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Stepwise evolution of Elk-1 in early deuterostomes (2016)
Journal Article
Saxton, J., Ferjentsik, Z., Ducker, C., & Shaw, P. E. (in press). Stepwise evolution of Elk-1 in early deuterostomes. FEBS Journal, 283(6), https://doi.org/10.1111/febs.13607

Metazoans have multiple ETS paralogues with overlapping or indiscriminate biological functions. Elk- 1, one of three mammalian Ternary Complex Factors (TCFs), is a well-conserved, ETS domain-containing transcriptional regulator of mitogen-responsive... Read More about Stepwise evolution of Elk-1 in early deuterostomes.

Housing stakeholder preferences for the “soft” features of sustainable and healthy housing design in the UK (2016)
Journal Article
Prochorskaite, A., Couch, C., Malys, N., & Maliene, V. (2016). Housing stakeholder preferences for the “soft” features of sustainable and healthy housing design in the UK. International Journal of Environmental Research and Public Health, 13(1), https://doi.org/10.3390/ijerph13010111

It is widely recognised that the quantity and sustainability of new homes in the UK need to increase. However, it is important that sustainable housing is regarded holistically, and not merely in environmental terms, and incorporates elements that en... Read More about Housing stakeholder preferences for the “soft” features of sustainable and healthy housing design in the UK.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands (2015)
Journal Article
Southan, C., Sharman, J. L., Benson, H. E., Faccenda, E., Pawson, A. J., Alexander, S. P., …Davies, J. A. (2016). The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Research, 44(D1), D1054-D1068. https://doi.org/10.1093/nar/gkv1037

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Bas... Read More about The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands.

The use of viral 2A sequence for the simultaneous over-expression of both the vgf gene and enhanced green fluorescent protein eGFP (2015)
Journal Article
Lewis, J. E., Brameld, J. M., Hill, P., Barrett, P., Ebling, F. J., & Jethwa, P. (in press). The use of viral 2A sequence for the simultaneous over-expression of both the vgf gene and enhanced green fluorescent protein eGFP. Journal of Neuroscience Methods, 256, https://doi.org/10.1016/j.jneumeth.2015.08.013

Introduction: The viral 2A sequence has become an attractive alternative to the traditional internal ribosomal entry site (IRES) for simultaneous over-expression of two genes and in combination with recombinant adeno-associated viruses (rAAV) has bee... Read More about The use of viral 2A sequence for the simultaneous over-expression of both the vgf gene and enhanced green fluorescent protein eGFP.

Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone (2015)
Journal Article
Shortall, S. E., Spicer, C. H., Ebling, F. J., Green, A. R., Fone, K. C., & King, M. V. (2016). Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone. Addiction Biology, 21(6), 1127-1139. https://doi.org/10.1111/adb.12283

© 2015 Society for the Study of Addiction The psychoactive effects of mephedrone are commonly compared with those of 3,4-methylenedioxymethamphetamine, but because of a shorter duration of action, users often employ repeated administration to mainta... Read More about Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone.

Comparative analysis of MCDM methods for the assessment of sustainable housing affordability (2015)
Journal Article
Mulliner, E., Malys, N., & Maliene, V. (2016). Comparative analysis of MCDM methods for the assessment of sustainable housing affordability. Omega, 59(Part B), https://doi.org/10.1016/j.omega.2015.05.013

While affordability is traditionally assessed in economic terms, this paper tests a new assessment method that draws closer links with sustainability by considering economic, social and environmental criteria that impact on a household’s quality of l... Read More about Comparative analysis of MCDM methods for the assessment of sustainable housing affordability.

Close-range photogrammetry enables documentation of environment-induced deformation of architectural heritage (2015)
Journal Article
Sužiedelytė-Visockienė, J., Bagdžiūnaitė, R., Malys, N., & Maliene, V. (2015). Close-range photogrammetry enables documentation of environment-induced deformation of architectural heritage. Environmental Engineering and Management Journal, 14(6),

Deformation, damage and permanent loss of heritage assets due to various physical and environmental factors has always been a major problem. As the availability of funds for conservation and restoration is limited, the digital documentation of herita... Read More about Close-range photogrammetry enables documentation of environment-induced deformation of architectural heritage.

The role of Cas8 in type I CRISPR interference (2015)
Journal Article
Cass, S., Haas, K., Stoll, B., Alkhnbashi, O., Sharma, K., Urlaub, H., …Bolt, E. (2015). The role of Cas8 in type I CRISPR interference. Bioscience Reports, 35, Article e00197. https://doi.org/10.1042/BSR20150043

CRISPR (clustered regularly interspaced short palindromic repeat) systems provide bacteria and archaea with adapt- ive immunity to repel invasive genetic elements. Type I systems use ‘cascade’ [CRISPR-associated (Cas) complex for antiviral defence] r... Read More about The role of Cas8 in type I CRISPR interference.

Mitotic activity of survivin is regulated by acetylation at K129 (2015)
Journal Article
Aljaberi, A. M., Webster, J. R., & Wheatley, S. P. (2015). Mitotic activity of survivin is regulated by acetylation at K129. Cell Cycle, 14(11), https://doi.org/10.1080/15384101.2015.1033597

Survivin is a cancer-associated protein regulated by multiple factors, including acetylation at K129 within its C-terminal alpha-helical tail. Acetylation of survivin is being pursued as a potential prognostic marker in breast cancer. This modificat... Read More about Mitotic activity of survivin is regulated by acetylation at K129.

Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system (2015)
Journal Article
Malys, M. K., Campbell, L., & Malys, N. (2015). Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system. Medicina, 51(2), https://doi.org/10.1016/j.medici.2015.03.001

The human gut commensal microbiota forms a complex population of microorganisms that survive by maintaining a symbiotic relationship with the host. Amongst the metabolic benefits it brings, formation of adaptive immune system and maintenance of its h... Read More about Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system.

Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5 (2015)
Journal Article
Scott, D., Layfield, R., & Oldham, N. J. (2015). Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5. Proteomics, 15(16), https://doi.org/10.1002/pmic.201400457

Many proteins exhibit conformation flexibility as part of their biological function, whether through the presence of a series of well-defined states or by the existence of intrinsic disorder. Ion mobility spectrometry, in combination with MS (IM–MS),... Read More about Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.

The functional repertoire of survivin's tails (2015)
Journal Article
Wheatley, S. P. (2015). The functional repertoire of survivin's tails. Cell Cycle, 14(2), https://doi.org/10.4161/15384101.2014.979680

Survivin is a multitasking protein that can inhibit cell death and that is essential for mitosis. Due to these prosurvival activities and the correlation of its expression with tumour resistance to conventional cancer treatments, survivin has receive... Read More about The functional repertoire of survivin's tails.

Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3 (2014)
Journal Article
Gong, B., Shin, M., Sun, J., Jung, C., Bolt, E. L., van der oost, J., & Kim, J. (2014). Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3. Proceedings of the National Academy of Sciences, 111(46), https://doi.org/10.1073/pnas.1410806111

Mobile genetic elements in bacteria are neutralized by a system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins. Type I CRISPR-Cas systems use a “Cascade” ribonucleoprotein complex to... Read More about Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3.

Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer (2014)
Journal Article
Aljaberi, A. M., Webster, J. R., & Wheatley, S. P. (in press). Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer. Cancer Cell International, 14, Article 78. https://doi.org/10.1186/s12935-014-0078-8

Background Survivin is a protein that is normally present only in G2 and M-phases in somatic cells, however, in cancer cells, it is expressed throughout the cell cycle. A prosurvival factor, survivin is both an inhibitor of apoptosis and an essentia... Read More about Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer.

Etiology of the membrane potential of rat white fat adipocytes (2014)
Journal Article
Bentley, D. C., Pulbutr, P., Chan, S., & Smith, P. A. (2014). Etiology of the membrane potential of rat white fat adipocytes. AJP - Endocrinology and Metabolism, 307(2), E161-E175. https://doi.org/10.1152/ajpendo.00446.2013

The plasma membrane potential (Vm) is key to many physiological processes, however its ionic aetiology in white fat adipocytes is poorly characterised. To address this question, we have employed the perforated patch current-clamp and cell-attached pa... Read More about Etiology of the membrane potential of rat white fat adipocytes.

Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage (2014)
Journal Article
Yang, X., Hamner, M. A., Brown, A. M., Evans, R. D., Ye, Z., Chen, S., & Ransom, B. R. (2014). Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage. Annals of Neurology, 75(4), https://doi.org/10.1002/ana.24050

Objective: Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined if glutamate receptors were involved in hypoglycemic WM injury. Methods: Mouse optic nerves (MON), CNS WM tracts, were mai... Read More about Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.

Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training (2014)
Journal Article
Murton, A. J., Billeter, R., Stephens, F. B., Des Etages, S., Graber, F., Hill, R., …Greenhaff, P. L. (2014). Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training. Journal of Applied Physiology, 116(1), https://doi.org/10.1152/japplphysiol.00426.2013

We sought to ascertain the time course of transcriptional events that occur in human skeletal muscle at the outset of resistance exercise (RE) training in RE naive individuals and determine whether the magnitude of response was associated with exerci... Read More about Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training.

Surgical resection of primary tumour improves aerobic performance in colorectal cancer (2013)
Journal Article
Williams, J. P., Nyasavajjala, S. M., Phillips, B. E., Chakrabarty, M., & Lund, J. N. (2014). Surgical resection of primary tumour improves aerobic performance in colorectal cancer. EJSO - European Journal of Surgical Oncology, 40(2), https://doi.org/10.1016/j.ejso.2013.11.009

Background Colorectal cancer is the third most common cancer in the UK, with patients suffering declines in muscle mass and aerobic function. We hypothesised that tumour removal in non-metastatic colorectal cancer would lead to a restoration of le... Read More about Surgical resection of primary tumour improves aerobic performance in colorectal cancer.