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All Outputs (106)

Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts (2019)
Journal Article
McWilliams, D. F., Dawson, O., Young, A., Kiely, P., Ferguson, E., & Walsh, D. A. (2019). Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts. Journal of Pain, 20(6), 716-727. https://doi.org/10.1016/j.jpain.2019.01.001

Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesised that discrete RA subgroups might display favourable or unfa... Read More about Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts.

Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis (2018)
Journal Article
Wyatt, L. A., Nwosu, L. N., Wilson, D., Hill, R., Spendlove, I., Bennett, A. J., …Walsh, D. A. (2018). Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis. Osteoarthritis and Cartilage, 27(4), 667-675. https://doi.org/10.1016/j.joca.2018.12.012

Objective: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium associated with symptomatic knee... Read More about Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.

Thresholds of ultrasound synovial abnormalities for knee osteoarthritis: a cross sectional study in the general population (2018)
Journal Article
Sarmanova, A., Hall, M., Fernandes, G., Valdes, A., Walsh, D., Doherty, M., & Zhang, W. (2019). Thresholds of ultrasound synovial abnormalities for knee osteoarthritis: a cross sectional study in the general population. Osteoarthritis and Cartilage, 27(3), 435-443. https://doi.org/10.1016/j.joca.2018.09.018

Objective To establish “normal” ranges for synovial thickness and effusion detected by ultrasound (US) and to determine cut-offs associated with knee pain (KP) and radiographic knee osteoarthritis (RKOA) in the community. Methods 147 women a... Read More about Thresholds of ultrasound synovial abnormalities for knee osteoarthritis: a cross sectional study in the general population.

Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain (2018)
Journal Article
Nwosu, L. N., Gowler, P. R., Burston, J. J., Rizoska, B., Tunblad, K., Lindström, E., …Chapman, V. (2018). Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain. PAIN Reports, 3(6), Article 685. https://doi.org/10.1097/PR9.0000000000000685

© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. Introduction: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to invest... Read More about Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain.

Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample (2018)
Journal Article
Fernandes, G. S., Valdes, A. M., Walsh, D. A., Zhang, W., & Doherty, M. (2018). Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample. Arthritis Research and Therapy, 20(1), Article 215. https://doi.org/10.1186/s13075-018-1717-6

Background Neuropathic-like knee pain (NKP) is often reported in individuals with knee pain (KP), but the contribution of specific central and peripheral risk factors to NKP has not been studied previously. The aims of the present study were to de... Read More about Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample.

Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study (2018)
Journal Article
Sarmanova, A., Fernandes, G., Richardson, H., Valdes, A., Walsh, D., Zhang, W., & Doherty, M. (2018). Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study. Osteoarthritis and Cartilage, 26(11), 1461-1473. https://doi.org/10.1016/j.joca.2018.07.013

Aim To explore risk factors that may influence knee pain (KP) through central or peripheral mechanisms. Methods A questionnaire-based prospective community cohort study with KP defined as pain in or around a knee on most days for at least a... Read More about Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study.

Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC) (2018)
Conference Proceeding
McWilliams, D. F., Frowd, N., Marshall, L., Stocks, J., Sarmanova, A., Fernandes, G. S., …Walsh, D. A. (2018). Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC).

Background: Knee pain results from a combination of nociceptive input from the joint, and processing by the central nervous system. Pressure pain detection thresholds (PPTs) are lower and pain is more severe in people with greater central sensitisat... Read More about Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC).

Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants (2018)
Journal Article
Stocks, J., Tang, N. K., Walsh, D. A., Warner, S. C., Harvey, H., Jenkins, W., …Valdes, A. M. (2018). Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants. Journal of Pain Research, 2018(11), 1087—1093. https://doi.org/10.2147/JPR.S149830

Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic pain-like symptoms. 423 individuals who had undergone total joint... Read More about Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants.

