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All Outputs (117)

Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease-modifying anti-rheumatic drugs (2020)
Journal Article
Mallen, C. D., Nakafero, G., Grainge, M. J., Myles, P. R., Zhang, W., Doherty, M., …Abhishek, A. (2020). Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease-modifying anti-rheumatic drugs. Rheumatology, 59(12), 3666–3675. https://doi.org/10.1093/rheumatology/keaa078

Objectives The effectiveness of inactivated influenza vaccine in people with autoimmune rheumatic disease (AIRDs) is not known. We investigated whether the influenza vaccine is effective in preventing respiratory morbidity, mortality and all-cause m... Read More about Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease-modifying anti-rheumatic drugs.

Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis (2019)
Journal Article
Lansbury, L. E., Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., & Shen Lim, W. (2020). Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis. Critical Care Medicine, 48(2), e98-e106. https://doi.org/10.1097/ccm.0000000000004093

Objective: Corticosteroids may be beneficial in sepsis but uncertainty remains over their effects in severe influenza. This systematic review updates the current evidence regarding corticosteroids in the treatment of influenza and examines the effect... Read More about Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis.

A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic (2019)
Journal Article
Venkatesan, S., Nguyen-Van-Tam, J., & Siebers, P. (2019). A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic. PLoS ONE, 14(10), https://doi.org/10.1371/journal.pone.0223946

© 2019 Venkatesan et al. The importance of accounting for social and behavioural processes when studying public health emergencies has been well-recognised. For infectious disease outbreaks in particular, several methods of incorporating individual b... Read More about A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic.

Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS) (2019)
Journal Article
Roosenhoff, R., Reed, V., Kenwright, A., Schutten, M., Boucher, C. A., Monto, A., …Fraaij, P. L. A. (2020). Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS). Clinical Infectious Diseases, 71(5), 1186–1194. https://doi.org/10.1093/cid/ciz939

Background We studied the effect of age, baseline viral load, vaccination status, antiviral therapy, and emergence of drug resistance on viral shedding in children infected with influenza A or B virus. Methods Samples from children (aged ≤13... Read More about Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS).

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection (2019)
Journal Article
Venkatesan, S., Myles, P. R., Bolton, K. J., Muthuri, S. G., Al Khuwaitir, T., Anovadiya, A. P., …Nguyen-Van-Tam, J. S. (2020). Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection. Journal of Infectious Diseases, 221(3), 356–366. https://doi.org/10.1093/infdis/jiz152

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment o... Read More about Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection.

A Rapid Evidence Appraisal of influenza vaccination in health workers: an important policy in an area of imperfect evidence (2019)
Journal Article
Jenkin, D. C., Mahgoub, H., Morales, K. F., Lambach, P., & Nguyen-Van-Tam, J. S. (2019). A Rapid Evidence Appraisal of influenza vaccination in health workers: an important policy in an area of imperfect evidence. Vaccine, 2, https://doi.org/10.1016/j.jvacx.2019.100036

Introduction The World Health Organization recommends vaccination of health workers (HWs) against influenza, but low uptake is intransigent. We conducted a Rapid Evidence Appraisal on: the risk of influenza in HWs, transmission risk from HWs to... Read More about A Rapid Evidence Appraisal of influenza vaccination in health workers: an important policy in an area of imperfect evidence.

Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M. J., Myles, P., Mallen, C. D., Zhang, W., Doherty, M., …Abhishek, A. (2019). Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 78(8), 1122-1126. https://doi.org/10.1136/annrheumdis-2019-215086

Objectives To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis, and unexplained fever in people w... Read More about Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink.

Corticosteroids as adjunctive therapy in the treatment of influenza (2019)
Journal Article
Lansbury, L., Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., & Lim, W. S. (2019). Corticosteroids as adjunctive therapy in the treatment of influenza. Cochrane Database of Systematic Reviews, 2019(2), Article CD010406. https://doi.org/10.1002/14651858.CD010406.pub3

Background Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti‐inflammatory and immunomodulatory properti... Read More about Corticosteroids as adjunctive therapy in the treatment of influenza.

The effect of influenza virus on the human oropharyngeal microbiome (2018)
Journal Article
Ramos-Sevillano, E., Wade, W. G., Mann, A., Gilbert, A., Lambkin-Williams, R., Killingley, B., …Tang, C. M. (2019). The effect of influenza virus on the human oropharyngeal microbiome. Clinical Infectious Diseases, 68(12), 1993-2002. https://doi.org/10.1093/cid/ciy821

© The Author(s) 2018. Background. Secondary bacterial infections are an important cause of morbidity and mortality associated with influenza infections. As bacterial disease can be caused by a disturbance of the host microbiome, we examined the impac... Read More about The effect of influenza virus on the human oropharyngeal microbiome.

Deposition of respiratory virus pathogens on frequently touched surfaces at airports (2018)
Journal Article
Ikonen, N., Savolainen-Kopra, C., Enstone, J. E., Kulmala, I., Pasanen, P., Salmela, A., …Ruutu, P. (2018). Deposition of respiratory virus pathogens on frequently touched surfaces at airports. BMC Infectious Diseases, 18, Article 437. https://doi.org/10.1186/s12879-018-3150-5

BACKGROUND: International and national travelling has made the rapid spread of infectious diseases possible. Little information is available on the role of major traffic hubs, such as airports, in the transmission of respiratory infections, including... Read More about Deposition of respiratory virus pathogens on frequently touched surfaces at airports.

Antiviral treatment for outpatient use during an influenza pandemic: a decision tree model of outcomes averted and cost-effectiveness (2018)
Journal Article
Myles, P. R., Venkatesan, S., Carias, C., Biggerstaff, M., Campbell, A. P., Nguyen-Van-Tam, J. S., …Meltzer, M. I. (2019). Antiviral treatment for outpatient use during an influenza pandemic: a decision tree model of outcomes averted and cost-effectiveness. Journal of Public Health, 41(2), 379–390. https://doi.org/10.1093/pubmed/fdy108

Background: Many countries have acquired antiviral stockpiles for pandemic influenza mitigation and a significant part of the stockpile may be focussed towards community-based treatment. Methods: We developed a spreadsheet-based, decision tree mod... Read More about Antiviral treatment for outpatient use during an influenza pandemic: a decision tree model of outcomes averted and cost-effectiveness.

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study (2018)
Journal Article
Nakafero, G., Grainge, M. J., Myles, P. R., Mallen, C., Zhang, W., Doherty, M., …Abhishek, A. (2018). Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study. Rheumatology, 57(10), 1726-1734. https://doi.org/10.1093/rheumatology/key156

Objectives: To [1] examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK, [2] explore disease and demographic factors associated with vaccination. Methods: 32,751 people with auto-immune rheumatic diseases (AIRDs) prescribed... Read More about Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study.

Clinicians' attitude towards a placebo-controlled randomised clinical trial investigating the effect of neuraminidase inhibitors in adults hospitalised with influenza (2018)
Journal Article
Bradbury, N., Nguyen-Van-Tam, J. S., & Lim, W. S. (2018). Clinicians' attitude towards a placebo-controlled randomised clinical trial investigating the effect of neuraminidase inhibitors in adults hospitalised with influenza. BMC Health Services Research, 18, 1-9. https://doi.org/10.1186/s12913-018-3122-x

Background: The value of neuraminidase inhibitors (NAIs) in reducing severe clinical outcomes from influenza is debated. A clinical trial to generate better evidence is desirable. However, it is unknown whether UK clinicians would support a placebo c... Read More about Clinicians' attitude towards a placebo-controlled randomised clinical trial investigating the effect of neuraminidase inhibitors in adults hospitalised with influenza.

Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study (IRIS) (2018)
Journal Article
Lina, B., Boucher, C., Osterhaus, A., Monto, A. S., Schutten, M., Whitley, R. J., & Nguyen-Van-Tam, J. S. (2018). Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study (IRIS). Influenza and Other Respiratory Viruses, 12(2), 267-278. https://doi.org/10.1111/irv.12534

Effects of seasonal and pandemic influenza on health-related quality of life, work and school absence in England: Results from the Flu Watch cohort study (2017)
Journal Article
Fragaszy, E. B., Warren-Gash, C., White, P. J., Zambon, M., Edmunds, W. J., Nguyen-Van-Tam, J. S., & Hayward, A. C. (2018). Effects of seasonal and pandemic influenza on health-related quality of life, work and school absence in England: Results from the Flu Watch cohort study. Influenza and Other Respiratory Viruses, 12(1), 171-182. https://doi.org/10.1111/irv.12506

Background: Estimates of health?related quality of life (HRQoL) and work/school absences for influenza are typically based on medically attended cases or those meeting influenza?like?illness (ILI) case definitions and thus biased towards severe disea... Read More about Effects of seasonal and pandemic influenza on health-related quality of life, work and school absence in England: Results from the Flu Watch cohort study.

Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe (2017)
Journal Article
Alimi, Y., Lim, W., Lansbury, L. E., Leonardi-Bee, J., & Nguyen-Van-Tam, J. S. (2017). Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe. Journal of Clinical Virology, 95, https://doi.org/10.1016/j.jcv.2017.07.019

Community-acquired pneumonia (CAP) is an important respiratory disease and the fifth leading cause of mortality in Europe. The development of molecular diagnostic tests has highlighted the contributions of respiratory viruses to the aetiology of CAP,... Read More about Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe.

Influenza in long-term care facilities (2017)
Journal Article
Lansbury, L. E., Brown, C. S., & Nguyen-Van-Tam, J. S. (2017). Influenza in long-term care facilities. Influenza and Other Respiratory Viruses, 11(5), 356-366. https://doi.org/10.1111/irv.12464

Long-term care facility environments and the vulnerability of their residents provide a setting conducive to the rapid spread of influenza virus and other respiratory pathogens. Infections may be introduced by staff, visitors or new or transferred re... Read More about Influenza in long-term care facilities.

Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage (2017)
Journal Article
Watson, S. I., Chen, Y., Nguyen-Van-Tam, J. S., Myles, P. R., Venkatesan, S., Zambon, M., …Lilford, R. J. (2017). Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage. F1000Research, 5, Article 2293. https://doi.org/10.12688/f1000research.9414.2

Objectives: The stockpiling of neuraminidase inhibitor (NAI) antivirals as a defence against pandemic influenza is a significant public health policy decision that must be made despite a lack of conclusive evidence from randomised controlled trials r... Read More about Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage.

Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage (2017)
Journal Article
Watson, S. I., Chen, Y., Nguyen-Van-Tam, J. S., Myles, P. R., Venkatesan, S., Zambon, M., …Lilford, R. J. (2017). Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage. F1000Research, 5, Article 2293. https://doi.org/10.12688/f1000research.9414.2

Objectives: The stockpiling of neuraminidase inhibitor (NAI) antivirals as a defence against pandemic influenza is a significant public health policy decision that must be made despite a lack of conclusive evidence from randomised controlled trials r... Read More about Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage.