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Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis (2021)
Journal Article
Keppie, S. J., Mansfield, J. C., Tang, X., Philp, C. J., Graham, H. K., Önnerfjord, P., …Vincent, T. L. (2021). Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis. Function, 2(5), Article zqab037. https://doi.org/10.1093/function/zqab037

Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here, we describe t... Read More about Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis.

Magnetic Field Mapping and Correction for Moving OP-MEG (2021)
Journal Article
Mellor, S., Tierney, T. M., O'Neill, G. C., Alexander, N., Seymour, R. A., Holmes, N., …Barnes, G. R. (2022). Magnetic Field Mapping and Correction for Moving OP-MEG. IEEE Transactions on Biomedical Engineering, 69(2), 528-536. https://doi.org/10.1109/TBME.2021.3100770

Background: Optically pumped magnetometers (OPMs) have made moving, wearable magnetoencephalography (MEG) possible. The OPMs typically used for MEG require a low background magnetic field to operate, which is achieved using both passive and active ma... Read More about Magnetic Field Mapping and Correction for Moving OP-MEG.

Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T (2021)
Journal Article
Dewey, R. S., Dineen, R. A., Clemence, M., Dick, O., Bowtell, R., & Kitterick, P. T. (2021). Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T. Otology and Neurotology, 42(10), e1449-e1456. https://doi.org/10.1097/MAO.0000000000003281

Background:Brain magnetic resonance imaging in patients with cochlear implants (CIs) is impacted by image artefacts.Hypothesis:The optimal positioning of the CI to minimize artefacts is unknown. This study aimed to characterize the dependence of the... Read More about Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T.

Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI (2021)
Journal Article
Dewey, R. S., Hall, D. A., Plack, C. J., & Francis, S. T. (2021). Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI. Magnetic Resonance in Medicine, 86(5), 2577-2588. https://doi.org/10.1002/mrm.28902

Purpose Detecting sound-related activity using functional MRI requires the auditory stimulus to be more salient than the intense background scanner acoustic noise. Various strategies can reduce the impact of scanner acoustic noise, including “sparse... Read More about Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI.

Comparison of continuous sampling with active noise cancellation and sparse sampling for cortical and subcortical auditory fMRI (2021)
Journal Article
Dewey, R. S., Hall, D. A., Plack, C. J., & Francis, S. T. (2021). Comparison of continuous sampling with active noise cancellation and sparse sampling for cortical and subcortical auditory fMRI. Magnetic Resonance in Medicine, 86(5), 2577-2588. https://doi.org/10.1002/mrm.28902

Purpose Detecting sound-related activity using functional MRI requires the auditory stimulus to be more salient than the intense background scanner acoustic noise. Various strategies can reduce the impact of scanner acoustic noise, including “sparse... Read More about Comparison of continuous sampling with active noise cancellation and sparse sampling for cortical and subcortical auditory fMRI.

Interlayer connectivity reconstruction for multilayer brain networks using phase oscillator models (2021)
Journal Article
Tewarie, P., Prasse, B., Meier, J. M., Byrne, Á., De Domenico, M., Stam, C. J. (., …Van Mieghem, P. (2021). Interlayer connectivity reconstruction for multilayer brain networks using phase oscillator models. New Journal of Physics, 23(6), Article 063065. https://doi.org/10.1088/1367-2630/ac066d

Large-scale neurophysiological networks are often reconstructed from band-pass filtered time series derived from magnetoencephalography (MEG) data. Common practice is to reconstruct these networks separately for different frequency bands and to treat... Read More about Interlayer connectivity reconstruction for multilayer brain networks using phase oscillator models.

Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI (2021)
Journal Article
Sharif, H., Hoad, C. L., Abrehart, N., Gowland, P. A., Spiller, R. C., Kirkham, S., …Marciani, L. (2021). Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI. Diagnostics, 11(6), Article 974. https://doi.org/10.3390/diagnostics11060974

Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provid... Read More about Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.

Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia (2021)
Journal Article
Dineen, R. A., Blanchard, C. C., Pszczolkowski, S., Paine, S., Prasad, M., Chow, G., …Auer, D. P. (2021). Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia. American Journal of Neuroradiology, 42(6), 1144-1150. https://doi.org/10.3174/ajnr.a7107

Background and Purpose Susceptibility-weighted imaging (SWI) hypointense cerebral lesions have been reported in adults with the inherited cerebellar neurodegenerative disorder ataxia telangiectasia (A-T). This study aims to establish the prevalence... Read More about Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia.

Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts (2021)
Journal Article
Elkrief, L., Spinney, S., Vosberg, D. E., Banaschewski, T., Bokde, A., Quinlan, E. B., …Conrod, P. (2021). Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts. Frontiers in Psychiatry, 12, Article 645746. https://doi.org/10.3389/fpsyt.2021.645746

Genetic markers of endocannabinoid system have been linked to a variety of addiction-related behaviours that extend beyond cannabis use. In the current study we investigate the relationship between eCB genetic markers and AUDs in European adolescents... Read More about Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts.

Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modelling Study (2021)
Journal Article
Hodkinson, D. J., Bungert, A., Bowtell, R. W., Jackson, S. R., & Jung, J. (2021). Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modelling Study. Journal of Neurophysiology, 125(4), 1180-1190. https://doi.org/10.1152/jn.00670.2020

The ability to induce neuroplasticity with non-invasive brain stimulation techniques offers a unique opportunity to examine the human brain systems involved in pain modulation. In experimental and clinical settings, the primary motor cortex (M1) is c... Read More about Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modelling Study.

Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA) (2021)
Journal Article
Ní Leidhin, C., McMorrow, J., Carey, D., Newman, L., Williamson, W., Fagan, A. J., …Knight, S. P. (2021). Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA). NeuroImage, 229, Article 117741. https://doi.org/10.1016/j.neuroimage.2021.117741

Objective To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. Backgroun... Read More about Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA).

MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability (2020)
Journal Article
Scott, R. A., Williams, H. G., Hoad, C. L., Alyami, A., Ortori, C. A., Grove, J. I., …Gowland, P. A. (2021). MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability. Journal of Magnetic Resonance Imaging, 53(5), 1422-1431. https://doi.org/10.1002/jmri.27463

Background: Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the efficacy of... Read More about MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability.

Thermal taster status: Temperature modulation of cortical response to sweetness perception (2020)
Journal Article
Eldeghaidy, S., Yang, Q., Abualait, T., Williamson, A., Hort, J., & Francis, S. T. (2021). Thermal taster status: Temperature modulation of cortical response to sweetness perception. Physiology and Behavior, 230, Article 113266. https://doi.org/10.1016/j.physbeh.2020.113266

© 2020 Temperature is known to impact taste perception, but its reported effect on sweet taste perception in humans is inconsistent. Here, we assess whether thermal taste phenotype alters the temperature modulation of the brains’ response to sweet sa... Read More about Thermal taster status: Temperature modulation of cortical response to sweetness perception.

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants (2020)
Journal Article
Heissam, K., Abrehart, N., Hoad, C. L., Wright, J., Menys, A., Murray, K., …Marciani, L. (2020). Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants. PLoS ONE, 15(11), e0241441. https://doi.org/10.1371/journal.pone.0241441

Objective The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo dat... Read More about Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.

Circadian variation in renal blood flow and kidney function in healthy volunteers monitored using non-invasive magnetic resonance imaging (2020)
Journal Article
Eckerbom, P., Hansell, P., Cox, E., Buchanan, C., Weis, J., Palm, F., …Liss, P. (2020). Circadian variation in renal blood flow and kidney function in healthy volunteers monitored using non-invasive magnetic resonance imaging. AJP - Renal Physiology, 319(6), F966-F978. https://doi.org/10.1152/ajprenal.00311.2020

Circadian regulation of kidney function is involved in maintaining whole-body homeostasis and dysfunctional circadian rhythm can potentially be involved in disease development. Magnetic Resonance Imaging (MRI)provides reliable and reproducible repeti... Read More about Circadian variation in renal blood flow and kidney function in healthy volunteers monitored using non-invasive magnetic resonance imaging.

Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation (2020)
Journal Article
Sharif, H., Abrehart, N., Hoad, C., Murray, K., Perkins, A., Smith, M., …Marciani, L. (2020). Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation. Journal of Pediatric Gastroenterology and Nutrition, 71(5), 604-611. https://doi.org/10.1097/MPG.0000000000002910

Objective: In England, 27,500 children are referred annually to hospital with constipation. An objective measure of whole gut transit time (WGTT) could aid management. The current standard WGTT assessment, the X-ray radiopaque marker (ROM) test, give... Read More about Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation.

Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study (2020)
Journal Article
Safavi, S., Arthofer, C., Cooper, A., Harkin, J. W., Prayle, A. P., Sovani, M. P., …Hall, I. P. (2020). Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study. European Journal of Radiology, 130, Article 109196. https://doi.org/10.1016/j.ejrad.2020.109196

Purpose The diaphragm is the most important muscle of respiration. Disorders of the diaphragm can have a deleterious impact on respiratory function. We aimed to evaluate the use of an open-configuration upright low-field MRI system to assess diaphra... Read More about Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study.

A nociresponsive specific area of human somatosensory cortex within BA3a: BA3c? (2020)
Journal Article
Sanchez Panchuelo, R. M., Eldeghaidy, S., Marshall, A., McGlone, F., Francis, S. T., & Favorov, O. (2020). A nociresponsive specific area of human somatosensory cortex within BA3a: BA3c?. NeuroImage, 221, https://doi.org/10.1016/j.neuroimage.2020.117187

© 2020 It is well recognized that in primates, including humans, noxious body stimulation evokes a neural response in the posterior bank of the central sulcus, in Brodmann cytoarchitectonic subdivisions 3b and 1 of the primary somatosensory cortex. T... Read More about A nociresponsive specific area of human somatosensory cortex within BA3a: BA3c?.

Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques (2020)
Journal Article
Stamatopoulos, K., Karandikar, S., Goldstein, M., O’Farrell, C., Marciani, L., Sulaiman, S., …Batchelor, H. K. (2020). Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques. Pharmaceutics, 12(7), Article 659. https://doi.org/10.3390/pharmaceutics12070659

This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particl... Read More about Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques.