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Modelling a kinetic deviation of the magnesium hydrogenation reaction at conditions close to equilibrium (2019)
Journal Article
Adams, M., Grant, D. M., Stuart, A., & Walker, G. S. (2019). Modelling a kinetic deviation of the magnesium hydrogenation reaction at conditions close to equilibrium. International Journal of Hydrogen Energy, 44(55), 29123-29131. https://doi.org/10.1016/j.ijhydene.2019.04.036

A model has been derived for the magnesium hydrogenation reaction at conditions close to equilibrium. The reaction mechanism involves an adsorption element, where the model is an extension of the Langmuir adsorption model. The concept of site availab... Read More about Modelling a kinetic deviation of the magnesium hydrogenation reaction at conditions close to equilibrium.

Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model (2019)
Journal Article
McLaren, J. S., Macri-Pellizzeri, L., Zakir Hossain, K. M., Patel, U., Grant, D. M., Scammell, B. E., …Sottile, V. (2019). Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model. ACS Applied Materials and Interfaces, 11(17), 15436–15446. https://doi.org/10.1021/acsami.9b04603

Phosphate-based glasses (PBG) are bioactive and fully degradable materials with tailorable degradation rates. PBGs can be produced as porous microspheres through a single-step process, using changes in their formulation and geometry to produce varyin... Read More about Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model.

Integrated multi-assay culture model for stem cell chondrogenic differentiation (2019)
Journal Article
Prosser, A., Scotchford, C., Roberts, G., Grant, D., & Sottile, V. (2019). Integrated multi-assay culture model for stem cell chondrogenic differentiation. International Journal of Molecular Sciences, 20(4), https://doi.org/10.3390/ijms20040951

Recent osteochondral repair strategies highlight the promise of mesenchymal progenitors, an accessible stem cell source with osteogenic and chondrogenic potential, used in conjunction with biomaterials for tissue engineering. For this, regenerative m... Read More about Integrated multi-assay culture model for stem cell chondrogenic differentiation.

In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration (2019)
Journal Article
Patel, U., Macri-Pellizzeri, L., Hossain, K. M. Z., Scammell, B. E., Grant, D. M., Scotchford, C. A., …Sottile, V. (2019). In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration. Journal of Tissue Engineering and Regenerative Medicine, 13(3), 396-405. https://doi.org/10.1002/term.2796

Phosphate glasses (PBG) are ideal materials for regenerative medicine strategies since their composition, degradation rates and ion release profiles can easily be controlled. Strontium has previously been found to simultaneously affect bone resorptio... Read More about In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration.

Computational mechanical characterization of geometrically transformed Schwarz P lattice tissue scaffolds fabricated via two photon polymerization (2PP) (2018)
Journal Article
Zabidi, A. Z., Li, S., Felfel, R. M., Thomas, K. G., Grant, D. M., Mcnally, D., & Scotchford, C. (2019). Computational mechanical characterization of geometrically transformed Schwarz P lattice tissue scaffolds fabricated via two photon polymerization (2PP). Additive Manufacturing, 25, 399-411. https://doi.org/10.1016/j.addma.2018.11.021

Schwarz P unit cell-based tissue scaffolds comprised of poly(D,L-lactide-co-caprolactone)(PLCL) fabricated via the additive manufacturing technique, two-photon polymerisation (2PP) were found to undergo geometrical transformations from the original i... Read More about Computational mechanical characterization of geometrically transformed Schwarz P lattice tissue scaffolds fabricated via two photon polymerization (2PP).

Structural, mechanical and swelling characteristics of 3D scaffolds from chitosan-agarose blends (2018)
Journal Article
Felfel, R. M., Gideon-Adeniyi, M. J., Hossain, K. M. Z., Roberts, G. A., & Grant, D. M. (2019). Structural, mechanical and swelling characteristics of 3D scaffolds from chitosan-agarose blends. Carbohydrate Polymers, 204, 59-67. https://doi.org/10.1016/j.carbpol.2018.10.002

This study aimed to explore the correlation between mechanical and structural properties of chitosan-agarose blend (Ch-Agrs) scaffolds. Porosity of Ch-Agrs scaffolds was constant at 93%, whilst pore sizes varied between 150 and 550 μm. Pore sizes of... Read More about Structural, mechanical and swelling characteristics of 3D scaffolds from chitosan-agarose blends.

Two step porosification of biomimetic thin-film hydroxyapatite/alpha-tri calcium phosphate coatings by pulsed electron beam irradation (2018)
Journal Article
Stuart, B. W., Murray, J. W., & Grant, D. M. (2018). Two step porosification of biomimetic thin-film hydroxyapatite/alpha-tri calcium phosphate coatings by pulsed electron beam irradation. Scientific Reports, 8, Article 14530. https://doi.org/10.1038/s41598-018-32612-x

Here we show a new and effective methodology for rapid/controllable porosification of thin-film ceramics, which may be applied, in medical devices/electronics and membrane nano-filtration. Dense hydroxyapatite applied to Ti6Al4V by plasma-assisted PV... Read More about Two step porosification of biomimetic thin-film hydroxyapatite/alpha-tri calcium phosphate coatings by pulsed electron beam irradation.

Performance of multiphase scaffolds for bone repair based on two-photon polymerized poly(d,l-lactide-co-?-caprolactone), recombinamers hydrogel and nano-HA (2018)
Journal Article
Felfel, R. M., Gupta, D., Zabidi, A. Z., Prosser, A., Scotchford, C. A., Sottile, V., & Grant, D. M. (2018). Performance of multiphase scaffolds for bone repair based on two-photon polymerized poly(d,l-lactide-co-?-caprolactone), recombinamers hydrogel and nano-HA. Materials and Design, 160, 455-467. https://doi.org/10.1016/j.matdes.2018.09.035

Multiphase hybrids were fabricated from poly(d,l-lactide-co-ɛ-caprolactone) (PLCL) copolymer scaffolds impregnated with silk-elastin-like recombinamers (SELRs) hydrogel containing 2 wt% hydroxyapatite nanoparticles (nHA). The PLCL scaffolds, triply-p... Read More about Performance of multiphase scaffolds for bone repair based on two-photon polymerized poly(d,l-lactide-co-?-caprolactone), recombinamers hydrogel and nano-HA.

Suspension high velocity oxy-fuel (SHVOF) spray of delta-theta alumina suspension: Phase transformation and tribology (2018)
Journal Article
Owoseni, T., Murray, J., Pala, Z., Lester, E., Grant, D., & Hussain, T. (2018). Suspension high velocity oxy-fuel (SHVOF) spray of delta-theta alumina suspension: Phase transformation and tribology. Surface and Coatings Technology, https://doi.org/10.1016/j.surfcoat.2018.08.047

Suspension high-velocity oxy-fuel (SHVOF) thermal spray is an emerging spray technology that enables the processing of nanometric feedstock. Although SHVOF thermal sprayed alumina coatings prepared from alpha alumina feedstock have been widely report... Read More about Suspension high velocity oxy-fuel (SHVOF) spray of delta-theta alumina suspension: Phase transformation and tribology.

Dielectric breakdown of alumina thin films produced by pulsed direct current magnetron sputtering (2018)
Journal Article
Hanby, B. V., Stuart, B. W., Grant, C., Moffat, J., Blissett, J., Gerada, C., …Grant, D. M. (2018). Dielectric breakdown of alumina thin films produced by pulsed direct current magnetron sputtering. Thin Solid Films, 662, 145-154. https://doi.org/10.1016/j.tsf.2018.07.004

Alumina films (~2 μm thick) were deposited with a mixed Cu/Al interlayer onto copper. Direct current (DC)/Pulsed DC (PDC) magnetron sputtering techniques were independently compared for reactive alumina sputtering. In DC sputtered films, elemental al... Read More about Dielectric breakdown of alumina thin films produced by pulsed direct current magnetron sputtering.

Laser sintering of nano-hydroxyapatite coated polyamide 12 powders (2018)
Journal Article
Hui, D., Goodridge, R. D., Scotchford, C., & Grant, D. M. (2018). Laser sintering of nano-hydroxyapatite coated polyamide 12 powders. Additive Manufacturing, 22, 560-570. https://doi.org/10.1016/j.addma.2018.05.045

As part of a larger study on the laser sintering (LS) of nano-composite structures for biomedical applications, a wet mixing method was used to coat Polyamide 12 (PA12) particles with nano-hydroxyapatite (nHA). The addition of nHA significantly affec... Read More about Laser sintering of nano-hydroxyapatite coated polyamide 12 powders.

Generation and characterisation of gallium titanate surfaces through hydrothermal ion-exchange processes (2018)
Journal Article
Wadge, M. D., Stuart, B. W., Thomas, K. G., & Grant, D. M. (2018). Generation and characterisation of gallium titanate surfaces through hydrothermal ion-exchange processes. Materials and Design, 155, https://doi.org/10.1016/j.matdes.2018.05.060

Infection negation and biofilm prevention are necessary developments needed for implant materials. Furthermore, an increase in publications regarding gallium (Ga) as an antimicrobial ion has resulted in bacterial-inhibitory surfaces incorporating gal... Read More about Generation and characterisation of gallium titanate surfaces through hydrothermal ion-exchange processes.

Flexible and transparent films produced from cellulose nanowhisker reinforced agarose (2018)
Journal Article
Felfel, R. M., Hossain, K. M. Z., Kabir, S. F., Yee, S. L., Ahmed, I., & Grant, D. M. (2018). Flexible and transparent films produced from cellulose nanowhisker reinforced agarose. Carbohydrate Polymers, 194, https://doi.org/10.1016/j.carbpol.2018.04.005

Transparent and flexible nanocomposite films with a range of Agarose to Cellulose Nano-Whisker (CNW) ratios were produced using never-dried CNWs. The incorporation of never-dried CNWs within Agarose played an important role in the surface roughness (... Read More about Flexible and transparent films produced from cellulose nanowhisker reinforced agarose.

Gallium incorporation into phosphate based glasses: bulk and thin film properties (2018)
Journal Article
Stuart, B. W., Grant, C. A., Stan, G. E., Popa, A. C., Titman, J. J., & Grant, D. M. (2018). Gallium incorporation into phosphate based glasses: bulk and thin film properties. Journal of the Mechanical Behavior of Biomedical Materials, 82, https://doi.org/10.1016/j.jmbbm.2018.03.041

The osteogenic ions Ca2+, P5+, Mg2+, and antimicrobial ion Ga3+ were homogenously dispersed into a 1.45 mum thick phosphate glass coating by plasma assisted sputtering onto CP grade titanium. The objective was to deliver therapeutic ions in orthopedi... Read More about Gallium incorporation into phosphate based glasses: bulk and thin film properties.

Porous calcium phosphate glass microspheres for orthobiologic applications (2018)
Journal Article
Hossain, K. M. Z., Patel, U., Kennedy, A. R., Macri-Pellizzeri, L., Sottile, V., Grant, D. M., …Ahmed, I. (2018). Porous calcium phosphate glass microspheres for orthobiologic applications. Acta Biomaterialia, 72, 396-406. https://doi.org/10.1016/j.actbio.2018.03.040

© 2018 Orthobiologics is a rapidly advancing field utilising cell-based therapies and biomaterials to enable the body to repair and regenerate musculoskeletal tissues. This paper reports on a cost-effective flame spheroidisation process for producti... Read More about Porous calcium phosphate glass microspheres for orthobiologic applications.

Live quantitative monitoring of mineral deposition in stem cells using tetracycline hydrochloride (2018)
Journal Article
Macri-Pellizzeri, L., De Melo, N., Ahmed, I., Grant, D. M., Scammell, B., & Sottile, V. (2018). Live quantitative monitoring of mineral deposition in stem cells using tetracycline hydrochloride. Tissue Engineering Part C Methods, 24(3), https://doi.org/10.1089/ten.TEC.2017.0400

The final stage of in vitro osteogenic differentiation is characterized by the production of mineral deposits containing calcium cations and inorganic phosphates, which populate the extracellular matrix surrounding the cell monolayer. Conventional hi... Read More about Live quantitative monitoring of mineral deposition in stem cells using tetracycline hydrochloride.

Single solvent based film casting method for the production of porous polymer films (2018)
Journal Article
Hossain, K. M. Z., Felfel, R. M., Ogbilikana, P. S., Thakker, D., Grant, D. M., Scotchford, C., & Ahmed, I. (2018). Single solvent based film casting method for the production of porous polymer films. Macromolecular Materials and Engineering, 303, https://doi.org/10.1002/mame.201700628

A single solvent based film casting process for fabricating porous polymer films was developed in this study. The porous film was produced by mixing concentrated polylactic acid/ chloroform solution (20 wt%) and fresh chloroform solvent followed by f... Read More about Single solvent based film casting method for the production of porous polymer films.

Processing and properties of PLA-HA nanocomposites: The effect of particle morphology and dispersants (2017)
Conference Proceeding
Tomczynska, M. M., Ward, M., Choong, G. Y. H., Walton, K., De Focatiis, D. S. A., Grant, D. M., …Parsons, A. J. (2017). Processing and properties of PLA-HA nanocomposites: The effect of particle morphology and dispersants. In Proceedings of PPS-32: The 32nd International Conference of the Polymer Processing Society - Conference Papers (150004-1 - 150004-5). https://doi.org/10.1063/1.5016781

Biodegradable polylactic acid nanocomposites for orthopaedic implants require optimum particle dispersion and high molecular weight in load bearing applications. Novel coated hydroxyapatite nanoparticles can offer new opportunities for enhanced dispe... Read More about Processing and properties of PLA-HA nanocomposites: The effect of particle morphology and dispersants.

Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation (2017)
Journal Article
Gupta, D., Grant, D. M., Hossain, K. M. Z., Ahmed, I., & Sottile, V. (2018). Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation. Journal of Biomaterials Applications, 32(7), https://doi.org/10.1177/0885328217745699

Mesenchymal stem cells play a vital role in bone formation process by differentiating into osteoblasts, in a tissue that offers not a flat but a discontinuous three-dimensional (3D) topography in vivo. In order to understand how geometry may be affec... Read More about Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation.

Evolution of catalyst coated atomised magnesium spheres: an alternative thermal storage medium for concentrated solar power applications (2017)
Journal Article
Mistry, P. C., Grant, D. M., Stuart, A. D., Manickam, K., & Walker, G. S. (in press). Evolution of catalyst coated atomised magnesium spheres: an alternative thermal storage medium for concentrated solar power applications. International Journal of Hydrogen Energy, 42(47), https://doi.org/10.1016/j.ijhydene.2017.09.095

Elevated temperature cycling studies were performed on two commercial gas atomised Mg spherical powders (average diameter of 26 μm and 30 μm) with magnetron sputtered catalysts (chromium, iron, vanadium and stainless steel) applied to their surfaces.... Read More about Evolution of catalyst coated atomised magnesium spheres: an alternative thermal storage medium for concentrated solar power applications.