All Outputs (71)

Inhaled corticosteroids and the risk of pneumonia in people with asthma (2013)
Journal Article
McKeever, T. M., Harrison, T. W., Hubbard, R., & Shaw, D. E. (2013). Inhaled corticosteroids and the risk of pneumonia in people with asthma. Chest, 144(6), https://doi.org/10.1378/chest.13-0871

Background In clinical trials, the use of inhaled corticosteroids is associated with an increased risk of pneumonia in people with COPD, but whether the same is true for people with asthma is not known. Methods With the use of primary care dat... Read More about Inhaled corticosteroids and the risk of pneumonia in people with asthma.

The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study (2013)
Journal Article
Donaldson, J. W., McKeever, T. M., Hall, I. P., Hubbard, R., & Fogarty, A. W. (2014). The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study. Thorax, 69(2), 161-167. https://doi.org/10.1136/thoraxjnl-2013-203720

Background Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder of aberrant blood vessel development characterised by arteriovenous malformations. HHT is associated with significant morbidity due to complications inc... Read More about The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study.

A Novel Semisupervised Algorithm for Rare Prescription Side Effect Discovery (2013)
Journal Article
Reps, J. M., Garibaldi, J. M., Aickelin, U., Soria, D., Gibson, J. E., & Hubbard, R. B. (2014). A Novel Semisupervised Algorithm for Rare Prescription Side Effect Discovery. IEEE Journal of Biomedical and Health Informatics, 18(2), 537-547. https://doi.org/10.1109/JBHI.2013.2281505

Drugs are frequently prescribed to patients with the aim of improving each patient's medical state, but an unfortunate consequence of most prescription drugs is the occurrence of undesirable side effects. Side effects that occur in more than one in a... Read More about A Novel Semisupervised Algorithm for Rare Prescription Side Effect Discovery.

Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case–control study (2013)
Journal Article
Navaratnam, V., Fogarty, A. W., McKeever, T. M., Thompson, N., Jenkins, G., Johnson, S. R., …Hubbard, R. B. (2014). Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case–control study. Thorax, 69(3), 207-215. https://doi.org/10.1136/thoraxjnl-2013-203740

BACKGROUND: Laboratory studies suggest that the clotting cascade is activated in fibrotic lungs. Since humans vary in their tendency to clot due to a variety of inherited or acquired defects, we investigated whether a prothrombotic state increases th... Read More about Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case–control study.

Chronic Obstructive Pulmonary Disease and Risk of Lung Cancer: The Importance of Smoking and Timing of Diagnosis (2013)
Journal Article
Powell, H. A., Iyen-Omofoman, B., Hubbard, R. B., & Tata, L. J. (2013). Chronic Obstructive Pulmonary Disease and Risk of Lung Cancer: The Importance of Smoking and Timing of Diagnosis. Journal of Thoracic Oncology, 8(4), e34-e35. https://doi.org/10.1097/jto.0b013e31828950e3

The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study (2013)
Journal Article
Enocson, A., Hubbard, R., McKeever, T. M., Russell, N., Byrne, J., Das-Gupta, E., …Fogarty, A. W. (2013). The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study. BMC Pulmonary Medicine, 13(Januar), Article 6. https://doi.org/10.1186/1471-2466-13-2

Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function. Methods: Using a prospective study design, we quantified the changes in... Read More about The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study.

Attributes for causal inference in electronic healthcare databases (2013)
Conference Proceeding
Reps, J., Garibaldi, J. M., Aickelin, U., Soria, D., Gibson, J. E., & Hubbard, R. B. (2013). Attributes for causal inference in electronic healthcare databases.

Side effects of prescription drugs present a serious issue. Existing algorithms that detect side effects generally require further analysis to confirm causality. In this paper we investigate attributes based on the Bradford-Hill causality criteria... Read More about Attributes for causal inference in electronic healthcare databases.

135 Smoking and lung cancer in women (2012)
Journal Article
Powell, H., Iyen-Omofoman, B., Baldwin, D., Hubbard, R., & Tata, L. (2012). 135 Smoking and lung cancer in women. Lung Cancer, 71(Supplement 1), S44. https://doi.org/10.1016/S0169-5002%2812%2970136-8

Comparing data-mining algorithms developed for longitudinal observational databases
Conference Proceeding
Reps, J., Garibaldi, J. M., Aickelin, U., Soria, D., Gibson, J. E., & Hubbard, R. B. Comparing data-mining algorithms developed for longitudinal observational databases.

Longitudinal observational databases have become a recent interest in the post marketing drug surveillance community due to their ability of presenting a new perspective for detecting negative side effects. Algorithms mining longitudinal observation... Read More about Comparing data-mining algorithms developed for longitudinal observational databases.

Discovering sequential patterns in a UK general practice database
Conference Proceeding
Reps, J., Garibaldi, J. M., Aickelin, U., Soria, D., Gibson, J. E., & Hubbard, R. B. Discovering sequential patterns in a UK general practice database.

The wealth of computerised medical information becoming readily available presents the opportunity to examine patterns of illnesses, therapies and responses. These patterns may be able to predict illnesses that a patient is likely to develop, allowi... Read More about Discovering sequential patterns in a UK general practice database.

Investigating the detection of adverse drug events in a UK general practice electronic health-care database
Conference Proceeding
Reps, J., Feyereisl, J., Garibaldi, J. M., Aickelin, U., Gibson, J. E., & Hubbard, R. B. Investigating the detection of adverse drug events in a UK general practice electronic health-care database.

Data-mining techniques have frequently been developed for Spontaneous reporting databases. These techniques aim to find adverse drug events accurately and efficiently. Spontaneous reporting databases are prone to missing information,under reporting... Read More about Investigating the detection of adverse drug events in a UK general practice electronic health-care database.