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Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score (2020)
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Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., …Harrison, E. M. Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

Objectives To develop and validate a pragmatic risk score to predict mortality for patients admitted to hospital with covid-19. Design Prospective observational cohort study: ISARIC WHO CCP-UK study (ISARIC Coronavirus Clinical Characterisation Conso... Read More about Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.

Response to Call for Evidence – Joint Select Committee on Human Rights: The Government’s response to COVID-19: human rights implications (2020)
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McAuley, D., Koene, A., & Chen, J. (2020). Response to Call for Evidence – Joint Select Committee on Human Rights: The Government’s response to COVID-19: human rights implications

This submission addresses the three questions formulated in the Joint Select Committee’s call with a particular focus on both the digital rights implications of the Government’s measures against COVID-19 and the wider human rights implications of the... Read More about Response to Call for Evidence – Joint Select Committee on Human Rights: The Government’s response to COVID-19: human rights implications.

Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles (2020)
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Jain, A., Trindade, G., Hicks, J. M., Potts, J. C., Rahman, R., Hague, R., …Rawson, F. Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles

Protein orientation in nanoparticle-protein conjugates plays a crucial role in binding to cell receptors and ultimately, defines their targeting efficiency. Therefore, understanding fundamental aspects of the role of protein orientation upon adsorpti... Read More about Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles.

The Modern Slavery (Victim Support) Bill: a cost-benefit analysis (2020)
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Nicholson, A., Schwarz, K., Landman, T., & Griffith, A. (2020). The Modern Slavery (Victim Support) Bill: a cost-benefit analysis. Nottingham

This report provides an analysis of the costs and benefits of extending support to adult conclusive victims of human trafficking in England and Wales for 12 months after exiting the National Referral Mechanism (NRM), the UK’s identification and suppo... Read More about The Modern Slavery (Victim Support) Bill: a cost-benefit analysis.

Persistent intestinal abnormalities and symptoms in cystic fibrosis: The underpinning mechanisms impacting gut health and motility. Protocol for a systematic review. (2020)
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Marsh, R. J., Ng, C., Major, G., Rivett, D. W., Smyth, A. R., & Gast, C. V. D. Persistent intestinal abnormalities and symptoms in cystic fibrosis: The underpinning mechanisms impacting gut health and motility. Protocol for a systematic review

Background Patients with cystic fibrosis (CF) are characterised by abnormalities of the intestinal tract relating to gut motility and physiological issues, with daily symptoms of disease including abdominal pain, flatulence, bloating, and constipatio... Read More about Persistent intestinal abnormalities and symptoms in cystic fibrosis: The underpinning mechanisms impacting gut health and motility. Protocol for a systematic review..

Uclacyanin proteins are required for lignified nanodomain formation within Casparian strips (2020)
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Reyt, G., Chao, Z., Flis, P., Castrillo, G., Chao, D., & Salt, D. E. Uclacyanin proteins are required for lignified nanodomain formation within Casparian strips

Casparian strips (CS) are cell wall modifications of vascular plants restricting extracellular free diffusion into and out the vascular system. This barrier plays a critical role in controlling the acquisition of nutrients and water necessary for nor... Read More about Uclacyanin proteins are required for lignified nanodomain formation within Casparian strips.

Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (2020)
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Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H. E., Pius, R., Norman, L., …Semple, M. G. Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol

Objective: To characterize the clinical features of patients with severe COVID-19 in the UK. Design: Prospective observational cohort study with rapid data gathering and near real-time analysis, using a pre-approved questionnaire adopted by the WHO.... Read More about Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol.

Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy. (2020)
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Wheatley, S., & Townley, A. R. Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy

Survivin is a cancer-associated protein that is pivotal for cellular life and death: it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria, the function of which rema... Read More about Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy..

Combinatorial metabolic engineering platform enabling stable overproduction of lycopene from carbon dioxide by cyanobacteria (2020)
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Taylor, G. M., & Heap, J. T. Combinatorial metabolic engineering platform enabling stable overproduction of lycopene from carbon dioxide by cyanobacteria

Cyanobacteria are simple, efficient, genetically-tractable photosynthetic microorganisms representing ideal biocatalysts for CO2 capture and conversion, in principle. In practice, genetic instability and low productivity are key, linked problems in e... Read More about Combinatorial metabolic engineering platform enabling stable overproduction of lycopene from carbon dioxide by cyanobacteria.

Atomic Legacies (2020)
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Pestova, X. (2020). Atomic Legacies. Dublin

This full-length album features two substantial semi-improvised original compositions for the magnetic resonator piano (MRP), "Glowing Radioactive Elements" for solo MRP (2018) and "Atomic Legacies" for MRP and string quartet (2019). The Magnetic... Read More about Atomic Legacies.

Coordinated prefrontal state transition leads extinction of reward-seeking behaviors (2020)
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Russo, E., Ma, T., Spanagel, R., Durstewitz, D., Toutounji, H., & Köhr, G. Coordinated prefrontal state transition leads extinction of reward-seeking behaviors

Extinction learning suppresses conditioned reward responses and is thus fundamental to adapt to changing environmental demands and to control excessive reward seeking. The medial prefrontal cortex (mPFC) monitors and controls conditioned reward respo... Read More about Coordinated prefrontal state transition leads extinction of reward-seeking behaviors.

Response to the CMA’s Market Study Interim Report on Online Platforms and Digital Advertising (2020)
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McAuley, D., & Chen, J. (2020). Response to the CMA’s Market Study Interim Report on Online Platforms and Digital Advertising

Horizon is a Research Institute centred at The University of Nottingham and a Research Hub within the UKRI Digital Economy programme. Horizon brings together researchers from a broad range of disciplines to investigate the opportunities and challenge... Read More about Response to the CMA’s Market Study Interim Report on Online Platforms and Digital Advertising.

Superusers’ Engagement in Asthma Online Communities: Asynchronous Web-Based Interview Study (2020)
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De Simoni, A., Shah, A. T., Fulton, O., Parkinson, J., Sheikh, A., Panzarasa, P., …Griffiths, C. J. Superusers’ Engagement in Asthma Online Communities: Asynchronous Web-Based Interview Study

Background: Superusers, defined as the 1% of users who write a large number of posts, play critical roles in online health communities (OHCs), catalysing engagement and influencing other users’ self-care. Their unique online behavior is key to susta... Read More about Superusers’ Engagement in Asthma Online Communities: Asynchronous Web-Based Interview Study.