All Outputs (68)

First trimester serum tests for Down's syndrome screening (2015)
Journal Article
Alldred, S. K., Takwoingi, Y., Guo, B., Pennant, M., Deeks, J. J., Neilson, J. P., & Alfirevic, Z. (2015). First trimester serum tests for Down's syndrome screening. Cochrane Database of Systematic Reviews, 11, Article CD011975. https://doi.org/10.1002/14651858.CD011975

Background Down's syndrome occurs when a person has three, rather than two copies of chromosome 21; or the specific area of chromosome 21 implicated in causing Down's syndrome. It is the commonest congenital cause of mental disability and also lea... Read More about First trimester serum tests for Down's syndrome screening.

Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD--'Assessing QbTest Utility in ADHD'(AQUA): a randomised controlled trial (2014)
Journal Article
Hall, C. L., Walker, G. M., Valentine, A. Z., Guo, B., Kaylor-Hughes, C., James, M., …Hollis, C. (2014). Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD--'Assessing QbTest Utility in ADHD'(AQUA): a randomised controlled trial. BMJ Open, 4(12), Article e006838. https://doi.org/10.1136/bmjopen-2014-006838

Introduction: The National Institute for Health and Care Excellence (NICE) guidelines for attention deficit/hyperactivity disorder (ADHD) state that young people need to have access to the best evidence-based care to improve outcome. The current ‘gol... Read More about Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD--'Assessing QbTest Utility in ADHD'(AQUA): a randomised controlled trial.

Can stroke specific vocational rehabilitation (SSVR) be delivered and measured?: feasibility RCT and economic analysis (2014)
Journal Article
Radford, K. A., Grant, M., Sinclair, E., Terry, J., Sampson, C. J., Edwards, C., …Jenkinson, M. (2014). Can stroke specific vocational rehabilitation (SSVR) be delivered and measured?: feasibility RCT and economic analysis. Clinical Rehabilitation, 28(4), https://doi.org/10.1177/0269215513506172

Background: A quarter of UK strokes occur in working age people. Fewer than half resume work. Rehabilitation frequently fails to address work needs and evidence for post-stroke vocational rehabilitation is lacking. This pilot trial tested the feas... Read More about Can stroke specific vocational rehabilitation (SSVR) be delivered and measured?: feasibility RCT and economic analysis.

Individual participant data meta-analyses should not ignore clustering (2013)
Journal Article
Abo-Zaid, G., Guo, B., Deeks, J. J., Debray, T. P., Steyerberg, E. W., Moons, K. G., & Riley, R. D. (2013). Individual participant data meta-analyses should not ignore clustering. Journal of Clinical Epidemiology, 66(8), Article 865-873.e4. https://doi.org/10.1016/j.jclinepi.2012.12.017

Objectives Individual participant data (IPD) meta-analyses often analyze their IPD as if coming from a single study. We compare this approach with analyses that rather account for clustering of patients within studies. Study Design and Setting... Read More about Individual participant data meta-analyses should not ignore clustering.

An oral health intervention for people with serious mental illness (Three Shires Early Intervention Dental Trial): study protocol for a randomised controlled trial (2013)
Journal Article
Jones, H. F., Adams, C. E., Clifton, A., Simpson, J., Tosh, G., Liddle, P. F., …Furtado, V. (2013). An oral health intervention for people with serious mental illness (Three Shires Early Intervention Dental Trial): study protocol for a randomised controlled trial. Trials, 14, Article 158. https://doi.org/10.1186/1745-6215-14-158

Background Oral health is an important part of general physical health and is essential for self-esteem, self-confidence and overall quality of life. There is a well-established link between mental illness and poor oral health. Oral health problems... Read More about An oral health intervention for people with serious mental illness (Three Shires Early Intervention Dental Trial): study protocol for a randomised controlled trial.

Second trimester serum tests for Down's Syndrome screening (2012)
Journal Article
Alldred, S. K., Deeks, J. J., Guo, B., Neilson, J. P., & Alfirevic, Z. (2012). Second trimester serum tests for Down's Syndrome screening. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD009925

Background Down's syndrome occurs when a person has three copies of chromosome 21 - or the specific area of chromosome 21 implicated in causing Down's syndrome - rather than two. It is the commonest congenital cause of mental retardation. Noninvas... Read More about Second trimester serum tests for Down's Syndrome screening.

Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK) (2011)
Journal Article
Glazebrook, C., Batty, M. J., Mullan, N., MacDonald, I., Nathan, D., Sayal, K., …Hollis, C. (2011). Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK). BMC Public Health, 11, Article 830. https://doi.org/10.1186/1471-2458-11-830

Background Low levels of physical activity in children have been linked to an increased risk of obesity, but many children lack confidence in relation to exercise (exercise self-efficacy). Factors which can impact on confidence include a chronic hea... Read More about Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK).

Achieving Quality and Effectiveness in Dementia Using Crisis Teams (AQUEDUCT): A Study Protocol for a Randomised Controlled Trial of a Resource Kit.
Working Paper
Coleston-Shields, D. M., Challis, D., Worden, A., Broome, E., Dening, T., Guo, B., …Orrell, M. Achieving Quality and Effectiveness in Dementia Using Crisis Teams (AQUEDUCT): A Study Protocol for a Randomised Controlled Trial of a Resource Kit

BACKGROUND Improving care at home for people with dementia is a core policy goal in the dementia strategies of many European countries. A challenge to effective home support is the occurrence of crises in the care of people with dementia which ari... Read More about Achieving Quality and Effectiveness in Dementia Using Crisis Teams (AQUEDUCT): A Study Protocol for a Randomised Controlled Trial of a Resource Kit..