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All Outputs (56)

Childbirth experience questionnaire: validating its use in the United Kingdom (2015)
Journal Article
Walker, K. F., Wilson, P., Bugg, G., Dencker, A., & Thornton, J. (2015). Childbirth experience questionnaire: validating its use in the United Kingdom. BMC Pregnancy and Childbirth, 15(86), https://doi.org/10.1186/s12884-015-0513-4

BACKGROUND: The Childbirth Experience Questionnaire (CEQ) was developed in Sweden in 2010 and validated in 920 primiparous women. It has not been validated in the United Kingdom (UK). Measuring the impact of an intervention on a woman's childbirth e... Read More about Childbirth experience questionnaire: validating its use in the United Kingdom.

Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study. (2015)
Journal Article
Cooper, N. A., Clark, T. J., Middleton, L., Diwakar, L., Smith, P., Denny, E., …Thornton, J. (2015). Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study. BMJ, 350, Article h1398. https://doi.org/10.1136/bmj.h1398

© BMJ Publishing Group Ltd 2015. To compare the effectiveness and acceptability of outpatient polypectomy with inpatient polypectomy. Design Pragmatic multicentre randomised controlled noninferiority study. Setting Outpatient hysteroscopy clinics in... Read More about Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study..

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (2015)
Journal Article
John, M., Cockcroft, J. R., McKeever, T. M., Coward, W. R., Shale, D. J., Johnson, S. R., …Bolton, C. E. (2015). Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease, 10(1), https://doi.org/10.2147/COPD.S76061

BACKGROUND: There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the... Read More about Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial..

Less-tight versus tight control of hypertension in pregnancy (2015)
Journal Article
Magee, L. A., von Dadelszen, P., Rey, E., Ross, S., Asztalos, E., Murphy, K. E., …Moutquin, J. (2015). Less-tight versus tight control of hypertension in pregnancy. New England Journal of Medicine, 372(5), https://doi.org/10.1056/NEJMoa1404595

BACKGROUND The effects of less-tight versus tight control of hypertension on pregnancy complications are unclear. METHODS We performed an open, international, multicenter trial involving women at 14 weeks 0 days to 33 weeks 6 days of gestation who... Read More about Less-tight versus tight control of hypertension in pregnancy.

Rehabilitation of memory following brain injury (ReMemBrIn): study protocol for a randomised controlled trial (2015)
Journal Article
das Nair, R., Lincoln, N., Ftizsimmons, D., Brain, N., Montgomery, A., Bradshaw, L., …Pink, A. (2015). Rehabilitation of memory following brain injury (ReMemBrIn): study protocol for a randomised controlled trial. Trials, 16(6), https://doi.org/10.1186/1745-6215-16-6

Background Impairments of memory are commonly reported by people with traumatic brain injuries (TBI). Such deficits are persistent, debilitating, and can severely impact quality of life. Currently, many do not routinely receive follow-up appointment... Read More about Rehabilitation of memory following brain injury (ReMemBrIn): study protocol for a randomised controlled trial.

Surgical intervention versus expectant management for endometrial polyps in subfertile women (2014)
Journal Article
Jayaprakasan, K., Polanski, L., Sahu, B., Thornton, J., & Raine-Fenning, N. (2014). Surgical intervention versus expectant management for endometrial polyps in subfertile women. Cochrane Library, https://doi.org/10.1002/14651858.CD009592.pub2

BACKGROUND: Endometrial polyps, which are benign growths of the endometrium, may be a factor in female subfertility. Possible mechanisms include physical interference with gamete transport, alteration of the endometrial milieu and unresponsiveness t... Read More about Surgical intervention versus expectant management for endometrial polyps in subfertile women.

The SNAP trial: A randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - Clinical effectiveness and safety until 2 years after delivery, with economic evaluation (2014)
Journal Article
Cooper, S., Lewis, S., Thornton, J., Marlow, N., Watts, K., Britton, J., …Coleman, T. (2014). The SNAP trial: A randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - Clinical effectiveness and safety until 2 years after delivery, with economic evaluation. Health Technology Assessment, 18(54), 1-128. https://doi.org/10.3310/hta18540

Background: Smoking during pregnancy causes many adverse pregnancy and birth outcomes. Nicotine replacement therapy (NRT) is effective for cessation outside pregnancy but efficacy and safety in pregnancy are unknown. We hypothesised that NRT would in... Read More about The SNAP trial: A randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - Clinical effectiveness and safety until 2 years after delivery, with economic evaluation.

Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial (2014)
Journal Article
Pushpa-Rajah, A., Bradshaw, L., Dorling, J., Gyte, G., Mitchell, E. J., Thornton, J., & Duley, L. (2014). Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial. Trials, 15(258), https://doi.org/10.1186/1745-6215-15-258

Background: Preterm birth is the most important single determinant of adverse outcome in the United Kingdom; one in every 70 babies (1.4%) is born before 32 weeks (very preterm), yet these births account for over half of infant deaths. Deferring cor... Read More about Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial.

Discrepancies between registration and publication of randomised controlled trials: an observational study (2014)
Journal Article
Walker, K. F., Stevenson, G., & Thornton, J. (2014). Discrepancies between registration and publication of randomised controlled trials: an observational study. Journal of the Royal Society of Medicine, 5(5), https://doi.org/10.1177/2042533313517688

Abstract OBJECTIVES: To determine the consistency between information contained in the registration and publication of randomised controlled trials (RCTs). DESIGN: An observational study of RCTs published between May 2011 and May 2012 in the Brit... Read More about Discrepancies between registration and publication of randomised controlled trials: an observational study.

The dangers of the day of birth (2014)
Journal Article
Walker, K., Cohen, A., Walker, S., Allen, K., Baines, D., & Thornton, J. (2014). The dangers of the day of birth. BJOG: An International Journal of Obstetrics and Gynaecology, 121(6), 714-718. doi:10.1111/1471-0528.12544

Heparin for assisted reproduction (Review) (2013)
Journal Article
Akhtar, M. A., Sur, S. D., Raine-Fenning, N., Jayaprakasan, K., Thornton, J., & Quenby, S. (2013). Heparin for assisted reproduction (Review). Cochrane Library, https://doi.org/10.1002/14651858.CD009452.pub2

Abstract BACKGROUND: Heparin as an adjunct in assisted reproduction (peri-implantation heparin) is given at or after egg collection or at embryo transfer during assisted reproduction. Heparin has been advocated to improve embryo implantation and cl... Read More about Heparin for assisted reproduction (Review).

Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. (2013)
Journal Article
Churchill, D., Duley, L., Thornton, J., & Jones, L. (2013). Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. Cochrane Library, 7, Article CD003106. https://doi.org/10.1002/14651858.CD003106.pub2

Background: Severe pre-eclampsia can cause significant mortality and morbidity for both mother and child, particularly when it occurs remote from term, between 24 and 34 weeks' gestation. The only known cure for this disease is delivery. Some obstetr... Read More about Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation..

Interventions for treating cholestasis in pregnancy (Review) (2013)
Journal Article
Gurung, V., Stokes, M., Middleton, P., Milan, S. J., Hague, W., & Thornton, J. (2013). Interventions for treating cholestasis in pregnancy (Review). Cochrane Library, 6, Article CD000493. https://doi.org/10.1002/14651858.CD000493.pub2

BACKGROUND: Obstetric cholestasis has been linked to adverse maternal and fetal/neonatal outcomes. As the pathophysiology is poorly understood, therapies have been empiric. The first version of this review, published in 2001, and including nine rand... Read More about Interventions for treating cholestasis in pregnancy (Review).

Elective preterm birth for fetal gastroschisis (Review) (2013)
Journal Article
Grant, N. H., Dorling, J., & Thornton, J. (2013). Elective preterm birth for fetal gastroschisis (Review). Cochrane Database of Systematic Reviews, 2013(6), Article CD009394. https://doi.org/10.1002/14651858.CD009394.pub2

Background: Gastroschisis is an uncommon congenital defect of the interior abdominal wall that results in herniation of intestinal loops outside the abdominal cavity. Babies with gastroschisis generally do well, but there remains a mortality rate of... Read More about Elective preterm birth for fetal gastroschisis (Review).

Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial (2012)
Journal Article
Walker, K. F., Bugg, G., Macpherson, M., McCormick, C., Wildsmith, C., Smith, G., & Thornton, J. (2012). Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial. BMC Pregnancy and Childbirth, 12(Decemb), Article 8. https://doi.org/10.1186/1471-2393-12-145

Background: British women are increasingly delaying childbirth. The proportion giving birth over the age of 35 rose from 12% in 1996 to 20% in 2006. Women over this age are at a higher risk of perinatal death, and antepartum stillbirth accounts for 6... Read More about Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial.

Final Protocol and Statistical Analysis Plan for the SNAP Trial - a randomised, double-blind, placebo-controlled trial of nicotine replacement therapy in pregnancy
Other
Coleman, T., Cooper, S., Thornton, J., Britton, J., Lewis, S., Watts, K., …Grainge, M. J. Final Protocol and Statistical Analysis Plan for the SNAP Trial - a randomised, double-blind, placebo-controlled trial of nicotine replacement therapy in pregnancy

This NIHR HTA-funded smoking, nicotine and pregnancy (SNAP) trial investigated whether or not nicotine replacement therapy (NRT) is effective, cost-effective and safe when used for smoking cessation by pregnant women. We randomised 1050 women who wer... Read More about Final Protocol and Statistical Analysis Plan for the SNAP Trial - a randomised, double-blind, placebo-controlled trial of nicotine replacement therapy in pregnancy.