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Outputs (41)

The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae (2024)
Journal Article
Hill, V., Lopez-Viso, C., Brameld, J., Salter, A., & Parr, T. (2024). The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae. Journal of Insects as Food and Feed, https://doi.org/10.1163/23524588-00001043

Maximising the yield of product from livestock is common practice in the agriculture industry and there is potential to extend this practice to the emerging insect industry, to produce high-quality, sustainable protein. Tenebrio molitor larvae, commo... Read More about The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae.

Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter (2023)
Journal Article
Alliband, K. H., Parr, T., Jethwa, P. H., & Brameld, J. M. (2023). Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter. Frontiers in Physiology, 14, Article 1322677. https://doi.org/10.3389/fphys.2023.1322677

Background: Skeletal muscle development during embryogenesis depends on proliferation of myoblasts followed by differentiation into myotubes/multinucleated myofibers. Vitamin D (VD) has been shown to affect these processes, but there is conflicting e... Read More about Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter.

Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor) (2023)
Journal Article
Lopez-Viso, C., Castellanos-Uribe, M., May, T., Brameld, J., Salter, A., & Parr, T. (2023). Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor). Journal of Insects as Food and Feed, https://doi.org/10.1163/23524588-20230143

Insects are of high interest as a sustainable source of nutrients to be included in the food production system. The larvae of Tenebrio molitor, commonly known as yellow mealworms (MW), have a high protein content, which means potential applications i... Read More about Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor).

Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review (2023)
Journal Article
Tee, A. J., Lim, Y. S., Brameld, J. M., Massawe, F., Parr, T., & Salter, A. M. (2023). Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review. Food Biotechnology, 37(2), 106-135. https://doi.org/10.1080/08905436.2023.2201307

Bambara groundnut (BG) offers great potential for sustainable food and nutritional security in the face of a growing population and changing climate. However, its utilization remains restricted by the hard-to-cook phenomenon of seed and the presence... Read More about Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review.

The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat (2022)
Journal Article
Dale, T., Bedford, M. R., King, J., Tucker, G. A., Brameld, J. M., & Parr, T. (2023). The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat. Animal Feed Science and Technology, 295, Article 115526. https://doi.org/10.1016/j.anifeedsci.2022.115526

Wheat is a widely used cereal grain for pig and poultry feeds globally. Despite this, there are noticeable differences in its nutritive value, potentially due to varying characteristics like inherent non-starch polysaccharide (NSP) content and compos... Read More about The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat.

The effects of exogenous fibrolytic enzymes on the in vitro generation of xylooligosaccharides and monosaccharides is dependent upon cereal type (2022)
Journal Article
Dale, T., Bedford, M. R., Tucker, G. A., Brameld, J. M., & Parr, T. (2022). The effects of exogenous fibrolytic enzymes on the in vitro generation of xylooligosaccharides and monosaccharides is dependent upon cereal type. Animal Feed Science and Technology, 292, Article 115406. https://doi.org/10.1016/j.anifeedsci.2022.115406

Fibrolytic enzymes are routinely added to non-ruminant livestock feeds to help degrade the non-starch polysaccharide (NSP) contents and thereby improve feed efficiency. This study investigated the range of xylooligosaccharides (XOS) and monosaccharid... Read More about The effects of exogenous fibrolytic enzymes on the in vitro generation of xylooligosaccharides and monosaccharides is dependent upon cereal type.

Effect of AAV-mediated overexpression of ATF5 and downstream targets of an integrated stress response in murine skeletal muscle (2021)
Journal Article
Brearley-Sholto, M. C., Loczenski-Brown, D. M., Jones, S., Daniel, Z. C., Ebling, F. J., Parr, T., & Brameld, J. M. (2021). Effect of AAV-mediated overexpression of ATF5 and downstream targets of an integrated stress response in murine skeletal muscle. Scientific Reports, 11(1), 1-13. https://doi.org/10.1038/s41598-021-99432-4

We previously reported that growth promoter-induced skeletal muscle hypertrophy co-ordinately upregulated expression of genes associated with an integrated stress response (ISR), as well as potential ISR regulators. We therefore used Adeno-Associated... Read More about Effect of AAV-mediated overexpression of ATF5 and downstream targets of an integrated stress response in murine skeletal muscle.

In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review (2021)
Journal Article
Alliband, K. H., Kozhevnikova, S. V., Parr, T., Jethwa, P. H., & Brameld, J. M. (2021). In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review. Frontiers in Physiology, 12, Article 736708. https://doi.org/10.3389/fphys.2021.736708

Vitamin D (VD) deficiency is associated with muscle weakness. A reduction in the incidence of falls in the elderly following VD supplementation and identification of the VD receptor within muscle cells suggests a direct effect of VD on muscle, but li... Read More about In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review.

Suitability of insects for animal feeding. (2021)
Book Chapter
Hawkey, K., Brameld, J., Parr, T., Salter, A., & Hall, H. (2021). Suitability of insects for animal feeding. In H. Hall, E. Fitches, & R. Smith (Eds.), Insects as Animal Feed: Novel Ingredients for Use in Pet, Aquaculture and Livestock Diets (26-38). CAB International. https://doi.org/10.1079/9781789245929.0004

This chapter explores the nutritional composition of insects and the potential benefits and drawbacks for their inclusion into pet, poultry, pig, ruminant and aquatic animal feeds. Six species are most commonly described for use in animal feed, namel... Read More about Suitability of insects for animal feeding..

98 The effect of mezquite pod flour in a wheat-based diet on broiler chicken growth performance (2021)
Journal Article
Bone, G., Parr, T., Brameld, J., Elmes, M., Gonzalez-Carranza, Z., & Koech, O. (2021). 98 The effect of mezquite pod flour in a wheat-based diet on broiler chicken growth performance. Animal - Science proceedings, 12(1), 77. https://doi.org/10.1016/j.anscip.2021.03.099

Application Inclusion of Mezquite pod flour in broiler chicken diets significantly reduced weight gain, this could inform a recommendation against the use of non-processed Mezquite in broiler chicken diets. Introduction Mezquite is an under-utilised... Read More about 98 The effect of mezquite pod flour in a wheat-based diet on broiler chicken growth performance.

Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro (2021)
Journal Article
Brearley, M. C., Loczenski-Brown, D. M., Loughna, P. T., Parr, T., & Brameld, J. M. (2021). Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro. Biochemistry and Biophysics Reports, 25, Article 100924. https://doi.org/10.1016/j.bbrep.2021.100924

© 2021 The Authors Myosin heavy chain-IIB (MyHC-IIB; encoded by MYH4 or Myh4) expression is often associated with muscle hypertrophic growth. Unlike other large mammals, domestic pig breeds express MyHC-IIB at both the mRNA and protein level. Aim: To... Read More about Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro.

The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells (2020)
Journal Article
Brearley, M. C., Daniel, Z. C., Loughna, P. T., Parr, T., & Brameld, J. M. (2020). The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells. Scientific Reports, 10, Article 22177. https://doi.org/10.1038/s41598-020-79324-9

Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells... Read More about The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells.

Insects: A Potential Source of Protein and Other Nutrients for Feed and Food (2020)
Journal Article
Hawkey, K. J., Lopez-Viso, C., Brameld, J. M., Parr, T., & Salter, A. M. (2021). Insects: A Potential Source of Protein and Other Nutrients for Feed and Food. Annual Review of Animal Biosciences, 9(1), 333-354. https://doi.org/10.1146/annurev-animal-021419-083930

© 2021 Annual Reviews Inc.. All rights reserved. Sustainable production of healthy food for a growing global population, in the face of the uncertainties of climate change, represents a major challenge for the coming decade. Livestock provide food wi... Read More about Insects: A Potential Source of Protein and Other Nutrients for Feed and Food.

The effects of exogenous xylanase supplementation on the in vivo generation of xylooligosaccharides and monosaccharides in broilers fed a wheat-based diet (2020)
Journal Article
Dale, T., Hannay, I., Bedford, M. R., Tucker, G. A., Brameld, J., & Parr, T. (2020). The effects of exogenous xylanase supplementation on the in vivo generation of xylooligosaccharides and monosaccharides in broilers fed a wheat-based diet. British Poultry Science, 61(4), 471-481. https://doi.org/10.1080/00071668.2020.1751805

1. This study aimed to quantify xylanase-induced changes in soluble monosaccharides, xylooligosaccharides (XOS) and volatile fatty acid (VFA) contents of the different sections of the GIT and whether these relate to altered bird performance. 2. An... Read More about The effects of exogenous xylanase supplementation on the in vivo generation of xylooligosaccharides and monosaccharides in broilers fed a wheat-based diet.