A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis (2018)
Journal Article
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G., Valdes, A., …Walsh, D. (2018). A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis. Osteoarthritis and Cartilage, 26(Supplement 1), S231-S232. https://doi.org/10.1016/j.joca.2018.02.483

Purpose: Approximately 1 in 4 individuals in the UK over the age of 55 experience knee pain (KP), predominantly due to osteoarthritis (OA). Following treatment targeted at the affected knee, pain relief is reported in only 60%–80% of individuals with... Read More about A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis.

General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer (2018)
Journal Article
James, R. J. E., Walsh, D. A., & Ferguson, E. (2018). General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer. BMC Medicine, 16, Article 51. https://doi.org/10.1186/s12916-018-1031-9

Background: While the heterogeniety of pain progression has been studied in chronic diseases, it is unclear the extent to which patterns of pain progression among people in general as well as across different diseases impacts on social, civic and po... Read More about General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer.

Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis (2018)
Journal Article
McWilliams, D. F., Kiely, P. D., Young, A., Joharatnam, N., Wilson, D., & Walsh, D. A. (in press). Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis. BMC Rheumatology, 2(8), https://doi.org/10.1186/s41927-018-0016-9

Background: DAS28 is interpreted as the inflammatory disease activity of RA. Non-inflammatory pain mechanisms can confound assessment. We aimed to examine the use of DAS28 components or DAS28-derived measures that have been published as indices of no... Read More about Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis.

Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort (2018)
Journal Article
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G. S., Valdes, A. M., …Walsh, D. A. (2018). Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort. PAIN, 159(6), 1035–1044. https://doi.org/10.1097/j.pain.0000000000001183

This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain thres... Read More about Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort.

Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial (2018)
Journal Article
das Nair, R., Mhizha-Murira, J. R., Anderson, P., Carpenter, H., Clarke, S., Groves, S., …Lincoln, N. B. (2018). Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial. Clinical Rehabilitation, 32(6), 777-789. https://doi.org/10.1177/0269215518755426

Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: Multi-centre, mixed-methods feasibi... Read More about Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial.

Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data (2017)
Journal Article
Sarmanova, A., Hall, M. C., Fernandes, G. S., Bhattacharya, A., Valdes, A. M., Walsh, D. A., …Zhang, W. (in press). Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data. Arthritis Research and Therapy, 19(281), https://doi.org/10.1186/s13075-017-1486-7

Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee... Read More about Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data.

Pain mechanisms in rheumatoid arthritis (2017)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2017). Pain mechanisms in rheumatoid arthritis. Clinical and Experimental Rheumatology, 35(S107), Article s94-s101

Understanding of the causes and underlying mechanisms of pain in people with RA is rapidly changing. With the advent of more effective disease modifying drugs, joint inflammation is becoming a more treatable cause of pain, and joint damage can often... Read More about Pain mechanisms in rheumatoid arthritis.

Knee pain and related health in the community study (KPIC): a cohort study protocol (2017)
Journal Article
Fernandes, G. S., Sarmanova, A., Warner, S. C., Harvey, H., Akin-Akinyosoye, K., Richardson, H., …Doherty, M. (in press). Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskeletal Disorders, 18(404), https://doi.org/10.1186/s12891-017-1761-4

Background: The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify possible phenotypes and their a... Read More about Knee pain and related health in the community study (KPIC): a cohort study protocol.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., …Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

New therapeutic targets for osteoarthritis pain (2017)
Journal Article
Walsh, D. A., & Stocks, J. (2017). New therapeutic targets for osteoarthritis pain. Slas Discovery, 22(8), https://doi.org/10.1177/2472555217716912

Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe... Read More about New therapeutic targets for osteoarthritis pain.

Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene (2017)
Journal Article
Warner, S., Walsh, D. A., Laslett, L., Maciewicz, R., Soni, A., Hart, D., …Valdes, A. M. (2017). Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene. European Journal of Pain, 21(7), 1277-1284. https://doi.org/10.1002/ejp.1027

Background: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1). SP and NK1 receptors have been implicated in joint pain, inflammation and damage in animal models and human s... Read More about Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene.