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All Outputs (63)

Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study (2021)
Journal Article
Blake, H., Knight, H., Jia, R., Corner, J., Morling, J. R., Denning, C., …Vedhara, K. (2021). Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study. International Journal of Environmental Research and Public Health, 18(8), Article 4182. https://doi.org/10.3390/ijerph18084182

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation, during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups condu... Read More about Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study.

Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements (2021)
Journal Article
Hamed, A., Todd, I., Tighe, P. J., Powell, R. J., Harrison, T., & Fairclough, L. (2021). Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements. Journal of Immunological Methods, 492, Article 112999. https://doi.org/10.1016/j.jim.2021.112999

© 2021 Elsevier B.V. Skin prick testing (SPT) and measurement of serum allergen-specific IgE (sIgE) are used to investigate asthma and other allergic conditions. Measurement of serum total IgE (tIgE) and allergen-specific IgG4 (sIgG4) may also be use... Read More about Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements.

Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study (2021)
Working Paper
Blake, H., Knight, H., Jia, R., Corner, J., Morling, J. R., Denning, C., …Vedhara, K. Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups conduc... Read More about Students’ Views Towards SARS-CoV-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study.

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2020)
Journal Article
Blake, H., Corner, J., Cirelli, C., Hassard, J., Briggs, L., Daly, J. M., …Ball, J. (2021). Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study. International Journal of Environmental Research and Public Health, 18(1), 1-26. https://doi.org/10.3390/ijerph18010188

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. We aimed to explore student and staff perceptions and experiences of a pilot SARS-CoV-2 asymptomatic testing service (P-ATS) in a UK university campus setting. This was a mixed-method study co... Read More about Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study.

Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort (2020)
Working Paper
Jia, R., Knight, H., Blake, H., Corner, J., Denning, C., Ball, J., …Vedhara, K. Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort

Objective: This study examined the COVID-19 risk perceptions and mental health of university students on returning to campus in the midst of the COVID-19 pandemic. Methods: An online survey was completed during the first four weeks of the academic... Read More about Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort.

Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells (2020)
Journal Article
Chen, I. L., Todd, I., Tighe, P. J., & Fairclough, L. C. (2020). Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells. Archives of Toxicology, 94(6), 2097-2112 . https://doi.org/10.1007/s00204-020-02757-8

© 2020, The Author(s). Dendritic cells (DCs) are professional antigen presenting cells that play a critical role in bridging innate and adaptive immunity. Numerous studies have shown that tobacco constituents present in conventional cigarettes affect... Read More about Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells.

Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review (2019)
Journal Article
Tarbiah, N., Todd, I., Tighe, P. J., & Fairclough, L. C. (2019). Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review. Basic and Clinical Pharmacology and Toxicology, 125(5), 474-483. https://doi.org/10.1111/bcpt.13278

The aim of the present study was to compare concentrations of IgG, IgA, IgM and IgD in both serum and saliva samples from smoking and non-smoking subjects using a protein microarray assay. The findings were also compared to previous studies. Serum an... Read More about Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review.

A Hybrid Evolutionary Strategy to Optimise Early-Stage Cancer Screening (2019)
Conference Proceeding
Figueredo, G. P., Shi, P., Parkes, A. J., Evans, K., Garibaldi, J. M., Negm, O., …Robertson, J. (2019). A Hybrid Evolutionary Strategy to Optimise Early-Stage Cancer Screening. In 2019 IEEE Congress on Evolutionary Computation (CEC) (95-102). https://doi.org/10.1109/CEC.2019.8790316

Current methods to identify cutoff values for tumour-associated molecules (antigens) discrimination are based on statistics and brute force. These methods applied to cancer screening problems are very inefficient, especially with large data sets with... Read More about A Hybrid Evolutionary Strategy to Optimise Early-Stage Cancer Screening.

Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation (2019)
Journal Article
Negm, O. H., Singh, S., Abduljabbar, W., Hamed, M. R., Radford, P., McDermott, E. M., …Tighe, P. J. (2019). Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation. Clinical and Experimental Immunology, 197(3), 352-360. https://doi.org/10.1111/cei.13306

Tumour necrosis factor receptor‐associated periodic syndrome (TRAPS) is an hereditary autoinflammatory disorder characterised by recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNFRSF1A, which encod... Read More about Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation.

Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential (2019)
Journal Article
Raghunathan, D., Radford, P. M., Gell, C., Negus, D., Moore, C., Till, R., …Tyson, J. (2019). Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential. Scientific Reports, 9, 1-16. https://doi.org/10.1038/s41598-019-40223-3

In assessing the potential of predatory bacteria, such as Bdellovibrio bacteriovorus, to become live therapeutic agents against bacterial infections, it is crucial to understand and quantify Bdellovibrio host cell interactions at a molecular level. H... Read More about Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential.

Contribution of the alkylquinolone quorum sensing system to the interaction of Pseudomonas aeruginosa with bronchial epithelial cells. (2018)
Journal Article
Liu, Y., Hussain, F., Negm, O., Pavia, A., Halliday, N., Frédéric Dubern, J., …Martínez-Pomares, L. (2018). Contribution of the alkylquinolone quorum sensing system to the interaction of Pseudomonas aeruginosa with bronchial epithelial cells. Frontiers in Microbiology, 9, Article 3018. https://doi.org/10.3389/fmicb.2018.03018

Pseudomonas aeruginosa causes infections in patients with compromised epithelial 32 barrier function. Multiple virulence factors produced by P. aeruginosa are controlled 33 by quorum sensing (QS) via 2-alkyl-4(1H)-quinolone (AQ) signal molecules. Her... Read More about Contribution of the alkylquinolone quorum sensing system to the interaction of Pseudomonas aeruginosa with bronchial epithelial cells..

Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells (2018)
Journal Article
Alkhattabi, N., Todd, I., Negm, O., Tighe, P. J., & Fairclough, L. C. (2018). Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells. Toxicology Letters, 299, 40-46. https://doi.org/10.1016/j.toxlet.2018.09.002

Cigarette smoke has significant toxic effects on the immune system, and increases the risk of developing autoimmune diseases; one immunosuppressive effect of cigarette smoke is that it inhibits the T cell-stimulating, immunogenic properties of myeloi... Read More about Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells.

Highly sensitive label-free antibody detection using a long period fibre grating sensor (2018)
Journal Article
Liu, L., Marques, L., Correia, R., Morgan, S. P., Lee, S., Tighe, P. J., …Korposh, S. (2018). Highly sensitive label-free antibody detection using a long period fibre grating sensor. Sensors and Actuators B: Chemical, 271, 24-32. https://doi.org/10.1016/j.snb.2018.05.109

An optical fibre long period grating (LPG) biosensor is appealing in the detection of biomolecules because of the high sensitivity, label-free and real-time measurement. The miniaturized size, ability of remote sensing and immunity to electromagnetic... Read More about Highly sensitive label-free antibody detection using a long period fibre grating sensor.

Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885 (2018)
Journal Article
Shortall, S. E., Negm, O. H., Fowler, M., Fairclough, L. C., Tighe, P. J., Wigmore, P. M., & King, M. (2018). Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885. Molecular Neurobiology, 55(9), https://doi.org/10.1007/s12035-018-0940-0

Post-weaning social isolation of rats produces neuroanatomical, neurochemical and behavioral alterations resembling some core features of schizophrenia. This study examined the ability of the 5-HT? receptor antagonist SB-399885 to reverse isolation-i... Read More about Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885.

IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review (2017)
Journal Article
Hadjikyriacou Saniklidou, A., Tighe, P. J., Fairclough, L. C., & Todd, I. (in press). IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review. Archives of Dermatological Research, 310(1), https://doi.org/10.1007/s00403-017-1789-1

Bullous Pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type X... Read More about IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review.

Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease (2017)
Journal Article
Shindi, R., Al-Mehairi, A., Negm, O. H., Kalsheker, N., Gale, N., Shale, D. J., …Fairclough, L. C. (2017). Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease. Clinical Immunology, 183, https://doi.org/10.1016/j.clim.2017.09.020

Autoimmunity occurs in chronic obstructive pulmonary disease (COPD). We describe an antigen microarray for detecting serum autoantibodies (AAbs) to determine how IgM, as well as IgG, AAbs distinguish patients with COPD from controls with a history of... Read More about Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease.

Positive mood on the day of influenza vaccination predicts vaccine effectiveness: A prospective observational cohort study (2017)
Journal Article
Ayling, K., Fairclough, L., Tighe, P., Todd, I., Halliday, V., Garibaldi, J., …Vedhara, K. (2018). Positive mood on the day of influenza vaccination predicts vaccine effectiveness: A prospective observational cohort study. Brain, Behavior, and Immunity, 67, 314-323. https://doi.org/10.1016/j.bbi.2017.09.008

© 2017 Influenza vaccination is estimated to only be effective in 17–53% of older adults. Multiple patient behaviors and psychological factors have been shown to act as ‘immune modulators’ sufficient to influence vaccination outcomes. However, the re... Read More about Positive mood on the day of influenza vaccination predicts vaccine effectiveness: A prospective observational cohort study.