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Glutathione and glutamate in schizophrenia: a 7T MRS study (2018)
Journal Article
Kumar, J., Liddle, E. B., Fernandes, C. C., Palaniyappan, L., Hall, E. L., Robson, S. E., …Liddle, P. F. (2018). Glutathione and glutamate in schizophrenia: a 7T MRS study. Molecular Psychiatry, 25(4), 873–882. https://doi.org/10.1038/s41380-018-0104-7

© 2018 The Author(s) In schizophrenia, abnormal neural metabolite concentrations may arise from cortical damage following neuroinflammatory processes implicated in acute episodes. Inflammation is associated with increased glutamate, whereas the antio... Read More about Glutathione and glutamate in schizophrenia: a 7T MRS study.

Relationships Between Neuronal Oscillatory Amplitude and Dynamic Functional Connectivity (2018)
Journal Article
Tewarie, P., Hunt, B. A. E., O'Neill, G. C., Byrne, A., Aquino, K., Bauer, M., …Brookes, M. J. (2018). Relationships Between Neuronal Oscillatory Amplitude and Dynamic Functional Connectivity. Cerebral Cortex, 29(6), 2668-2681. https://doi.org/10.1093/cercor/bhy136

Event related fluctuations of neural oscillatory amplitude are reported widely in the context of cognitive processing and are typically interpreted as a marker of brain ‘activity’. However, the precise nature of these effects remains unclear; in part... Read More about Relationships Between Neuronal Oscillatory Amplitude and Dynamic Functional Connectivity.

Moving magnetoencephalography towards real-world applications with a wearable system (2018)
Journal Article
Boto, E., Holmes, N., Leggett, J., Roberts, G., Shah, V., Meyer, S. S., …Brookes, M. J. (2018). Moving magnetoencephalography towards real-world applications with a wearable system. Nature, 555, 657-661. https://doi.org/10.1038/nature26147

Imaging human brain function with techniques such as magnetoencephalography1 (MEG) typically requires a subject to perform tasks whilst their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessibl... Read More about Moving magnetoencephalography towards real-world applications with a wearable system.

Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment (2018)
Journal Article
Brookes, M. J., Groom, M. J., Liuzzi, L., Hill, R. M., Smith, H. J., Briley, P. M., …Liddle, E. B. (2018). Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment. NeuroImage, 174, https://doi.org/10.1016/j.neuroimage.2018.03.008

Network connectivity is an integral feature of human brain function, and characterising its maturational trajectory is a critical step towards understanding healthy and atypical neurodevelopment. Here, we used magnetoencephalography (MEG) to investig... Read More about Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment.

A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks (2018)
Journal Article
Abeysuriya, R. G., Hadida, J., Sotiropoulos, S. N., Jbabdi, S., Becker, R., Hunt, B. A., …Woolrich, M. W. (in press). A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks. PLoS Computational Biology, 14(2), Article e1006007. https://doi.org/10.1371/journal.pcbi.1006007

Over long timescales, neuronal dynamics can be robust to quite large perturbations, such as changes in white matter connectivity and grey matter structure through processes including learning, aging, development and certain disease processes. One pos... Read More about A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks.

Comparing multilayer brain networks between groups: Introducing graph metrics and recommendations (2017)
Journal Article
Mandke, K., Meier, J., Brookes, M. J., O'Dea, R. D., Van Mieghem, P., Stam, C. J., …Tewarie, P. K. (2018). Comparing multilayer brain networks between groups: Introducing graph metrics and recommendations. NeuroImage, 166, https://doi.org/10.1016/j.neuroimage.2017.11.016

There is an increasing awareness of the advantages of multi-modal neuroimaging. Networks obtained from different modalities are usually treated in isolation, which is however contradictory to accumulating evidence that these networks show non-trivial... Read More about Comparing multilayer brain networks between groups: Introducing graph metrics and recommendations.

Dynamics of large-scale electrophysiological networks: a technical review (2017)
Journal Article
O'Neill, G. C., Tewarie, P. K., Vidaurre, D., Liuzzi, L., Woolrich, M. W., & Brookes, M. J. (2017). Dynamics of large-scale electrophysiological networks: a technical review. NeuroImage, https://doi.org/10.1016/j.neuroimage.2017.10.003

For several years it has been argued that neural synchronisation is crucial for cognition. The idea that synchronised temporal patterns between different neural groups carries information above and beyond the isolated activity of these groups has ins... Read More about Dynamics of large-scale electrophysiological networks: a technical review.

A mean field model for movement induced changes in the beta rhythm (2017)
Journal Article
Byrne, Á., Brookes, M. J., & Coombes, S. (2017). A mean field model for movement induced changes in the beta rhythm. Journal of Computational Neuroscience, 43(2), https://doi.org/10.1007/s10827-017-0655-7

In electrophysiological recordings of the brain, the transition from high amplitude to low amplitude signals are most likely caused by a change in the synchrony of underlying neuronal population firing patterns. Classic examples of such modulations... Read More about A mean field model for movement induced changes in the beta rhythm.

An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography (2017)
Journal Article
Glover, P. M., Watkins, R. H., O’Neill, G. C., Ackerley, R. M., Sánchez-Panchuelo, R., McGlone, F., …Francis, S. T. (2017). An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography. Journal of Neuroscience Methods, 290, 69-78. https://doi.org/10.1016/j.jneumeth.2017.07.016

Background Intra-neural microstimulation (INMS) is a technique that allows the precise delivery of low-current electrical pulses into human peripheral nerves. Single unit INMS can be used to stimulate individual afferent nerve fibres during micron... Read More about An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography.

Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study (2017)
Journal Article
Barratt, E. L., Tewarie, P. K., Clarke, M. A., Hall, E. L., Gowland, P. A., Morris, P. G., …Brookes, M. J. (2017). Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study. Human Brain Mapping, 38(5), 2441-2453. https://doi.org/10.1002/hbm.23531

Multiple sclerosis (MS) is a debilitating disease commonly attributed to degradation of white matter myelin. Symptoms include fatigue, as well as problems associated with vision and movement. Although areas of demyelination in white matter are observ... Read More about Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study.

The effect of physical fatigue on oscillatory dynamics of the sensorimotor cortex (2017)
Journal Article
Fry, A., Mullinger, K. J., O'Neill, G. C., Brookes, M. J., & Folland, J. P. (2018). The effect of physical fatigue on oscillatory dynamics of the sensorimotor cortex. Acta Physiologica, 220(3), 370-381. https://doi.org/10.1111/apha.12843

Aim: While physical fatigue is known to arise in part from supraspinal mechanisms within the brain exactly how brain activity is modulated during fatigue is not well understood. Therefore, this study examined how typical neural oscillatory responses... Read More about The effect of physical fatigue on oscillatory dynamics of the sensorimotor cortex.

A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers (2017)
Journal Article
Boto, E., Meyer, S. S., Shah, V., Alem, O., Knappe, S., Kruger, P., …Brookes, M. J. (2017). A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers. NeuroImage, 149, 404-414. https://doi.org/10.1016/j.neuroimage.2017.01.034

© 2017 The Authors Advances in the field of quantum sensing mean that magnetic field sensors, operating at room temperature, are now able to achieve sensitivity similar to that of cryogenically cooled devices (SQUIDs). This means that room temperatur... Read More about A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers.

Optimising experimental design for MEG resting state functional connectivity measurement (2016)
Journal Article
Liuzzi, L., Gascoyne, L. E., Tewarie, P. K., Barratt, E. L., Boto, E., & Brookes, M. J. (2017). Optimising experimental design for MEG resting state functional connectivity measurement. NeuroImage, 155, 565-576. https://doi.org/10.1016/j.neuroimage.2016.11.064

The study of functional connectivity using magnetoencephalography (MEG) is an expanding area of neuroimaging, and adds an extra dimension to the more common assessments made using fMRI. The importance of such metrics is growing, with recent demonstra... Read More about Optimising experimental design for MEG resting state functional connectivity measurement.

Relationships between cortical myeloarchitecture and electrophysiological networks (2016)
Journal Article
Hunt, B. A. E., Tewarie, P. K., Mougin, O. E., Geades, N., Jones, D. K., Singh, K. D., …Brookes, M. J. (2016). Relationships between cortical myeloarchitecture and electrophysiological networks. Proceedings of the National Academy of Sciences, 113(47), 13510-13515. https://doi.org/10.1073/pnas.1608587113

The human brain relies upon the dynamic formation and dissolution of a hierarchy of functional networks to support ongoing cognition. However, how functional connectivities underlying such networks are supported by cortical microstructure remains poo... Read More about Relationships between cortical myeloarchitecture and electrophysiological networks.

Measurement of dynamic task related functional networks using MEG (2016)
Journal Article
O’Neill, G. C., Tewarie, P. K., Colclough, G. L., Gascoyne, L. E., Hunt, B. A., Morris, P. G., …Brookes, M. J. (2017). Measurement of dynamic task related functional networks using MEG. NeuroImage, 146, 667-678. https://doi.org/10.1016/j.neuroimage.2016.08.061

The characterisation of dynamic electrophysiological brain networks, which form and dissolve in order to support ongoing cognitive function, is one of the most important goals in neuroscience. Here, we introduce a method for measuring such networks i... Read More about Measurement of dynamic task related functional networks using MEG.

On the potential of a new generation of magnetometers for MEG: a beamformer simulation study (2016)
Journal Article
Boto, E., Bowtell, R. W., Kruger, P., Fromhold, T. M., Morris, P. G., Meyer, S. S., …Brookes, M. J. (2016). On the potential of a new generation of magnetometers for MEG: a beamformer simulation study. PLoS ONE, 11(8), Article e0157655. https://doi.org/10.1371/journal.pone.0157655

Magnetoencephalography (MEG) is a sophisticated tool which yields rich information on the spatial, spectral and temporal signatures of human brain function. Despite unique potential, MEG is limited by a low signal-to-noise ratio (SNR) which is caused... Read More about On the potential of a new generation of magnetometers for MEG: a beamformer simulation study.

Integrating cross-frequency and within band functional networks in resting-state MEG: A multi-layer network approach (2016)
Journal Article
Van Mieghem, P., Tewarie, P., Hillebrand, A., van Dijk, B. W., Stam, C. J., O'Neill, G. C., …Brookes, M. J. (2016). Integrating cross-frequency and within band functional networks in resting-state MEG: A multi-layer network approach. NeuroImage, 142, 324-336. https://doi.org/10.1016/j.neuroimage.2016.07.057

Neuronal oscillations exist across a broad frequency spectrum, and are thought to provide a mechanism of interaction between spatially separated brain regions. Since ongoing mental activity necessitates the simultaneous formation of multiple networks... Read More about Integrating cross-frequency and within band functional networks in resting-state MEG: A multi-layer network approach.

The UK National Quantum Technologies Hub in sensors and metrology (Keynote Paper) (2016)
Journal Article
Bongs, K., Boyer, V., Cruise, M., Freise, A., Holynski, M., Hughes, J., …John, P. (2016). The UK National Quantum Technologies Hub in sensors and metrology (Keynote Paper). Proceedings of SPIE, 9900, Article 990009. https://doi.org/10.1117/12.2232143

The UK National Quantum Technology Hub in Sensors and Metrology is one of four flagship initiatives in the UK National of Quantum Technology Program. As part of a 20-year vision it translates laboratory demonstrations to deployable practical devices,... Read More about The UK National Quantum Technologies Hub in sensors and metrology (Keynote Paper).

How reliable are MEG resting-state connectivity metrics? (2016)
Journal Article
Colclough, G., Woolrich, M., Tewarie, P., Brookes, M., Quinn, A., & Smith, S. (2016). How reliable are MEG resting-state connectivity metrics?. NeuroImage, 138, 284-293. https://doi.org/10.1016/j.neuroimage.2016.05.070

MEG offers dynamic and spectral resolution for resting-state connectivity which is unavailable in fMRI. However, there are a wide range of available network estimation methods for MEG, and little in the way of existing guidance on which ones to emplo... Read More about How reliable are MEG resting-state connectivity metrics?.

Modulation of post-movement beta rebound by contraction force and rate of force development (2016)
Journal Article
Fry, A., Mullinger, K. J., O'Neill, G. C., Barratt, E. L., Morris, P. G., Bauer, M., …Brookes, M. J. (2016). Modulation of post-movement beta rebound by contraction force and rate of force development. Human Brain Mapping, 37(7), https://doi.org/10.1002/hbm.23189

Movement induced modulation of the beta rhythm is one of the most robust neural oscillatory phenomena in the brain. In the preparation and execution phases of movement, a loss in beta amplitude is observed (movement related beta decrease (MRBD)). Thi... Read More about Modulation of post-movement beta rebound by contraction force and rate of force development.