Leucine and mTORc1 act independently to regulate 2-deoxyglucose uptake in L6 myotubes (2020)
Journal Article
Yin, Q., Brameld, J. M., Parr, T., & Murton, A. J. (2020). Leucine and mTORc1 act independently to regulate 2-deoxyglucose uptake in L6 myotubes. Amino Acids, 52, 477–486. https://doi.org/10.1007/s00726-020-02829-0

© 2020, The Author(s). Chronic mTORc1 hyperactivation via obesity-induced hyperleucinaemia has been implicated in the development of insulin resistance, yet the direct impact of leucine on insulin-stimulated glucose uptake in muscle cells remains unc... Read More about Leucine and mTORc1 act independently to regulate 2-deoxyglucose uptake in L6 myotubes.

Author Correction: The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2019)
Journal Article
Brown, D., Ryan, K., Daniel, Z., Mareko, M., Talbot, R., Moreton, J., …Brameld, J. M. (2019). Author Correction: The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program. Scientific Reports, 9(1), Article 15412. https://doi.org/10.1038/s41598-019-43807-1

© 2019, The Author(s). In the Supplementary Information file originally published with this Article, Table 2 was omitted. This error has been corrected in the Supplementary Information that now accompanies the Article.

Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells (2019)
Journal Article
Brearley, M. C., Li, C., Daniel, Z. C., Loughna, P. T., Parr, T., & Brameld, J. M. (2019). Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells. Biochemistry and Biophysics Reports, 20, Article 100694. https://doi.org/10.1016/j.bbrep.2019.100694

Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is... Read More about Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells.

Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth (2019)
Journal Article
Loczenski-Brown, D. M., Jones, S., Luckett, J., Daniel, Z., Brearley, M. C., Ebling, F. J. P., …Brameld, J. M. (2019). Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth. PLoS ONE, 14(6), 1-12. https://doi.org/10.1371/journal.pone.0218970

We previously identified PEPCK-M (encoded by the Pck2 gene) to be highly up-regulated in skeletal muscle of pigs treated with Ractopamine, an anabolic beta-adrenergic receptor agonist. To determine whether PEPCK-M had a causative role in modulating t... Read More about Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth.

The association between faecal host DNA or faecal calprotectin and feed efficiency in pigs fed yeast-enriched protein concentrate (2019)
Journal Article
Slinger, K. R., Stewart, A. H., Daniel, Z. C. T. R., Hall, H., Masey O’Neill, H. V., Bedford, M. R., …Brameld, J. M. (2019). The association between faecal host DNA or faecal calprotectin and feed efficiency in pigs fed yeast-enriched protein concentrate. Animal, 13(11), 2483-2491. https://doi.org/10.1017/s1751731119000818

Gut cell losses contribute to overall feed efficiency due to the energy requirement for cell replenishment. Intestinal epithelial cells are sloughed into the intestinal lumen as digesta passes through the gastrointestinal tract, where cells are degra... Read More about The association between faecal host DNA or faecal calprotectin and feed efficiency in pigs fed yeast-enriched protein concentrate.

The commercial pig as a model of spontaneously-occurring osteoarthritis (2019)
Journal Article
Macfadyen, M. A., Daniel, Z., Kelly, S., Parr, T., Brameld, J. M., Murton, A. J., & Jones, S. W. (2019). The commercial pig as a model of spontaneously-occurring osteoarthritis. BMC Musculoskeletal Disorders, 20, Article 70. https://doi.org/10.1186/s12891-019-2452-0

Background: Preclinical osteoarthritis models where damage occurs spontaneously may better reflect the initiation and development of human osteoarthritis. The aim was to assess the commercial pig as a model of spontaneous osteoarthritis development b... Read More about The commercial pig as a model of spontaneously-occurring osteoarthritis.

The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2018)
Journal Article
Brown, D., Ryan, K., Daniel, Z., Mareko, M., Talbot, R., Moreton, J., …Brameld, J. M. (2018). The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program. Scientific Reports, 8, Article 15915. https://doi.org/10.1038/s41598-018-34315-9

Synthetic beta-adrenergic agonists (BA) have broad biomedical and agricultural application for increasing lean body mass, yet a poor understanding of the biology underpinning these agents is limiting further drug discovery potential. Growing female p... Read More about The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program.

Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth (2018)
Journal Article
Brown, D. M., Jones, S., Daniel, Z. C., Brearley, M. C., Lewis, J. E., Ebling, F. J., …Brameld, J. M. (2018). Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth. PLoS ONE, 13(7), Article e0201481. https://doi.org/10.1371/journal.pone.0201481

Previously, we highlighted induction of an integrated stress response (ISR) gene program in skeletal muscle of pigs treated with a beta-adrenergic agonist. Hence we tested the hypothesis that the ER-stress inhibitor, sodium 4-phenylbutyrate (PBA), wo... Read More about Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth.

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth (2016)
Journal Article
Brown, D. M., Williams, H., Ryan, K., Wilson, T., Daniel, Z. C., Mareko, M. H. D., …Parr, T. (2016). Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth. Scientific Reports, 6(1), https://doi.org/10.1038/srep28693

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20 ppm in feed) or Reporcin (recombi... Read More about Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.

The impact of growth promoters on muscle growth and the potential consequences for meat quality (2016)
Journal Article
Parr, T., Mareko, M. H., Ryan, K. J., Hemmings, K. M., Brown, D. M., & Brameld, J. M. (2016). The impact of growth promoters on muscle growth and the potential consequences for meat quality. Meat Science, 120, 93-99. doi:10.1016/j.meatsci.2016.04.022

To meet the demands of increased global meat consumption, animal production systems will have to become more efficient, or at least maintain the current efficiency utilizing feed ingredients that are not also used for human consumption. Use of growth... Read More about The impact of growth promoters on muscle growth and the potential consequences for meat quality.

Improving efficiency in meat production (2016)
Journal Article
Brameld, J. M., & Parr, T. (in press). Improving efficiency in meat production. Proceedings of the Nutrition Society, https://doi.org/10.1017/S0029665116000161

Selective breeding and improved nutritional management over the past 20–30 years has resulted in dramatic improvements in growth efficiency for pigs and poultry, particularly lean tissue growth. However, this has been achieved using high-quality feed... Read More about Improving efficiency in meat production.

Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs (2015)
Journal Article
Jing, L., Wu, H., Miao, Y., Cao, J., Brameld, J. M., Parr, T., & Zhao, S. (2015). Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs. Scientific Reports, 5, Article 11953. https://doi.org/10.1038/srep11953

Feed efficiency (FE) can be measured by feed conversion ratio (FCR) or residual feed intake (RFI). In this study, we measured the FE related phenotypes of 236 castrated purebred Yorkshire boars, and selected 10 extreme individuals with high and low R... Read More about Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs.

Expression of the myosin heavy chain IIB gene in porcine skeletal muscle: the role of the CArG-box promoter response element (2014)
Journal Article
Brown, D. M., Brameld, J. M., & Parr, T. (2014). Expression of the myosin heavy chain IIB gene in porcine skeletal muscle: the role of the CArG-box promoter response element. PLoS ONE, 9(12), Article e114365. https://doi.org/10.1371/journal.pone.0114365

Due to its similarity to humans, the pig is increasingly being considered as a good animal model for studying a range of human diseases. Despite their physiological similarities, differential expression of the myosin heavy chain (MyHC) IIB gene (MYH4... Read More about Expression of the myosin heavy chain IIB gene in porcine skeletal muscle: the role of the CArG-box promoter response element.

Differential effects of short-term ? agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle (2014)
Journal Article
Hemmings, K. M., Daniel, Z. C., Buttery, P. J., Parr, T., & Brameld, J. M. (2015). Differential effects of short-term ? agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle. animal, 9(2), 285-294. https://doi.org/10.1017/s175173111400233x

Growth hormone (GH) and ? agonists increase muscle mass, but the mechanisms for this response are unclear and the magnitude of response is thought to vary with age of animal. To investigate the mechanisms driving the muscle response to these agents,... Read More about Differential effects of short-term ? agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle.

Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells (2013)
Journal Article
Ryan, K. J., Daniel, Z. C., Craggs, L. J., Parr, T., & Brameld, J. M. (2013). Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells. Journal of Endocrinology, 217(1), 45-58. https://doi.org/10.1530/JOE-12-0234

Fat infiltration within muscle is one of a number of features of vitamin D deficiency, which leads to a decline in muscle functionality. The origin of this fat is unclear, but one possibility is that it forms from myogenic precursor cells present in... Read More about Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells.

Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis (2011)
Journal Article
Brown, D. M., Parr, T., & Brameld, J. M. (2012). Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis. Journal of Muscle Research and Cell Motility, 32(6), 383-390. https://doi.org/10.1007/s10974-011-9267-4

The regulation of muscle fibre transitions has mainly been studied in vivo using conventional histological or immunohistochemical techniques. In order to investigate the molecular regulation of myosin heavy chain (MyHC) isoform expression in cell cul... Read More about Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis.

Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes (2011)
Journal Article
Graham, N. S., May, S. T., Daniel, Z. C., Emmerson, Z. F., Brameld, J. M., & Parr, T. (2011). Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes. animal, 5(6), 861-866. https://doi.org/10.1017/S1751731110002533

Affymetrix GeneChip microarrays are a powerful tool to study global gene expression profiles and have been used on many species. However, no sheep-specific Affymetrix GeneChip is currently available and the bovine array is fairly limited in its cover... Read More about Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes.

Calpastatin is associated with lymphovascular invasion in breast cancer (2011)
Journal Article
Storr, S. J., Mohammed, R. A., Woolston, C. M., Green, A. R., Parr, T., Spiteri, I., …Martin, S. G. (2011). Calpastatin is associated with lymphovascular invasion in breast cancer. Breast, 20(5), 413-418. https://doi.org/10.1016/j.breast.2011.04.002

Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to e... Read More about Calpastatin is associated with lymphovascular invasion in breast cancer.

The calpain system and cancer (2011)
Journal Article
Storr, S. J., Carragher, N. O., Frame, M. C., Parr, T., & Martin, S. G. (2011). The calpain system and cancer. Nature Reviews Cancer, 11(5), 364-374. https://doi.org/10.1038/nrc3050

The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates. Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellu... Read More about The calpain system and cancer.

Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols (2010)
Journal Article
Zulkifli, R. M., Parr, T., Salter, A. M., & Brameld, J. M. (2010). Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols. Journal of Animal Science, 88(8), 2565-2575. https://doi.org/10.2527/jas.2009-2603

Stearoyl CoA desaturase (SCD) is responsible for converting SFA into MUFA and plays an important role in regulating the fatty acid composition of tissues. Although the number of SCD isoforms differs among species, SCD-1 is the predominant isoform exp... Read More about Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols.

Examination of myosin heavy chain isoform expression in ovine skeletal muscles (2009)
Journal Article
Hemmings, K. M., Parr, T., Daniel, Z. C., Picard, B., Buttery, P. J., & Brameld, J. M. (2009). Examination of myosin heavy chain isoform expression in ovine skeletal muscles. Journal of Animal Science, 87(12), 3915-3922. https://doi.org/10.2527/jas.2009-2067

The contractile and associated metabolic characteristics of muscles are determined by their myosin heavy chain (MHC) isoform expression. In large mammals, the level of MHCIIB expression, which is associated with fast glycolytic-type muscle fibers, ha... Read More about Examination of myosin heavy chain isoform expression in ovine skeletal muscles.

The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb (2005)
Journal Article
Fahey, A. J., Brameld, J. M., Parr, T., & Buttery, P. J. (2005). The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb. Journal of Animal Science, 83(11), 2564-2571. https://doi.org/10.2527/2005.83112564x

There is a need to improve the lean tissue content of ruminant animals destined for meat production. Muscle fiber number is set during fetal development. The effect of undernutrition of pregnant ewes on subsequent muscle fiber characteristics of thei... Read More about The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb.

The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb (2005)
Journal Article
Fahey, A. J., Brameld, J. M., Parr, T., & Buttery, P. J. (2005). The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb. Journal of Animal Science, 83(11), 2564-2571. https://doi.org/10.2527/2005.83112564x

There is a need to improve the lean tissue content of ruminant animals destined for meat production. Muscle fiber number is set during fetal development. The effect of undernutrition of pregnant ewes on subsequent muscle fiber characteristics of thei... Read More about The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb.

Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus (2005)
Journal Article
Fahey, A. J., Brameld, J. M., Parr, T., & Buttery, P. J. (2005). Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus. Journal of Animal Science, 83(10), 2330-2338. https://doi.org/10.2527/2005.83102330x

The number of muscle fibers within a muscle has been found to be of high importance for the growth potential of an animal, and this number is set during fetal development. The objective of this study was to identify the ontogeny of muscle cell differ... Read More about Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus.

Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus (2005)
Journal Article
Fahey, A. J., Brameld, J. M., Parr, T., & Buttery, P. J. (2005). Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus. Journal of Animal Science, 83(10), 2330-2338

The number of muscle fibers within a muscle has been found to be of high importance for the growth potential of an animal, and this number is set during fetal development. The objective of this study was to identify the ontogeny of muscle cell differ... Read More about Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus.

Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters (2004)
Journal Article
Parr, T., Jewell, K. K., Sensky, P. L., Brameld, J. M., Bardsley, R. G., & Buttery, P. J. (2004). Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters. Archives of Biochemistry and Biophysics, 427(1), 8-15. https://doi.org/10.1016/j.abb.2004.04.001

Calpastatin is the specific endogenous inhibitor of calpain proteinase that is encoded by a single gene. Transient transfection assays in both a non-fusing skeletal muscle and non-muscle cell-line demonstrated that the putative porcine calpastatin pr... Read More about Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters.