Skip to main content

Research Repository

Advanced Search

All Outputs (111)

Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study (2018)
Journal Article
Sarmanova, A., Fernandes, G., Richardson, H., Valdes, A., Walsh, D., Zhang, W., & Doherty, M. (2018). Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study. Osteoarthritis and Cartilage, 26(11), 1461-1473. https://doi.org/10.1016/j.joca.2018.07.013

Aim To explore risk factors that may influence knee pain (KP) through central or peripheral mechanisms. Methods A questionnaire-based prospective community cohort study with KP defined as pain in or around a knee on most days for at least a... Read More about Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study.

Urate-lowering treatment and risk of total joint replacement in patients with gout (2018)
Journal Article
Kuo, C., Chou, I., See, L., Chen, J., Yu, K., Luo, S., …Doherty, M. (2018). Urate-lowering treatment and risk of total joint replacement in patients with gout. Rheumatology, 57(12), 2129-2139. https://doi.org/10.1093/rheumatology/key212

Objectives: To examine whether gout is an independent risk factor for total joint replacement (TJR) and whether urate-lowering treatment (ULT) reduces this risk. Methods: Using the Taiwan National Health Insurance database and the UK Clinical Pract... Read More about Urate-lowering treatment and risk of total joint replacement in patients with gout.

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis (2018)
Journal Article
Valdes, A. M., Ravipati, S., Pousinis, P., Menni, C., Mangino, M., Abhishek, A., …Doherty, M. (in press). Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis. Journal of Lipid Research, 59(7), Article jlr.P085118. https://doi.org/10.1194/jlr.P085118

Omega-6 fatty acids are important inflammatory mediators increased in joints with osteoarthritis (OA) joints. To investigate the relationship between omega-6 fatty acids and knee OA 22 omega-6 lipids (arachidonic acid, linoleic acid and 20 oxylipins)... Read More about Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.

Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials (2018)
Journal Article
Persson, M. S., Sarmanova, A., Doherty, M., & Zhang, W. (2018). Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials. Rheumatology, 57(10), 1830-1837. https://doi.org/10.1093/rheumatology/key131

Objectives The role of inflammation in OA is controversial and it is unclear whether suppressing inflammation with conventional or biologic DMARDs is effective. A systematic review and meta-analysis of randomized controlled trials (RCTs) was condu... Read More about Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials.

Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC) (2018)
Conference Proceeding
McWilliams, D. F., Frowd, N., Marshall, L., Stocks, J., Sarmanova, A., Fernandes, G. S., …Walsh, D. A. (2018). Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC).

Background: Knee pain results from a combination of nociceptive input from the joint, and processing by the central nervous system. Pressure pain detection thresholds (PPTs) are lower and pain is more severe in people with greater central sensitisat... Read More about Prediction of persistent knee pain by pressure pain detection thresholds: results from the Knee Pain In the Community cohort (KPIC).

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study (2018)
Journal Article
Nakafero, G., Grainge, M. J., Myles, P. R., Mallen, C., Zhang, W., Doherty, M., …Abhishek, A. (2018). Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study. Rheumatology, 57(10), 1726-1734. https://doi.org/10.1093/rheumatology/key156

Objectives: To [1] examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK, [2] explore disease and demographic factors associated with vaccination. Methods: 32,751 people with auto-immune rheumatic diseases (AIRDs) prescribed... Read More about Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study.

Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants (2018)
Journal Article
Stocks, J., Tang, N. K., Walsh, D. A., Warner, S. C., Harvey, H., Jenkins, W., …Valdes, A. M. (2018). Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants. Journal of Pain Research, 2018(11), 1087—1093. https://doi.org/10.2147/JPR.S149830

Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic pain-like symptoms. 423 individuals who had undergone total joint... Read More about Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants.

Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study (2018)
Journal Article
Abhishek, A., Courtney, P., Jenkins, W., Sandoval-Plata, G., Jones, A., Zhang, W., & Doherty, M. (2018). Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study. Arthritis and Rheumatology, 70(11), 1847-1852. https://doi.org/10.1002/art.40572

Objective To estimate the prevalence and distribution of asymptomatic monosodium urate (MSU) crystal deposition in sons of people with gout. Method People with gout were mailed an explanatory letter enclosing a postage-paid study-pack to mail to t... Read More about Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study.

Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study (2018)
Journal Article
Fenton, S. A., Neogi, T., Dunlop, D., Nevitt, M., Doherty, M., Duda, J. L., …White, D. K. (2018). Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study. Osteoarthritis and Cartilage, 26(9), 1181-1189. https://doi.org/10.1016/j.joca.2018.04.015

Objective Knee osteoarthritis (OA) is a risk factor for a decline in gait speed. Daily walking reduces the risk of developing slow gait speed and future persistent functional limitation. However, the protective role of walking intensity is unclear... Read More about Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study.

A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis (2018)
Journal Article
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G., Valdes, A., …Walsh, D. (2018). A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis. Osteoarthritis and Cartilage, 26(Supplement 1), S231-S232. https://doi.org/10.1016/j.joca.2018.02.483

Purpose: Approximately 1 in 4 individuals in the UK over the age of 55 experience knee pain (KP), predominantly due to osteoarthritis (OA). Following treatment targeted at the affected knee, pain relief is reported in only 60%–80% of individuals with... Read More about A clinical assessment tool to improve the use of pain relieving treatments in knee osteoarthritis.

Rheumatoid arthritis and excess mortality: down but not out: a primary care cohort study using data from Clinical Practice Research Datalink (2018)
Journal Article
Abhishek, A., Nakafero, G., Kuo, C., Mallen, C., Zhang, W., Grainge, M. J., & Doherty, M. (2018). Rheumatoid arthritis and excess mortality: down but not out: a primary care cohort study using data from Clinical Practice Research Datalink. Rheumatology, 57(6), 977–981. https://doi.org/10.1093/rheumatology/key013

Objectives: To examine temporal trends in all-cause and cause-specific mortality in RA. Methods: Data from the Clinical Practice Research Datalink (CPRD) were used. Incident RA cases and four age, sex and general practice matched controls were id... Read More about Rheumatoid arthritis and excess mortality: down but not out: a primary care cohort study using data from Clinical Practice Research Datalink.

Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort (2018)
Journal Article
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G. S., Valdes, A. M., …Walsh, D. A. (2018). Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort. PAIN, 159(6), 1035–1044. https://doi.org/10.1097/j.pain.0000000000001183

This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain thres... Read More about Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort.

Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies (2018)
Journal Article
Zeng, C., Wei, J., Persson, M. S., Sarmanova, A., Doherty, M., Xie, D., …Zhang, W. (2018). Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. British Journal of Sports Medicine, 52(10), 642-650. https://doi.org/10.1136/bjsports-2017-098043

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Objectives To compare the efficacy and safety of topical non-s... Read More about Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies.

Proportion of contextual effects in the treatment of fibromyalgia - a meta-analysis of randomised controlled trials (2017)
Journal Article
Whiteside, N., Sarmanova, A., Chen, X., Zou, K., Abdullah, N., Doherty, M., & Zhang, W. (in press). Proportion of contextual effects in the treatment of fibromyalgia - a meta-analysis of randomised controlled trials. Clinical Rheumatology, https://doi.org/10.1007/s10067-017-3948-3

Objectives: To examine the proportion of the total treatment effect that is attributable to contextual effects in randomised controlled trials (RCTs) of treatments for fibromyalgia. Methods: A systematic literature search was undertaken in Medline,... Read More about Proportion of contextual effects in the treatment of fibromyalgia - a meta-analysis of randomised controlled trials.

Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data (2017)
Journal Article
Sarmanova, A., Hall, M. C., Fernandes, G. S., Bhattacharya, A., Valdes, A. M., Walsh, D. A., …Zhang, W. (in press). Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data. Arthritis Research and Therapy, 19(281), https://doi.org/10.1186/s13075-017-1486-7

Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee... Read More about Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data.

Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared to men in the general population: a cross-sectional study (2017)
Journal Article
Fernandes, G. S., Parekh, S. M., Moses, J., Fuller, C., Scammell, B. E., Batt, M. E., …Doherty, M. (2017). Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared to men in the general population: a cross-sectional study. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2017-097503

Objectives: To determine the prevalence of knee pain, radiographic knee osteoarthritis (RKOA), total knee replacement (TKR) and associated risk factors in male ex-professional footballers compared to men in the general population (comparison group).... Read More about Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared to men in the general population: a cross-sectional study.

Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study (2017)
Journal Article
Abhishek, A., Valdes, A. M., Jenkins, W., Zhang, W., & Doherty, M. (2017). Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study. PLoS ONE, 12(10), Article e0186096. https://doi.org/10.1371/journal.pone.0186096

Objectives To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute... Read More about Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study.

Knee pain and related health in the community study (KPIC): a cohort study protocol (2017)
Journal Article
Fernandes, G. S., Sarmanova, A., Warner, S. C., Harvey, H., Akin-Akinyosoye, K., Richardson, H., …Doherty, M. (in press). Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskeletal Disorders, 18(404), https://doi.org/10.1186/s12891-017-1761-4

Background: The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify possible phenotypes and their a... Read More about Knee pain and related health in the community study (KPIC): a cohort study protocol.

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans (2017)
Journal Article
Valdes, A. M., Ravipati, S., Menni, C., Abhishek, A., Metrustry, S., Harris, J., …Barrett, D. A. (in press). Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Scientific Reports, 7, Article 10748. https://doi.org/10.1038/s41598-017-09516-3

Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models... Read More about Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.