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Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery (2019)
Journal Article
Breen, A. F., Scurr, D., Cassioli, M. L., Wells, G., Thomas, N. R., Zhang, J., …Bradshaw, T. D. (2019). Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery. International Journal of Nanomedicine, 14, 9525-9534. https://doi.org/10.2147/IJN.S226293

Introduction: Advancment of novel anticancer drugs into clinic is frequently halted by their lack of solubility, reduced stability under physiological conditions, and non-specific uptake by normal tissues, causing systemic toxicity. Their progress to... Read More about Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery.

Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells (2019)
Journal Article
Quilles Junior, J. C., Bradshaw, T. D., Turyanska, L., Carlos, F. D. R. R., Montanari, A., Leitão, A., …Bradshaw, T. D. (2019). Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. RSC Advances, 9(63), 36699-36706. https://doi.org/10.1039/c9ra07161j

Cysteine proteases play a key role in tumorigenesis causing protein degradation and promoting invasive tumour growth. Cathepsin L is overexpressed in cancer cells and could provide a specific target for delivery of anticancer agents. We encapsulated... Read More about Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells.

Immobilized Enzymes on Gold Nanoparticles: From Enhanced Stability to Cleaning of Heritage Textiles (2019)
Journal Article
Gherardi, F., Turyanska, L., Ferrari, E., Weston, N., Fay, M. W., & Colston, B. J. (2019). Immobilized Enzymes on Gold Nanoparticles: From Enhanced Stability to Cleaning of Heritage Textiles. ACS Applied Bio Materials, 2(11), 5136-5143. https://doi.org/10.1021/acsabm.9b00802

Enzyme-based treatments are used in heritage conservation for the effective removal of glues and other damaging organic layers from the surfaces of historic and artistic works. Despite their potential, however, the application of enzymatic treatments... Read More about Immobilized Enzymes on Gold Nanoparticles: From Enhanced Stability to Cleaning of Heritage Textiles.

In search of effective therapies to overcome resistance to Temozolomide in brain tumours (2019)
Journal Article
Grundy, R., Bouzinab, K., Summers, H., Zhang, J., Stevens, M. F. G., Moody, C. J., …Bradshaw, T. D. (2019). In search of effective therapies to overcome resistance to Temozolomide in brain tumours. Cancer Drug Resistance, 2(4), 1018-1031. https://doi.org/10.20517/cdr.2019.64

Glioblastoma multiforme is the most common and lethal brain tumour-type. The current standard of care includes Temozolomide (TMZ) chemotherapy. However, inherent and acquired resistance to TMZ thwart successful treatment. The direct repair protein me... Read More about In search of effective therapies to overcome resistance to Temozolomide in brain tumours.

Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells (2019)
Journal Article
Liu, Z., Turyanska, L., Zamberlan, F., Pacifico, S., Bradshaw, T. D., Moro, F., …Thomas, N. R. (2019). Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells. Nanotechnology, 30(50), Article 505102. https://doi.org/10.1088/1361-6528/ab437c

We report on the synthesis of water-soluble gold nanoclusters capped with polyethylene glycol (PEG)-based ligands and further functionalized with folic acid for specific cellular uptake. The dihydrolipoic acid-PEG-based ligands terminated with -OMe,... Read More about Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells.

Hybrid light emitting diodes based on stable, high brightness all-inorganic CsPbI 3 perovskite nanocrystals and InGaN (2019)
Journal Article
Zhang, C., Turyanska, L., Cao, H., Zhao, L., Fay, M. W., Temperton, R., …Patanè, A. (2019). Hybrid light emitting diodes based on stable, high brightness all-inorganic CsPbI 3 perovskite nanocrystals and InGaN. Nanoscale, 11(28), 13450-13457. https://doi.org/10.1039/C9NR03707A

Despite important advances in the synthesis of inorganic perovskite nanocrystals (NCs), the long-term instability and degradation of their quantum yield (QY) over time need to be addressed to enable the further development and exploitation of these n... Read More about Hybrid light emitting diodes based on stable, high brightness all-inorganic CsPbI 3 perovskite nanocrystals and InGaN.

Realization of Universal Quantum Gates with Spin-Qudits in Colloidal Quantum Dots (2019)
Journal Article
Moro, F., Fielding, A. J., Turyanska, L., & Patanè, A. (2019). Realization of Universal Quantum Gates with Spin-Qudits in Colloidal Quantum Dots. Advanced Quantum Technologies, 2(10), 1-6. https://doi.org/10.1002/qute.201900017

Hyperfine interactions in a single Mn‐ion confined in a quantum dot (QD) are exploited to create a qudit, that is, a multilevel quantum‐bit system, with well‐defined, addressable, and robust set of spin states for the realization of universal quantum... Read More about Realization of Universal Quantum Gates with Spin-Qudits in Colloidal Quantum Dots.

Listeria innocua Dps as a nanoplatform for bioluminescence based photodynamic therapy utilizing Gaussia princeps luciferase and zinc protoporphyrin IX (2019)
Journal Article
Al-Ani, A. W., Zhang, L., Ferreira, L., Turyanska, L., Bradshaw, T. D., & Thomas, N. R. (2019). Listeria innocua Dps as a nanoplatform for bioluminescence based photodynamic therapy utilizing Gaussia princeps luciferase and zinc protoporphyrin IX. Nanomedicine: Nanotechnology, Biology and Medicine, 20, Article 102005. https://doi.org/10.1016/j.nano.2019.04.008

Listeria innocua DNA binding protein from starved cells (LiDps) belongs to the ferritin family and provides a promising self-assembling spherical 12-mer protein scaffold for the generation of functional nanomaterials. We report the creation of a Gaus... Read More about Listeria innocua Dps as a nanoplatform for bioluminescence based photodynamic therapy utilizing Gaussia princeps luciferase and zinc protoporphyrin IX.

Development of novel apoferritin formulations for antitumour benzothiazoles (2019)
Journal Article
Breen, A. F., Wells, G., Turyanska, L., & Bradshaw, T. D. (2019). Development of novel apoferritin formulations for antitumour benzothiazoles. Cancer Reports, 2(4), 1-7. https://doi.org/10.1002/cnr2.1155

Background The benzothiazole structure is important in medicinal chemistry, and 5‐fluoro‐2‐(3,4‐dimethoxyphenyl) benzothiazole (GW 610) is of particular interest as it shows outstanding anticancer activity in sensitive breast and colorectal carcinom... Read More about Development of novel apoferritin formulations for antitumour benzothiazoles.

Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging (2018)
Journal Article
Zamberlan, F., Turyanska, L., Patanè, A., Liu, Z., Williams, H., Fay, M., …Grabowska, A. (in press). Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging. Journal of Materials Chemistry B, 6, https://doi.org/10.1039/c7tb02912h

The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glyco... Read More about Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging.

Enhancing optoelectronic properties of SiC-grown graphene by a surface layer of colloidal quantum dots (2017)
Journal Article
Makarovsky, O., Turyanska, L., Mori, N., Greenaway, M., Eaves, L., Patanè, A., …Yakimova, R. (in press). Enhancing optoelectronic properties of SiC-grown graphene by a surface layer of colloidal quantum dots. 2D Materials, 4(3), https://doi.org/10.1088/2053-1583/aa76bb

We report a simultaneous increase of carrier concentration, mobility and photoresponsivity when SiC-grown graphene is decorated with a surface layer of colloidal PbS quantum dots, which act as electron donors. The charge on the ionised dots is spatia... Read More about Enhancing optoelectronic properties of SiC-grown graphene by a surface layer of colloidal quantum dots.

Mobility enhancement of CVD graphene by spatially correlated charges (2017)
Journal Article
Turyanska, L., Makarovsky, O., Eaves, L., Patanè, A., & Mori, N. (2017). Mobility enhancement of CVD graphene by spatially correlated charges. 2D Materials, 4(2), Article 025026. https://doi.org/10.1088/2053-1583/aa55b4

The manuscript presents a strategy for enhancing the carrier mobility of single layer CVD graphene (CVD SLG) based on spatially correlated charges. Our Monte Carlo simulations, numerical modeling and the experimental results confirm that spatial corr... Read More about Mobility enhancement of CVD graphene by spatially correlated charges.

Developing Mn-doped lead sulfide quantum dots for MRI labels (2016)
Journal Article
Turyanska, L., Moro, F., Patanè, A., Barr, J., Köckenberger, W., Taylor, A., …Thomas, N. R. (2016). Developing Mn-doped lead sulfide quantum dots for MRI labels. Journal of Materials Chemistry B, 4(42), 6797-6802. https://doi.org/10.1039/c6tb02574a

Magnetic interactions of Mn2+ions in lead sulfide (PbS) nanocrystals with protons in water are probed by NMR and MRI. A thin layer of capping molecules enables free solvent diffusion to the nanocrystal surface resulting in a decrease of proton relaxa... Read More about Developing Mn-doped lead sulfide quantum dots for MRI labels.

Surface sensing of quantum dots by electron spins (2016)
Journal Article
Moro, F., Turyanska, L., Wilman, J., Williams, H. E., Fielding, A. J., & Patanè, A. (in press). Surface sensing of quantum dots by electron spins. Nano Letters, 16(10), https://doi.org/10.1021/acs.nanolett.6b02727

The nanoscale design of quantum dots (QDs) requires advanced analytical techniques. However, those that are commonly used do not have sufficient sensitivity or spatial resolution. Here, we use magnetic resonance techniques combined with paramagnetic... Read More about Surface sensing of quantum dots by electron spins.

Electron spin coherence near room temperature in magnetic quantum dots (2015)
Journal Article
Moro, F., Turyanska, L., Wilman, J., Fielding, A. J., Fay, M. W., Granwehr, J., & Patanè, A. (2015). Electron spin coherence near room temperature in magnetic quantum dots. Scientific Reports, 5, Article 10855. https://doi.org/10.1038/srep10855

We report on an example of confined magnetic ions with long spin coherence near room temperature. This was achieved by confining single Mn 2+ spins in colloidal semiconductor quantum dots (QDs) and by dispersing the QDs in a proton-spin free matrix.... Read More about Electron spin coherence near room temperature in magnetic quantum dots.

Ligand-Induced Control of Photoconductive Gain and Doping in a Hybrid Graphene–Quantum Dot Transistor (2015)
Journal Article
Turyanska, L., Makarovsky, O., Svatek, S. A., Beton, P. H., Mellor, C. J., Patanè, A., …Wilson, N. R. (2015). Ligand-Induced Control of Photoconductive Gain and Doping in a Hybrid Graphene–Quantum Dot Transistor. Advanced Electronic Materials, 1(7), 1500062. https://doi.org/10.1002/aelm.201500062

In graphene devices decorated with a layer of near-infrared colloidal PbS quantum dots (QDs), the choice of the QD capping ligands and the integrity of the QD layer have a strong influence on the doping, carrier mobility, and photoresponse. By using... Read More about Ligand-Induced Control of Photoconductive Gain and Doping in a Hybrid Graphene–Quantum Dot Transistor.

Spin manipulation and spin-lattice interaction in magnetic colloidal quantum dots (2014)
Journal Article
Moro, F., Turyanska, L., Granwehr, J., & Patanè, A. (2014). Spin manipulation and spin-lattice interaction in magnetic colloidal quantum dots. Physical review B: Condensed matter and materials physics, 90(20), Article 205428. https://doi.org/10.1103/PhysRevB.90.205428

We report on the spin-lattice interaction and coherent manipulation of electron spins in Mn-doped colloidal PbS quantum dots (QDs) by electron spin resonance. We show that the phase memory time,TM, is limited by Mn–Mn dipolar interactions, hyperfine... Read More about Spin manipulation and spin-lattice interaction in magnetic colloidal quantum dots.

Tuneable paramagnetic susceptibility and exciton g-factor in Mn-doped PbS colloidal nanocrystals (2014)
Journal Article
Turyanska, L., Hill, R. J. A., Makarovsky, O., Moro, F., Knott, A. N., Larkin, O. J., …Curry, R. J. (2014). Tuneable paramagnetic susceptibility and exciton g-factor in Mn-doped PbS colloidal nanocrystals. Nanoscale, 6(15), 8919-8925. https://doi.org/10.1039/c4nr02336f

We report on PbS colloidal nanocrystals that combine within one structure solubility in physiological solvents with near-infrared photoluminescence, and magnetic and optical properties tuneable by the controlled incorporation of magnetic impurities (... Read More about Tuneable paramagnetic susceptibility and exciton g-factor in Mn-doped PbS colloidal nanocrystals.

Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells (2013)
Journal Article
Bradshaw, T. D., Junor, M., Patanè, A., Clarke, P., Thomas, N. R., Li, M., …Turyanska, L. (2013). Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells. Journal of Materials Chemistry B, 45, 6254-6260. https://doi.org/10.1039/c3tb21197e

Colorectal carcinoma (CRC) is the 3rd most common cancer worldwide, thus development of novel therapeutic strategies is imperative. Herein potent, selective dose-dependent antitumor activity of horse spleen apoferritin encapsulated PbS quantum dots (... Read More about Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells.