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Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping (2015)
Journal Article
Tres, F., Aylott, J., Patient, J. D., Williams, P. M., Treacher, K., Booth, J., …Burley, J. C. (2015). Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping. Molecular Pharmaceutics, 12(5), 1512–1522. https://doi.org/10.1021/mp500829v

Real-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallization transitions of amorphous bicalutamide formulated as a molecular dispersion in a copovidone VA64 matrix. The dissolution performance was also investi... Read More about Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping.

Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption (2015)
Journal Article
Hook, A. L., Williams, P. M., Alexander, M. R., & Scurr, D. J. (2015). Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption. Biointerphases, 10, Article 019005. https://doi.org/10.1116/1.4906484

The complexity of hyperspectral time of flight secondary ion mass spectrometry (ToF-SIMS) datasets makes their subsequent analysis and interpretation challenging, and is often an impasse to the identification of trends and differences within large sa... Read More about Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption.

Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity (2014)
Journal Article
Sanni, O., Chang, C., Anderson, D. G., Langer, R., Davies, M. C., Williams, P. M., …Hook, A. L. (2015). Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity. Advanced Healthcare Materials, 4(5), 695-701. https://doi.org/10.1002/adhm.201400648

A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria i... Read More about Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity.

Atomic force microscopy study of human amylin (20-29) fibrils (2005)
Journal Article
Sedman, V. L., Allen, S., Chan, W. C., Davies, M. C., Roberts, C. J., Tendler, S. J., & Williams, P. M. (2005). Atomic force microscopy study of human amylin (20-29) fibrils. Protein and Peptide Letters, 12(1), 79-83. https://doi.org/10.2174/0929866053406129

Here we present atomic force microscopy images of the fibrils formed by human amylin(20-29). This peptide is a fragment of the polypeptide amylin, the major proteinaceous component of amyloid deposits found in cases of type-II diabetes mellitus. Our... Read More about Atomic force microscopy study of human amylin (20-29) fibrils.