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All Outputs (113)

Anticholinergic drug burden tools/scales and adverse outcomes in different clinical settings: a systematic review of reviews (2018)
Journal Article
Welsh, T. J., van der Wardt, V., Ojo, G., Gordon, A. L., & Gladman, J. R. (in press). Anticholinergic drug burden tools/scales and adverse outcomes in different clinical settings: a systematic review of reviews. Drugs and Aging, https://doi.org/10.1007/s40266-018-0549-z

Background: Cumulative anticholinergic exposure (anticholinergic burden) has been linked to a number of adverse outcomes. To conduct research in this area, an agreed approach to describing anticholinergic burden is needed. Objective: This review set... Read More about Anticholinergic drug burden tools/scales and adverse outcomes in different clinical settings: a systematic review of reviews.

Scaling the Peaks Research Protocol: understanding the barriers and drivers to providing and using dementia-friendly community services in rural areas—a mixed methods study (2018)
Journal Article
Marshall, F., Basiri, A., Riley, M., Dening, T., Gladman, J. R., Griffiths, A., & Lewis, S. (2018). Scaling the Peaks Research Protocol: understanding the barriers and drivers to providing and using dementia-friendly community services in rural areas—a mixed methods study. BMJ Open, 8(4), 1-10. https://doi.org/10.1136/bmjopen-2017-020374

Introduction: Scaling the Peaks is a cross-disciplinary research study which draws on medical ethnography, human geography and Geospatial Information Science (GIS) to address the issues surrounding the design and delivery of dementia friendly service... Read More about Scaling the Peaks Research Protocol: understanding the barriers and drivers to providing and using dementia-friendly community services in rural areas—a mixed methods study.

Chair based exercise in community settings: a cluster randomised feasibility study (2018)
Journal Article
Robinson, K., Long, A., Leighton, P., Armstrong, S., Pulikottill-Jacob, R., Gladman, J., …Masud, T. (2018). Chair based exercise in community settings: a cluster randomised feasibility study. BMC Geriatrics, 18(1), Article 82. https://doi.org/10.1186/s12877-018-0769-4

Background: Some older people who find standard exercise programmes too strenuous may be encouraged to exercise while remaining seated - chair based exercises (CBE). We previously developed a consensus CBE programme (CCBE) following a modified Delphi... Read More about Chair based exercise in community settings: a cluster randomised feasibility study.

A development study and randomised feasibility trial of a tailored intervention to improve activity and reduce falls in older adults with mild cognitive impairment and mild dementia (2018)
Journal Article
Harwood, R. H., van der Wardt, V., Goldberg, S. E., Keamey, F., Logan, P., Hood-Moore, V., …Orrell, M. (2018). A development study and randomised feasibility trial of a tailored intervention to improve activity and reduce falls in older adults with mild cognitive impairment and mild dementia. Pilot and Feasibility Studies, 4, Article 49. https://doi.org/10.1186/s40814-018-0239-y

Background: People with dementia progressively lose abilities and are prone to falling. Exercise- and activity-based interventions hold the prospect of increasing abilities, reducing falls, and slowing decline in cognition. Current falls prevention... Read More about A development study and randomised feasibility trial of a tailored intervention to improve activity and reduce falls in older adults with mild cognitive impairment and mild dementia.

Withdrawal of antihypertensive therapy in people with dementia: feasibility study (2018)
Journal Article
van der Wardt, V., Burton, J. K., Conroy, S., Welsh, T., Logan, P., Taggar, J., …Gladman, J. (2018). Withdrawal of antihypertensive therapy in people with dementia: feasibility study. Pilot and Feasibility Studies, 4(1), Article 29. https://doi.org/10.1186/s40814-017-0221-0

© 2018 The Author(s). Background: This study explored the feasibility of a randomised controlled withdrawal trial of antihypertensive medication in normotensive people with dementia. Feasibility aspects included response, recruitment, exclusion and d... Read More about Withdrawal of antihypertensive therapy in people with dementia: feasibility study.

PHysical activity Implementation Study In Community-dwelling AduLts (PHISICAL): study protocol (2018)
Journal Article
Carpenter, H., Audsley, S., Coupland, C., Gladman, J. R., Kendrick, D., Lafond, N., …Orton, E. (in press). PHysical activity Implementation Study In Community-dwelling AduLts (PHISICAL): study protocol. Injury Prevention, https://doi.org/10.1136/injuryprev-2017-042627

Background: Falls in older people are a leading causes of unintentional injury. Due to an ageing population, injuries are likely to increase unless more is done to reduce older people’s falls risk. In clinical trials, the Falls Management Exercise (F... Read More about PHysical activity Implementation Study In Community-dwelling AduLts (PHISICAL): study protocol.

Optimal healthcare delivery to care homes in the UK: a realist evaluation of what supports effective working to improve healthcare outcomes (2018)
Journal Article
Gordon, A. L., Goodman, C., Davies, S. L., Dening, T., Gage, H., Meyer, J., …Zubair, M. (2018). Optimal healthcare delivery to care homes in the UK: a realist evaluation of what supports effective working to improve healthcare outcomes. Age and Ageing, 47(4), 595-603. https://doi.org/10.1093/ageing/afx195

Introduction: care home residents have high healthcare needs not fully met by prevailing healthcare models. This study explored how healthcare configuration influences resource use. Methods: a realist evaluation using qualitative and quantitative... Read More about Optimal healthcare delivery to care homes in the UK: a realist evaluation of what supports effective working to improve healthcare outcomes.

Optimal NHS service delivery to care homes: a realist evaluation of the features and mechanisms that support effective working for the continuing care of older people in residential settings (2017)
Journal Article
Goodman, C., Davies, S. L., Gordon, A. L., Dening, T., Gage, H., Meyer, J., …Zubair, M. (2017). Optimal NHS service delivery to care homes: a realist evaluation of the features and mechanisms that support effective working for the continuing care of older people in residential settings. Health Services and Delivery Research, 5(29), https://doi.org/10.3310/hsdr05290

Background: Care homes are the institutional providers of long-term care for older people. The OPTIMAL study argued that it is probable that there are key activities within different models of health-care provision that are important for residents’ h... Read More about Optimal NHS service delivery to care homes: a realist evaluation of the features and mechanisms that support effective working for the continuing care of older people in residential settings.

Using comprehensive geriatric assessment for quality improvements in healthcare of older people in UK care homes: protocol for realist review within Proactive Healthcare of Older People in Care Homes (PEACH) study (2017)
Journal Article
Zubair, M., Chadborn, N., Gladman, J. R., Dening, T., Gordon, A. L., & Goodman, C. (2017). Using comprehensive geriatric assessment for quality improvements in healthcare of older people in UK care homes: protocol for realist review within Proactive Healthcare of Older People in Care Homes (PEACH) study. BMJ Open, 7(10), Article e017270. https://doi.org/10.1136/bmjopen-2017-017270

Introduction Care home residents are relatively high users of healthcare resources and may have complex needs. Comprehensive geriatric assessment (CGA) may benefit care home residents and improve efficiency of care delivery. This is an approach t... Read More about Using comprehensive geriatric assessment for quality improvements in healthcare of older people in UK care homes: protocol for realist review within Proactive Healthcare of Older People in Care Homes (PEACH) study.

Characteristics and outcomes of hospitalised patients with vertebral fragility fractures: a systematic review (2017)
Journal Article
Ong, T., Kantachuvesiri, P., Sahota, O., & Gladman, J. R. (2018). Characteristics and outcomes of hospitalised patients with vertebral fragility fractures: a systematic review. Age and Ageing, 47(1), 17-25. https://doi.org/10.1093/ageing/afx079

Background: The complex management for patients presenting to hospital with vertebral fragility fractures provides justification for the development of specific services for them. A systematic review was undertaken to determine the incidence of hospi... Read More about Characteristics and outcomes of hospitalised patients with vertebral fragility fractures: a systematic review.

Withdrawal of antihypertensive medication: a systematic review (2017)
Journal Article
van der Wardt, V., Harrison, J. K., Welsh, T. J., Conroy, S., & Gladman, J. R. (2017). Withdrawal of antihypertensive medication: a systematic review. Journal of Hypertension, 35, https://doi.org/10.1097/HJH.0000000000001405

Although antihypertensive medication is usually continued indefinitely, observations during wash-out phases in hypertension trials have shown that withdrawal of antihypertensive medication might be well tolerated to do in a considerable proportion of... Read More about Withdrawal of antihypertensive medication: a systematic review.

Benchmarking the prevalence of care problems in UK care homes using the LPZ-i: a feasibility study (2017)
Journal Article
Darby, J., Horne, J., Lewin, J., Crocker, C., Coates, E., McEwan, K., …Gordon, A. L. (2017). Benchmarking the prevalence of care problems in UK care homes using the LPZ-i: a feasibility study. East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series, 13,

Background: UK care homes have no mechanism for counting, collating or analyzing prevalence of care problems to benchmark quality of care. This study investigated the feasibility of the International Prevalence Measurement of Quality of... Read More about Benchmarking the prevalence of care problems in UK care homes using the LPZ-i: a feasibility study.

Challenges and opportunities in understanding dementia and delirium in the acute hospital (2017)
Journal Article
Jackson, T. A., Gladman, J. R., Harwood, R. H., MacLullich, A. M., Sampson, E. L., Sheehan, B., & Davis, D. H. (2017). Challenges and opportunities in understanding dementia and delirium in the acute hospital. PLoS Medicine, 14(3), Article e1002247. https://doi.org/10.1371/journal.pmed.1002247

What is the problem? Dementia in general hospitals Dementia is very common in patients admitted to acute hospitals, affecting one in four patients, with 6% of people living with dementia being inpatients in acute hospitals at any given time [1,... Read More about Challenges and opportunities in understanding dementia and delirium in the acute hospital.

Understanding the models of community hospital rehabilitation activity (MoCHA): a mixed method study (2017)
Journal Article
Gladman, J., Buckell, J., Young, J., Smith, A., Hulme, C., Saggu, S., …Tucker, H. (2017). Understanding the models of community hospital rehabilitation activity (MoCHA): a mixed method study. BMJ Open, 7(2), Article e010483. https://doi.org/10.1136/bmjopen-2015-010483

Introduction To understand the variation in performance between community hospitals, our objectives are: to measure the relative performance (cost efficiency) of rehabilitation services in community hospitals; to identify the characteristics of c... Read More about Understanding the models of community hospital rehabilitation activity (MoCHA): a mixed method study.

The effective ingredients of social care support at home for people with dementia: a literature review (2017)
Journal Article
Argyle, E., Kelly, T., Gladman, J. R., & Jones, R. (2017). The effective ingredients of social care support at home for people with dementia: a literature review. Journal of Integrated Care, 25(2), 110-119. https://doi.org/10.1108/JICA-09-2016-0032

Purpose: Formal ties between the theatre and research dissemination have only recently developed and its general efficacy is largely unknown. Here the purpose of this paper is to redress this neglect by examining the effectiveness of a research-base... Read More about The effective ingredients of social care support at home for people with dementia: a literature review.

Acetylcholinesterase activity measurement and clinical features of delirium (2016)
Journal Article
Jackson, T., Moorey, H., Sheehan, B., Maclullich, A., Gladman, J., & Lord, J. (2017). Acetylcholinesterase activity measurement and clinical features of delirium. Dementia and Geriatric Cognitive Disorders, 43(1-2), https://doi.org/10.1159/000452832

Aims: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum AChE activity and (1) clinical features of delirium and (2) outcomes, among older hospita... Read More about Acetylcholinesterase activity measurement and clinical features of delirium.

New horizons: the management of hypertension in people with dementia (2016)
Journal Article
Harrison, J. K., Van Der Wardt, V., Conroy, S. P., Stott, D. J., Dening, T., Gordon, A. L., …Gladman, J. R. (2016). New horizons: the management of hypertension in people with dementia. Age and Ageing, 45(6), 740-746. https://doi.org/10.1093/ageing/afw155

The optimal management of hypertension in people with dementia is uncertain. This review explores if people with dementia experience greater adverse effects from antihypertensive medications, if cognitive function is protected or worsened by controll... Read More about New horizons: the management of hypertension in people with dementia.

Effective health care for older people living and dying in care homes: a realist review (2016)
Journal Article
Goodman, C., Dening, T., Gordon, A. L., Davies, S. L., Meyer, J., Martin, F. C., …Zubair, M. (in press). Effective health care for older people living and dying in care homes: a realist review. BMC Health Services Research, 16(269), https://doi.org/10.1186/s12913-016-1493-4

Background: Care home residents in England have variable access to health care services. There is currently no coherent policy or consensus about the best arrangements to meet these needs. The purpose of this review was to explore the evidence for ho... Read More about Effective health care for older people living and dying in care homes: a realist review.

Qualitative study investigating the commissioning process for older people's services provided by third sector organisations: SOPRANO study protocol (2016)
Journal Article
Sands, G., Chadborn, N., Craig, C., & Gladman, J. R. (2016). Qualitative study investigating the commissioning process for older people's services provided by third sector organisations: SOPRANO study protocol. BMJ Open, 6(5), Article e010724. https://doi.org/10.1136/bmjopen-2015-010724

Introduction The commissioning of third sector services for older people may influence the quality, availability and coordination of services for older people. The SOPRANO study aims to understand the relationships between and processes of commissio... Read More about Qualitative study investigating the commissioning process for older people's services provided by third sector organisations: SOPRANO study protocol.