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Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development (2014)
Journal Article
Dunford, L. J., Sinclair, K. D., Kwong, W. Y., Sturrock, C., Clifford, B. L., Giles, T. C., & Gardner, D. S. (2014). Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development. FASEB Journal, 28(11), 4880-4892. https://doi.org/10.1096/fj.14-255364

This paper identifies a common nutritional pathway relating maternal through to fetal protein-energy malnutrition (PEM) and compromised fetal kidney development. Thirty-one twin-bearing sheep were fed either a control (n=15) or low-protein diet (n=16... Read More about Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.

Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism? (2014)
Journal Article
Gardner, D. S., Welham, S. J., Dunford, L. J., McCulloch, T. A., Hodi, Z., Sleeman, P., …Devonald, M. A. (2014). Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?. AJP - Renal Physiology, 306(8), F873-F884. https://doi.org/10.1152/ajprenal.00576.2013

Acute kidney injury is common, serious with no specific treatment. Ischemia-reperfusion is a common cause of acute kidney injury (AKI). Clinical trials suggest that preoperative erythropoietin (EPO) or remote ischemic preconditioning may have a renop... Read More about Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?.

Maternal fructose and/or salt intake and reproductive outcome in the rat: effects on growth, fertility, sex ratio, and birth order (2013)
Journal Article
Gray, C., Long, S., Green, C., Gardiner, S. M., Craigon, J., & Gardner, D. S. (2013). Maternal fructose and/or salt intake and reproductive outcome in the rat: effects on growth, fertility, sex ratio, and birth order. Biology of Reproduction, 89(3), Article 51. https://doi.org/10.1095/biolreprod.113.109595

Maternal diet can significantly skew the secondary sex ratio away from the expected value of 0.5 (proportion males), but the details of how diet may do this are unclear. Here, we altered dietary levels of salt (4% salt in the feed) and/or fructose (1... Read More about Maternal fructose and/or salt intake and reproductive outcome in the rat: effects on growth, fertility, sex ratio, and birth order.

Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling (2013)
Journal Article
Gray, C., Al-Dujaili, E. A., Sparrow, A. J., Gardiner, S. M., Craigon, J., Welham, S. J., & Gardner, D. S. (2013). Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling. PLoS ONE, 8(8), Article e72682. https://doi.org/10.1371/journal.pone.0072682

Hypertension is common and contributes, via cardiovascular disease, towards a large proportion of adult deaths in the Western World. High salt intake leads to high blood pressure, even when occurring prior to birth – a mechanism purported to reside i... Read More about Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling.

Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep (2013)
Journal Article
Bloor, I. D., Sébert, S. P., Saroha, V., Gardner, D. S., Keisler, D. H., Budge, H., …Mahajan, R. P. (2013). Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep. Endocrinology, 154(10), https://doi.org/10.1210/en.2013-1207

Sex is a major factor determining adipose tissue distribution and the subsequent adverse effects of obesity-related disease including type 2 diabetes. The role of gender on juvenile obesity and the accompanying metabolic and inflammatory responses is... Read More about Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep.