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Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial (2020)
Journal Article
Beishon, L., Woodhouse, L. J., Bereczki, D., Christensen, H. K., Collins, R., Gommans, J., …Bath, P. M. (2021). Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial. Stroke and Vascular Neurology, 6(2), 180-186. https://doi.org/10.1136/svn-2020-000498

Introduction Nitrate-induced headache is common and may signify responsive cerebral vasculature. We assessed the relationship between nitrate headache and outcome in patients with acute stroke. Materials and methods Patients were those randomised to... Read More about Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial.

Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis (2020)
Journal Article
Appleton, J. P., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., & Bath, P. M. (2020). Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis. Frontiers in Neurology, 11, Article 584038. https://doi.org/10.3389/fneur.2020.584038

Background: Thrombolysis, with or without thrombectomy, for acute ischaemic stroke is associated with an increased risk of intracranial bleeding. We assessed whether treatment with glyceryl trinitrate (GTN), a nitric oxide donor, may influence the as... Read More about Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis.

Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol (2020)
Journal Article
Wardlaw, J. M., Doubal, F., Brown, R., Backhouse, E., Woodhouse, L., Bath, P., …R4VaD Investigators. (2021). Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol. European Stroke Journal, 6(1), 89-101. https://doi.org/10.1177/2396987320953312

Background: Stroke commonly affects cognition and, by definition, much vascular dementia follows stroke. However, there are fundamental limitations in our understanding of vascular cognitive impairment, restricting understanding of prevalence, trajec... Read More about Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol.

A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke (2020)
Journal Article
Kontou, E., Kettlewell, J., Condon, L., Thomas, S., Lee, A. R., Sprigg, N., …Shokraneh, F. (2021). A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke. Topics in Stroke Rehabilitation, 28(5), 390-400. https://doi.org/10.1080/10749357.2020.1818473

Background: Psychoeducation can provide information and support to cope with the physical and emotional effects of a health condition. This scoping review aimed to identify the evidence regarding psychoeducational interventions for people after a Tra... Read More about A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke.

Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel (2020)
Journal Article
Appleton, J. P., Richardson, C., Dovlatova, N., May, J., Sprigg, N., Heptinstall, S., & Bath, P. M. (2021). Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel. Stroke and Vascular Neurology, 6(1), 103-108. https://doi.org/10.1136/svn-2020-000346

Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients, in part because of treatment resistance. The primary aim was to assess the proportion of patients who are insensitive to clopidogrel. The... Read More about Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel.

Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial (2020)
Journal Article
Kang Law, Z., Dineen, R., England, T. J., Cala, L., Mistri, A. K., Appleton, J. P., …TICH-2 investigators. (2021). Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial. Translational Stroke Research, 12, 275-283. https://doi.org/10.1007/s12975-020-00845-6

Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexa... Read More about Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial.

Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study (2020)
Journal Article
Drummond, A., Ablewhite, J., Condon, L., Nair, R. D., Jones, A., Jones, F., …Thomas, S. (2020). Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study. British Journal of Occupational Therapy, 83(11), 674-679. https://doi.org/10.1177/0308022620944797

Introduction: Post-stroke fatigue (PSF) is common and is one of the most distressing symptoms after stroke. It has a negative impact on physical, social and psychological functioning: it is also associated with poor outcomes and increased mortality.... Read More about Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study.

Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) (2020)
Journal Article
Drummond, A., Ablewhite, J., Condon, L., das Nair, R., Jones, A., Jones, F., …Thomas, S. (2020). Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2). British Journal of Occupational Therapy, 83(11), 674-679. https://doi.org/10.1177/0308022620944797

Introduction Post-stroke fatigue is common and is one of the most distressing symptoms after stroke. It has a negative impact on physical, social and psychological functioning; it is also associated with poor outcomes and increased mortality. The... Read More about Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2).

Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management (OPTIMISM): Protocol for a feasibility randomised controlled trial (2020)
Journal Article
Kontou, E., Walker, M., Thomas, S., Watkins, C., Griffiths, H., Golding-Day, M., …Sprigg, N. (2020). Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management (OPTIMISM): Protocol for a feasibility randomised controlled trial. AMRC Open Research, 2, Article 24. https://doi.org/10.12688/amrcopenres.12911.1

Background: A transient ischaemic attack (TIA) and minor stroke are medical emergencies and often a warning sign of future strokes if remain untreated. Few studies have investigated the long-term psychosocial effects of TIA and minor stroke. Secondar... Read More about Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management (OPTIMISM): Protocol for a feasibility randomised controlled trial.

Biopsychosocial intervention for stroke carers (BISC): results of a feasibility randomised controlled trial and nested qualitative interview study (2020)
Journal Article
Walker, M. F., Birchall, S., Cobley, C., Condon, L., Fisher, R., Fletcher-Smith, J., …Whitehead, P. J. (2020). Biopsychosocial intervention for stroke carers (BISC): results of a feasibility randomised controlled trial and nested qualitative interview study. Clinical Rehabilitation, 34(10), 1268-1281. https://doi.org/10.1177/0269215520937039

Objective: To determine the feasibility of recruiting to and delivering a biopsychosocial intervention for carers of stroke survivors. Design: Feasibility randomised controlled study with nested qualitative interview study. Setting: The interventio... Read More about Biopsychosocial intervention for stroke carers (BISC): results of a feasibility randomised controlled trial and nested qualitative interview study.

Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan (2020)
Journal Article
Mair, G., Chappell, F., Martin, C., Dye, D., Bath, P. M., Muir, K. W., …Wardlaw, J. M. (2020). Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan. AMRC Open Research, 2, Article 20. https://doi.org/10.12688/amrcopenres.12904.1

Background: Artificial intelligence-based software may automatically detect ischaemic stroke lesions and provide an Alberta Stroke Program Early CT score (ASPECTS) on CT, and identify arterial occlusion and provide a collateral score on CTA. Large-sc... Read More about Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan.

Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease (2020)
Journal Article
Wardlaw, J., Bath, P. M., Doubal, F., Heye, A., Sprigg, N., Woodhouse, L. J., …The LACI-2 Trial Investigators. (2020). Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease. European Stroke Journal, 5(3), 297-308. https://doi.org/10.1177/2396987320920110

Background Small vessel disease causes a quarter of ischaemic strokes (lacunar subtype), up to 45% of dementia either as vascular or mixed types, cognitive impairment and physical frailty. However, there is no specific treatment to prevent progressi... Read More about Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease.

Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2) (2020)
Journal Article
Muir, K. W., Bulters, D., Willmot, M., Sprigg, N., Dixit, A., Ward, N., …Sinden, J. (2020). Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2). Journal of Neurology, Neurosurgery and Psychiatry, 91(4), 396-401. https://doi.org/10.1136/jnnp-2019-322515

Background Human neural stem cell implantation may offer improved recovery from stroke. We investigated the feasibility of intracerebral implantation of the allogeneic human neural stem cell line CTX0E03 in the subacute—chronic recovery phase of... Read More about Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2).

Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid (2020)
Journal Article
Law, Z. K., England, T. J., Mistri, A. K., Woodhouse, L. J., Cala, L., Dineen, R., …TICH-2 investigators. (2020). Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid. European Stroke Journal, 5(2), 123-129. https://doi.org/10.1177/2396987320901391

Introduction: Seizures are common after intracerebral haemorrhage. Tranexamic acid increases the risk of seizures in non-intracerebral haemorrhage population but its effect on post-intracerebral haemorrhage seizures is unknown. We explored the risk f... Read More about Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid.

Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage (2020)
Journal Article
Law, Z. K., Desborough, M., Rakkar, K., Bath, P. M., Bayraktutan, U., & Sprigg, N. (2020). Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage. Brain Hemorrhages, 1(1), 75-79. https://doi.org/10.1016/j.hest.2019.12.001

Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center st... Read More about Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage.

Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study (2020)
Journal Article
Othman, O., Rakkar, K., Sprigg, N., Bath, P., & Bayraktutan, U. (2020). Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study. Neural Regeneration Research, 15(7), 1300-1307. https://doi.org/10.4103/1673-5374.269028

Ischemic stroke is a devastating, life altering event which can severely reduce patient quality of life. Despite years of research there have been minimal therapeutic advances. Endothelial progenitor cells (EPCs), stem cells involved in both vasculog... Read More about Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study.

How do patients spend their time in stroke rehabilitation units in England? The REVIHR study (2019)
Journal Article
Chouliara, N., Fisher, R., Crosbie, B., Guo, B., Sprigg, N., & Walker, M. (2021). How do patients spend their time in stroke rehabilitation units in England? The REVIHR study. Disability and Rehabilitation, 43(16), 2312-2319. https://doi.org/10.1080/09638288.2019.1697764

Aim: To examine how patients spend their time in stroke rehabilitation units in England. Methods: We recruited 144 patients within a month after stroke from four stroke rehabilitation units and observed their activity type, interactions and locati... Read More about How do patients spend their time in stroke rehabilitation units in England? The REVIHR study.

Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage (2019)
Journal Article
Law, Z. K., Ali, A., Krishnan, K., Bischoff, A., Appleton, J., Scutt, P., …Sprigg, N. (2020). Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage. Stroke, 51(1), 121–128. https://doi.org/10.1161/STROKEAHA.119.026128

Background and purpose Blend, black hole and island signs and hypodensities are reported to predict hematoma expansion in acute intracerebral hemorrhage (ICH). We explored the value of these noncontrast CT (NCCT) signs in predicting hematoma expan... Read More about Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage.