). Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition. Pharmacology Biochemistry and Behavior, 98(1), https://doi.org/10.1016/j.pbb.2010.11.025

Latent inhibition (LI) manifests as poorer conditioning to a CS that has previously been presented without consequence. There is some evidence that LI can be potentiated by reduced mesoaccumbal dopamine (DA) function but the locus within the nucleus... Read More about Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition.

Impaired Pavlovian conditioned inhibition in offenders with personality disorders (2011)
Journal Article
He, Z., Cassaday, H. J., Howard, R. C., Khalifa, N., & Bonardi, C. (2011). Impaired Pavlovian conditioned inhibition in offenders with personality disorders. Quarterly Journal of Experimental Psychology, 64(12), https://doi.org/10.1080/17470218.2011.616933

Certain types of violent offending are often accompanied by evidence of personality disorders (PDs), a range of heterogeneous conditions characterised by disinhibited behaviours that are generally described as impulsive. The tasks previously used to... Read More about Impaired Pavlovian conditioned inhibition in offenders with personality disorders.

Associative learning in ADHD: improved expression under methylphenidate (2011)
Journal Article
Kantini, E., Cassaday, H. J., Batty, M. J., Hollis, C., & Jackson, G. M. (2011). Associative learning in ADHD: improved expression under methylphenidate. Open Journal of Psychiatry, 1(2), https://doi.org/10.4236/ojpsych.2011.12004

Attention Deficit/Hyperactivity Disorder (ADHD) is characterised by developmentally inappropriate levels of inattention, impulsivity and hyperactivity. As might be expected of a disorder in which inhibitory deficits form part of the diagnostic criter... Read More about Associative learning in ADHD: improved expression under methylphenidate.

The normal inhibition of associations is impaired by clonidine in Tourette syndrome (2011)
Journal Article
Kantini, E., Cassaday, H. J., Hollis, C., & Jackson, G. M. (2011). The normal inhibition of associations is impaired by clonidine in Tourette syndrome. Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent, 20(2),

Objective: We examined the inhibition of stimulus-stimulus associations (formally ‘conditioned inhibition’) in Tourette syndrome (TS). Method: The present study used video game style conditioned inhibition procedures suitable for children and adolesc... Read More about The normal inhibition of associations is impaired by clonidine in Tourette syndrome.

Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place (2010)
Journal Article
Nelson, A. J., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2010). Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place. Behavioral Neuroscience, 124(6), https://doi.org/10.1037/a0021114

There is increasing focus on the role of the nucleus accumbens (NAc) in learning and memory, but there is little consensus as to how the core and medial shell subregions of the NAc contribute to these processes. In the current experiments, we used sp... Read More about Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place.

Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition (2010)
Journal Article
Nelson, A. J., Thur, K. E., Marsden, C., & Cassaday, H. J. (2010). Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition. Neuroscience, 170(1), https://doi.org/10.1016/j.neuroscience.2010.06.066

Latent inhibition (LI) refers to the reduction in conditioning to a stimulus that has received repeated non-reinforced pre-exposure. Investigations into the neural substrates of LI have focused on the nucleus accumbens (NAc) and its inputs from the h... Read More about Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition.

Corticosterone differences rather than social housing predict performance of T-maze alternation in male CD-1 mice (2009)
Journal Article
Fitchett, A. E., Barnard, C. J., & Cassaday, H. J. (2009). Corticosterone differences rather than social housing predict performance of T-maze alternation in male CD-1 mice. Animal Welfare Journal, 18(1),

This study examined the effects of social housing manipulations on body weight, corticosterone levels, and performance of T-maze alternation in male CD-1 mice. Males that adopted a dominant social rank were heavier than those that adopted a subordina... Read More about Corticosterone differences rather than social housing predict performance of T-maze alternation in male CD-1 mice.

There’s no place like home: cage odours and place preference in subordinate CD-1 male mice (2006)
Journal Article
Fitchett, A. E., Barnard, C. J., & Cassaday, H. J. (2006). There’s no place like home: cage odours and place preference in subordinate CD-1 male mice. Physiology and Behavior, 87(5), https://doi.org/10.1016/j.physbeh.2006.02.010

Prior studies using mice have shown that scent marks are an important source of information and can cause behavioural changes in other individuals. Studies have also shown that scent marks in the environment can affect the outcome of social interacti... Read More about There’s no place like home: cage odours and place preference in subordinate CD-1 male mice.

What’s special about the ethical challenges of studying disorders with altered brain activity?
Book Chapter
Cassaday, H. J. What’s special about the ethical challenges of studying disorders with altered brain activity?. In G. Lee, J. Illes, & F. Ohl (Eds.), Ethical issues in behavioral neuroscience. Springer-Verlag. https://doi.org/10.1007/7854_2014_333

Where there is no viable alternative, studies of neuronal activity are conducted on animals. The use of animals, particularly for invasive studies of the brain, raises a number of ethical issues. Practical or normative ethics are enforced by legislat... Read More about What’s special about the ethical challenges of studying disorders with altered brain activity?.

Effects of SKF-83566 and haloperidol on performance on progressive ratio schedules maintained by sucrose and corn oil reinforcement: quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR)
Journal Article
Olarte-Sánchez, C., Valencia-Torres, L., Cassaday, H. J., Bradshaw, C., & Szabadi, E. Effects of SKF-83566 and haloperidol on performance on progressive ratio schedules maintained by sucrose and corn oil reinforcement: quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR). Psychopharmacology, 230(4), https://doi.org/10.1007/s00213-013-3189-3

Rationale Mathematical models can assist the interpretation of the effects of interventions on schedule-controlled behaviour and help to differentiate between processes that may be confounded in traditional performance measures such as response rate... Read More about Effects of SKF-83566 and haloperidol on performance on progressive ratio schedules maintained by sucrose and corn oil reinforcement: quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR).

Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule
Journal Article
Olarte-Sánchez, C., Valencia Torres, L., Body, S., Cassaday, H. J., Bradshaw, C., & Szabadi, E. Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule. Journal of Psychopharmacology, 26(6), https://doi.org/10.1177/0269881111409607

It has been suggested that a sub-population of orexinergic neurones whose somata lie in the lateral hypothalamic area (LHA) play an important role in regulating the reinforcing value of both food and drugs. This experiment examined the effect of disr... Read More about Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule.