A systematic review finds variable use of the intention-to-treat principle in musculoskeletal randomized controlled trials with missing data

Joseph, Royes; Ogollah, Reuben; Sim, Julius; Lewis, Martyn

doi:10.1016/j.jclinepi.2014.09.002

Responsiveness and Minimal Important Change for Pain and Disability Outcome Measures in Pregnancy-Related Low Back and Pelvic Girdle Pain (2019)
Journal Article
Ogollah, R., Bishop, A., Lewis, M., Grotle, M., & Foster, N. E. (2019). Responsiveness and Minimal Important Change for Pain and Disability Outcome Measures in Pregnancy-Related Low Back and Pelvic Girdle Pain. Physical Therapy, 99(11), 1551-1561. https://doi.org/10.1093/ptj/pzz107

Background Pregnancy-related low back pain and pelvic girdle pain (LBP/PGP) are common and negatively impact the lives of many pregnant women. Several patient-based outcome instruments measure treatment effect but there is no consensus about which m... Read More about Responsiveness and Minimal Important Change for Pain and Disability Outcome Measures in Pregnancy-Related Low Back and Pelvic Girdle Pain.

Non-traditional support workers delivering a brief psychosocial intervention for older people with anxiety and depression: the NOTEPAD feasibility study (2019)
Journal Article
Burroughs, H., Bartlam, B., Bullock, P., Lovell, K., Ogollah, R., Ray, M., …Chew-Graham, C. A. (2019). Non-traditional support workers delivering a brief psychosocial intervention for older people with anxiety and depression: the NOTEPAD feasibility study. Health Services and Delivery Research, 7(25), 1-120. https://doi.org/10.3310/hsdr07250

Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm (2019)
Journal Article
Konstantinou, K., Dunn, K. M., van der Windt, D., Ogollah, R., Jasani, V., Foster, N. E., & SCOPiC study team, . (2019). Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm. BMC Musculoskeletal Disorders, 20, 1-9. https://doi.org/10.1186/s12891-019-2686-x

Background Sciatica is a painful condition managed by a stepped care approach for most patients. Currently, there are no decision-making tools to guide matching care pathways for patients with sciatica without evidence of serious pathology, early in... Read More about Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm.

Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis (2019)
Journal Article
Kigozi, J., Konstantinou, K., Ogollah, R., Dunn, K., Martyn, L., & Jowett, S. (2019). Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis. BMC Health Services Research, 19, 1-9. https://doi.org/10.1186/s12913-019-4257-0

© 2019 The Author(s). Background: There is limited research on the economic burden of low back-related leg pain, including sciatica. The aim of this study was to describe healthcare resource utilisation and factors associated with cost and health out... Read More about Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis.

Willingness to adhere to current UK low-risk alcohol guidelines to potentially reduce dementia risk: a national survey of people aged 50 and over (2019)
Journal Article
Oliveira, D., Jones, K. A., Ozupek, S., Ogollah, R., Hogervorst, E., & Orrell, M. (2019). Willingness to adhere to current UK low-risk alcohol guidelines to potentially reduce dementia risk: a national survey of people aged 50 and over. Journal of Alzheimer's Disease, 69(3), 829-837. https://doi.org/10.3233/JAD-181224

Air pollution is a risk factor for cardiovascular and respiratory morbidity and mortality. A growing literature also links exposure to diverse air pollutants (e.g., nanoparticles, particulate matter, ozone, traffic-related air pollution) with brain h... Read More about Willingness to adhere to current UK low-risk alcohol guidelines to potentially reduce dementia risk: a national survey of people aged 50 and over.

‘Acute flare-ups’ in patients with, or at high risk of, knee osteoarthritis: a daily diary study with case-crossover analysis (2019)
Journal Article
Parry, E., Ogollah, R., & Peat, G. (2019). ‘Acute flare-ups’ in patients with, or at high risk of, knee osteoarthritis: a daily diary study with case-crossover analysis. Osteoarthritis and Cartilage, 27(8), 1124-1128. https://doi.org/10.1016/j.joca.2019.04.003

OBJECTIVE: To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures. DESIGN: Adults aged ≥45 years with a recent primary care consultation for knee OA/arthralgia completed a daily pen-and-pape... Read More about ‘Acute flare-ups’ in patients with, or at high risk of, knee osteoarthritis: a daily diary study with case-crossover analysis.

Factors associated with physiotherapists' preference for MRI in primary care patients with low back and leg pain (2018)
Journal Article
Ely, S., Stynes, S., Ogollah, R., Foster, N. E., & Konstantinou, K. (2018). Factors associated with physiotherapists' preference for MRI in primary care patients with low back and leg pain. Musculoskeletal Science and Practice, 38, 46-52. https://doi.org/10.1016/j.msksp.2018.09.003

© 2018 Background: Criticisms about overuse of MRI in low back pain are well documented. Yet, with the exception of suspicion of serious pathology, little is known about factors that influence clinicians’ preference for magnetic resonance imaging (MR... Read More about Factors associated with physiotherapists' preference for MRI in primary care patients with low back and leg pain.

Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain (2018)
Journal Article
Stynes, S., Konstantinou, K., Ogollah, R. O., Hay, E. M., & Dunn, K. M. (2018). Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain. PLoS ONE, 13(4), Article e0191852. https://doi.org/10.1371/journal.pone.0191852

Background Identification of sciatica may assist timely management but can be challenging in clinical practice. Diagnostic models to identify sciatica have mainly been developed in secondary care settings with conflicting reference standard select... Read More about Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain.

Determining one-year trajectories of low back related leg pain in primary care patients: growth mixture modelling of a prospective cohort study (2018)
Journal Article
Ogollah, R. O., Konstantinou, K., Stynes, S., & Dunn, K. M. (2018). Determining one-year trajectories of low back related leg pain in primary care patients: growth mixture modelling of a prospective cohort study. Arthritis Care and Research, 70(12), 1840-1848. https://doi.org/10.1002/acr.23556

Objective The clinical presentation and outcome of patients with back and leg pain in primary care are heterogeneous and may be better understood by identification of homogeneous and clinically meaningful subgroups. Subgroups of patients with diff... Read More about Determining one-year trajectories of low back related leg pain in primary care patients: growth mixture modelling of a prospective cohort study.

A feasibility study for NOn-Traditional providers to support the management of Elderly People with Anxiety and Depression: the NOTEPAD study Protocol (2018)
Journal Article
Burroughs, H., Bartlam, B., Kingstone, T., Shepherd, T., Ogollah, R. O., Proctor, J., …Chew-Graham, C. (2018). A feasibility study for NOn-Traditional providers to support the management of Elderly People with Anxiety and Depression: the NOTEPAD study Protocol. Trials, 19, Article 172. https://doi.org/10.1186/s13063-018-2550-6

BACKGROUND: Anxiety and depression are common among older people, with up to 20% reporting such symptoms, and the prevalence increases with co-morbid chronic physical health problems. Access to treatment for anxiety and depression in this population... Read More about A feasibility study for NOn-Traditional providers to support the management of Elderly People with Anxiety and Depression: the NOTEPAD study Protocol.

Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial (2018)
Journal Article
Quicke, J. G., Foster, N. E., Croft, P. R., Ogollah, R. O., & Holden, M. A. (2018). Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial. BMC Musculoskeletal Disorders, 19, Article 59. https://doi.org/10.1186/s12891-018-1968-z

BACKGROUND: Exercise interventions improve clinical outcomes of pain and function in adults with knee pain due to osteoarthritis and higher levels of physical activity are associated with lower severity of pain and higher levels of physical function... Read More about Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial.

Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up (2018)
Journal Article
Stynes, S., Konstantinou, K., Ogollah, R. O., Hay, E. M. H., & Dunn, K. M. (2018). Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up. PAIN, 159(4), https://doi.org/10.1097/j.pain.0000000000001147

Traditionally, low back-related leg pain (LBLP) is diagnosed clinically as referred leg pain or sciatica (nerve root involvement). However, within the spectrum of LBLP, we hypothesised that there may be other unrecognised patient subgroups. This stud... Read More about Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up.

Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort (2017)
Journal Article
Konstantinou, K., Dunn, K. M., Ogollah, R. O., Lewis, M., Windt, D. V. D., & Hay, E. M. H. (2018). Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort. Spine Journal, 18(6), https://doi.org/10.1016/j.spinee.2017.10.071

BACKGROUND CONTEXT: Evidence is lacking on the prognosis and prognostic factors of back-related leg pain and sciatica in patients seeing their primary care physicians. This evidence could guide timely appropriate treatment and referral decisions. PU... Read More about Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort.

Relationship Between Attitudes and Beliefs and Physical Activity in Older Adults With Knee Pain: Secondary Analysis of a Randomized Controlled Trial: Attitudes About Physical Activity in Older Adults With Knee Pain (2017)
Journal Article
Quicke, J. G., Foster, N. E., Ogollah, R. O., Croft, P. R., & Holden, M. A. (2017). Relationship Between Attitudes and Beliefs and Physical Activity in Older Adults With Knee Pain: Secondary Analysis of a Randomized Controlled Trial: Attitudes About Physical Activity in Older Adults With Knee Pain. Arthritis Care and Research, 69(8), 1192-1200. https://doi.org/10.1002/acr.23104

OBJECTIVE: To investigate how attitudes and beliefs about exercise relate to physical activity behavior in older adults with knee pain attributable to osteoarthritis (OA). METHODS: We conducted secondary data analyses of a randomized controlled... Read More about Relationship Between Attitudes and Beliefs and Physical Activity in Older Adults With Knee Pain: Secondary Analysis of a Randomized Controlled Trial: Attitudes About Physical Activity in Older Adults With Knee Pain.

STEMS pilot trial: a pilot cluster randomised controlled trial to investigate the addition of patient direct access to physiotherapy to usual GP-led primary care for adults with musculoskeletal pain (2017)
Journal Article
Bishop, A., Ogollah, R. O., Jowett, S., Kigozi, J., Tooth, S., Protheroe, J., …Foster, N. E. (2017). STEMS pilot trial: a pilot cluster randomised controlled trial to investigate the addition of patient direct access to physiotherapy to usual GP-led primary care for adults with musculoskeletal pain. BMJ Open, 7(3), Article e012987. https://doi.org/10.1136/bmjopen-2016-012987

INTRODUCTION: Around 17% of general practitioner (GP) consultations are for musculoskeletal conditions, which will rise as the population ages. Patient direct access to physiotherapy provides one solution, yet adoption in the National Health Service... Read More about STEMS pilot trial: a pilot cluster randomised controlled trial to investigate the addition of patient direct access to physiotherapy to usual GP-led primary care for adults with musculoskeletal pain.

Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): A feasibility study and pilot randomised trial (2016)
Journal Article
Foster, N. E., Bishop, A., Bartlam, B., Ogollah, R., Barlas, P., Holden, M., …Young, J. (2016). Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): A feasibility study and pilot randomised trial. Health Technology Assessment, 20(33), 1-235. https://doi.org/10.3310/hta20330

© Queen’s Printer and Controller of HMSO 2016. Background: Many pregnant women experience low back pain. Acupuncture appears to be a safe, promising intervention but evidence is needed about its clinical effectiveness and cost-effectiveness. Objectiv... Read More about Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): A feasibility study and pilot randomised trial.

A systematic review finds variable use of the intention-to-treat principle in musculoskeletal randomized controlled trials with missing data (2014)
Journal Article
Joseph, R., Ogollah, R., Sim, J., & Lewis, M. (2015). A systematic review finds variable use of the intention-to-treat principle in musculoskeletal randomized controlled trials with missing data. Journal of Clinical Epidemiology, 68(1), 15-24. https://doi.org/10.1016/j.jclinepi.2014.09.002

Objectives: In randomized trials, the primary analysis should be consistent with the intention-to-treat (ITT) principle and should address missing data appropriately to draw valid inferences. This review focuses on current practices relating to the... Read More about A systematic review finds variable use of the intention-to-treat principle in musculoskeletal randomized controlled trials with missing data.

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