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Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration (2017)
Journal Article
Negm, O. H., MacKenzie, B., Hamed, M., Ahmad, O., Shone, C. C., Humphreys, D., …Monaghan, T. M. (2017). Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration. Clinical and Experimental Immunology, 188(3), 437-443. https://doi.org/10.1111/cei.12946

The prevalence of serum antibodies against Clostridium difficile (CD) toxins A and B in healthy populations have prompted interest in evaluating the therapeutic activity of intravenous immunoglobulin (IVIg) in individuals experiencing severe or recur... Read More about Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration.

Clostridium difficile infection: epidemiology, diagnosis and understanding transmission (2016)
Journal Article
Martin, J. S., Monaghan, T. M., & Wilcox, M. H. (2016). Clostridium difficile infection: epidemiology, diagnosis and understanding transmission. Nature Reviews Gastroenterology and Hepatology, 13(4), 206–216. https://doi.org/10.1038/nrgastro.2016.25

Clostridium difficile infection (CDI) continues to affect patients in hospitals and communities worldwide. The spectrum of clinical disease ranges from mild diarrhoea to toxic megacolon, colonic perforation and death. However, this bacterium might al... Read More about Clostridium difficile infection: epidemiology, diagnosis and understanding transmission.

Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis (2015)
Journal Article
Negm, O. H., Hamed, M. R., Dilnot, E. M., Shone, C. C., Marszalowska, I., Lynch, M., …Monaghan, T. M. (2015). Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis. Clinical and Vaccine Immunology, 22(9), 1033-1039. https://doi.org/10.1128/CVI.00190-15

Clostridium difficile is an anaerobic, Gram-positive, and spore-forming bacterium that is the leading worldwide infective cause of hospital-acquired and antibiotic-associated diarrhea. Several studies have reported associations between humoral immuni... Read More about Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis.

Pathogenesis of Clostridium difficile infection and its potential role in inflammatory bowel disease (2015)
Journal Article
Monaghan, T. M., Cockayne, A., & MAHIDA, Y. (2015). Pathogenesis of Clostridium difficile infection and its potential role in inflammatory bowel disease. Inflammatory Bowel Diseases, 21(8), doi:10.1097/MIB.0000000000000461

mild diarrhea to life-threatening colitis. Over the last 15 years, there has been a marked increase in the incidence of C. difficile infection, which predominantly affects elderly patients on antibiotics. More recently, there has been significant int... Read More about Pathogenesis of Clostridium difficile infection and its potential role in inflammatory bowel disease.

New perspectives in Clostridium difficile disease pathogenesis (2015)
Journal Article
Monaghan, T. M. (2015). New perspectives in Clostridium difficile disease pathogenesis. Infectious Disease Clinics of North America, 29(1), 1-11. doi:10.1016/j.idc.2014.11.007

Clostridium difficile is a gram-positive, endospore-forming, anaerobic, gastrointestinal pathogen that is the leading worldwide cause of hospital-acquired infective diarrhea.1 C. difficile exerts its major pathologic effects through the action of its... Read More about New perspectives in Clostridium difficile disease pathogenesis.

Circulating antibody and memory B-cell responses to C. difficile toxins A and B in patients with C. difficile- associated diarrhoea, inflammatory bowel disease and cystic fibrosis (2013)
Journal Article
Monaghan, T. M., Robins, A., Knox, A., Sewell, H. F., & Mahida, Y. R. (2013). Circulating antibody and memory B-cell responses to C. difficile toxins A and B in patients with C. difficile- associated diarrhoea, inflammatory bowel disease and cystic fibrosis. PLoS ONE, 8(9), Article e74452. https://doi.org/10.1371/journal.pone.0074452

C. difficile infection (CDI) is rarely reported in cystic fibrosis (CF) patients despite frequent hospitalisations and antibiotic usage. Conversely, the prevalence of CDI in inflammatory bowel disease (IBD) has received increased attention. We inve... Read More about Circulating antibody and memory B-cell responses to C. difficile toxins A and B in patients with C. difficile- associated diarrhoea, inflammatory bowel disease and cystic fibrosis.