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All Outputs (27)

Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition (2017)
Journal Article
Bast, T., Pezze, M., & McGarrity, S. (2017). Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition. British Journal of Pharmacology, 174(19), 3211-3225. https://doi.org/10.1111/bph.13850

We review recent evidence concerning the significance of inhibitory GABA transmission and of neural disinhibition, i.e. deficient GABA transmission, within prefrontal cortex and hippocampus for clinically relevant cognitive functions. Both regions su... Read More about Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition.

Hippocampal neural disinhibition causes attentional and memory deficits (2016)
Journal Article
McGarrity, S., Mason, R., Fone, K. C., Pezze, M. A., & Bast, T. (2017). Hippocampal neural disinhibition causes attentional and memory deficits. Cerebral Cortex, 27(9), https://doi.org/10.1093/cercor/bhw247

Subconvulsive hippocampal neural disinhibition, that is reduced GABAergic inhibition, has been implicated in neuropsychiatric disorders characterized by attentional and memory deficits, including schizophrenia and age-related cognitive decline. Consi... Read More about Hippocampal neural disinhibition causes attentional and memory deficits.

Hippocampus and two-way active avoidance conditioning: Contrasting effects of cytotoxic lesion and temporary inactivation (2015)
Journal Article
Wang, J., Bast, T., Wang, Y. C., & Zhang, W. N. (2015). Hippocampus and two-way active avoidance conditioning: Contrasting effects of cytotoxic lesion and temporary inactivation. Hippocampus, 25(12), 1517-1531. https://doi.org/10.1002/hipo.22471

© 2015 Wiley Periodicals, Inc. Hippocampal lesions tend to facilitate two-way active avoidance (2WAA) conditioning, where rats learn to cross to the opposite side of a conditioning chamber to avoid a tone-signaled footshock. This classical finding ha... Read More about Hippocampus and two-way active avoidance conditioning: Contrasting effects of cytotoxic lesion and temporary inactivation.

Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning (2015)
Journal Article
Voigt, J. P., Lee, J. L. C., Heath, F. C., Jurkus, R., Bast, T., Pezze, M. A., …Stevenson, C. W. (2015). Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning. Psychopharmacology, 232(14), 2619-2629. https://doi.org/10.1007/s00213-015-3897-y

RATIONALE: Dopamine D1-like receptor signalling is involved in contextual fear conditioning, but the brain regions involved and its role in other contextual fear memory processes remain unclear. OBJECTIVES: The objective of this study was to inves... Read More about Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning.

Spatial memory: behavioural determinants of persistence in the watermaze delayed matching-to-place task (2014)
Journal Article
da Silva, B. M., Bast, T., & Morris, R. G. (2014). Spatial memory: behavioural determinants of persistence in the watermaze delayed matching-to-place task. Learning and Memory, 21, https://doi.org/10.1101/lm.032169.113

The watermaze delayed matching-to-place (DMP) task was modified to include probe trials, to quantify search preference for the correct place. Using a zone-analysis of search-preference, a gradual decay of one-trial memory in rats was observed over 24... Read More about Spatial memory: behavioural determinants of persistence in the watermaze delayed matching-to-place task.

Temporary inhibition of dorsal or ventral hippocampus by muscimol: Distinct effects on measures of innate anxiety on the elevated plus maze, but similar disruption of contextual fear conditioning (2013)
Journal Article
Zhang, W., Bast, T., Yan, X., & Feldon, J. (2014). Temporary inhibition of dorsal or ventral hippocampus by muscimol: Distinct effects on measures of innate anxiety on the elevated plus maze, but similar disruption of contextual fear conditioning. Behavioural Brain Research, 262, 47-56. https://doi.org/10.1016/j.bbr.2013.10.044

Studies in rats, involving hippocampal lesions and hippocampal drug infusions, have implicated the hippocampus in the modulation of anxiety-related behaviors and conditioned fear. The ventral hippocampus is considered to be more important for anxiety... Read More about Temporary inhibition of dorsal or ventral hippocampus by muscimol: Distinct effects on measures of innate anxiety on the elevated plus maze, but similar disruption of contextual fear conditioning.