Professor PENNY GOWLAND's Outputs (20)

Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology (2017)
Journal Article
O'Halloran, L., Cao, Z., Ruddy, K., Jollans, L., Albaugh, M. D., Aleni, A., …Whelan, R. (2018). Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology. NeuroImage, 169, https://doi.org/10.1016/j.neuroimage.2017.12.030

Moment-to-moment reaction time variability on tasks of attention, often quantified by intra-individual response variability (IRV), provides a good indication of the degree to which an individual is vulnerable to lapses in sustained attention. Increa... Read More about Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology.

Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans (2017)
Journal Article
Alyami, J., Ladd, N., Pritchard, S. E., Hoad, C. L., Abdul Sultan, A., Spiller, R. C., Gowland, P. A., MacDonald, I. A., Aithal, G. P., Marciani, L., & Taylor, M. A. (2017). Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans. Food Research International, https://doi.org/10.1016/j.foodres.2017.11.071

Cereal grain based porridges are commonly consumed throughout the world. Whilst some data are available for varieties that are popular in the Western world such as oats and rye, other ‘ancient’ grains used in the East and in Africa such as millets ar... Read More about Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans.

The z-spectrum from human blood at 7T (2017)
Journal Article
Shah, S. M., Mougin, O. E., Carradus, A. J., Geades, N., Dury, R., Morley, W., & Gowland, P. A. (2018). The z-spectrum from human blood at 7T. NeuroImage, 167, https://doi.org/10.1016/j.neuroimage.2017.10.053

Chemical Exchange Saturation Transfer (CEST) has been used to assess healthy and pathological tissue in both animals and humans. However, the CEST signal from blood has not been fully assessed. This paper presents the CEST and nuclear Overhauser enha... Read More about The z-spectrum from human blood at 7T.

Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions (2017)
Journal Article
Chou, I.-J., Lim, S.-Y., Tanasescu, R., Al-Radaideh, A., Mougin, O. E., Tench, C. R., …Constantinescu, C. S. (in press). Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions. Journal of Neuroimaging, https://doi.org/10.1111/jon.12474

BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesio... Read More about Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions.

Overdominant effect of a CHRNA4 polymorphism on cingulo-opercular network activity and cognitive control (2017)
Journal Article
Sadaghiani, S., Ng, B., Altmann, A., Poline, J.-B., Banaschewski, T., Bokde, A. L., …Greicius, M. (2017). Overdominant effect of a CHRNA4 polymorphism on cingulo-opercular network activity and cognitive control. Journal of Neuroscience, 37(40), 9657-9666. https://doi.org/10.1523/JNEUROSCI.0991-17.2017

The nicotinic system plays an important role in cognitive control, and is implicated in several neuropsychiatric conditions. Yet, the contributions of genetic variability in this system to individuals' cognitive control abilities are poorly understoo... Read More about Overdominant effect of a CHRNA4 polymorphism on cingulo-opercular network activity and cognitive control.

MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans (2017)
Journal Article
Khalaf, A., Hoad, C., Menys, A., Nowak, A., Taylor, S. A., Paparo, S., …Moran, G. W. (2018). MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans. Neurogastroenterology and Motility, 30(1), Article e13182. https://doi.org/10.1111/nmo.13182

Background: Feeding triggers inter-related gastrointestinal (GI) motor, peptide and appetite responses. These are rarely studied together due to methodological limitations. Recent MRI advances allow pan-intestinal, non-invasive assessment of motility... Read More about MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans.

Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates: Decoding fMRI Events in SMN (2017)
Journal Article
Tan, F. M., Caballero-Gaudes, C., Mullinger, K. J., Cho, S.-Y., Zhang, Y., Dryden, I. L., …Gowland, P. A. (2017). Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates: Decoding fMRI Events in SMN. Human Brain Mapping, 38(11), 5778-5794. https://doi.org/10.1002/hbm.23767

Most functional MRI (fMRI) studies map task-driven brain activity using a block or event-related paradigm. Sparse paradigm free mapping (SPFM) can detect the onset and spatial distribution of BOLD events in the brain without prior timing information,... Read More about Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates: Decoding fMRI Events in SMN.

Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans (2017)
Journal Article
Murray, K., Hoad, C. L., Mudie, D. M., Wright, J., Heissam, K., Abrehart, N., …Marciani, L. (2017). Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans. Molecular Pharmaceutics, 14(8), 2629-2638. https://doi.org/10.1021/acs.molpharmaceut.7b00095

The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT). However, little is known about the time course of GIT liquid volumes after drinking a... Read More about Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans.

Presence of time-dependent diffusion in the brachial plexus (2017)
Journal Article
Mahbub, Z. B., Peters, A. M., & Gowland, P. A. (2018). Presence of time-dependent diffusion in the brachial plexus. Magnetic Resonance in Medicine, 79(2), 789-795. https://doi.org/10.1002/mrm.26733

© 2017 International Society for Magnetic Resonance in Medicine Purpose: This work describes the development of a method to measure the variation of apparent diffusion coefficient (ADC) with diffusion time (Δ) in the brachial plexus, as a potential m... Read More about Presence of time-dependent diffusion in the brachial plexus.

Psychosocial stress and brain function in adolescent psychopathology (2017)
Journal Article
Quinlan, E. B., Cattrell, A., Jia, T., Artiges, E., Banaschewski, T., Barker, G., …Schumann, G. (2017). Psychosocial stress and brain function in adolescent psychopathology. American Journal of Psychiatry, 174(8), 785-794. https://doi.org/10.1176/appi.ajp.2017.16040464

Objective: To explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships.
Method: Participants w... Read More about Psychosocial stress and brain function in adolescent psychopathology.

Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER (2017)
Journal Article
Chen, C., Sigurdsson, H. P., Pépés, S. E., Auer, D. P., Morris, P. G., Morgan, P. S., …Jackson, S. R. (2017). Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER. NeuroImage, 156, 207-213. https://doi.org/10.1016/j.neuroimage.2017.05.044

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric... Read More about Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER.

Assessment of motion of colonic contents in the human colon using MRI tagging (2017)
Journal Article
Pritchard, S. E., Paul, J., Major, G., Marciani, L., Gowland, P. A., Spiller, R. C., & Hoad, C. (2017). Assessment of motion of colonic contents in the human colon using MRI tagging. Neurogastroenterology and Motility, 29(9), Article e13091. https://doi.org/10.1111/nmo.13091

Background We have previously reported a non-invasive, semi-automated technique to assess motility of the wall of the ascending colon (AC) using Magnetic Resonance Imaging. This study investigated the feasibility of using a tagged MRI technique to vi... Read More about Assessment of motion of colonic contents in the human colon using MRI tagging.

Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis (2017)
Journal Article
Miller, T. D., Chong, T. T.-J., Aimola Davies, A. M., Ng, T. W., Johnson, M. R., Irani, S. R., Vincent, A., Husain, M., Jacob, S., Maddison, P., Kennard, C., Gowland, P. A., & Rosenthal, C. R. (2017). Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis. Brain, 140(5), 1212-1219. https://doi.org/10.1093/brain/awx070

Magnetic resonance imaging has linked chronic voltage-gated potassium channel (VGKC) complex antibody-mediated limbic encephalitis with generalized hippocampal atrophy. However, autoantibodies bind to specific rodent hippocampal subfields. Here, huma... Read More about Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis.

Functional neuroimaging predictors of self-reported psychotic symptoms in adolescents (2017)
Journal Article
Bourque, J., Spechler, P. A., Potvin, S., Whelan, R., Banaschewski, T., Bokde, A. L., …Gowland, P. (2017). Functional neuroimaging predictors of self-reported psychotic symptoms in adolescents. American Journal of Psychiatry, 174(6), 566-575. https://doi.org/10.1176/appi.ajp.2017.16080897

OBJECTIVE: This study aimed to investigate the neural correlates of psychotic-like experiences in youth on measures of inhibitory control, reward anticipation and emotion processing. A secondary aim was to test whether these neuro-functional correlat... Read More about Functional neuroimaging predictors of self-reported psychotic symptoms in adolescents.

³¹P magnetization transfer magnetic resonance spectroscopy: assessing the activation induced change in cerebral ATP metabolic rates at 3 T (2017)
Journal Article
Chen, C., Stephenson, M. C., Peters, A., Morris, P. G., Francis, S. T., & Gowland, P. A. (2018). ³¹P magnetization transfer magnetic resonance spectroscopy: assessing the activation induced change in cerebral ATP metabolic rates at 3 T. Magnetic Resonance in Medicine, 79(1), 22-30. https://doi.org/10.1002/mrm.26663

Purpose: In vivo ³¹P MRS magnetization transfer (MT) provides a direct measure of neuronal activity at the metabolic level. This work aims to use functional ³¹P MRS-MT to investigate the change in cerebral ATP metabolic rates in healthy adults upon r... Read More about ³¹P magnetization transfer magnetic resonance spectroscopy: assessing the activation induced change in cerebral ATP metabolic rates at 3 T.

Comparing GABA-­dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-­high-­field MRI (2017)
Journal Article
Dyke, K., Pépés, S. E., Chen, C., Kim, S., Sigurdsson, H. P., Draper, A., …Jackson, S. R. (2017). Comparing GABA-­dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-­high-­field MRI. NeuroImage, 152, 360-370. https://doi.org/10.1016/j.neuroimage.2017.03.011

Imbalances in glutamatergic (excitatory) and GABA (inhibitory) signalling within key brain networks are thought to underlie many brain and mental health disorders, and for this reason there is considerable interest in investigating how individual var... Read More about Comparing GABA-­dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-­high-­field MRI.

Impact of a common genetic variation associated with putamen volume on neural mechanisms of ADHD (2017)
Journal Article
Xu, B., Jia, T., Macare, C., Banaschewski, T., Bokde, A. L., Bromberg, U., …Desrivières, S. (2017). Impact of a common genetic variation associated with putamen volume on neural mechanisms of ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 56(5), 436-444.e4. https://doi.org/10.1016/j.jaac.2017.02.009

Objective: In a recent genome-wide association study of subcortical brain volumes, we have identified common genetic variation at rs945270 as having the strongest effect on putamen volume, a brain measure linked to familial risk for attentiondeficit/... Read More about Impact of a common genetic variation associated with putamen volume on neural mechanisms of ADHD.

ICNIRP statement on diagnostic devices using non-ionizing radiation: existing regulations and potential health risks (2017)
Journal Article
Green, A., Coggon, D., Sèze, R. D., Gowland, P. A., Marino, C., Peralta, A., …Watanabe, S. (2017). ICNIRP statement on diagnostic devices using non-ionizing radiation: existing regulations and potential health risks. Health Physics, 112(3), https://doi.org/10.1097/HP.0000000000000654

Use of non-ionizing radiation (NIR) for diagnostic purposes allows non-invasive assessment of the structure and function of the human body, and is widely employed in medical care. ICNIRP has published previous statements about the protection of patie... Read More about ICNIRP statement on diagnostic devices using non-ionizing radiation: existing regulations and potential health risks.

Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study (2017)
Journal Article
Barratt, E. L., Tewarie, P. K., Clarke, M. A., Hall, E. L., Gowland, P. A., Morris, P. G., …Brookes, M. J. (2017). Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study. Human Brain Mapping, 38(5), 2441-2453. https://doi.org/10.1002/hbm.23531

Multiple sclerosis (MS) is a debilitating disease commonly attributed to degradation of white matter myelin. Symptoms include fatigue, as well as problems associated with vision and movement. Although areas of demyelination in white matter are observ... Read More about Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study.

Endotoxemia in peritoneal dialysis patients: a pilot study to examine the role of intestinal perfusion and congestion (2017)
Journal Article
Grant, C., Harrison, L., Hoad, C., Marciani, L., Cox, E., Buchanan, C., …McIntyre, C. (2017). Endotoxemia in peritoneal dialysis patients: a pilot study to examine the role of intestinal perfusion and congestion. Peritoneal Dialysis International, 37(1), 111-115. https://doi.org/10.3747/pdi.2016.00079

Endotoxemia is common in advanced chronic kidney disease and is particularly severe in those receiving dialysis. In hemodialysis patients, translocation from the bowel occurs as a consequence of recurrent circulatory stress leading to a reduction in... Read More about Endotoxemia in peritoneal dialysis patients: a pilot study to examine the role of intestinal perfusion and congestion.