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Persistent intestinal abnormalities and symptoms in cystic fibrosis: The underpinning mechanisms impacting gut health and motility. Protocol for a systematic review. (2020)
Other
Marsh, R. J., Ng, C., Major, G., Rivett, D. W., Smyth, A. R., & Gast, C. V. D. Persistent intestinal abnormalities and symptoms in cystic fibrosis: The underpinning mechanisms impacting gut health and motility. Protocol for a systematic review

Background Patients with cystic fibrosis (CF) are characterised by abnormalities of the intestinal tract relating to gut motility and physiological issues, with daily symptoms of disease including abdominal pain, flatulence, bloating, and constipatio... Read More about Persistent intestinal abnormalities and symptoms in cystic fibrosis: The underpinning mechanisms impacting gut health and motility. Protocol for a systematic review..

Antimicrobial resistance: Concerns of healthcare providers and people with CF (2020)
Journal Article
Bullington, W., Hempstead, S., Smyth, A. R., Drevinek, P., Saiman, L., Waters, V. J., …Antimicrobial Resistance International Working Group in Cystic Fibrosis. (2021). Antimicrobial resistance: Concerns of healthcare providers and people with CF. Journal of Cystic Fibrosis, 20(3), 407-412. https://doi.org/10.1016/j.jcf.2020.05.009

Background Chronic lung infections and their treatment pose risks for the development of antimicrobial resistance (AMR) in people with cystic fibrosis (PWCF). In this study, we evaluated the attitudes of healthcare providers’ (HCP) and PWCF or their... Read More about Antimicrobial resistance: Concerns of healthcare providers and people with CF.

Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals (2020)
Journal Article
Leisman, D. E., Harhay, M. O., Lederer, D. J., Abramson, M., Adjei, A. A., Bakker, J., …Maslove, D. M. (2020). Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. Critical Care Medicine, 48(5), 623-633. https://doi.org/10.1097/ccm.0000000000004246

Prediction models aim to use available data to predict a health state or outcome that has not yet been observed. Prediction is primarily relevant to clinical practice, but is also used in research, and administration. While prediction modeling involv... Read More about Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals.

Smoking ban in cars protects children, but is vaping 'The Elephant in the Car'? (2020)
Journal Article
Ng, C., & Smyth, A. R. (2020). Smoking ban in cars protects children, but is vaping 'The Elephant in the Car'?. Thorax, 75(4), 297. https://doi.org/10.1136/thoraxjnl-2020-214660

In March 2006, smoking in public places was banned in Scotland. The following year a similar ban was introduced in England — the last of the UK home nations to adopt this policy. At the time, some suggested that the ban might paradoxically increase c... Read More about Smoking ban in cars protects children, but is vaping 'The Elephant in the Car'?.

A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (2020)
Journal Article
McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., …Pirmohamed, M. (2020). A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis. Scientific Reports, 10(1), Article 1796. https://doi.org/10.1038/s41598-020-58790-1

The PROteKT study tested the hypothesis that rosuvastatin can inhibit aminoglycoside-induced nephrotoxicity in children with Cystic Fibrosis (CF). This open label, parallel group, randomised controlled trial recruited children and young people aged 6... Read More about A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.

Can exercise replace airway clearance techniques in cystic fibrosis? A survey of patients and healthcare professionals (2019)
Journal Article
Rowbotham, N., Smith, S., Davies, G., Daniels, T., Elliott, Z., Gathercole, K., …Smyth, A. (2020). Can exercise replace airway clearance techniques in cystic fibrosis? A survey of patients and healthcare professionals. Journal of Cystic Fibrosis, 19(4), e19-e24. https://doi.org/10.1016/j.jcf.2019.10.026

Airway clearance techniques (ACTs) are recommended in cystic fibrosis (CF) to prevent accumulation of secretions and lung infection. “Can exercise replace chest physiotherapy for people with CF?” is one of the CF community's top 10 research questions... Read More about Can exercise replace airway clearance techniques in cystic fibrosis? A survey of patients and healthcare professionals.

Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials (2019)
Journal Article
Davies, G., Rowbotham, N. J., Smith, S., Elliot, Z. C., Gathercole, K., Rayner, O., …Smyth, A. R. (2020). Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials. Journal of Cystic Fibrosis, 19(3), 499-502. https://doi.org/10.1016/j.jcf.2019.10.025

In a recent James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF) the top priority clinical research question was: “What are effective ways of simplifying the treatment burden of people with CF?” We aimed to summarise the lived exp... Read More about Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials.

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis (2019)
Journal Article
Webb, K., Fogarty, A., Barrett, D. A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., …Cámara, M. (2019). Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis. Journal of Medical Microbiology, 68(12), 1823-1828. https://doi.org/10.1099/jmm.0.001099

Introduction : Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces in... Read More about Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.

Rojiroti microfinance and child nutrition: a cluster randomised trial (2019)
Journal Article
Ojha, S., Szatkowski, L., Sinha, R., Yaron, G., Fogarty, A., Allen, S., …Smyth, A. R. (2020). Rojiroti microfinance and child nutrition: a cluster randomised trial. Archives of Disease in Childhood, 105(3), 229-235. https://doi.org/10.1136/archdischild-2018-316471

Objective To determine whether Rojiroti microfinance, for poor Indian women, improves child nutrition. Design Cluster randomised trial. Setting Tolas (village communities) in Bihar State. Participants Women and children under 5 years. Int... Read More about Rojiroti microfinance and child nutrition: a cluster randomised trial.

Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: A state of the art review (2019)
Journal Article
Calthorpe, R. J., Smith, S., Gathercole, K., & Smyth, A. R. (2020). Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: A state of the art review. Thorax, 75(1), 72-77. https://doi.org/10.1136/thoraxjnl-2019-213233

Digital healthcare is a rapidly growing healthcare sector. Its importance has been recognised at both national and international level, with the WHO recently publishing its first global strategy for digital health. The use of digital technology withi... Read More about Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: A state of the art review.

Pro Con debates in clinical medicine Infection prevention and control in cystic fibrosis: one size fits all? The argument against (2019)
Journal Article
Smyth, A., Smith, S., & Robotham, N. (2020). Pro Con debates in clinical medicine Infection prevention and control in cystic fibrosis: one size fits all? The argument against. Paediatric Respiratory Reviews, 36, 94-96. https://doi.org/10.1016/j.prrv.2019.08.001

As awareness of the risks of cross infection has increased, infection prevention and control measures have become more draconian. Infection control measures can have a profound effect of the organisation and delivery of CF services and on the lives o... Read More about Pro Con debates in clinical medicine Infection prevention and control in cystic fibrosis: one size fits all? The argument against.

Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis (2019)
Journal Article
Rowbotham, N. J., Smith, S. J., Elliott, Z. C., Leighton, P. A., Rayner, O. C., Morley, R., & Smyth, A. R. (2019). Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis. Research Involvement and Engagement, 5(1), Article 24. https://doi.org/10.1186/s40900-019-0159-x

Background The James Lind Alliance (JLA) method is well recognised for setting research priorities. The JLA approach involves a combination of surveys and workshop interactions between patients, carers and health care professionals to identify and... Read More about Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis.

Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review (2019)
Journal Article
Kalaitzis, I., Rowbotham, N., Smith, S., & Smyth, A. (2019). Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.06.005

There are many uncertainties regarding Cystic Fibrosis (CF) treatment. Recently, the first James Lind Alliance (JLA) Priority Setting Partnership (PSP) in CF was completed, bringing clinicians, patients and carers together to identify the Top 10 rese... Read More about Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review.

An ex vivocystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection (2019)
Other
Sweeney, E., Hassan, M. M., Harrington, N. E., Smyth, A. R., Hurley, M. N., Tormo-Mas, M. Á., & Harrison, F. (2019). An ex vivocystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection

Staphylococcus aureus is one of the most prevalent organisms isolated from the airways of people with cystic fibrosis (CF), predominantly early in life. Yet its role in the pathology of lung disease is poorly understood. Clinical studies are limited... Read More about An ex vivocystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection.

Infection prevention and control in cystic fibrosis: a systematic review of interventions (2019)
Journal Article
Rowbotham, N. J., Palser, S. C., Smith, S. J., & Smyth, A. R. (2019). Infection prevention and control in cystic fibrosis: a systematic review of interventions. Expert Review of Respiratory Medicine, 13(5), 425-434. https://doi.org/10.1080/17476348.2019.1595594

Introduction: Cystic fibrosis is a life-limiting genetic condition characterized by recurrent pulmonary infection. Acquisition of infection can occur from environmental reservoirs, person-to-person transmission and from the healthcare environment. Pr... Read More about Infection prevention and control in cystic fibrosis: a systematic review of interventions.

Is microfinance associated with changes in women's wellbeing and children's nutrition? a systematic review and meta-analysis (2019)
Journal Article
Gichuru, W., Ojha, S., Smith, S., Smyth, A. R., & Szatkowski, L. (2019). Is microfinance associated with changes in women's wellbeing and children's nutrition? a systematic review and meta-analysis. BMJ Open, 9(1), Article e023658. https://doi.org/10.1136/bmjopen-2018-023658

Background: Microfinance is the provision of savings and small loans services, with no physical collateral. Most recipients are disadvantaged women. The social and health impacts of microfinance have not been comprehensively evaluated. Objective: To... Read More about Is microfinance associated with changes in women's wellbeing and children's nutrition? a systematic review and meta-analysis.

The prevalence, clinical status and genotype of cystic fibrosis patients living in Cuba using national registry data (2018)
Journal Article
Rodríguez-Calá, F., Suárez-Medina, R., Josefina Venero-Fernández, S., Smyth, A., Carr, S. B., & Fogarty, A. W. (2019). The prevalence, clinical status and genotype of cystic fibrosis patients living in Cuba using national registry data. Journal of Cystic Fibrosis, 18(4), 522-524. https://doi.org/10.1016/j.jcf.2018.10.007

Background: We aimed to establish a national cystic fibrosis (CF) registry for Cuba, a developing country. Methods: Regional centres that deliver care for all CF patients provided information for a national database. Findings: The prevalence of CF... Read More about The prevalence, clinical status and genotype of cystic fibrosis patients living in Cuba using national registry data.