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When all seems lost: management of refractory constipation—Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more (2018)
Journal Article
Wilkinson-Smith, V., Bharucha, A. E., Emmanuel, A., Knowles, C., Yiannakou, Y., & Corsetti, M. (2018). When all seems lost: management of refractory constipation—Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more. Neurogastroenterology and Motility, 30(5), Article e13352. https://doi.org/10.1111/nmo.13352

© 2018 John Wiley & Sons Ltd While the pharmacological armamentarium for chronic constipation has expanded over the past few years, a substantial proportion of constipated patients do not respond to these medications. This review summarizes the pha... Read More about When all seems lost: management of refractory constipation—Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more.

Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome (2017)
Journal Article
Vork, L., Keszthely, D., Mujagic, Z., Kruimel, J., Leue, C., Pontén, I., …Masclee, A. (in press). Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome. Neurogastroenterology and Motility, 30(3), Article e13244. https://doi.org/10.1111/nmo.13244

BACKGROUND: End-of-day questionnaires, which are considered the gold standard for assessing abdominal pain and other gastrointestinal (GI) symptoms in irritable bowel syndrome (IBS), are influenced by recall and ecological bias. The Experience Sampli... Read More about Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome.

The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature? (2017)
Journal Article
Corsetti, M., & Fox, M. (2017). The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?. F1000Research, 6, Article 1778. https://doi.org/10.12688/f1000research.12089.1

© 2017 Corsetti M and Fox M. Functional dyspepsia is a prevalent functional gastrointestinal disorder that can significantly erode the quality of life of sufferers and places a major cost burden on healthcare services. In this article, we review the... Read More about The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?.

Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts (2017)
Journal Article
Tack, J., Corsetti, M., Camilleri, M., Quigley, A., Simren, M., Suzuki, H., …Van Oudenhove, L. (in press). Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts. Gut, https://doi.org/10.1136/gutjnl-2016-312230

The functional gastrointestinal disorders (FGIDs), are extremely common conditions associated with a considerable personal, social and health economic burden. Managing FGIDs in clinical practice is challenging because of the uncertainty of symptom-ba... Read More about Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts.

Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers (2017)
Journal Article
Deloose, E., Corsetti, M., Van Oudenhove, L., Depoortere, I., & Tack, J. (2017). Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers. Neurogastroenterology and Motility, 30(1), Article e13171. https://doi.org/10.1111/nmo.13171

Intragastric administration of the bitter tastant denatonium benzoate inhibits the increase of motilin plasma levels and antral contractility. While these findings suggest that gastrointestinal bitter taste receptors could be new targets to modulate... Read More about Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers.

The global impact of IBS: time to think about IBS-specific models of care? (2017)
Journal Article
Corsetti, M., & Whorwell, P. (2017). The global impact of IBS: time to think about IBS-specific models of care?. Therapeutic Advances in Gastroenterology, 10(9), 727-736. doi:10.1177/1756283x17718677

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal (GI) disorder that can significantly erode the quality of life (QoL) of sufferers and places a major cost burden on healthcare services. This paper reviews the literature on th... Read More about The global impact of IBS: time to think about IBS-specific models of care?.

New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline (2017)
Journal Article
Corsetti, M., & Whorwell, P. (2017). New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline. Expert Review of Gastroenterology and Hepatology, 11(4), 285-292. https://doi.org/10.1080/17474124.2017.1298442

Introduction: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder which represents a major cost to healthcare services. IBS-D patients represent about one-third of the IBS population and are currently treated with antis... Read More about New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline.

Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers (2017)
Journal Article
Deloose, E., Janssen, P., Corsetti, M., Biesiekierski, J., Masuy, I., Rotondo, A., …Tack, J. (2017). Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers. American Journal of Clinical Nutrition, 105(3), 580-588. https://doi.org/10.3945/ajcn.116.138297

Background: Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion. Objective: We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concen... Read More about Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers.

Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities (2016)
Journal Article
Hens, B., Corsetti, M., Spiller, R. C., Marciani, L., Vanuytsel, T., Tack, J., …Augustijns, P. (2017). Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519(1-2), https://doi.org/10.1016/j.ijpharm.2016.11.063

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables i... Read More about Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities.

Manometric evaluation of anorectal function in patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer (2016)
Journal Article
De Nardi, P., Testoni, S. G. G., Corsetti, M., Andreoletti, H., Giollo, P., Passarett, S., & Testoni, P. A. (2017). Manometric evaluation of anorectal function in patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer. Digestive Diseases and Sciences, 49(1), https://doi.org/10.1016/j.dld.2016.09.005

BACKGROUND: An altered anorectal function is reported after chemoradiotherapy (CRT) and surgery for rectal cancer. AIM: The aim of this study was to clarify the relative contribution of neoadjuvant chemoradiation and surgical resection on the impair... Read More about Manometric evaluation of anorectal function in patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision for rectal cancer.

Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry (2016)
Journal Article
Corsetti, M., Pagliaro, G., Demedts, I., Deloose, E., Gevers, A., Scheerens, C., …Tack, J. (2017). Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry. American Journal of Gastroenterology, 112(3), https://doi.org/10.1038/ajg.2016.341

Background: Only few studies have applied high-resolution manometry (HRM) to the study of colonic motility in adults and none of them have concurrently evaluated colonic and anal motor activity. Aims: To evaluate colonic and anal motor activity by me... Read More about Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry.

Gastrointestinal and systemic monitoring of posaconazole in humans after fasted and fed state administration of a solid dispersion (2016)
Journal Article
Hens, B., Corsetti, M., Brouwers, J., & Augustijns, P. (2016). Gastrointestinal and systemic monitoring of posaconazole in humans after fasted and fed state administration of a solid dispersion. Journal of Pharmaceutical Sciences, 105(9), 2904-2912. doi:10.1016/j.xphs.2016.03.027

The purpose of this study was to explore the intraluminal behavior and systemic exposure of posaconazole in humans after oral intake of a novel delayed-release tablet (Noxafil®), containing posaconazole dispersed in a matrix of hydroxypropyl methylce... Read More about Gastrointestinal and systemic monitoring of posaconazole in humans after fasted and fed state administration of a solid dispersion.