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All Outputs (187)

Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID) (2023)
Working Paper
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L., …on behalf of the PHOSP-COVID Collaborative Group. Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged. PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitali... Read More about Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID).

Assessing the residual benefit of soil-applied zinc on grain zinc nutritional quality of maize grown under contrasting soil types in Malawi. (2023)
Working Paper
Botoman, L., Chimungu, J. G., Bailey, E. H., Munthali, M. W., Ander, E. L., Mossa, A., …Nalivata, P. C. Assessing the residual benefit of soil-applied zinc on grain zinc nutritional quality of maize grown under contrasting soil types in Malawi

A proper understanding of the residual value of zinc (Zn) is necessary for sustainable biofortification of food crops. This study aimed to establish the extent to which application of Zn at the national rate, plus two experimentally elevated rates, i... Read More about Assessing the residual benefit of soil-applied zinc on grain zinc nutritional quality of maize grown under contrasting soil types in Malawi..

Ukraine and the Netherlands v. Russia, Merits Amicus Curiae Brief Submitted on behalf of the Human Rights Law Centre of the University of Nottingham (2023)
Working Paper
Milanovic, M., & Shah, S. Ukraine and the Netherlands v. Russia, Merits Amicus Curiae Brief Submitted on behalf of the Human Rights Law Centre of the University of Nottingham

This is an amicus curiae brief at the merits stage in the case of Ukraine and the Netherlands v. Russia (nos 8019/16, 43800/14, 28525/20 and 11055/22) before the European Court of Human Rights, filed on behalf of the Human Rights Law Centre at the Un... Read More about Ukraine and the Netherlands v. Russia, Merits Amicus Curiae Brief Submitted on behalf of the Human Rights Law Centre of the University of Nottingham.

Genotypic Response of Finger Millet to Zinc and Iron Agronomic Biofortification, Location and Slope Position Towards Yield (2023)
Working Paper
Senbetu, D. T., Gashu, D., Joy, E. M., Lark, M. R., Bailey, E. H., Wilson, L., …Broadley, M. R. Genotypic Response of Finger Millet to Zinc and Iron Agronomic Biofortification, Location and Slope Position Towards Yield

The present study aimed to investigate influence of genotypic differences to zinc and iron agronomic biofortification responses among yield of finger millet. A field experiment was conducted over two seasons in farmers’ fields in Ethiopia (2019, 2020... Read More about Genotypic Response of Finger Millet to Zinc and Iron Agronomic Biofortification, Location and Slope Position Towards Yield.

‘We went from understanding, to disappointment, resentment and often grief all in the space of 6 months’ A qualitative study of the stories of family carers of care home residents during COVID-19 pandemic in 2020 (2023)
Working Paper
Hinsliff-Smith, K., Griffiths, S., Padley, W., De Vries, K., & Brown, J. (0000). ‘We went from understanding, to disappointment, resentment and often grief all in the space of 6 months’ A qualitative study of the stories of family carers of care home residents during COVID-19 pandemic in 2020

When the WHO announced a global pandemic in response to COVID-19, individual countries reacted in a similar way with care homes closing their doors to visits, including visits from family members. The UK was no different, initially they closed to pro... Read More about ‘We went from understanding, to disappointment, resentment and often grief all in the space of 6 months’ A qualitative study of the stories of family carers of care home residents during COVID-19 pandemic in 2020.

SteatoSITE: an Integrated Gene-to-Outcome Data Commons for Precision Medicine Research in NAFLD (2023)
Working Paper
Fallowfield, J., Kendall, T., Jimenez-Ramos, M., Turner, F., Ramachandran, P., Minnier, J., …Guha, I. SteatoSITE: an Integrated Gene-to-Outcome Data Commons for Precision Medicine Research in NAFLD

Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease worldwide and a growing healthcare burden. The pathobiology of NAFLD is complex, disease progression is variable and unpredictable, and there are no qualified pr... Read More about SteatoSITE: an Integrated Gene-to-Outcome Data Commons for Precision Medicine Research in NAFLD.

Competitive plasticity to reduce the energetic costs of learning (2023)
Working Paper
van Rossum, M. C. Competitive plasticity to reduce the energetic costs of learning

The brain is not only constrained by energy needed to fuel computation, but it is also constrained by energy needed to form memories. Experiments have shown that learning simple conditioning tasks already carries a significant metabolic cost. Yet, le... Read More about Competitive plasticity to reduce the energetic costs of learning.

Lazy learning: a biologically-inspired plasticity rule for fast and energy efficient synaptic plasticity (2023)
Working Paper
Pache, A., & Van Rossum, M. (0000). Lazy learning: a biologically-inspired plasticity rule for fast and energy efficient synaptic plasticity

When training neural networks for classification tasks with backpropagation, parameters are updated on every trial, even if the sample is classified correctly. In contrast, humans concentrate their learning effort on errors. Inspired by human learnin... Read More about Lazy learning: a biologically-inspired plasticity rule for fast and energy efficient synaptic plasticity.

Comparative Judgement Modeling to Map Forced Marriage at Local Levels (2023)
Working Paper
Seymour, R., Nyarko-Agyei, A., Severn, K., McCabe, H., Kypraios, T., Sirl, D., & Taylor, A. Comparative Judgement Modeling to Map Forced Marriage at Local Levels

Forcing someone into marriage against their will is a violation of their human rights. In 2021, the county of Nottinghamshire, UK, launched a strategy to tackle forced marriage and violence against women and girls. However, accessing information abou... Read More about Comparative Judgement Modeling to Map Forced Marriage at Local Levels.

Scenario set-up and forcing data for impact model evaluation and impact attribution within the third round of the Inter-Sectoral Model Intercomparison Project (ISIMIP3a) (2023)
Working Paper
Frieler, K., Volkholz, J., Lange, S., Schewe, J., Mengel, M., Rivas López, M. D. R., …Bechtold, M. Scenario set-up and forcing data for impact model evaluation and impact attribution within the third round of the Inter-Sectoral Model Intercomparison Project (ISIMIP3a)

This paper describes the rationale and the protocol of the first component of the third simulation round of the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP3a, www.isimip.org) and the associated set of climate-related and direct human... Read More about Scenario set-up and forcing data for impact model evaluation and impact attribution within the third round of the Inter-Sectoral Model Intercomparison Project (ISIMIP3a).

Early-Universe Model Building (2023)
Working Paper
Asadi, P., Bansal, S., Berlin, A., Co, R. T., Croon, D., Cui, Y., …Yu, H. (2023). Early-Universe Model Building

Theoretical investigations into the evolution of the early universe are an essential part of particle physics that allow us to identify viable extensions to the Standard Model as well as motivated parameter space that can be probed by various experim... Read More about Early-Universe Model Building.

Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports (2023)
Working Paper
Kovac, M., Aliev, R., Berestov, I., Aimaletdinov, A., Rutland, C., Rizvanov, A., & Zakirova, E. Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports

Injury to the proximal part of the equine suspensory ligament (SL), called proximal suspensory desmitis (PSD), commonly causes lameness in horses. PSD is extremely difficult to manage and treat, with present methods often unable to achieve full recov... Read More about Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports.

Differences between online trial participants who have used statutory mental health services and who have not: analysis of baseline data from two pragmatic trials of a digital health intervention (2023)
Working Paper
Rennick-Egglestone, S., Newby, C., Robinson, C., Yeo, C., Ng, F., Elliott, R. A., …Slade, M. Differences between online trial participants who have used statutory mental health services and who have not: analysis of baseline data from two pragmatic trials of a digital health intervention

Background: Digital health interventions have become an established part of mental health service provision internationally. Regulators have positioned the best-practice standard of evidence as an interventional study with a comparator reflective of... Read More about Differences between online trial participants who have used statutory mental health services and who have not: analysis of baseline data from two pragmatic trials of a digital health intervention.

Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy (2023)
Working Paper
Astbury, S., Baskar, A., Grove, J. I., Kaye, P., Aravinthan, A. D., James, M. W., …Venkatachalapathy, S. V. Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy

Background and study aims Pancreatic cysts are common incidental findings, with an estimated prevalence of 13-15% in imaging done for other reasons. It is difficult to identify cysts with malignant potential. Diagnosis often relies on collection of c... Read More about Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy.

Assessing changes in global fire regimes (2023)
Working Paper
Sayedi, S. S., Abbott, B., Vanniere, B., Leys, B., Colombaroli, D., Gil-Romera, G., …Daniau, A. Assessing changes in global fire regimes

Human activity has fundamentally altered wildfire on Earth, creating serious consequences for human health, global biodiversity, and climate change. However, it remains difficult to predict fire interactions with land use, management, and climate cha... Read More about Assessing changes in global fire regimes.

The influence of heteroresistance on minimum inhibitory concentration (MIC), investigated using weak-acid stress in food spoilage yeasts (2023)
Working Paper
Violet, J., Smid, J., Pielaat, A., Sanders, J., & Avery, S. V. The influence of heteroresistance on minimum inhibitory concentration (MIC), investigated using weak-acid stress in food spoilage yeasts

Populations of microbial cells may resist environmental stress by maintaining a high population-median resistance (IC50) or, potentially, a high variability in resistance between individual cells (heteroresistance); where heteroresistance would allow... Read More about The influence of heteroresistance on minimum inhibitory concentration (MIC), investigated using weak-acid stress in food spoilage yeasts.

The biocide triclosan induces (p)ppGpp dependent antibiotic tolerance and alters SarA dependent biofilm structures in Staphylococcus aureus (2023)
Working Paper
Walsh, D., Salzer, A., Wolz, C., Aylott, J., & Hardie, K. R. The biocide triclosan induces (p)ppGpp dependent antibiotic tolerance and alters SarA dependent biofilm structures in Staphylococcus aureus

The biocide triclosan is used extensively in both household and hospital settings. The chronic exposure to the biocide occurring in individuals that use triclosan-containing products results in low levels of triclosan present in the human body that h... Read More about The biocide triclosan induces (p)ppGpp dependent antibiotic tolerance and alters SarA dependent biofilm structures in Staphylococcus aureus.

AI4Green: An Open-Source ELN for Green and Sustainable Chemistry (2023)
Working Paper
Boobier, S., Davies, J., Derbenev, I., Handley, C., & Hirst, J. AI4Green: An Open-Source ELN for Green and Sustainable Chemistry

An Electronic Laboratory Notebook (ELN) combining features, including data archival, collaboration tools, and green and sustainability metrics for organic chemistry, is presented. AI4Green is a web-based application, available as open-source code and... Read More about AI4Green: An Open-Source ELN for Green and Sustainable Chemistry.

OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures (2023)
Working Paper
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Cavanagh, R., …Wright, A. J. OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures.

Estimating the energy requirements for long term memory formation (2023)
Working Paper
Girard, M., Jiang, J., & van Rossum, M. C. Estimating the energy requirements for long term memory formation

Brains consume metabolic energy to process information, but also to store memories. The energy required for memory formation can be substantial, for instance in fruit flies memory formation leads to a shorter lifespan upon subsequent starvation (Mery... Read More about Estimating the energy requirements for long term memory formation.